{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T07:45:34Z","timestamp":1767167134166,"version":"build-2238731810"},"reference-count":49,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2008,7,1]],"date-time":"2008-07-01T00:00:00Z","timestamp":1214870400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,7,1]],"date-time":"2008-07-01T00:00:00Z","timestamp":1214870400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["molpharm.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Pharmacology"],"published-print":{"date-parts":[[2008,7]]},"DOI":"10.1124\/mol.108.046045","type":"journal-article","created":{"date-parts":[[2008,4,15]],"date-time":"2008-04-15T21:11:45Z","timestamp":1208293905000},"page":"144-153","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["Fluvastatin Synergistically Improves the Antiproliferative Effect of Everolimus on Rat Smooth Muscle Cells by Altering p27 \/Cyclin E Expression"],"prefix":"10.1016","volume":"74","author":[{"given":"N.","family":"Ferri","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Granata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Pirola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Torti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.J.","family":"Pfister","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Dorent","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Corsini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1124\/mol.108.046045_REF1","first-page":"M123","article-title":"Regulation of the retinoblastoma tumor suppressor protein by cyclin\/cdks","volume":"1471","author":"Adams","year":"2001","journal-title":"Biochim Biophys Acta"},{"key":"10.1124\/mol.108.046045_REF2","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1038\/ncb1284","article-title":"Cdc2-cyclin E complexes regulate the G1\/S phase transition","volume":"7","author":"Aleem","year":"2005","journal-title":"Nat Cell Biol"},{"key":"10.1124\/mol.108.046045_REF3","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1097\/01.TP.0000101822.50960.AB","article-title":"Everolimus and mycophenolate mofetil are potent inhibitors of fibroblast proliferation after lung transplantation","volume":"77","author":"Azzola","year":"2004","journal-title":"Transplantation"},{"key":"10.1124\/mol.108.046045_REF4","doi-asserted-by":"crossref","first-page":"31101","DOI":"10.1074\/jbc.M503763200","article-title":"The farnesyl transferase inhibitor (FTI) SCH66336 (lonafarnib) inhibits Rheb farnesylation and mTOR signaling. Role in FTI enhancement of taxane and tamoxifen anti-tumor activity","volume":"280","author":"Basso","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1124\/mol.108.046045_REF5","doi-asserted-by":"crossref","first-page":"164","DOI":"10.3109\/07853890008998823","article-title":"Non-lipid-related effects of statins","volume":"32","author":"Bellosta","year":"2000","journal-title":"Ann Med"},{"key":"10.1124\/mol.108.046045_REF6","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1056\/NEJMoa070829","article-title":"Optimal medical therapy with or without PCI for stable coronary disease","volume":"356","author":"Boden","year":"2007","journal-title":"N Engl J Med"},{"key":"10.1124\/mol.108.046045_REF7","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1161\/hq0701.092104","article-title":"Cell cycle protein expression in vascular smooth muscle cells in vitro and in vivo is regulated through phosphatidylinositol 3-kinase and mammalian target of rapamycin","volume":"21","author":"Braun-Dullaeus","year":"2001","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1124\/mol.108.046045_REF8","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1038\/377441a0","article-title":"Control of p70 s6 kinase by kinase activity of FRAP in vivo","volume":"377","author":"Brown","year":"1995","journal-title":"Nature"},{"key":"10.1124\/mol.108.046045_REF9","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1161\/01.RES.0000216039.75913.9e","article-title":"The Rac and Rho hall of fame: a decade of hypertrophic signaling hits","volume":"98","author":"Brown","year":"2006","journal-title":"Circ Res"},{"key":"10.1124\/mol.108.046045_REF10","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1126\/science.277.5322.99","article-title":"Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin","volume":"277","author":"Brunn","year":"1997","journal-title":"Science"},{"key":"10.1124\/mol.108.046045_REF11","first-page":"125","article-title":"Incorporation