{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T08:13:44Z","timestamp":1777623224013,"version":"3.51.4"},"reference-count":27,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["molpharm.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Pharmacology"],"published-print":{"date-parts":[[2009,1]]},"DOI":"10.1124\/mol.108.050567","type":"journal-article","created":{"date-parts":[[2008,9,30]],"date-time":"2008-09-30T00:44:41Z","timestamp":1222735481000},"page":"134-142","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Thiophenecarboxylate Suppressor of Cyclic Nucleotides Discovered in a Small-Molecule Screen Blocks Toxin-Induced Intestinal Fluid Secretion"],"prefix":"10.1016","volume":"75","author":[{"given":"Lukmanee","family":"Tradtrantip","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Buranee","family":"Yangthara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prashant","family":"Padmawar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Morrison","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.S.","family":"Verkman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1124\/mol.108.050567_REF1","doi-asserted-by":"crossref","first-page":"296","DOI":"10.3109\/00313029209068884","article-title":"Effects of cholera toxin on human colon carcinoma cell lines","volume":"24","author":"Barkla","year":"1992","journal-title":"Pathology"},{"key":"10.1124\/mol.108.050567_REF2","doi-asserted-by":"crossref","first-page":"C859","DOI":"10.1152\/ajpcell.1993.265.4.C859","article-title":"Positive and negative regulation of chloride secretion in T84 cells","volume":"265","author":"Barrett","year":"1993","journal-title":"Am J Physiol"},{"key":"10.1124\/mol.108.050567_REF3","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1124\/pr.58.3.5","article-title":"Cyclic nucleotide phosphodiesterases: molecular regulation to clinical use","volume":"58","author":"Bender","year":"2006","journal-title":"Pharmacol Rev"},{"key":"10.1124\/mol.108.050567_REF4","doi-asserted-by":"crossref","first-page":"3953","DOI":"10.1021\/jo00141a028","article-title":"Novel synthesis of five- and six-membered spiro g-lactones in rigid bicyclic systems","volume":"47","author":"Canonne","year":"1982","journal-title":"J Org Chem"},{"key":"10.1124\/mol.108.050567_REF5","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1128\/IAI.74.3.1505-1515.2006","article-title":"Mutual enhancement of virulence by enterotoxigenic and enteropathogenic Escherichia coli","volume":"74","author":"Crane","year":"2006","journal-title":"Infect Immun"},{"key":"10.1124\/mol.108.050567_REF6","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1172\/JCI200318326","article-title":"Intestinal ion transport and the pathophysiology of diarrhea","volume":"111","author":"Field","year":"2003","journal-title":"J Clin Invest"},{"key":"10.1124\/mol.108.050567_REF7","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/j.cell.2007.09.037","article-title":"Spatiotemporal coupling of cAMP transporter to CFTR chloride channel function in the gut epithelia","volume":"131","author":"Li","year":"2007","journal-title":"Cell"},{"key":"10.1124\/mol.108.050567_REF8","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1172\/JCI0216112","article-title":"Thiazolidinone CFTR inhibitor identified by high throughput screening blocks cholera toxin-induced intestinal fluid secretion","volume":"110","author":"Ma","year":"2002","journal-title":"J Clin Invest"},{"key":"10.1124\/mol.108.050567_REF9","doi-asserted-by":"crossref","first-page":"6007","DOI":"10.1073\/pnas.86.15.6007","article-title":"Renal epithelial cyst formation and enlargement in vitro: dependence on cAMP","volume":"86","author":"Mangoo-Karim","year":"1989","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1124\/mol.108.050567_REF10","doi-asserted-by":"crossref","first-page":"143","DOI":"10.2174\/1568008054064805","article-title":"Ion transport across the gall bladder epithelium","volume":"5","author":"Meyer","year":"2005","journal-title":"Curr Drug Targets Immune Endocr Metabol Disord"},{"key":"10.1124\/mol.108.050567_REF11","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1007\/s00706-003-0161-7","article-title":"Preparation and structure of di-exo-condensed norbornane heterocycles","volume":"135","author":"Miklos","year":"2004","journal-title":"Monatsh Chem"},{"key":"10.1124\/mol.108.050567_REF12","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1085\/jgp.200409059","article-title":"Discovery of glycine hydrazide pore occluding CFTR inhibitors: mechanism, structure-activity analysis, and in vivo efficacy","volume":"124","author":"Muanprasat","year":"2004","journal-title":"J Gen Physiol"},{"key":"10.1124\/mol.108.050567_REF13","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/S0188-4409(99)00078-8","article-title":"Gs alpha mutations in hyperfunctioning thyroid adenomas","volume":"30","author":"Murakami","year":"1999","journal-title":"Arch Med Res"},{"key":"10.1124\/mol.108.050567_REF14","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1146\/annurev.physiol.68.040504.094707","article-title":"Signaling