{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T14:21:08Z","timestamp":1791037268165,"version":"4.1.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2008,7,1]],"date-time":"2008-07-01T00:00:00Z","timestamp":1214870400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,7,1]],"date-time":"2008-07-01T00:00:00Z","timestamp":1214870400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["molpharm.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Pharmacology"],"published-print":{"date-parts":[[2008,7]]},"DOI":"10.1124\/mol.107.044669","type":"journal-article","created":{"date-parts":[[2008,4,4]],"date-time":"2008-04-04T01:41:05Z","timestamp":1207273265000},"page":"255-263","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":49,"title":["Roles of Cytosolic Phospholipase A2 and Src Kinase in the Early Action of 2,3,7,8-Tetrachlorodibenzo-p-dioxin through a Nongenomic Pathway in MCF10A Cells"],"prefix":"10.1016","volume":"74","author":[{"given":"Bin","family":"Dong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumio","family":"Matsumura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1124\/mol.107.044669_REF1","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1038\/sj.ki.5000363","article-title":"Arachidonic acid induces ERK activation via Src SH2 domain association with the epidermal growth factor receptor","volume":"69","author":"Alexander","year":"2006","journal-title":"Kidney Int"},{"key":"10.1124\/mol.107.044669_REF2","doi-asserted-by":"crossref","first-page":"2532","DOI":"10.1073\/pnas.90.6.2532","article-title":"Mutual regulation of the transcriptional activator NF-kappa B and its inhibitor, I kappa B-alpha","volume":"90","author":"Brown","year":"1993","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1124\/mol.107.044669_REF3","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1186\/bcr1745","article-title":"Inflammation and breast cancer. Inflammatory component of mammary carcinogenesis in ErbB2 transgenic mice","volume":"9","author":"Calogero","year":"2007","journal-title":"Breast Cancer Res"},{"key":"10.1124\/mol.107.044669_REF4","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0169-5002(00)00168-9","article-title":"Prostaglandin E2 and vasoactive intestinal peptide increase vascular endothelial cell growth factor mRNAs in lung cancer cells","volume":"31","author":"Casibang","year":"2001","journal-title":"Lung Cancer"},{"key":"10.1124\/mol.107.044669_REF5","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/S0041-008X(03)00012-7","article-title":"The aryl hydrocarbon receptor antagonist, 3\u2032methoxy-4\u2032nitroflavone, attenuates 2,3,7,8-tetrachlorodibenzo-p-dioxin-dependent regulation of growth factor signaling and apoptosis in the MCF-10A cell line","volume":"188","author":"Davis","year":"2003","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1124\/mol.107.044669_REF6","first-page":"3314","article-title":"Prevention of apoptosis by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the MCF-10A cell line: correlation with increased transforming growth factor alpha production","volume":"61","author":"Davis","year":"2001","journal-title":"Cancer Res"},{"key":"10.1124\/mol.107.044669_REF7","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1186\/bcr1746","article-title":"Inflammation and breast cancer. Balancing immune response: crosstalk between adaptive and innate immune cells during breast cancer progression","volume":"9","author":"DeNardo","year":"2007","journal-title":"Breast Cancer Res"},{"key":"10.1124\/mol.107.044669_REF8","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0300-483X(02)00006-9","article-title":"Effects of src-deficiency on the expression of in vivo toxicity of TCDD in a strain of c-src knockout mice procured through six generations of backcrossings to C57BL\/6 mice","volume":"172","author":"Dunlap","year":"2002","journal-title":"Toxicology"},{"key":"10.1124\/mol.107.044669_REF9","doi-asserted-by":"crossref","first-page":"3359","DOI":"10.1210\/en.2002-221106","article-title":"17Beta-eEstradiol stimulates arachidonate release from human amnion-like WISH cells through a rapid mechanism involving a membrane receptor","volume":"144","author":"Fiorini","year":"2003","journal-title":"Endocrinology"},{"key":"10.1124\/mol.107.044669_REF10","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1002\/mc.2940010403","article-title":"Activation of transcription as a general mechanism of 2,3,7,8-tetrachlorodibenzo-p-dioxin action","volume":"1","author":"Fisher","year":"1989","journal-title":"Mol Carcinog"},{"key":"10.1124\/mol.107.044669_REF11","doi-asserted-by":"crossref","first-page":"29270","DOI":"10.1074\/jbc.270.49.29270","article-title":"Identification of functional domains of the aryl hydrocarbon receptor","volume":"270","author":"Fukunaga","year":"1995","journal-title":"J