{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T15:13:11Z","timestamp":1783955591039,"version":"3.55.0"},"reference-count":40,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T00:00:00Z","timestamp":1314835200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T00:00:00Z","timestamp":1314835200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["molpharm.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Pharmacology"],"published-print":{"date-parts":[[2011,9]]},"DOI":"10.1124\/mol.111.071126","type":"journal-article","created":{"date-parts":[[2011,6,23]],"date-time":"2011-06-23T04:04:11Z","timestamp":1308801851000},"page":"446-457","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":97,"title":["Resveratrol Restores Nrf2 Level and Prevents Ethanol-Induced Toxic Effects in the Cerebellum of a Rodent Model of Fetal Alcohol Spectrum Disorders"],"prefix":"10.1016","volume":"80","author":[{"given":"Ambrish","family":"Kumar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandra K.","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holly A.","family":"LaVoie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald J.","family":"DiPette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ugra S.","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1124\/mol.111.071126_bib1","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.brainres.2008.02.018","article-title":"Antioxidants prevent ethanol-associated apoptosis in fetal rhombencephalic neurons","volume":"1204","author":"Antonio","year":"2008","journal-title":"Brain Res"},{"key":"10.1124\/mol.111.071126_bib2","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1097\/GRF.0b013e31816fea3d","article-title":"Pregnancy and alcohol use: evidence and recommendations for prenatal care","volume":"51","author":"Bailey","year":"2008","journal-title":"Clin Obstet Gynecol"},{"key":"10.1124\/mol.111.071126_bib3","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1046\/j.1471-4159.1997.68020578.x","article-title":"Ethanol promotes apoptosis in cerebellar granule cells by inhibiting the trophic effect of NMDA","volume":"68","author":"Bhave","year":"1997","journal-title":"J Neurochem"},{"key":"10.1124\/mol.111.071126_bib4","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/j.1530-0277.1990.tb00455.x","article-title":"Alcohol-induced neuronal loss in developing rats: increased brain damage with binge exposure","volume":"14","author":"Bonthius","year":"1990","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1124\/mol.111.071126_bib5","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1007\/s00401-007-0199-4","article-title":"Chronic ethanol exposure causes mitochondrial dysfunction and oxidative stress in immature central nervous system neurons","volume":"113","author":"Chu","year":"2007","journal-title":"Acta Neuropathol"},{"key":"10.1124\/mol.111.071126_bib6","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0741-8329(96)00114-0","article-title":"Heme oxygenase activity and acute and chronic ethanol exposure in the hippocampus, frontal cerebral cortex, and cerebellum of the near-term fetal guinea pig","volume":"14","author":"Cook","year":"1997","journal-title":"Alcohol"},{"key":"10.1124\/mol.111.071126_bib7","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0378-3782(79)90022-7","article-title":"Comparative aspects of the brain growth spurt","volume":"3","author":"Dobbing","year":"1979","journal-title":"Early Hum Dev"},{"key":"10.1124\/mol.111.071126_bib8","doi-asserted-by":"crossref","first-page":"4556","DOI":"10.1016\/S0021-9258(20)64358-7","article-title":"Transcriptional regulation of the rat NAD(P)H:quinone reductase gene. Identification of regulatory elements controlling basal level expression and inducible expression by planar aromatic compounds and phenolic antioxidants","volume":"266","author":"Favreau","year":"1991","journal-title":"J Biol Chem"},{"key":"10.1124\/mol.111.071126_bib9","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/S0891-5849(00)00167-2","article-title":"Evaluation of the postprandial effects of a fast-food meal on human plasma F(2)-isoprostane levels","volume":"28","author":"Gopaul","year":"2000","journal-title":"Free Radic Biol Med"},{"key":"10.1124\/mol.111.071126_bib10","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/0896-6273(95)90287-2","article-title":"Superoxide dismutase delays neuronal apoptosis: a role for reactive oxygen species in programmed neuronal death","volume":"14","author":"Greenlund","year":"1995","journal-title":"Neuron"},{"key":"10.1124\/mol.111.071126_bib11","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1093\/alcalc\/agn105","article-title":"Foetal Alcohol Spectrum Disorders and alterations in brain and behaviour","volume":"44","author":"Guerri","year":"2009","journal-title":"Alcohol Alcohol"},{"key":"10.1124\/mol.111.071126_bib12","doi-asserted-by":"crossref","first-page":"3326","DOI":"10.2337\/db06-0169","article-title":"Hyperglycemia