{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T16:39:10Z","timestamp":1761237550670,"version":"3.37.3"},"reference-count":41,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2008,9,1]],"date-time":"2008-09-01T00:00:00Z","timestamp":1220227200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,9,1]],"date-time":"2008-09-01T00:00:00Z","timestamp":1220227200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["molpharm.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Pharmacology"],"published-print":{"date-parts":[[2008,9]]},"DOI":"10.1124\/mol.108.048769","type":"journal-article","created":{"date-parts":[[2008,6,25]],"date-time":"2008-06-25T02:48:40Z","timestamp":1214362120000},"page":"896-903","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":56,"title":["Local Not Systemic Modulation of Dendritic Cell S1P Receptors in Lung Blunts Virus-Specific Immune Responses to Influenza"],"prefix":"10.1016","volume":"74","author":[{"given":"David","family":"Marsolais","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bumsuk","family":"Hahm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kurt H.","family":"Edelmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin B.","family":"Walsh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"Guerrero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuko","family":"Hatta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiro","family":"Kawaoka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward","family":"Roberts","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael B.A.","family":"Oldstone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hugh","family":"Rosen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1124\/mol.108.048769_REF1","doi-asserted-by":"crossref","first-page":"F1516","DOI":"10.1152\/ajprenal.00311.2005","article-title":"Selective sphingosine 1-phosphate 1 receptor activation reduces ischemia-reperfusion injury in mouse kidney","volume":"290","author":"Awad","year":"2006","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1124\/mol.108.048769_REF2","doi-asserted-by":"crossref","first-page":"33697","DOI":"10.1074\/jbc.C500294200","article-title":"The immune modulator FTY720 inhibits sphingosine-1-phosphate lyase activity","volume":"280","author":"Bandhuvula","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1124\/mol.108.048769_REF3","doi-asserted-by":"crossref","first-page":"2189","DOI":"10.1002\/eji.1830260934","article-title":"Functionally distinct T cells in three compartments of the respiratory tract after influenza virus infection","volume":"26","author":"Baumgarth","year":"1996","journal-title":"Eur J Immunol"},{"key":"10.1124\/mol.108.048769_REF4","doi-asserted-by":"crossref","first-page":"8670","DOI":"10.1073\/pnas.0402644101","article-title":"Distinct migrating and nonmigrating dendritic cell populations are involved in MHC class I-restricted antigen presentation after lung infection with virus","volume":"101","author":"Belz","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1124\/mol.108.048769_REF5","doi-asserted-by":"crossref","first-page":"47408","DOI":"10.1074\/jbc.M307687200","article-title":"Phosphorylation of the immunomodulatory drug FTY720 by sphingosine kinases","volume":"278","author":"Billich","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1124\/mol.108.048769_REF6","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1161\/01.ATV.0000162171.30089.f6","article-title":"Sphingosine-1-phosphate prevents tumor necrosis factor-{alpha}-mediated monocyte adhesion to aortic endothelium in mice","volume":"25","author":"Bolick","year":"2005","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1124\/mol.108.048769_REF7","doi-asserted-by":"crossref","first-page":"21453","DOI":"10.1074\/jbc.C200176200","article-title":"The immune modulator FTY720 targets sphingosine 1-phosphate receptors","volume":"277","author":"Brinkmann","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1124\/mol.108.048769_REF8","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1097\/00007890-200109150-00002","article-title":"FTY720: altered lymphocyte traffic results in allograft protection","volume":"72","author":"Brinkmann","year":"2001","journal-title":"Transplantation"},{"issue":"Suppl 17","key":"10.1124\/mol.108.048769_REF9","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/j.1399-0012.2006.00596.x","article-title":"FTY720 (fingolimod) in renal transplantation","volume":"20","author":"Budde","year":"2006","journal-title":"Clin Transplant"},{"key":"10.1124\/mol.108.048769_REF10","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1172\/JCI200422557","article-title":"A viral epitope that mimics a self antigen can accelerate but not initiate autoimmune diabetes","volume":"114","author":"Christen","year":"2004","journal-title":"J Clin Invest"},{"key":"10.1124\/mol.108.048769_REF11","doi-asserted-by":"crossref","first-page":"2960","DOI":"10.4049\/jimmunol.175.5.2960","article-title":"Sphingosine-1-phosphate mediates migration of mature dendritic cells","volume":"175","author":"Czeloth","year":"2005","journal-title":"J