of radiolabeled prenyl alcohols and their analogs into mammalian cell proteins. A useful tool for studying protein prenylation","volume":"116","author":"Corsini","year":"1999","journal-title":"Methods Mol Biol"},{"key":"10.1124\/mol.108.046045_REF12","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/1043-6618(95)80042-5","article-title":"Pharmacology of competitive inhibitors of HMG-CoA reductase","volume":"31","author":"Corsini","year":"1995","journal-title":"Pharmacol Res"},{"key":"10.1124\/mol.108.046045_REF13","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/0021-9150(93)90107-6","article-title":"Relationship between mevalonate pathway and arterial myocyte proliferation: in vitro studies with inhibitors of HMG-CoA reductase","volume":"101","author":"Corsini","year":"1993","journal-title":"Atherosclerosis"},{"key":"10.1124\/mol.108.046045_REF14","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1016\/S0140-6736(05)66196-X","article-title":"Inhibitor of proliferation of arterial smooth-muscle cells by fluvastatin","volume":"348","author":"Corsini","year":"1996","journal-title":"Lancet"},{"key":"10.1124\/mol.108.046045_REF14a","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1161\/01.ATV.15.3.420","article-title":"Effects of 26-aminocholesterol, 27-hydroxycholesterol, and 25-hydroxycholesterol on proliferation and cholesterol homeostasis in arterial myocytes","volume":"15","author":"Corsini","year":"1995","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1124\/mol.108.046045_REF16","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1182\/blood-2002-01-0189","article-title":"Rapamycin-induced G1 arrest in cycling B-CLL cells is associated with reduced expression of cyclin D3, cyclin E, cyclin A, and survivin","volume":"101","author":"Decker","year":"2003","journal-title":"Blood"},{"key":"10.1124\/mol.108.046045_REF17","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/S0955-0674(00)00151-4","article-title":"Regulation of G(1) cyclin-dependent kinases in the mammalian cell cycle","volume":"12","author":"Ekholm","year":"2000","journal-title":"Curr Opin Cell Biol"},{"key":"10.1124\/mol.108.046045_REF18","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1016\/j.cub.2003.11.021","article-title":"PLD1 regulates mTOR signaling and mediates Cdc42 activation of S6K1","volume":"13","author":"Fang","year":"2003","journal-title":"Curr Biol"},{"key":"10.1124\/mol.108.046045_REF19","doi-asserted-by":"crossref","first-page":"2379","DOI":"10.1161\/01.CIR.0000033973.06059.04","article-title":"Oral everolimus inhibits in-stent neointimal growth","volume":"106","author":"Farb","year":"2002","journal-title":"Circulation"},{"key":"10.1124\/mol.108.046045_REF20","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1038\/sj.bjp.0705126","article-title":"Ajoene, a garlic compound, inhibits protein prenylation and arterial smooth muscle cell proliferation","volume":"138","author":"Ferri","year":"2003","journal-title":"Br J Pharmacol"},{"key":"10.1124\/mol.108.046045_REF21","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1128\/MCB.24.1.200-216.2004","article-title":"mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1\/eukaryotic translation initiation factor 4E","volume":"24","author":"Fingar","year":"2004","journal-title":"Mol Cell Biol"},{"key":"10.1124\/mol.108.046045_REF22","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1161\/01.RES.0000061180.03813.0F","article-title":"Mevastatin can cause G1 arrest and induce apoptosis in pulmonary artery smooth muscle cells through a p27Kip1-independent pathway","volume":"92","author":"Fouty","year":"2003","journal-title":"Circ Res"},{"key":"10.1124\/mol.108.046045_REF23","doi-asserted-by":"crossref","first-page":"5439","DOI":"10.1210\/en.2004-0959","article-title":"Minireview: cyclin D1: normal and abnormal functions","volume":"145","author":"Fu","year":"2004","journal-title":"Endocrinology"},{"key":"10.1124\/mol.108.046045_REF24","doi-asserted-by":"crossref","first-page":"2164","DOI":"10.1161\/01.CIR.99.16.2164","article-title":"Inhibition of intimal thickening after balloon angioplasty in porcine coronary arteries by targeting regulators of the cell