{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T06:33:21Z","timestamp":1792737201519,"version":"4.5.0"},"reference-count":39,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2009,11,1]],"date-time":"2009-11-01T00:00:00Z","timestamp":1257033600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,11,1]],"date-time":"2009-11-01T00:00:00Z","timestamp":1257033600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["molpharm.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Pharmacology"],"published-print":{"date-parts":[[2009,11]]},"DOI":"10.1124\/mol.109.058628","type":"journal-article","created":{"date-parts":[[2009,8,8]],"date-time":"2009-08-08T00:45:00Z","timestamp":1249692300000},"page":"992-997","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Altered G-Protein Coupling in an mGluR6 Point Mutant Associated with Congenital Stationary Night Blindness"],"prefix":"10.1016","volume":"76","author":[{"given":"Donald","family":"Beqollari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J.","family":"Betzenhauser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J.","family":"Kammermeier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1124\/mol.109.058628_bib1","doi-asserted-by":"crossref","unstructured":"Bahia DS, Wise A, Fanelli F, Lee M, Rees S and Milligan G (1998) Hydrophobicity of residue 351 of the G protein Gi1 alpha determines the extent of activation by the alpha 2A-adrenoceptor. Biochemistry 37:11555\u201311562.","DOI":"10.1021\/bi980284o"},{"key":"10.1124\/mol.109.058628_bib2","doi-asserted-by":"crossref","unstructured":"Bellone RR, Brooks SA, Sandmeyer L, Murphy BA, Forsyth G, Archer S, Bailey E and Grahn B (2008) Differential gene expression of TRPM1, the potential cause of congenital stationary night blindness and coat spotting patterns (LP) in the Appaloosa horse (Equus caballus). Genetics 179:1861\u20131870.","DOI":"10.1534\/genetics.108.088807"},{"key":"10.1124\/mol.109.058628_bib3","doi-asserted-by":"crossref","unstructured":"Bessis AS, Bertrand HO, Galvez T, De Colle C, Pin JP and Acher F (2000) Three-dimensional model of the extracellular domain of the type 4a metabotropic glutamate receptor: new insights into the activation process. Protein Sci 9:2200\u20132209.","DOI":"10.1110\/ps.9.11.2200"},{"key":"10.1124\/mol.109.058628_bib4","doi-asserted-by":"crossref","unstructured":"Blahos J, 2nd, Mary S, Perroy J, de Colle C, Brabet I, Bockaert J and Pin JP (1998) Extreme C terminus of G protein \u03b1-subunits contains a site that discriminates between Gi-coupled metabotropic glutamate receptors. J Biol Chem 273:25765\u201325769.","DOI":"10.1074\/jbc.273.40.25765"},{"key":"10.1124\/mol.109.058628_bib5","doi-asserted-by":"crossref","unstructured":"Chang B, Heckenlively JR, Bayley PR, Brecha NC, Davisson MT, Hawes NL, Hirano AA, Hurd RE, Ikeda A, Johnson BA, et al.. (2006) The nob2 mouse, a null mutation in Cacna1f: anatomical and functional abnormalities in the outer retina and their consequences on ganglion cell visual responses. Vis Neurosci 23:11\u201324.","DOI":"10.1017\/S095252380623102X"},{"key":"10.1124\/mol.109.058628_bib6","doi-asserted-by":"crossref","unstructured":"Dhingra A, Faurobert E, Dascal N, Sterling P and Vardi N (2004) A retinal-specific regulator of G-protein signaling interacts with Galpha(o) and accelerates an expressed metabotropic glutamate receptor 6 cascade. J Neurosci 24:5684\u20135693.","DOI":"10.1523\/JNEUROSCI.0492-04.2004"},{"key":"10.1124\/mol.109.058628_bib7","doi-asserted-by":"crossref","unstructured":"Dhingra A, Jiang M, Wang TL, Lyubarsky A, Savchenko A, Bar-Yehuda T, Sterling P, Birnbaumer L and Vardi N (2002) Light response of retinal ON bipolar cells requires a specific splice variant of Galpha(o). J Neurosci 22:4878\u20134884.","DOI":"10.1523\/JNEUROSCI.22-12-04878.2002"},{"key":"10.1124\/mol.109.058628_bib8","doi-asserted-by":"crossref","unstructured":"Dhingra