{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T01:18:46Z","timestamp":1777425526105,"version":"3.51.4"},"reference-count":38,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["molpharm.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Pharmacology"],"published-print":{"date-parts":[[2011,10]]},"DOI":"10.1124\/mol.111.072421","type":"journal-article","created":{"date-parts":[[2011,7,8]],"date-time":"2011-07-08T14:48:27Z","timestamp":1310136507000},"page":"621-629","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["The Antiepileptic Drugs Phenobarbital and Carbamazepine Reduce Transport of Methotrexate in Rat Choroid Plexus by Down-Regulation of the Reduced Folate Carrier"],"prefix":"10.1016","volume":"80","author":[{"given":"Sandra","family":"Halwachs","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cathleen","family":"Lakoma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingo","family":"Sch\u00e4fer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Seibel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walther","family":"Honscha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1124\/mol.111.072421_bib1","first-page":"417","article-title":"Potent and specific inhibition of the breast cancer resistance protein multidrug transporter in vitro and in mouse intestine by a novel analogue of fumitremorgin C","volume":"1","author":"Allen","year":"2002","journal-title":"Mol Cancer Ther"},{"key":"10.1124\/mol.111.072421_bib2","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1254\/jphs.CRJ06006X","article-title":"Organic anion transporter family: current knowledge","volume":"100","author":"Anzai","year":"2006","journal-title":"J Pharmacol Sci"},{"key":"10.1124\/mol.111.072421_bib3","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.drup.2006.09.001","article-title":"The role of multidrug resistance efflux transporters in antifolate resistance and folate homeostasis","volume":"9","author":"Assaraf","year":"2006","journal-title":"Drug Resist Updat"},{"key":"10.1124\/mol.111.072421_bib4","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1093\/jb\/mvp130","article-title":"Differential usage of the transport systems for folic acid and methotrexate in normal human T-lymphocytes and leukemic cells","volume":"146","author":"Biswal","year":"2009","journal-title":"J Biochem"},{"key":"10.1124\/mol.111.072421_bib5","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1056\/NEJM197310112891503","article-title":"Neurotoxicity and elevated cerebrospinal-fluid methotrexate concentration in meningeal leukemia","volume":"289","author":"Bleyer","year":"1973","journal-title":"N Engl J Med"},{"key":"10.1124\/mol.111.072421_bib6","doi-asserted-by":"crossref","first-page":"F562","DOI":"10.1152\/ajprenal.00045.2003","article-title":"Fluorescein-methotrexate transport in rat choroid plexus analyzed using confocal microscopy","volume":"287","author":"Breen","year":"2004","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1124\/mol.111.072421_bib7","first-page":"3144","article-title":"Analysis of methotrexate and folate transport by multidrug resistance protein 4 (ABCC4): MRP4 is a component of the methotrexate efflux system","volume":"62","author":"Chen","year":"2002","journal-title":"Cancer Res"},{"key":"10.1124\/mol.111.072421_bib8","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1124\/dmd.31.11.1337","article-title":"Constitutive expression of various xenobiotic and endobiotic transporter mRNAs in the choroid plexus of rats","volume":"31","author":"Choudhuri","year":"2003","journal-title":"Drug Metab Dispos"},{"key":"10.1124\/mol.111.072421_bib9","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1002\/1097-0142(19820801)50:3<444::AID-CNCR2820500311>3.0.CO;2-#","article-title":"Pharmacokinetics and biochemical effects of a fatal intrathecal methotrexate overdose","volume":"50","author":"Ettinger","year":"1982","journal-title":"Cancer"},{"key":"10.1124\/mol.111.072421_bib10","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1002\/1097-0142(19821101)50:9<1676::AID-CNCR2820500903>3.0.CO;2-S","article-title":"Pharmacokinetics of methotrexate following intravenous and intraventricular administration in acute lymphocytic leukemia and non-Hodgkin\u2019s lymphoma","volume":"50","author":"Ettinger","year":"1982","journal-title":"Cancer"},{"key":"10.1124\/mol.111.072421_bib11","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.ejcb.2005.01.008","article-title":"Endogenous expression of liver-specific drug transporters for organic anions in the rat hepatocytoma fusion cell line HPCT-1E3","volume":"84","author":"Halwachs","year":"2005","journal-title":"Eur J Cell Biol"},{"key":"10.1124\/mol.111.072421_bib12","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1016\/j.bbamem.2007.03.023","article-title":"Downregulation of the reduced folate carrier transport activity by phenobarbital-type cytochrome P450 inducers and protein kinase C activators","volume":"1768","author":"Halwachs","year":"2007","journal-title":"Biochem Biophys Acta"},{"key":"10.1124\/mol.111.072421_bib13","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1038\/leu.2009.6","article-title":"Antiepileptic drugs reduce efficacy of methotrexate chemotherapy by downregulation of Reduced folate carrier transport