cycle","volume":"99","author":"Gallo","year":"1999","journal-title":"Circulation"},{"key":"10.1124\/mol.108.046045_REF25","doi-asserted-by":"crossref","first-page":"830","DOI":"10.2144\/02324rr01","article-title":"Efficient expression of exogenous genes in primary vascular cells using IRES-based retroviral vectors","volume":"32","author":"Garton","year":"2002","journal-title":"Biotechniques"},{"key":"10.1124\/mol.108.046045_REF26","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/S0092-8674(03)00645-7","article-title":"Cyclin E ablation in the mouse","volume":"114","author":"Geng","year":"2003","journal-title":"Cell"},{"key":"10.1124\/mol.108.046045_REF27","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1097\/00007890-200109270-00002","article-title":"Fluvastatin in combination with rad significantly reduces graft vascular disease in rat cardiac allografts","volume":"72","author":"Gregory","year":"2001","journal-title":"Transplantation"},{"key":"10.1124\/mol.108.046045_REF28","doi-asserted-by":"crossref","first-page":"2168","DOI":"10.1161\/01.CIR.0000128850.84227.FD","article-title":"Six- and twelve-month results from first human experience using everolimus-eluting stents with bioabsorbable polymer","volume":"109","author":"Grube","year":"2004","journal-title":"Circulation"},{"key":"10.1124\/mol.108.046045_REF29","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.vph.2004.10.002","article-title":"Differential effects of rapamycin, cyclosporine A, and FK506 on human coronary artery smooth muscle cell proliferation and signalling","volume":"41","author":"Hafizi","year":"2004","journal-title":"Vascul Pharmacol"},{"key":"10.1124\/mol.108.046045_REF30","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1056\/NEJMra043430","article-title":"Inflammation, atherosclerosis, and coronary artery disease","volume":"352","author":"Hansson","year":"2005","journal-title":"N Engl J Med"},{"key":"10.1124\/mol.108.046045_REF31","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/sj.leu.2404471","article-title":"Antiproliferative activity of RAD001 (everolimus) as a single agent and combined with other agents in mantle cell lymphoma","volume":"21","author":"Haritunians","year":"2007","journal-title":"Leukemia"},{"key":"10.1124\/mol.108.046045_REF32","first-page":"117","article-title":"In vitro pharmacodynamics of 1-beta-D-arabinofuranosylcytosine: synergy of antitumor activity with cis-diamminedichloroplatinum(II)","volume":"48","author":"Kern","year":"1988","journal-title":"Cancer Res"},{"key":"10.1124\/mol.108.046045_REF33","doi-asserted-by":"crossref","first-page":"21926","DOI":"10.1074\/jbc.274.31.21926","article-title":"3-Hydroxy-3-methylglutaryl-CoA reductase inhibitors attenuate vascular smooth muscle proliferation by preventing rho GTPase-induced down-regulation of p27(Kip1)","volume":"274","author":"Laufs","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1124\/mol.108.046045_REF34","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/j.cub.2005.02.053","article-title":"Rheb binds and regulates the mTOR kinase","volume":"15","author":"Long","year":"2005","journal-title":"Curr Biol"},{"key":"10.1124\/mol.108.046045_REF35","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.cell.2005.02.031","article-title":"Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis","volume":"121","author":"Ma","year":"2005","journal-title":"Cell"},{"key":"10.1124\/mol.108.046045_REF36","series-title":"Restenosis: A Guide to Therapy","first-page":"97","article-title":"Pharmacological approaches to prevent restenosis","author":"Mody","year":"2001"},{"key":"10.1124\/mol.108.046045_REF37","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1097\/00007691-200202000-00010","article-title":"Early clinical experience with a novel rapamycin derivative","volume":"24","author":"Nashan","year":"2002","journal-title":"Ther Drug Monit"},{"key":"10.1124\/mol.108.046045_REF38","doi-asserted-by":"crossref","first-page":"5279","DOI":"10.1002\/j.1460-2075.1995.tb00212.x","article-title":"The principal target of rapamycin-induced p70s6k inactivation is a novel phosphorylation site within a conserved hydrophobic domain","volume":"14","author":"Pearson","year":"1995","journal-title":"EMBO J"},{"key":"10.1124\/mol.108.046045_REF39","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1126\/science.1380182","article-title":"Rapamycin-induced inhibition of the 70-kilodalton S6 protein