{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T12:50:23Z","timestamp":1780059023215,"version":"3.54.0"},"reference-count":43,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2007,12,1]],"date-time":"2007-12-01T00:00:00Z","timestamp":1196467200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,12,1]],"date-time":"2007-12-01T00:00:00Z","timestamp":1196467200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["molpharm.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Pharmacology"],"published-print":{"date-parts":[[2007,12]]},"DOI":"10.1124\/mol.107.040238","type":"journal-article","created":{"date-parts":[[2007,9,27]],"date-time":"2007-09-27T01:09:17Z","timestamp":1190855357000},"page":"1419-1424","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":49,"title":["In Vivo Oxidative Damage in Rats Is Associated with Barbiturate Response but Not Other Cytochrome P450 Inducers"],"prefix":"10.1016","volume":"72","author":[{"given":"Miroslav","family":"Dostalek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua D.","family":"Brooks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klarissa D.","family":"Hardy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ginger L.","family":"Milne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan M.","family":"Moore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sameer","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason D.","family":"Morrow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. Peter","family":"Guengerich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1124\/mol.107.040238_REF1","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1093\/toxsci\/kfj165","article-title":"Adenovirus-mediated expression of CYP2E1 produces liver toxicity in mice","volume":"91","author":"Bai","year":"2006","journal-title":"Toxicol Sci"},{"key":"10.1124\/mol.107.040238_REF2","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0090-9556(25)07635-4","article-title":"Temporal variations in the pharmacokinetics of isoniazid and N-acetylisoniazid in rats","volume":"17","author":"Belanger","year":"1989","journal-title":"Drug Metab Dispos"},{"key":"10.1124\/mol.107.040238_REF3","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1073\/pnas.0610216104","article-title":"In the regulation of cytochrome P450 genes, phenobarbital targets LKB1 for necessary activation of AMP-activated protein kinase","volume":"104","author":"Bl\u00e4ttler","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1124\/mol.107.040238_REF4","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1146\/annurev.pharmtox.44.101802.121704","article-title":"Oxidative stress, toxicology, and pharmacology of CYP2E1","volume":"44","author":"Caro","year":"2004","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"10.1124\/mol.107.040238_REF5","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0009-2797(02)00067-4","article-title":"Induction of cellular oxidative stress by aryl hydrocarbon receptor activation","volume":"141","author":"Dalton","year":"2002","journal-title":"Chem Biol Interact"},{"key":"10.1124\/mol.107.040238_REF6","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1093\/alcalc\/35.1.98","article-title":"Cytochrome P-450 2E1 activity and oxidative stress in alcoholic patients","volume":"35","author":"Dupont","year":"2000","journal-title":"Alcohol Alcohol"},{"key":"10.1124\/mol.107.040238_REF7","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1016\/0006-2952(89)90338-9","article-title":"Rat liver microsomal NADPH-supported oxidase activity and lipid peroxidation dependent on ethanol-inducible cytochrome P-450 (P-450IIE1)","volume":"38","author":"Ekstr\u00f6m","year":"1989","journal-title":"Biochem Pharmacol"},{"key":"10.1124\/mol.107.040238_REF8","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/0006-2952(89)90217-7","article-title":"Human liver microsomal cytochrome P-450IIE1. Immunological evaluation of its contribution to microsomal ethanol oxidation, carbon tetrachloride reduction and NADPH oxidase activity","volume":"38","author":"Ekstr\u00f6m","year":"1989","journal-title":"Biochem Pharmacol"},{"key":"10.1124\/mol.107.040238_REF9","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1080\/01926230590888298","article-title":"Differential