Biol Chem"},{"key":"10.1124\/mol.107.044669_REF12","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1146\/annurev.pa.35.040195.001515","article-title":"The aryl hydrocarbon receptor complex","volume":"35","author":"Hankinson","year":"1995","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"10.1124\/mol.107.044669_REF13","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/0300-483X(96)03346-X","article-title":"Stimulation of calcium uptake in cultured rat hippocampal neurons by 2,3,7,8-tetrachlorodibenzo-p-dioxin","volume":"112","author":"Hanneman","year":"1996","journal-title":"Toxicology"},{"key":"10.1124\/mol.107.044669_REF14","doi-asserted-by":"crossref","first-page":"2490","DOI":"10.1172\/JCI117258","article-title":"Induction of vascular endothelial growth factor expression by prostaglandin E2 and E1 in osteoblasts","volume":"93","author":"Harada","year":"1994","journal-title":"J Clin Investig"},{"issue":"Suppl 1","key":"10.1124\/mol.107.044669_REF15","doi-asserted-by":"crossref","first-page":"S53","DOI":"10.1677\/erc.1.01297","article-title":"Src as a therapeutic target in anti-hormone\/anti-growth factor-resistant breast cancer","volume":"13","author":"Hiscox","year":"2006","journal-title":"Endocrine-related cancer"},{"key":"10.1124\/mol.107.044669_REF16","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1006\/taap.1996.0081","article-title":"2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) elevates basal B-cell intracellular calcium concentration and suppresses surface Ig-but not CD40-induced antibody secretion","volume":"137","author":"Karras","year":"1996","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1124\/mol.107.044669_REF17","doi-asserted-by":"crossref","first-page":"pe28","DOI":"10.1126\/stke.2882005pe28","article-title":"Rapid, estrogen receptor-mediated signaling: why is the endothelium so special?","volume":"2005","author":"Kim","year":"2005","journal-title":"Sci STKE"},{"key":"10.1124\/mol.107.044669_REF18","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.canlet.2006.11.015","article-title":"Cigarette smoke as a trigger for the dioxin receptor-mediated signaling pathway","volume":"252","author":"Kitamura","year":"2007","journal-title":"Cancer Lett"},{"key":"10.1124\/mol.107.044669_REF19","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1002\/jbt.20131","article-title":"Mechanistic investigation on the cause for reduced toxicity of TCDD in wa-1 homozygous TGFalpha mutant strain of mice as compared its matching wild-type counterpart, C57BL\/6J mice","volume":"20","author":"Kitamura","year":"2006","journal-title":"J Biochem Mol Toxicol"},{"key":"10.1124\/mol.107.044669_REF20","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1080\/10408440500534164","article-title":"Neurochemical targets and behavioral effects of organohalogen compounds: an update","volume":"36","author":"Mariussen","year":"2006","journal-title":"Crit Rev Toxicol"},{"key":"10.1124\/mol.107.044669_REF21","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1093\/toxsci\/kfh272","article-title":"EGR1 is a novel target for AhR agonists in human lung epithelial cells","volume":"82","author":"Martinez","year":"2004","journal-title":"Toxicol Sci"},{"key":"10.1124\/mol.107.044669_REF22","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/0006-2952(94)90089-2","article-title":"How important is the protein phosphorylation pathway in the toxic expression of dioxin-type chemicals?","volume":"48","author":"Matsumura","year":"1994","journal-title":"Biochem Pharmacol"},{"key":"10.1124\/mol.107.044669_REF23","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/S0006-2952(03)00157-6","article-title":"On the significance of the role of cellular stress response reactions in the toxic actions of dioxin","volume":"66","author":"Matsumura","year":"2003","journal-title":"Biochem Pharmacol"},{"key":"10.1124\/mol.107.044669_REF24","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1002\/jbt.20041","article-title":"Studies on the mechanism of rapid activation of protein tyrosine phosphorylation activities, particularly c-Src kinase, by TCDD in MCF10A","volume":"18","author":"Mazina","year":"2004","journal-title":"J Biochem Mol Toxicol"},{"key":"10.1124\/mol.107.044669_REF25","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1021\/bp960067j","article-title":"Possible role of arachidonic acid in stress-induced cytochrome P450IA1 activity","volume":"12","author":"Mufti","year":"1996","journal-title":"Biotechnol Prog"},{"key":"10.1124\/mol.107.044669_REF26","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1021\/bi061925f","article-title":"Rapid activation of c-Src kinase by dioxin is mediated by the Cdc37-HSP90 complex as part of Ah receptor signaling in MCF10A