{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T12:24:47Z","timestamp":1768566287763,"version":"3.49.0"},"reference-count":27,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2008,7,1]],"date-time":"2008-07-01T00:00:00Z","timestamp":1214870400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,7,1]],"date-time":"2008-07-01T00:00:00Z","timestamp":1214870400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["molpharm.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Pharmacology"],"published-print":{"date-parts":[[2008,7]]},"DOI":"10.1124\/mol.108.046615","type":"journal-article","created":{"date-parts":[[2008,4,11]],"date-time":"2008-04-11T01:49:58Z","timestamp":1207878598000},"page":"50-58","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Molecular Determinants for the Activating\/Blocking Actions of the 2H-1,4-Benzoxazine Derivatives, a Class of Potassium Channel Modulators Targeting the Skeletal Muscle KATP Channels"],"prefix":"10.1016","volume":"74","author":[{"given":"Domenico","family":"Tricarico","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonietta","family":"Mele","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia Maria","family":"Camerino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Laghezza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Carbonara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Fracchiolla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Tortorella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fulvio","family":"Loiodice","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana Conte","family":"Camerino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1124\/mol.108.046615_REF1","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/j.yjmcc.2005.02.022","article-title":"ATP-sensitive K+ channel channel\/enzyme multimer: metabolic gating in the heart","volume":"38","author":"Alekseev","year":"2005","journal-title":"J Mol Cell Cardiol"},{"key":"10.1124\/mol.108.046615_REF2","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/BF00370419","article-title":"Nucleotides diphosphates activate the ATP-sensitive potassium channels in mouse skeletal muscle","volume":"422","author":"Allard","year":"1992","journal-title":"Pflugers Arch"},{"key":"10.1124\/mol.108.046615_REF3","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1111\/j.1600-0773.1992.tb00466.x","article-title":"Clinical pharmacology of potassium channel openers","volume":"70","author":"Andersson","year":"1992","journal-title":"Pharmacol Toxicol"},{"key":"10.1124\/mol.108.046615_REF4","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1096\/fj.00-0027com","article-title":"ATPase activity of the sulfonylurea receptor: a catalytic function for the KATP channel complex","volume":"14","author":"Bienengraeber","year":"2000","journal-title":"FASEB J"},{"key":"10.1124\/mol.108.046615_REF5","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.nurt.2007.01.013","article-title":"Ion channel pharmacology","volume":"4","author":"Camerino","year":"2007","journal-title":"Neurotherapeutics"},{"key":"10.1124\/mol.108.046615_REF6","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.2174\/156802606777323683","article-title":"From cromakalim to different structural classes of KATP channel openers","volume":"6","author":"Cecchetti","year":"2006","journal-title":"Curr Top Med Chem"},{"key":"10.1124\/mol.108.046615_REF7","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1113\/jphysiol.2007.130955","article-title":"KATP channel deficiency in mouse flexor digitorum brevis causes fibre damage and impairs Ca2+ release and force development during fatigue in vitro","volume":"582","author":"Cifelli","year":"2007","journal-title":"J Physiol"},{"key":"10.1124\/mol.108.046615_REF8","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/S1262-3636(07)70311-7","article-title":"Diabetes and hypoglycaemia in young children and mutations in the Kir6.2 subunit of the potassium channel: therapeutic consequences","volume":"32","author":"Flechtner","year":"2006","journal-title":"Diabetes Metab"},{"key":"10.1124\/mol.108.046615_REF9","doi-asserted-by":"crossref","first-page":"3643","DOI":"10.1021\/bi062210f","article-title":"Molecular dynamics simulations of inwardly rectifying (Kir) potassium channels: a comparative study","volume":"46","author":"Haider","year":"2007","journal-title":"Biochemistry"},{"key":"10.1124\/mol.108.046615_REF10","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.yjmcc.2005.04.006","article-title":"KATP channel therapeutics at the bedside","volume":"39","author":"Jahangir","year":"2005","journal-title":"J Mol Cell Cardiol"},{"key":"10.1124\/mol.108.046615_REF11","doi-asserted-by":"crossref","first-page":"2645","DOI":"10.2337\/diabetes.54.9.2645","article-title":"ATP and sulfonylurea sensitivity of mutant ATP-sensitive K+ channels in neonatal diabetes. Implications for pharmacogenomic therapy","volume":"54","author":"Koster","year":"2005","journal-title":"Diabetes"},{"key":"10.1124\/mol.108.046615_REF11a","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1002\/j.1552-4604.1995.tb04061.x","article-title":"Potassium channel modulation: effect of pinacidil on insulin release in healthy volunteers","volume":"35","author":"Links","year":"1995","journal-title":"J Clin Pharmacol"},{"key":"10.1124\/mol.108.046615_REF13","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/med.2610120202","article-title":"Potassium channel activator drugs: mechanism of action, pharmacological properties, and therapeutic potential","volume":"12","author":"Longman","year":"1992","journal-title":"Med