display in rat livers treated for 13 weeks with phenobarbital implicates a role for metabolic and oxidative stress in nongenotoxic carcinogenicity","volume":"33","author":"Elrick","year":"2005","journal-title":"Toxicol Pathol"},{"key":"10.1124\/mol.107.040238_REF10","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/0076-6879(67)10099-2","article-title":"Microsomal lipid peroxidation","volume":"10","author":"Ernster","year":"1967","journal-title":"Methods Enzymol"},{"key":"10.1124\/mol.107.040238_REF11","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/S0022-3565(25)11915-0","article-title":"The oxidation of drugs by liver microsomes: on the role of TPNH and oxygen","volume":"119","author":"Gillette","year":"1957","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/mol.107.040238_REF12","series-title":"Principles and Methods of Toxicology","first-page":"1625","article-title":"Analysis and characterization of enzymes and nucleic acids","author":"Guengerich","year":"2001"},{"key":"10.1124\/mol.107.040238_REF13","doi-asserted-by":"crossref","first-page":"6019","DOI":"10.1021\/bi00266a045","article-title":"Purification and characterization of liver microsomal cytochromes P-450: electrophoretic, spectral, catalytic, and immunochemical properties and inducibility of eight isozymes isolated from rats treated with phenobarbital or \u03b2-naphthoflavone","volume":"21","author":"Guengerich","year":"1982","journal-title":"Biochemistry"},{"key":"10.1124\/mol.107.040238_REF14","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1021\/bi00536a035","article-title":"Estimation of isozymes of microsomal cytochrome P-450 in rats, rabbits, and humans using immunochemical staining coupled with sodium dodecyl sulfate-polyacrylamide gel electrophoresis","volume":"21","author":"Guengerich","year":"1982","journal-title":"Biochemistry"},{"key":"10.1124\/mol.107.040238_REF15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0076-6879(90)86093-B","article-title":"Role of free radicals and catalytic metal ions in human disease: an overview","volume":"186","author":"Halliwell","year":"1990","journal-title":"Methods Enzymol"},{"key":"10.1124\/mol.107.040238_REF16","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/S0076-6879(78)52037-5","article-title":"Hydrogen peroxide in hepatic microsomes","volume":"52","author":"Hildebrandt","year":"1978","journal-title":"Methods Enzymol"},{"key":"10.1124\/mol.107.040238_REF17","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.canlet.2003.09.009","article-title":"Role of phenobarbital-inducible cytochrome P450s as a source of active oxygen species in DNA-oxidation","volume":"203","author":"Imaoka","year":"2004","journal-title":"Cancer Lett"},{"key":"10.1124\/mol.107.040238_REF18","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1016\/j.freeradbiomed.2003.09.007","article-title":"The CYP inhibitor 1-aminobenzotriazole does not prevent oxidative stress associated with alcohol-induced liver injury in rats and mice","volume":"35","author":"Isayama","year":"2003","journal-title":"Free Radic Biol Med"},{"key":"10.1124\/mol.107.040238_REF19","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/j.freeradbiomed.2004.10.024","article-title":"Biomarkers of oxidative stress study III. Effects of the nonsteroidal anti-inflammatory agents indomethacin and meclofenamic acid on measurements of oxidative products of lipids in CCl4 poisoning","volume":"38","author":"Kadiiska","year":"2005","journal-title":"Free Radic Biol Med"},{"key":"10.1124\/mol.107.040238_REF20","doi-asserted-by":"crossref","first-page":"7379","DOI":"10.1021\/bi00529a009","article-title":"Metabolism of dichlorobiphenyls by highly purified isozymes of rat liver cytochrome P-450","volume":"20","author":"Kaminsky","year":"1981","journal-title":"Biochemistry"},{"key":"10.1124\/mol.107.040238_REF21","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1023\/A:1017904912654","article-title":"Effect of cytochrome P450 1A induction on oxidative damage in rat brain","volume":"223","author":"Liu","year":"2001","journal-title":"Mol Cell