A, Lyubarsky A, Jiang M, Pugh EN, Jr, Birnbaumer L, Sterling P and Vardi N (2000) The light response of ON bipolar neurons requires G[alpha]o. J Neurosci 20:9053\u20139058.","DOI":"10.1523\/JNEUROSCI.20-24-09053.2000"},{"key":"10.1124\/mol.109.058628_bib9","doi-asserted-by":"crossref","unstructured":"Dryja TP, McGee TL, Berson EL, Fishman GA, Sandberg MA, Alexander KR, Derlacki DJ and Rajagopalan AS (2005) Night blindness and abnormal cone electroretinogram ON responses in patients with mutations in the GRM6 gene encoding mGluR6. Proc Natl Acad Sci U S A 102:4884\u20134889.","DOI":"10.1073\/pnas.0501233102"},{"key":"10.1124\/mol.109.058628_bib10","doi-asserted-by":"crossref","unstructured":"Elmslie KS, Zhou W and Jones SW (1990) LHRH and GTP-gamma-S modify calcium current activation in bullfrog sympathetic neurons. Neuron 5:75\u201380.","DOI":"10.1016\/0896-6273(90)90035-E"},{"key":"10.1124\/mol.109.058628_bib11","doi-asserted-by":"crossref","unstructured":"Francesconi A and Duvoisin RM (1998) Role of the second and third intracellular loops of metabotropic glutamate receptors in mediating dual signal transduction activation. J Biol Chem 273:5615\u20135624.","DOI":"10.1074\/jbc.273.10.5615"},{"key":"10.1124\/mol.109.058628_bib12","doi-asserted-by":"crossref","unstructured":"Herlitze S, Garcia DE, Mackie K, Hille B, Scheuer T and Catterall WA (1996) Modulation of Ca2+ channels by G-protein bg subunits. Nature 380:258\u2013262.","DOI":"10.1038\/380258a0"},{"key":"10.1124\/mol.109.058628_bib13","doi-asserted-by":"crossref","unstructured":"Ikeda SR (1991) Double-pulse calcium channel current facilitation in adult rat sympathetic neurones. J Physiol 439:181\u2013214.","DOI":"10.1113\/jphysiol.1991.sp018663"},{"key":"10.1124\/mol.109.058628_bib14","doi-asserted-by":"crossref","unstructured":"Ikeda SR (1996) Voltage-dependent modulation of N-type calcium channels by G-protein \u03b2\u03b3 subunits. Nature 380:255\u2013258.","DOI":"10.1038\/380255a0"},{"key":"10.1124\/mol.109.058628_bib15","doi-asserted-by":"crossref","unstructured":"Ikeda SR (1997) Heterologous expression of receptors and signaling proteins in adult mammalian sympathetic neurons by microinjection, in Methods in Molecular Biology (Challis RAJ ed) pp 191\u2013202, Humana Press, Inc., Totowa, NJ.","DOI":"10.1385\/0-89603-495-X:191"},{"key":"10.1124\/mol.109.058628_bib16","doi-asserted-by":"crossref","unstructured":"Ikeda SR and Dunlap K (1999) Voltage-dependent modulation of N-type calcium channels: role of G protein subunits. Adv Second Messenger Phosphoprotein Res 33:131\u2013151.","DOI":"10.1016\/S1040-7952(99)80008-1"},{"key":"10.1124\/mol.109.058628_bib17","doi-asserted-by":"crossref","unstructured":"Kammermeier PJ, Davis MI and Ikeda SR (2003) Specificity of metabotropic glutamate receptor 2 coupling to G proteins. Mol Pharmacol 63:183\u2013191.","DOI":"10.1124\/mol.63.1.183"},{"key":"10.1124\/mol.109.058628_bib18","doi-asserted-by":"crossref","unstructured":"Kowal D, Nawoschik S, Ochalski R and Dunlop J (2003) Functional calcium coupling with the human metabotropic glutamate receptor subtypes 2 and 4 by stable co-expression with a calcium pathway facilitating G-protein chimera in Chinese hamster ovary cells. Biochem Pharmacol 66:785\u2013790.","DOI":"10.1016\/S0006-2952(03)00399-X"},{"key":"10.1124\/mol.109.058628_bib19","doi-asserted-by":"crossref","unstructured":"Kowal D, Zhang J, Nawoschik S, Ochalski R, Vlattas A, Shan Q, Schechter L and Dunlop J (2002) The C-terminus of Gi family G-proteins as a determinant of 5-HT1A receptor coupling. Biochem Biophys Res Commun 294:655\u2013659.","DOI":"10.1016\/S0006-291X(02)00535-1"},{"key":"10.1124\/mol.109.058628_bib20","doi-asserted-by":"crossref","unstructured":"Masland RH (2001) The fundamental plan of