Res Rev"},{"key":"10.1124\/mol.108.046615_REF13a","doi-asserted-by":"crossref","first-page":"19097","DOI":"10.1074\/jbc.M414065200","article-title":"Molecular determinants of cardiac KATP channel activation by epoxyeicosatrienoic acids","volume":"280","author":"Lu","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1124\/mol.108.046615_REF15","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1002\/med.10060","article-title":"KATP channel structure-activity relationships and therapeutic potential","volume":"24","author":"Mannhold","year":"2004","journal-title":"Med Res Rev"},{"key":"10.1124\/mol.108.046615_REF16","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1038\/nature04711","article-title":"KATP channels as molecular sensors of cellular metabolism","volume":"440","author":"Nichols","year":"2006","journal-title":"Nature"},{"key":"10.1124\/mol.108.046615_REF17","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/0014-2999(90)94068-9","article-title":"K+ channel openers suppress myotonic activity of human skeletal muscle in vitro","volume":"186","author":"Quasthoff","year":"1990","journal-title":"Eur J Pharmacol"},{"key":"10.1124\/mol.108.046615_REF18","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1038\/sj.bjp.0706895","article-title":"A new benzoxazine compound blocks KATP channels in pancreatic \u03b2 cells: molecular basis for tissue selectivity in vitro and hypoglycaemic action in vivo","volume":"149","author":"Rolland","year":"2006","journal-title":"Br J Pharmacol"},{"key":"10.1124\/mol.108.046615_REF19","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/0165-6147(94)90073-6","article-title":"Lower efficacy: interaction with an inhibitory receptor or partial agonism?","volume":"15","author":"Rovati","year":"1994","journal-title":"Trends Pharmacol Sci"},{"key":"10.1124\/mol.108.046615_REF20","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1038\/sj.bjp.0705238","article-title":"Binding and effect of K ATP channel openers in the absence of Mg2+","volume":"139","author":"Russ","year":"2003","journal-title":"Br J Pharmacol"},{"key":"10.1124\/mol.108.046615_REF21","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1007\/s00540-005-0336-y","article-title":"Drugs to facilitate recovery of neuromuscular blockade and muscle strength","volume":"19","author":"Saitoh","year":"2005","journal-title":"J Anesth"},{"key":"10.1124\/mol.108.046615_REF22","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1038\/sj.bjp.0704042","article-title":"Dual action of SZ6169, a novel K+ channel opener, on ATP-sensitive K+ channels in pig urethral myocytes","volume":"133","author":"Teramoto","year":"2001","journal-title":"Br J Pharmacol"},{"key":"10.1124\/mol.108.046615_REF23","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/sj.bjp.0705233","article-title":"Dualistic actions of cromakalim and new potent 2H-1,4-benzoxazine derivatives on the native skeletal muscle KATP channel","volume":"139","author":"Tricarico","year":"2003","journal-title":"Br J Pharmacol"},{"key":"10.1124\/mol.108.046615_REF24","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1096\/fj.03-0722fje","article-title":"Carbonic anhydrase inhibitors are specific openers of skeletal muscle BK channel of K+-deficient rats","volume":"18","author":"Tricarico","year":"2004","journal-title":"FASEB J"},{"key":"10.1124\/mol.108.046615_REF25","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1073\/pnas.0505974103","article-title":"Hybrid assemblies of ATP-sensitive K+ channels determine their muscletype-dependent biophysical and pharmacological properties","volume":"103","author":"Tricarico","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1124\/mol.108.046615_REF26","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1124\/mol.54.1.197","article-title":"The biophysical and pharmacological characteristics of skeletal muscle ATP-sensitive K+ channels are modified in K+-depleted rat, an animal model of hypokalemic periodic paralysis","volume":"54","author":"Tricarico","year":"1998","journal-title":"Mol Pharmacol"},{"key":"10.1124\/mol.108.046615_REF27","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1172\/JCI4552","article-title":"Impairment of skeletal muscle adenosine triphosphate-sensitive K+ channels in patients with hypokalemic periodic paralysis","volume":"103","author":"Tricarico","year":"1999","journal-title":"J Clin Invest"}],"container-title":["Molecular Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026895X2404906X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026895X2404906X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/mol.108.046615","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T11:55:42Z","timestamp":1739966142000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0026895X2404906X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,7]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,7]]}},"alternative-id":["S0026895X2404906X"],"URL":"https:\/\/doi.org\/10.1124\/mol.108.046615","relation":{},"ISSN":["0026-895X"],"issn-type":[{"value":"0026-895X","type":"print"}],"subject":[],"published":{"date-parts":[[2008,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Molecular Determinants for the Activating\/Blocking Actions of the 2H-1,4-Benzoxazine Derivatives, a Class of Potassium Channel Modulators Targeting the Skeletal Muscle KATP Channels","name":"articletitle","label":"Article Title"},{"value":"Molecular Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/mol.108.046615","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2008 The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}