inhibits retinoic acid-induced activation of Rac1, prevents differentiation of cortical neurons, and causes oxidative stress in a rat model of diabetic pregnancy","volume":"55","author":"Guleria","year":"2006","journal-title":"Diabetes"},{"key":"10.1124\/mol.111.071126_bib13","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0304-3940(02)01123-0","article-title":"Ethanol-mediated generation of reactive oxygen species in developing rat cerebellum","volume":"334","author":"Heaton","year":"2002","journal-title":"Neurosci Lett"},{"key":"10.1124\/mol.111.071126_bib14","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.tox.2007.09.015","article-title":"Protective effects of resveratrol on ethanol-induced apoptosis in embryonic stem cells and disruption of embryonic development in mouse blastocysts","volume":"242","author":"Huang","year":"2007","journal-title":"Toxicology"},{"key":"10.1124\/mol.111.071126_bib15","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1089\/ars.2010.3581","article-title":"Neuronal death and oxidative stress in the developing brain","volume":"14","author":"Ikonomidou","year":"2011","journal-title":"Antioxid Redox Signal"},{"key":"10.1124\/mol.111.071126_bib16","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S0168-0102(99)00097-8","article-title":"Comparative study of survival signal withdrawal- and 4-hydroxynonenal-induced cell death in cerebellar granule cells","volume":"35","author":"Ito","year":"1999","journal-title":"Neurosci Res"},{"key":"10.1124\/mol.111.071126_bib17","doi-asserted-by":"crossref","first-page":"16502","DOI":"10.1074\/jbc.M611336200","article-title":"GSK-3beta acts upstream of Fyn kinase in regulation of nuclear export and degradation of NF-E2 related factor 2","volume":"282","author":"Jain","year":"2007","journal-title":"J Biol Chem"},{"key":"10.1124\/mol.111.071126_bib18","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/S0891-5849(00)00306-3","article-title":"Regulation of genes encoding NAD(P)H:quinone oxidoreductases","volume":"29","author":"Jaiswal","year":"2000","journal-title":"Free Radic Biol Med"},{"key":"10.1124\/mol.111.071126_bib19","doi-asserted-by":"crossref","first-page":"2859","DOI":"10.1007\/s00018-006-6333-y","article-title":"Ethanol impairs Rho GTPase signaling and differentiation of cerebellar granule neurons in a rodent model of fetal alcohol syndrome","volume":"63","author":"Joshi","year":"2006","journal-title":"Cell Mol Life Sci"},{"key":"10.1124\/mol.111.071126_bib20","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0928-4680(00)00053-5","article-title":"Oxidative stress and apoptosis","volume":"7","author":"Kannan","year":"2000","journal-title":"Pathophysiology"},{"key":"10.1124\/mol.111.071126_bib21","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1042\/BJ20100208","article-title":"What does the commonly used DCF test for oxidative stress really show?","volume":"428","author":"Karlsson","year":"2010","journal-title":"Biochem J"},{"key":"10.1124\/mol.111.071126_bib22","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1089\/ars.2005.7.385","article-title":"Molecular mechanisms activating the Nrf2-Keap1 pathway of antioxidant gene regulation","volume":"7","author":"Kobayashi","year":"2005","journal-title":"Antioxid Redox Signal"},{"key":"10.1124\/mol.111.071126_bib23","doi-asserted-by":"crossref","first-page":"5089","DOI":"10.1523\/JNEUROSCI.17-13-05089.1997","article-title":"Evidence that 4-hydroxynonenal mediates oxidative stress-induced neuronal apoptosis","volume":"17","author":"Kruman","year":"1997","journal-title":"J Neurosci"},{"key":"10.1124\/mol.111.071126_bib24","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1111\/j.1530-0277.2010.01166.x","article-title":"Ethanol impairs activation of retinoic acid receptors in cerebellar granule cells in a rodent model of fetal alcohol spectrum disorders","volume":"34","author":"Kumar","year":"2010","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1124\/mol.111.071126_bib25","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1007\/s12035-009-8075-y","article-title":"GSK3beta in ethanol neurotoxicity","volume":"40","author":"Luo","year":"2009","journal-title":"Mol Neurobiol"},{"key":"10.1124\/mol.111.071126_bib26","first-page":"159","article-title":"Estimating the prevalence of fetal alcohol syndrome. A summary","volume":"25","author":"May","year":"2001","journal-title":"Alcohol Res Health"},{"key":"10.1124\/mol.111.071126_bib27","doi-asserted-by":"crossref","first-page":"9383","DOI":"10.1073\/pnas.87.23.9383","article-title":"A series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanism","volume":"87","author":"Morrow","year":"1990","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/mol.111.071126_bib28","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1016\/S0006-2952(03)00083-2","article-title":"Evaluation of the probes 2\u2032,7\u2032-dichlorofluorescin diacetate, luminol, and lucigenin as indicators of reactive