Immunol"},{"key":"10.1124\/mol.108.048769_REF12","doi-asserted-by":"crossref","first-page":"15833","DOI":"10.1074\/jbc.M609124200","article-title":"Essential requirement for sphingosine kinase 2 in a sphingolipid apoptosis pathway activated by FTY720 analogues","volume":"282","author":"Don","year":"2007","journal-title":"J Biol Chem"},{"key":"10.1124\/mol.108.048769_REF13","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1016\/j.cellsig.2007.03.011","article-title":"Pulmonary endothelial cell barrier enhancement by FTY720 does not require the S1P1 receptor","volume":"19","author":"Dudek","year":"2007","journal-title":"Cell Signal"},{"key":"10.1124\/mol.108.048769_REF14","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.virol.2004.03.011","article-title":"Measles virus interacts with human SLAM receptor on dendritic cells to cause immunosuppression","volume":"323","author":"Hahm","year":"2004","journal-title":"Virology"},{"key":"10.1124\/mol.108.048769_REF15","unstructured":"Hahm B, Marsolais D, Edelmann KH, Hatta Y, Kawaoka Y, Rosen H, and Oldstone MB (2007) Chemical amelioration of T cell-mediated influenza injury with retention of antibody protection [abstract], in Workshop on Replication and Cell Biology of Negative Strand RNA Viruses; 2007 Sep 15-19; Evanston, IL."},{"key":"10.1124\/mol.108.048769_REF16","doi-asserted-by":"crossref","first-page":"2935","DOI":"10.1172\/JCI28295","article-title":"Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function","volume":"116","author":"Idzko","year":"2006","journal-title":"J Clin Invest"},{"key":"10.1124\/mol.108.048769_REF17","doi-asserted-by":"crossref","first-page":"2946","DOI":"10.1021\/jm000173z","article-title":"Synthesis and immunosuppressive activity of 2-substituted 2-aminopropane-1,3-diols and 2-aminoethanols","volume":"43","author":"Kiuchi","year":"2000","journal-title":"J Med Chem"},{"key":"10.1124\/mol.108.048769_REF18","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0960-894X(97)10188-3","article-title":"Synthesis and biological evaluation of 2,2-disubstituted 2-aminoethanols: analogues of FTY720","volume":"8","author":"Kiuchi","year":"1998","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1124\/mol.108.048769_REF19","doi-asserted-by":"crossref","first-page":"2649","DOI":"10.1111\/j.1600-6143.2005.01085.x","article-title":"The sphingosine-1-phosphate receptor agonist FTY720 modulates dendritic cell trafficking in vivo","volume":"5","author":"Lan","year":"2005","journal-title":"Am J Transplant"},{"key":"10.1124\/mol.108.048769_REF20","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/S1388-1981(02)00132-4","article-title":"Sphingosine-1-phosphate and lipid phosphohydrolases","volume":"1582","author":"Le Stunff","year":"2002","journal-title":"Biochim Biophys Acta"},{"key":"10.1124\/mol.108.048769_REF21","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1038\/ni1534","article-title":"The sphingosine 1-phosphate receptor 1 causes tissue retention by inhibiting the entry of peripheral tissue T lymphocytes into afferent lymphatics","volume":"9","author":"Ledgerwood","year":"2008","journal-title":"Nat Immunol"},{"key":"10.1124\/mol.108.048769_REF22","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1038\/emm.2004.54","article-title":"Sphingosine mediates FTY720-induced apoptosis in LLC-PK1 cells","volume":"36","author":"Lee","year":"2004","journal-title":"Exp Mol Med"},{"key":"10.1124\/mol.108.048769_REF23","doi-asserted-by":"crossref","first-page":"19513","DOI":"10.1074\/jbc.M002759200","article-title":"Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform","volume":"275","author":"Liu","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1124\/mol.108.048769_REF24","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0022-1759(98)00204-X","article-title":"An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow","volume":"223","author":"Lutz","year":"1999","journal-title":"J Immunol Methods"},{"key":"10.1124\/mol.108.048769_REF25","doi-asserted-by":"crossref","first-page":"3437","DOI":"10.4049\/jimmunol.178.6.3437","article-title":"Migration of CD4 T cells and dendritic cells toward sphingosine 1-phosphate (S1P) is mediated by different receptor subtypes: S1P regulates the functions of murine mature dendritic cells via S1P receptor type 3","volume":"178","author":"Maeda","year":"2007","journal-title":"J Immunol"},{"key":"10.1124\/mol.108.048769_REF26","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1126\/science.1070238","article-title":"Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists","volume":"296","author":"Mandala","year":"2002","journal-title":"Science"},{"key":"10.1124\/mol.108.048769_REF27","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1056\/NEJMp068159","article-title":"Fingolimod and sphingosine-1-phosphate-modifiers of lymphocyte migration","volume":"355","author":"Massberg","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1124\/mol.108.048769_REF28","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/nature02284","article-title":"Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1","volume":"427","author":"Matloubian","year":"2004","journal-title":"Nature"},{"key":"10.1124\/mol.108.048769_REF29","doi-asserted-by":"crossref","first-page":"9345","DOI":"10.1073\/pnas.96.16.9345","article-title":"Generation