the retina. Nat Neurosci 4:877\u2013886.","DOI":"10.1038\/nn0901-877"},{"key":"10.1124\/mol.109.058628_bib21","doi-asserted-by":"crossref","unstructured":"Nakajima Y, Iwakabe H, Akazawa C, Nawa H, Shigemoto R, Mizuno N and Nakanishi S (1993) Molecular characterization of a novel retinal metabotropic glutamate receptor mGluR6 with a high agonist selectivity for L-2-amino-4- phosphonobutyrate. J Biol Chem 268:11868\u201311873.","DOI":"10.1016\/S0021-9258(19)50280-0"},{"key":"10.1124\/mol.109.058628_bib22","doi-asserted-by":"crossref","unstructured":"Nakajima Y, Moriyama M, Hattori M, Minato N and Nakanishi S (2009) Isolation of ON bipolar cell genes via hrGFP-coupled cell enrichment using the mGluR6 promoter. J Biochem 145:811\u2013818.","DOI":"10.1093\/jb\/mvp038"},{"key":"10.1124\/mol.109.058628_bib23","doi-asserted-by":"crossref","unstructured":"Nawy S (1999) The metabotropic receptor mGluR6 may signal through G(o), but not phosphodiesterase, in retinal bipolar cells. J Neurosci 19:2938\u20132944.","DOI":"10.1523\/JNEUROSCI.19-08-02938.1999"},{"key":"10.1124\/mol.109.058628_bib24","doi-asserted-by":"crossref","unstructured":"Pinto LH, Vitaterna MH, Shimomura K, Siepka SM, Balannik V, McDearmon EL, Omura C, Lumayag S, Invergo BM, Glawe B, et al.. (2007) Generation, identification and functional characterization of the nob4 mutation of Grm6 in the mouse. Vis Neurosci 24:111\u2013123.","DOI":"10.1017\/S0952523807070149"},{"key":"10.1124\/mol.109.058628_bib25","doi-asserted-by":"crossref","unstructured":"Pr\u00e9zeau L, Carrette J, Helpap B, Curry K, Pin JP and Bockaert J (1994) Pharmacological characterization of metabotropic glutamate receptors in several types of brain cells in primary cultures. Mol Pharmacol 45:570\u2013577.","DOI":"10.1016\/S0026-895X(25)10140-5"},{"key":"10.1124\/mol.109.058628_bib26","doi-asserted-by":"crossref","unstructured":"Quraishi S, Gayet J, Morgans CW and Duvoisin RM (2007) Distribution of group-III metabotropic glutamate receptors in the retina. J Comp Neurol 501:931\u2013943.","DOI":"10.1002\/cne.21274"},{"key":"10.1124\/mol.109.058628_bib27","doi-asserted-by":"crossref","unstructured":"Rondard P, Liu J, Huang S, Malhaire F, Vol C, Pinault A, Labesse G and Pin JP (2006) Coupling of agonist binding to effector domain activation in metabotropic glutamate-like receptors. J Biol Chem 281:24653\u201324661.","DOI":"10.1074\/jbc.M602277200"},{"key":"10.1124\/mol.109.058628_bib28","doi-asserted-by":"crossref","unstructured":"Rosemond E, Peltekova V, Naples M, Th\u00f8gersen H and Hampson DR (2002) Molecular determinants of high affinity binding to group III metabotropic glutamate receptors. J Biol Chem 277:7333\u20137340.","DOI":"10.1074\/jbc.M110476200"},{"key":"10.1124\/mol.109.058628_bib29","doi-asserted-by":"crossref","unstructured":"Schoepp DD (2001) Unveiling the functions of presynaptic metabotropic glutamate receptors in the central nervous system. J Pharmacol Exp Ther 299:12\u201320.","DOI":"10.1016\/S0022-3565(24)29296-X"},{"key":"10.1124\/mol.109.058628_bib30","doi-asserted-by":"crossref","unstructured":"Sekine-Aizawa Y and Huganir RL (2004) Imaging of receptor trafficking by using alpha-bungarotoxin-binding-site-tagged receptors. Proc Natl Acad Sci U S A 101:17114\u201317119.","DOI":"10.1073\/pnas.0407563101"},{"key":"10.1124\/mol.109.058628_bib31","doi-asserted-by":"crossref","unstructured":"Shen Y, Heimel JA, Kamermans M, Peachey NS, Gregg RG and Nawy S (2009) A transient receptor potential-like channel mediates synaptic transmission in rod bipolar cells. J Neurosci 29:6088\u20136093.","DOI":"10.1523\/JNEUROSCI.0132-09.2009"},{"key":"10.1124\/mol.109.058628_bib32","doi-asserted-by":"crossref","unstructured":"Takao M, Morigiwa K, Sasaki H, Miyoshi T, Shima T, Nakanishi S, Nagai K and Fukuda Y (2000) Impaired behavioral suppression by light