Biochem"},{"key":"10.1124\/mol.107.040238_REF22","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1006\/faat.1994.1042","article-title":"A 13-week toxicologic and pathologic evaluation of prolonged cytochromes P450 inhibition by 1-aminobenzotriazole in male rats","volume":"22","author":"Meschter","year":"1994","journal-title":"Fundam Appl Toxicol"},{"key":"10.1124\/mol.107.040238_REF23","doi-asserted-by":"crossref","first-page":"2502","DOI":"10.1172\/JCI116143","article-title":"Formation of novel non-cyclooxygenase-derived prostanoids (F2-isoprostanes) in carbon tetrachloride hepatotoxicity. An animal model of lipid peroxidation","volume":"90","author":"Morrow","year":"1992","journal-title":"J Clin Invest"},{"key":"10.1124\/mol.107.040238_REF24","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1056\/NEJM199505043321804","article-title":"Increase in circulating products of lipid peroxidation (F2-isoprostanes) in smokers: smoking as a cause of oxidative damage","volume":"332","author":"Morrow","year":"1995","journal-title":"New Engl J Med"},{"key":"10.1124\/mol.107.040238_REF25","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0076-6879(99)00106-8","article-title":"Mass spectrometric quantification of F2-isoprostanes in biological fluids and tissues as measure of oxidant stress","volume":"300","author":"Morrow","year":"1999","journal-title":"Methods Enzymol"},{"key":"10.1124\/mol.107.040238_REF26","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1006\/abbi.1998.0645","article-title":"Comparison of formation of D2\/E2-isoprostanes and F2-isoprostanes in vitro and in vivo-effects of oxygen tension and glutathione","volume":"353","author":"Morrow","year":"1998","journal-title":"Arch Biochem Biophys"},{"key":"10.1124\/mol.107.040238_REF27","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/0003-9861(77)90047-9","article-title":"Hydrogen peroxide formation and stoichiometry of hydroxylation reactions catalyzed by highly purified liver microsomal cytochrome P-450","volume":"180","author":"Nordblom","year":"1977","journal-title":"Arch Biochem Biophys"},{"key":"10.1124\/mol.107.040238_REF28","doi-asserted-by":"crossref","first-page":"2370","DOI":"10.1016\/S0021-9258(20)82244-3","article-title":"The carbon monoxide-binding pigment of liver microsomes. I. Evidence for its hemoprotein nature","volume":"239","author":"Omura","year":"1964","journal-title":"J Biol Chem"},{"key":"10.1124\/mol.107.040238_REF29","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1042\/bj1950761","article-title":"Autocatalytic alkylation of the cytochrome P-450 prosthetic haem group by 1-aminobenzotriazole","volume":"195","author":"Ortiz de Montellano","year":"1981","journal-title":"Biochem J"},{"key":"10.1124\/mol.107.040238_REF30","doi-asserted-by":"crossref","first-page":"887","DOI":"10.3109\/00498259009046904","article-title":"Cytochrome P-450-dependent formation of reactive oxygen radicals: isozyme-specific inhibition of P-450-mediated reduction of oxygen and carbon tetrachloride","volume":"20","author":"Persson","year":"1990","journal-title":"Xenobiotica"},{"key":"10.1124\/mol.107.040238_REF31","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1021\/tx00018a012","article-title":"Hydroxylation of chlorzoxazone as a specific probe for human liver cytochrome P-450 IIE1","volume":"3","author":"Peter","year":"1990","journal-title":"Chem Res Toxicol"},{"key":"10.1124\/mol.107.040238_REF32","doi-asserted-by":"crossref","first-page":"2652","DOI":"10.1016\/S0021-9258(19)73803-4","article-title":"Hepatic triphosphopyridine nucleotide-cytochrome c reductase: isolation, characterization, and kinetic studies","volume":"237","author":"Phillips","year":"1962","journal-title":"J Biol Chem"},{"key":"10.1124\/mol.107.040238_REF33","doi-asserted-by":"crossref","first-page":"G1135","DOI":"10.1152\/ajpgi.2001.281.5.G1135","article-title":"Nonalcoholic steatosis and steatohepatitis. II. Cytochrome P-450 enzymes and oxidative stress","volume":"281","author":"Robertson","year":"2001","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1124\/mol.107.040238_REF34","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/S0891-5849(99)00150-1","article-title":"Attenuation of endogenous oxidative stress-induced cell death by