{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T04:56:00Z","timestamp":1773291360681,"version":"3.50.1"},"reference-count":40,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2009,5,1]],"date-time":"2009-05-01T00:00:00Z","timestamp":1241136000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,5,1]],"date-time":"2009-05-01T00:00:00Z","timestamp":1241136000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["molpharm.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Pharmacology"],"published-print":{"date-parts":[[2009,5]]},"DOI":"10.1124\/mol.108.053157","type":"journal-article","created":{"date-parts":[[2009,2,10]],"date-time":"2009-02-10T01:54:30Z","timestamp":1234230870000},"page":"1198-1209","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"title":["Prolyl Hydroxylase Inhibitors Depend on Extracellular Glucose and Hypoxia-Inducible Factor (HIF)-2\u03b1 to Inhibit Cell Death Caused by Nerve Growth Factor (NGF) Deprivation: Evidence that HIF-2\u03b1 Has a Role in NGF-Promoted Survival of Sympathetic Neurons"],"prefix":"10.1016","volume":"75","author":[{"given":"David J.","family":"Lomb","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lynette A.","family":"Desouza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James L.","family":"Franklin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert S.","family":"Freeman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1124\/mol.108.053157_REF1","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1111\/j.1471-4159.2008.05427.x","article-title":"Pin1 promotes cell death in NGF-dependent neurons through a mechanism requiring c-Jun activity","volume":"106","author":"Barone","year":"2008","journal-title":"J Neurochem"},{"key":"10.1124\/mol.108.053157_REF2","doi-asserted-by":"crossref","first-page":"3386","DOI":"10.1128\/MCB.02041-07","article-title":"Abnormal sympathoadrenal development and systemic hypotension in PHD3-\/-mice","volume":"28","author":"Bishop","year":"2008","journal-title":"Mol Cell Biol"},{"key":"10.1124\/mol.108.053157_REF3","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1126\/science.1066373","article-title":"A conserved family of prolyl-4-hydroxylases that modify HIF","volume":"294","author":"Bruick","year":"2001","journal-title":"Science"},{"key":"10.1124\/mol.108.053157_REF4","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1083\/jcb.123.5.1207","article-title":"Temporal analysis of events associated with programmed cell death (apoptosis) of sympathetic neurons deprived of nerve growth factor","volume":"123","author":"Deckwerth","year":"1993","journal-title":"J Cell Biol"},{"key":"10.1124\/mol.108.053157_REF5","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1038\/nrc2468","article-title":"Hypoxia, HIF1 and glucose metabolism in the solid tumour","volume":"8","author":"Denko","year":"2008","journal-title":"Nat Rev Cancer"},{"key":"10.1124\/mol.108.053157_REF6","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1083\/jcb.135.5.1341","article-title":"Genetic and metabolic status of NGF-deprived sympathetic neurons saved by an inhibitor of ICE family proteases","volume":"135","author":"Deshmukh","year":"1996","journal-title":"J Cell Biol"},{"key":"10.1124\/mol.108.053157_REF7","doi-asserted-by":"crossref","first-page":"2140","DOI":"10.1111\/j.1471-4159.1991.tb06434.x","article-title":"The death programme in cultured sympathetic neurones can be suppressed at the posttranslational level by nerve growth factor, cyclic AMP, and depolarization","volume":"57","author":"Edwards","year":"1991","journal-title":"J Neurochem"},{"key":"10.1124\/mol.108.053157_REF8","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0092-8674(01)00507-4","article-title":"C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation","volume":"107","author":"Epstein","year":"2001","journal-title":"Cell"},{"key":"10.1124\/mol.108.053157_REF9","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1523\/JNEUROSCI.16-03-01150.1996","article-title":"Cell cycle blockers mimosine, ciclopirox, and deferoxamine prevent the death of PC12 cells and postmitotic sympathetic neurons after removal of trophic support","volume":"16","author":"Farinelli","year":"1996","journal-title":"J Neurosci"},{"key":"10.1124\/mol.108.053157_REF10","doi-asserted-by":"crossref","first-page":"85","DOI":"10.2174\/1568007053005154","article-title":"Targeting hypoxia-inducible factor (HIF) as a therapeutic strategy for CNS disorders","volume":"4","author":"Freeman","year":"2005","journal-title":"Curr Drug Targets CNS Neurol Disord"},{"key":"10.1124\/mol.108.053157_REF11","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0079-6123(03)46008-1","article-title":"NGF deprivation-induced gene expression: after ten years, where do we stand?","volume":"146","author":"Freeman","year":"2004","journal-title":"Prog Brain Res"},{"key":"10.1124\/mol.108.053157_REF12","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1146\/annurev.neuro.28.061604.135659","article-title":"Growth