species formation","volume":"65","author":"Myhre","year":"2003","journal-title":"Biochem Pharmacol"},{"key":"10.1124\/mol.111.071126_bib29","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/sj.cdd.4401161","article-title":"Degradation of chromosomal DNA during apoptosis","volume":"10","author":"Nagata","year":"2003","journal-title":"Cell Death Differ"},{"key":"10.1124\/mol.111.071126_bib30","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1002\/cne.903620210","article-title":"Permanent neuronal cell loss in the cerebellum of rats exposed to continuous low blood alcohol levels during the brain growth spurt: a stereological investigation","volume":"362","author":"Napper","year":"1995","journal-title":"J Comp Neurol"},{"key":"10.1124\/mol.111.071126_bib31","doi-asserted-by":"crossref","first-page":"D506","DOI":"10.2741\/Niemela","article-title":"Aldehyde-protein adducts in the liver as a result of ethanol-induced oxidative stress","volume":"4","author":"Niemel\u00e4","year":"1999","journal-title":"Front Biosci"},{"key":"10.1124\/mol.111.071126_bib32","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1023\/A:1009685428847","article-title":"Ethanol-induced apoptotic neurodegeneration in the developing brain","volume":"5","author":"Olney","year":"2000","journal-title":"Apoptosis"},{"key":"10.1124\/mol.111.071126_bib33","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1006\/nbdi.2001.0475","article-title":"Ethanol-induced caspase-3 activation in the in vivo developing mouse brain","volume":"9","author":"Olney","year":"2002","journal-title":"Neurobiol Dis"},{"key":"10.1124\/mol.111.071126_bib34","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1016\/S0891-5849(00)00238-0","article-title":"Distribution of hydroxynonenal-modified proteins in the kainate-lesioned rat hippocampus: evidence that hydroxynonenal formation precedes neuronal cell death","volume":"28","author":"Ong","year":"2000","journal-title":"Free Radic Biol Med"},{"key":"10.1124\/mol.111.071126_bib35","first-page":"862","article-title":"In utero ethanol exposure causes mitochondrial dysfunction, which can result in apoptotic cell death in fetal brain: a potential role for 4-hydroxynonenal","volume":"25","author":"Ramachandran","year":"2001","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1124\/mol.111.071126_bib36","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1111\/j.1471-4159.2007.05124.x","article-title":"GSK-3beta down-regulates the transcription factor Nrf2 after oxidant damage: relevance to exposure of neuronal cells to oxidative stress","volume":"105","author":"Rojo","year":"2008","journal-title":"J Neurochem"},{"key":"10.1124\/mol.111.071126_bib37","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1002\/mnfr.200800148","article-title":"Resveratrol addiction: to die or not to die","volume":"53","author":"Shakibaei","year":"2009","journal-title":"Mol Nutr Food Res"},{"key":"10.1124\/mol.111.071126_bib38","first-page":"678","article-title":"Resveratrol prevents alcohol-induced cognitive deficits and brain damage by blocking inflammatory signaling and cell death cascade in neonatal rat brain","volume":"117","author":"Tiwari","year":"2011","journal-title":"J Neurochem"},{"key":"10.1124\/mol.111.071126_bib39","first-page":"279","article-title":"Fetal alcohol spectrum disorders","volume":"72","author":"Wattendorf","year":"2005","journal-title":"Am Fam Physician"},{"key":"10.1124\/mol.111.071126_bib40","doi-asserted-by":"crossref","first-page":"35359","DOI":"10.1074\/jbc.M110.138636","article-title":"Ethanol-induced HO-1 and NQO1 are differentially regulated by HIF-1alpha and Nrf2 to attenuate inflammatory cytokine expression","volume":"285","author":"Yeligar","year":"2010","journal-title":"J Biol Chem"}],"container-title":["Molecular Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026895X24032784?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026895X24032784?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/mol.111.071126","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T10:12:33Z","timestamp":1739959953000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0026895X24032784"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9]]},"references-count":40,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,9]]}},"alternative-id":["S0026895X24032784"],"URL":"https:\/\/doi.org\/10.1124\/mol.111.071126","relation":{},"ISSN":["0026-895X"],"issn-type":[{"value":"0026-895X","type":"print"}],"subject":[],"published":{"date-parts":[[2011,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Resveratrol Restores Nrf2 Level and Prevents Ethanol-Induced Toxic Effects in the Cerebellum of a Rodent Model of Fetal Alcohol Spectrum Disorders","name":"articletitle","label":"Article Title"},{"value":"Molecular Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/mol.111.071126","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2011 The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}