for contraction and relaxation in smooth muscle of the gut","volume":"68","author":"Murthy","year":"2006","journal-title":"Annu Rev Physiol"},{"key":"10.1124\/mol.108.050567_REF15","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1161\/01.RES.0000256354.95791.f1","article-title":"Overview of PDEs and their regulation","volume":"100","author":"Omori","year":"2007","journal-title":"Circ Res"},{"key":"10.1124\/mol.108.050567_REF16","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1124\/mol.63.5.1094","article-title":"Characterization of the transport of nucleoside analog drugs by the human multidrug resistance protein-MRP4 and MRP5","volume":"63","author":"Reid","year":"2003","journal-title":"Mol Pharmacol"},{"key":"10.1124\/mol.108.050567_REF17","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1161\/01.RES.0000087541.15600.2B","article-title":"Cyclic GMP phosphodiesterase and regulation of smooth muscle function","volume":"93","author":"Rybalkin","year":"2003","journal-title":"Circ Res"},{"key":"10.1124\/mol.108.050567_REF18","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0140-6736(03)15328-7","article-title":"Cholera","volume":"363","author":"Sack","year":"2004","journal-title":"Lancet"},{"key":"10.1124\/mol.108.050567_REF19","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1007\/s00441-006-0226-0","article-title":"Molecular and cellular pathophysiology of autosomal recessive polycystic kidney disease (ARPKD)","volume":"326","author":"Sweeney","year":"2006","journal-title":"Cell Tissue Res"},{"key":"10.1124\/mol.108.050567_REF20","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1053\/j.gastro.2003.11.005","article-title":"Prevention of toxin-induced intestinal ion and fluid secretion by a small-molecule CFTR inhibitor","volume":"126","author":"Thiagarajah","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1124\/mol.108.050567_REF21","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.tips.2005.02.003","article-title":"New drug targets for cholera therapy","volume":"26","author":"Thiagarajah","year":"2005","journal-title":"Trends Pharmacol Sci"},{"key":"10.1124\/mol.108.050567_REF22","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.semnephrol.2008.03.003","article-title":"Vasopressin antagonists in polycystic kidney disease","volume":"28","author":"Torres","year":"2008","journal-title":"Semin Nephrol"},{"key":"10.1124\/mol.108.050567_REF23","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1023\/A:1014231722696","article-title":"Structure and function of the heat-stable enterotoxin receptor\/guanylyl cyclase C","volume":"230","author":"Vaandrager","year":"2002","journal-title":"Mol Cell Biochem"},{"key":"10.1124\/mol.108.050567_REF24","doi-asserted-by":"crossref","first-page":"571","DOI":"10.4161\/cc.5.6.2582","article-title":"Negative feedbacks in normal cell growth and their suppression in tumorigenesis","volume":"5","author":"van Staveren","year":"2006","journal-title":"Cell Cycle"},{"key":"10.1124\/mol.108.050567_REF25","doi-asserted-by":"crossref","first-page":"17664","DOI":"10.1074\/jbc.M212723200","article-title":"Charcaterization of the MRP4- and MRP5-mediated transport of cyclic nucleotides from intact cells","volume":"278","author":"Wielinga","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1124\/mol.108.050567_REF26","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1681\/ASN.2007070828","article-title":"Small-molecule CFTR inhibitors slow cyst growth in polycystic kidney disease","volume":"19","author":"Yang","year":"2008","journal-title":"J Am Soc Nephrol"},{"key":"10.1124\/mol.108.050567_REF27","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1124\/mol.107.034496","article-title":"Small-molecule vasopressin-2 receptor antagonist identified by a G-protein coupled receptor \u201cpathway\u201d screen","volume":"72","author":"Yangthara","year":"2007","journal-title":"Mol Pharmacol"}],"container-title":["Molecular Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026895X24146597?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026895X24146597?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/mol.108.050567","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T10:26:53Z","timestamp":1740047213000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0026895X24146597"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,1]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,1]]}},"alternative-id":["S0026895X24146597"],"URL":"https:\/\/doi.org\/10.1124\/mol.108.050567","relation":{},"ISSN":["0026-895X"],"issn-type":[{"value":"0026-895X","type":"print"}],"subject":[],"published":{"date-parts":[[2009,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Thiophenecarboxylate Suppressor of Cyclic Nucleotides Discovered in a Small-Molecule Screen Blocks Toxin-Induced Intestinal Fluid Secretion","name":"articletitle","label":"Article Title"},{"value":"Molecular Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/mol.108.050567","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2009 The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}