and survival signals controlling sympathetic nervous system development","volume":"28","author":"Glebova","year":"2005","journal-title":"Annu Rev Neurosci"},{"key":"10.1124\/mol.108.053157_REF13","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/0896-6273(95)90287-2","article-title":"Superoxide dismutase delays neuronal apoptosis: a role for reactive oxygen species in programmed neuronal death","volume":"14","author":"Greenlund","year":"1995","journal-title":"Neuron"},{"key":"10.1124\/mol.108.053157_REF14","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/j.tibs.2004.09.008","article-title":"Beginnings of a signal-transduction pathway for bioenergetic control of cell survival","volume":"29","author":"Hammerman","year":"2004","journal-title":"Trends Biochem Sci"},{"key":"10.1124\/mol.108.053157_REF15","doi-asserted-by":"crossref","first-page":"30772","DOI":"10.1074\/jbc.M304982200","article-title":"Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor","volume":"278","author":"Hirsil\u00e4","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1124\/mol.108.053157_REF16","doi-asserted-by":"crossref","first-page":"9361","DOI":"10.1128\/MCB.23.24.9361-9374.2003","article-title":"Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation","volume":"23","author":"Hu","year":"2003","journal-title":"Mol Cell Biol"},{"key":"10.1124\/mol.108.053157_REF17","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1126\/science.1059817","article-title":"HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing","volume":"292","author":"Ivan","year":"2001","journal-title":"Science"},{"key":"10.1124\/mol.108.053157_REF18","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1126\/science.1059796","article-title":"Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation","volume":"292","author":"Jaakkola","year":"2001","journal-title":"Science"},{"key":"10.1124\/mol.108.053157_REF19","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.molcel.2008.04.009","article-title":"Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway","volume":"30","author":"Kaelin","year":"2008","journal-title":"Mol Cell"},{"key":"10.1124\/mol.108.053157_REF20","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.cmet.2006.02.002","article-title":"HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia","volume":"3","author":"Kim","year":"2006","journal-title":"Cell Metab"},{"key":"10.1124\/mol.108.053157_REF21","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1523\/JNEUROSCI.21-06-01949.2001","article-title":"Evidence for redox regulation of cytochrome C release during programmed neuronal death: antioxidant effects of protein synthesis and caspase inhibition","volume":"21","author":"Kirkland","year":"2001","journal-title":"J Neurosci"},{"key":"10.1124\/mol.108.053157_REF22","doi-asserted-by":"crossref","first-page":"11315","DOI":"10.1523\/JNEUROSCI.3590-07.2007","article-title":"Rapid activation of antioxidant defenses by nerve growth factor suppresses reactive oxygen species during neuronal apoptosis: evidence for a role in cytochrome c redistribution","volume":"27","author":"Kirkland","year":"2007","journal-title":"J Neurosci"},{"key":"10.1124\/mol.108.053157_REF23","doi-asserted-by":"crossref","first-page":"6480","DOI":"10.1523\/JNEUROSCI.22-15-06480.2002","article-title":"A Bax-induced pro-oxidant state is critical for cytochrome c release during programmed neuronal death","volume":"22","author":"Kirkland","year":"2002","journal-title":"J Neurosci"},{"key":"10.1124\/mol.108.053157_REF24","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.ccr.2005.06.015","article-title":"Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: developmental culling and cancer","volume":"8","author":"Lee","year":"2005","journal-title":"Cancer Cell"},{"key":"10.1124\/mol.108.053157_REF25","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1046\/j.1471-4159.1999.0730429.x","article-title":"Expression of the SM-20 gene promotes death in nerve growth factor-dependent sympathetic neurons","volume":"73","author":"Lipscomb","year":"1999","journal-title":"J Neurochem"},{"key":"10.1124\/mol.108.053157_REF26","doi-asserted-by":"crossref","first-page":"5085","DOI":"10.1074\/jbc.M008407200","article-title":"SM-20 is a novel mitochondrial protein that causes caspase-dependent cell death in nerve growth factor-dependent neurons","volume":"276","author":"Lipscomb","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1124\/mol.108.053157_REF27","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1111\/j.1471-4159.2007.04873.x","article-title":"Prolyl hydroxylase inhibitors delay neuronal cell death caused by trophic factor deprivation","volume":"103","author":"Lomb","year":"2007","journal-title":"J Neurochem"},{"key":"10.1124\/mol.108.053157_REF28","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1089\/ars.2006.8.1941","article-title":"Redox control of neural function: background, mechanisms, and significance","volume":"8","author":"Maher","year":"2006","journal-title":"Antioxid