in metabotropic glutamate receptor subtype 6-deficient mice. Neuroscience 97:779\u2013787.","DOI":"10.1016\/S0306-4522(00)00053-1"},{"key":"10.1124\/mol.109.058628_bib33","doi-asserted-by":"crossref","unstructured":"Tian L and Kammermeier PJ (2006) G protein coupling profile of mGluR6 and expression of G alpha proteins in retinal ON bipolar cells. Vis Neurosci 23:909\u2013916.","DOI":"10.1017\/S0952523806230268"},{"key":"10.1124\/mol.109.058628_bib34","doi-asserted-by":"crossref","unstructured":"Vardi N, Duvoisin R, Wu G and Sterling P (2000) Localization of mGluR6 to dendrites of ON bipolar cells in primate retina. J Comp Neurol 423:402\u2013412.","DOI":"10.1002\/1096-9861(20000731)423:3<402::AID-CNE4>3.0.CO;2-E"},{"key":"10.1124\/mol.109.058628_bib35","doi-asserted-by":"crossref","unstructured":"Walker MW, Jones KA, Tamm J, Zhong H, Smith KE, Gerald C, Vaysse P and Branchek TA (2005) Use of Caenorhabditis elegans G{alpha}q chimeras to detect G-protein-coupled receptor signals. J Biomol Screen 10:127\u2013136.","DOI":"10.1177\/1087057104272006"},{"key":"10.1124\/mol.109.058628_bib36","doi-asserted-by":"crossref","unstructured":"Zeitz C, Forster U, Neidhardt J, Feil S, K\u00e4lin S, Leifert D, Flor PJ and Berger W (2007) Night blindness-associated mutations in the ligand-binding, cysteine-rich, and intracellular domains of the metabotropic glutamate receptor 6 abolish protein trafficking. Hum Mutat 28:771\u2013780.","DOI":"10.1002\/humu.20499"},{"key":"10.1124\/mol.109.058628_bib37","doi-asserted-by":"crossref","unstructured":"Zeitz C, Kloeckener-Gruissem B, Forster U, Kohl S, Magyar I, Wissinger B, M\u00e1ty\u00e1s G, Borruat FX, Schorderet DF, Zrenner E, et al.. (2006) Mutations in CABP4, the gene encoding the Ca2+-binding protein 4, cause autosomal recessive night blindness. Am J Hum Genet 79:657\u2013667.","DOI":"10.1086\/508067"},{"key":"10.1124\/mol.109.058628_bib38","doi-asserted-by":"crossref","unstructured":"Zeitz C, van Genderen M, Neidhardt J, Luhmann UF, Hoeben F, Forster U, Wycisk K, M\u00e1ty\u00e1s G, Hoyng CB, Riemslag F, et al.. (2005) Mutations in GRM6 cause autosomal recessive congenital stationary night blindness with a distinctive scotopic 15-Hz flicker electroretinogram. Invest Ophthalmol Vis Sci 46:4328\u20134335.","DOI":"10.1167\/iovs.05-0526"},{"key":"10.1124\/mol.109.058628_bib39","doi-asserted-by":"crossref","unstructured":"Zhang JY, Nawoschik S, Kowal D, Smith D, Spangler T, Ochalski R, Schechter L and Dunlop J (2003) Characterization of the 5-HT6 receptor coupled to Ca2+ signaling using an enabling chimeric G-protein. Eur J Pharmacol 472:33\u201338.","DOI":"10.1016\/S0014-2999(03)01855-7"}],"container-title":["Molecular Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026895X24020698?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026895X24020698?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/mol.109.058628","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T09:41:05Z","timestamp":1739958065000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0026895X24020698"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,11]]},"references-count":39,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2009,11]]}},"alternative-id":["S0026895X24020698"],"URL":"https:\/\/doi.org\/10.1124\/mol.109.058628","relation":{},"ISSN":["0026-895X"],"issn-type":[{"value":"0026-895X","type":"print"}],"subject":[],"published":{"date-parts":[[2009,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Altered G-Protein Coupling in an mGluR6 Point Mutant Associated with Congenital Stationary Night Blindness","name":"articletitle","label":"Article Title"},{"value":"Molecular Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/mol.109.058628","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2009 The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}