kinase","volume":"257","author":"Price","year":"1992","journal-title":"Science"},{"key":"10.1124\/mol.108.046045_REF40","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1016\/S0022-3565(24)36722-9","article-title":"Pharmacological control of the mevalonate pathway: effect on arterial smooth muscle cell proliferation","volume":"281","author":"Raiteri","year":"1997","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/mol.108.046045_REF41","doi-asserted-by":"crossref","first-page":"7797","DOI":"10.1073\/pnas.96.14.7797","article-title":"Lovastatin-mediated G1 arrest is through inhibition of the proteasome, independent of hydroxymethyl glutaryl-CoA reductase","volume":"96","author":"Rao","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1124\/mol.108.046045_REF42","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1056\/NEJM199901143400207","article-title":"Atherosclerosis-an inflammatory disease","volume":"340","author":"Ross","year":"1999","journal-title":"N Engl J Med"},{"key":"10.1124\/mol.108.046045_REF43","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1016\/j.cub.2004.06.054","article-title":"Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton","volume":"14","author":"Sarbassov","year":"2004","journal-title":"Curr Biol"},{"key":"10.1124\/mol.108.046045_REF44","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1097\/00007890-199707150-00008","article-title":"SDZ RAD, a new rapamycin derivative: pharmacological properties in vitro and in vivo","volume":"64","author":"Schuler","year":"1997","journal-title":"Transplantation"},{"key":"10.1124\/mol.108.046045_REF45","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1038\/nature04869","article-title":"Ras, PI(3)K and mTOR signalling controls tumour cell growth","volume":"441","author":"Shaw","year":"2006","journal-title":"Nature"},{"key":"10.1124\/mol.108.046045_REF46","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/S0955-0674(03)00008-5","article-title":"Cyclin D1 serves as a cell cycle regulatory switch in actively proliferating cells","volume":"15","author":"Stacey","year":"2003","journal-title":"Curr Opin Cell Biol"},{"key":"10.1124\/mol.108.046045_REF47","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1056\/NEJMoa067193","article-title":"Safety and efficacy of sirolimus- and paclitaxel-eluting coronary stents","volume":"356","author":"Stone","year":"2007","journal-title":"N Engl J Med"},{"key":"10.1124\/mol.108.046045_REF48","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/nrc1612","article-title":"Post-prenylation-processing enzymes as new targets in oncogenesis","volume":"5","author":"Winter-Vann","year":"2005","journal-title":"Nat Rev Cancer"},{"key":"10.1124\/mol.108.046045_REF49","doi-asserted-by":"crossref","first-page":"3509","DOI":"10.1182\/blood-2006-06-030833","article-title":"Rapamycin derivatives reduce mTORC2 signaling and inhibit AKT activation in AML","volume":"109","author":"Zeng","year":"2007","journal-title":"Blood"}],"updated-by":[{"DOI":"10.1124\/mol.74.3.924","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2008,9,1]],"date-time":"2008-09-01T00:00:00Z","timestamp":1220227200000}}],"container-title":["Molecular Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026895X24049150?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026895X24049150?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/mol.108.046045","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T06:55:59Z","timestamp":1739948159000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0026895X24049150"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,7]]},"references-count":49,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,7]]}},"alternative-id":["S0026895X24049150"],"URL":"https:\/\/doi.org\/10.1124\/mol.108.046045","relation":{},"ISSN":["0026-895X"],"issn-type":[{"value":"0026-895X","type":"print"}],"subject":[],"published":{"date-parts":[[2008,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fluvastatin Synergistically Improves the Antiproliferative Effect of Everolimus on Rat Smooth Muscle Cells by Altering p27Kip1\/Cyclin E Expression","name":"articletitle","label":"Article Title"},{"value":"Molecular Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/mol.108.046045","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2008 The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}