Redox Signal"},{"key":"10.1124\/mol.108.053157_REF29","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1101\/gad.981002","article-title":"Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells","volume":"16","author":"Paddison","year":"2002","journal-title":"Genes Dev"},{"key":"10.1124\/mol.108.053157_REF30","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/nmeth1104-163","article-title":"Cloning of short hairpin RNAs for gene knockdown in mammalian cells","volume":"1","author":"Paddison","year":"2004","journal-title":"Nat Methods"},{"key":"10.1124\/mol.108.053157_REF31","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.cmet.2006.01.012","article-title":"HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption","volume":"3","author":"Papandreou","year":"2006","journal-title":"Cell Metab"},{"key":"10.1124\/mol.108.053157_REF32","first-page":"4010","article-title":"Hypoxia-inducible factor-1alpha is a positive factor in solid tumor growth","volume":"60","author":"Ryan","year":"2000","journal-title":"Cancer Res"},{"key":"10.1124\/mol.108.053157_REF33","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1073\/pnas.85.4.1257","article-title":"cAMP analogs promote survival and neurite out-growth in cultures of rat sympathetic and sensory neurons independently of nerve growth factor","volume":"85","author":"Rydel","year":"1988","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1124\/mol.108.053157_REF34","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1101\/gad.1648608","article-title":"The kinesin KIF1Bbeta acts downstream from EglN3 to induce apoptosis and is a potential 1p36 tumor suppressor","volume":"22","author":"Schlisio","year":"2008","journal-title":"Genes Dev"},{"key":"10.1124\/mol.108.053157_REF35","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/nrm1366","article-title":"Oxygen sensing by HIF hydroxylases","volume":"5","author":"Schofield","year":"2004","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1124\/mol.108.053157_REF36","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/ng1266","article-title":"Multiple organ pathology, metabolic abnormalities and impaired homeostasis of reactive oxygen species in Epas1-\/-mice","volume":"35","author":"Scortegagna","year":"2003","journal-title":"Nat Genet"},{"key":"10.1124\/mol.108.053157_REF37","doi-asserted-by":"crossref","first-page":"41732","DOI":"10.1074\/jbc.M504963200","article-title":"Hypoxia-inducible factor prolyl 4-hydroxylase inhibition. A target for neuroprotection in the central nervous system","volume":"280","author":"Siddiq","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1124\/mol.108.053157_REF38","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1523\/JNEUROSCI.5323-07.2008","article-title":"The good, the bad, and the cell type-specific roles of hypoxia inducible factor-1 alpha in neurons and astrocytes","volume":"28","author":"Vangeison","year":"2008","journal-title":"J Neurosci"},{"key":"10.1124\/mol.108.053157_REF39","doi-asserted-by":"crossref","first-page":"20235","DOI":"10.1074\/jbc.M301391200","article-title":"Activation of the prolyl hydroxylase oxygen-sensor results in induction of GLUT1, HO-1, NOS-2 proteins, and confers protection from metabolic inhibition to cardiomyocytes","volume":"278","author":"Wright","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1124\/mol.108.053157_REF40","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1083\/jcb.200407079","article-title":"Inhibition of NGF deprivation-induced death by low oxygen involves suppression of BIM(EL) and activation of HIF-1","volume":"168","author":"Xie","year":"2005","journal-title":"J Cell Biol"}],"container-title":["Molecular Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026895X24147864?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026895X24147864?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/mol.108.053157","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T10:32:08Z","timestamp":1740047528000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0026895X24147864"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,5]]},"references-count":40,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2009,5]]}},"alternative-id":["S0026895X24147864"],"URL":"https:\/\/doi.org\/10.1124\/mol.108.053157","relation":{},"ISSN":["0026-895X"],"issn-type":[{"value":"0026-895X","type":"print"}],"subject":[],"published":{"date-parts":[[2009,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prolyl Hydroxylase Inhibitors Depend on Extracellular Glucose and Hypoxia-Inducible Factor (HIF)-2\u03b1 to Inhibit Cell Death Caused by Nerve Growth Factor (NGF) Deprivation: Evidence that HIF-2\u03b1 Has a Role in NGF-Promoted Survival of Sympathetic Neurons","name":"articletitle","label":"Article Title"},{"value":"Molecular Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/mol.108.053157","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2009 The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}