cytochrome P450 inhibitors in primary cultures of rat hepatocytes","volume":"27","author":"Shiba","year":"1999","journal-title":"Free Radic Biol Med"},{"key":"10.1124\/mol.107.040238_REF35","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1080\/004982599238038","article-title":"Association of cytochrome P450 induction with oxidative stress in vivo as evidenced by 3-hydroxylation of salicylate","volume":"29","author":"Strolin-Benedetti","year":"1999","journal-title":"Xenobiotica"},{"key":"10.1124\/mol.107.040238_REF36","doi-asserted-by":"crossref","first-page":"2280","DOI":"10.1021\/bi00382a031","article-title":"Regulation of cytochrome P-450j, a high-affinity N-nitrosodimethylamine demethylase, in rat hepatic microsomes","volume":"26","author":"Thomas","year":"1987","journal-title":"Biochemistry"},{"key":"10.1124\/mol.107.040238_REF37","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1016\/S0891-5849(03)00151-5","article-title":"The effect of valproic acid on hepatic and plasma levels of 15-F2t-isoprostane in rats","volume":"34","author":"Tong","year":"2003","journal-title":"Free Radic Biol Med"},{"key":"10.1124\/mol.107.040238_REF38","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1006\/taap.2000.9114","article-title":"Polychlorinated biphenyl-induced effects on metabolic enzymes, AP-1 binding, vitamin E, and oxidative stress in the rat liver","volume":"171","author":"Twaroski","year":"2001","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1124\/mol.107.040238_REF39","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.biocel.2006.07.001","article-title":"Free radicals and antioxidants in normal physiological functions and human disease","volume":"39","author":"Valko","year":"2007","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1124\/mol.107.040238_REF40","doi-asserted-by":"crossref","first-page":"5649","DOI":"10.1016\/S0021-9258(20)81942-5","article-title":"Metabolism of \u03b1-naphthoflavone and \u03b2-naphthoflavone by rat liver microsomes and highly purified reconstituted cytochrome P-450 systems","volume":"258","author":"Vyas","year":"1983","journal-title":"J Biol Chem"},{"key":"10.1124\/mol.107.040238_REF41","doi-asserted-by":"crossref","first-page":"12279","DOI":"10.1074\/jbc.M411019200","article-title":"Kinetic analysis of oxidation of coumarins by human cytochrome P450 2A6","volume":"280","author":"Yun","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1124\/mol.107.040238_REF42","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1038\/clpt.1993.125","article-title":"Inhibition and induction of cytochrome P4502E1-catalyzed oxidation by isoniazid in humans","volume":"54","author":"Zand","year":"1993","journal-title":"Clin Pharmacol Therapeut"},{"key":"10.1124\/mol.107.040238_REF43","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.taap.2004.01.018","article-title":"Mechanisms that regulate production of reactive oxygen species by cytochrome P450","volume":"199","author":"Zangar","year":"2004","journal-title":"Toxicol Appl Pharmacol"}],"container-title":["Molecular Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026895X24046571?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026895X24046571?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/mol.107.040238","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T09:53:17Z","timestamp":1739958797000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0026895X24046571"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,12]]},"references-count":43,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2007,12]]}},"alternative-id":["S0026895X24046571"],"URL":"https:\/\/doi.org\/10.1124\/mol.107.040238","relation":{},"ISSN":["0026-895X"],"issn-type":[{"value":"0026-895X","type":"print"}],"subject":[],"published":{"date-parts":[[2007,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"In Vivo Oxidative Damage in Rats Is Associated with Barbiturate Response but Not Other Cytochrome P450 Inducers","name":"articletitle","label":"Article Title"},{"value":"Molecular Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/mol.107.040238","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2007 The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}