of influenza A viruses entirely from cloned cDNAs","volume":"96","author":"Neumann","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1124\/mol.108.048769_REF30","first-page":"707","article-title":"Effects of FTY720 in MRL-1pr\/1pr mice: therapeutic potential in systemic lupus erythematosus","volume":"29","author":"Okazaki","year":"2002","journal-title":"J Rheumatol"},{"key":"10.1124\/mol.108.048769_REF31","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1016\/j.chembiol.2006.09.017","article-title":"A monoselective sphingosine-1-phosphate receptor-1 agonist prevents allograft rejection in a stringent rat heart transplantation model","volume":"13","author":"Pan","year":"2006","journal-title":"Chem Biol"},{"key":"10.1124\/mol.108.048769_REF32","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1164\/rccm.200309-1258OC","article-title":"Protective effects of sphingosine 1-phosphate in murine endotoxin-induced inflammatory lung injury","volume":"169","author":"Peng","year":"2004","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1124\/mol.108.048769_REF33","doi-asserted-by":"crossref","first-page":"5761","DOI":"10.4049\/jimmunol.164.11.5761","article-title":"FTY720 immunosuppression impairs effector T cell peripheral homing without affecting induction, expansion, and memory","volume":"164","author":"Pinschewer","year":"2000","journal-title":"J Immunol"},{"key":"10.1124\/mol.108.048769_REF34","doi-asserted-by":"crossref","first-page":"10907","DOI":"10.1073\/pnas.1832725100","article-title":"Rapid induction of medullary thymocyte phenotypic maturation and egress inhibition by nanomolar sphingosine 1-phosphate receptor agonist","volume":"100","author":"Rosen","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1124\/mol.108.048769_REF35","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1038\/nri1650","article-title":"Sphingosine 1-phosphate and its receptors: an auto-crine and paracrine network","volume":"5","author":"Rosen","year":"2005","journal-title":"Nat Rev Immunol"},{"key":"10.1124\/mol.108.048769_REF36","doi-asserted-by":"crossref","first-page":"13839","DOI":"10.1074\/jbc.M311743200","article-title":"Sphingosine 1-phosphate (S1P) receptor subtypes S1P1 and S1P3, respectively, regulate lymphocyte recirculation and heart rate","volume":"279","author":"Sanna","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1124\/mol.108.048769_REF37","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1038\/nchembio804","article-title":"Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo","volume":"2","author":"Sanna","year":"2006","journal-title":"Nat Chem Biol"},{"key":"10.1124\/mol.108.048769_REF38","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1126\/science.1113640","article-title":"Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradients","volume":"309","author":"Schwab","year":"2005","journal-title":"Science"},{"key":"10.1124\/mol.108.048769_REF39","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1038\/ni1269","article-title":"Sphingosine 1-phosphate type 1 receptor agonism inhibits transendothelial migration of medullary T cells to lymphatic sinuses","volume":"6","author":"Wei","year":"2005","journal-title":"Nat Immunol"},{"key":"10.1124\/mol.108.048769_REF40","doi-asserted-by":"crossref","first-page":"2913","DOI":"10.4049\/jimmunol.175.5.2913","article-title":"Sphingosine 1-phosphate receptors regulate chemokine-driven transendothelial migration of lymph node but not splenic T cells","volume":"175","author":"Yopp","year":"2005","journal-title":"J Immunol"},{"key":"10.1124\/mol.108.048769_REF41","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1182\/blood-2005-07-2628","article-title":"Sphingosine kinase type 2 is essential for lymphopenia induced by the immunomodulatory drug FTY720","volume":"107","author":"Zemann","year":"2006","journal-title":"Blood"}],"container-title":["Molecular Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026895X24145464?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026895X24145464?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/mol.108.048769","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T10:23:08Z","timestamp":1740046988000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0026895X24145464"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,9]]},"references-count":41,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,9]]}},"alternative-id":["S0026895X24145464"],"URL":"https:\/\/doi.org\/10.1124\/mol.108.048769","relation":{},"ISSN":["0026-895X"],"issn-type":[{"type":"print","value":"0026-895X"}],"subject":[],"published":{"date-parts":[[2008,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Local Not Systemic Modulation of Dendritic Cell S1P Receptors in Lung Blunts Virus-Specific Immune Responses to Influenza","name":"articletitle","label":"Article Title"},{"value":"Molecular Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/mol.108.048769","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2008 The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}