cells","volume":"46","author":"Park","year":"2007","journal-title":"Biochemistry"},{"key":"10.1124\/mol.107.044669_REF27","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1002\/jbt.20040","article-title":"TCDD causes suppression of growth and differentiation of MCF10A, human mammary epithelial cells by interfering with their insulin receptor signaling through c-Src kinase and ERK activation","volume":"18","author":"Park","year":"2004","journal-title":"J Biochem Mol Toxicol"},{"key":"10.1124\/mol.107.044669_REF28","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1146\/annurev.pa.22.040182.002505","article-title":"2,3,7,8-Tetrachlorodibenzo-p-dioxin and related halogenated aromatic hydrocarbons: examination of the mechanism of toxicity","volume":"22","author":"Poland","year":"1982","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"10.1124\/mol.107.044669_REF29","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1016\/S0006-2952(97)00417-6","article-title":"Sustained increase in intracellular free calcium and activation of cyclooxygenase-2 expression in mouse hepatoma cells treated with dioxin","volume":"54","author":"Puga","year":"1997","journal-title":"Biochem Pharmacol"},{"key":"10.1124\/mol.107.044669_REF30","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1002\/(SICI)1098-2744(199707)19:2<91::AID-MC4>3.0.CO;2-O","article-title":"Downregulation of aryl hydrocarbon receptor function and cytochrome P450 1A1 induction by expression of Ha-ras oncogenes","volume":"19","author":"Reiners","year":"1997","journal-title":"Mol Carcinog"},{"key":"10.1124\/mol.107.044669_REF31","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1210\/me.2007-0109","article-title":"Integration of steroid and growth factor pathways in breast cancer: focus on signal transducers and activators of transcription and their potential role in resistance","volume":"21","author":"Silva","year":"2007","journal-title":"Mol Endocrinol"},{"key":"10.1124\/mol.107.044669_REF32","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1124\/mol.106.028365","article-title":"Role of dioxin response element and nuclear factor-\u03baB motifs in 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated regulation of Fas and Fas ligand expression","volume":"71","author":"Singh","year":"2007","journal-title":"Mol Pharmacol"},{"key":"10.1124\/mol.107.044669_REF33","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1126\/science.8096091","article-title":"NF-kappa B controls expression of inhibitor I kappa B alpha: evidence for an inducible autoregulatory pathway","volume":"259","author":"Sun","year":"1993","journal-title":"Science"},{"key":"10.1124\/mol.107.044669_REF34","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/S0022-3565(24)37463-4","article-title":"Glycine site antagonists and partial agonists inhibit N-methyl-d-aspartate receptor-mediated [3H]arachidonic acid release in cerebellar granule cells","volume":"285","author":"Viu","year":"1998","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/mol.107.044669_REF35","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1016\/j.bbalip.2006.08.003","article-title":"Control of phospholipase A2 activities for the treatment of inflammatory conditions","volume":"1761","author":"Yedgar","year":"2006","journal-title":"Biochim Biophys Acta"},{"key":"10.1124\/mol.107.044669_REF36","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1292\/jvms.68.663","article-title":"Gene expression profile by 2,3,7,8-tetrachlorodibenzo-pdioxin in the liver of wild-type (AhR+\/+) and aryl hydrocarbon receptor-deficient (AhR-\/-) mice","volume":"68","author":"Yoon","year":"2006","journal-title":"J Vet Med Sci"}],"container-title":["Molecular Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026895X24049265?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026895X24049265?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/mol.107.044669","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T11:56:07Z","timestamp":1739966167000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0026895X24049265"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,7]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,7]]}},"alternative-id":["S0026895X24049265"],"URL":"https:\/\/doi.org\/10.1124\/mol.107.044669","relation":{},"ISSN":["0026-895X"],"issn-type":[{"value":"0026-895X","type":"print"}],"subject":[],"published":{"date-parts":[[2008,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Roles of Cytosolic Phospholipase A2 and Src Kinase in the Early Action of 2,3,7,8-Tetrachlorodibenzo-p-dioxin through a Nongenomic Pathway in MCF10A Cells","name":"articletitle","label":"Article Title"},{"value":"Molecular Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/mol.107.044669","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2008 The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}