activity","volume":"23","author":"Halwachs","year":"2009","journal-title":"Leukemia"},{"key":"10.1124\/mol.111.072421_bib14","doi-asserted-by":"crossref","first-page":"e3","DOI":"10.4081\/ejh.2011.e3","article-title":"Subcellular localization and distribution of the reduced folate carrier in normal rat tissues","volume":"55","author":"Hinken","year":"2011","journal-title":"Eur J Histochem"},{"key":"10.1124\/mol.111.072421_bib15","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1053\/jhep.2000.7478","article-title":"Cloning and functional characterization of the bile acid-sensitive methotrexate carrier from rat liver cells","volume":"31","author":"Honscha","year":"2000","journal-title":"Hepatology"},{"key":"10.1124\/mol.111.072421_bib16","doi-asserted-by":"crossref","first-page":"G660","DOI":"10.1152\/ajpgi.00309.2007","article-title":"Functional characterization of PCFT\/HCP1 as the molecular entity of the carrier-mediated intestinal folate transport system in the rat model","volume":"294","author":"Inoue","year":"2008","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1124\/mol.111.072421_bib17","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1080\/03009740310004333","article-title":"Multidrug resistance proteins in rheumatoid arthritis, role in disease-modifying antirheumatic drug efficacy and inflammatory processes: an overview","volume":"32","author":"Jansen","year":"2003","journal-title":"Scand J Rheumatol"},{"key":"10.1124\/mol.111.072421_bib18","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1093\/toxsci\/66.1.16","article-title":"Increase in bile flow and biliary excretion of glutathione-derived sulfhydryls in rats by drug-metabolizing enzyme inducers is mediated by multidrug resistance protein 2","volume":"66","author":"Johnson","year":"2002","journal-title":"Toxicol Sci"},{"key":"10.1124\/mol.111.072421_bib19","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/1743-8454-7-11","article-title":"Characterization of immortalized choroid plexus epithelial cell lines for studies of transport processes across the blood-cerebrospinal fluid barrier","volume":"7","author":"Kl\u00e4s","year":"2010","journal-title":"Cerebrospinal Fluid Res"},{"key":"10.1124\/mol.111.072421_bib20","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.febslet.2004.04.010","article-title":"The H(+)-dependent reduced folate carrier 1 of humans and the sodium-dependent methotrexate carrier-1 of the rat are orthologs","volume":"566","author":"Kneuer","year":"2004","journal-title":"FEBS Lett"},{"key":"10.1124\/mol.111.072421_bib21","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s00277-008-0645-y","article-title":"Intrathecal chemotherapy for hematologic malignancies: drugs and toxicities","volume":"88","author":"Kwong","year":"2009","journal-title":"Ann Hematol"},{"key":"10.1124\/mol.111.072421_bib22","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1042\/bj3140433","article-title":"ATP-dependent glutathione disulphide transport mediated by the MRP gene-encoded conjugate export pump","volume":"314","author":"Leier","year":"1996","journal-title":"Biochem J"},{"key":"10.1124\/mol.111.072421_bib23","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0083-6729(03)01012-4","article-title":"Membrane transport of folates","volume":"66","author":"Matherly","year":"2003","journal-title":"Vitam Horm"},{"key":"10.1124\/mol.111.072421_bib24","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1111\/j.1528-1157.1995.tb01622.x","article-title":"Prognosis and treatment of seizures in children with acute lymphoblastic leukemia","volume":"36","author":"Maytal","year":"1995","journal-title":"Epilepsia"},{"key":"10.1124\/mol.111.072421_bib25","first-page":"71","article-title":"Indicative therapeutic and toxic drug concentrations in plasma: a tabulation","volume":"32","author":"Meyer","year":"1994","journal-title":"Int J Clin Pharmacol Ther"},{"key":"10.1124\/mol.111.072421_bib26","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.canlet.2006.12.023","article-title":"The role of membrane transporters in drug delivery to brain tumors","volume":"254","author":"Nies","year":"2007","journal-title":"Cancer Lett"},{"key":"10.1124\/mol.111.072421_bib27","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1177\/000456329903600102","article-title":"New antiepileptic drugs","volume":"36","author":"Patsalos","year":"1999","journal-title":"Ann Clin Biochem"},{"key":"10.1124\/mol.111.072421_bib28","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.tiv.2007.07.007","article-title":"Use of Z310 cells as an in vitro blood-cerebrospinal fluid barrier model: tight junction proteins and transport properties","volume":"22","author":"Shi","year":"2008","journal-title":"Toxicol In Vitro"},{"key":"10.1124\/mol.111.072421_bib29","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.brainres.2005.07.046","article-title":"Establishment of an in vitro brain barrier epithelial transport system for pharmacological and toxicological study","volume":"1057","author":"Shi","year":"2005","journal-title":"Brain Res"},{"key":"10.1124\/mol.111.072421_bib30","first-page":"1050","article-title":"Methotrexate-related neurotoxicity in the treatment of childhood acute lymphoblastic leukemia","volume":"4","author":"Shuper","year":"2002","journal-title":"Isr Med Assoc J"},{"key":"10.1124\/mol.111.072421_bib31","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1007\/s11095-010-0162-2","article-title":"Vectorial ligand transport through mammalian choroid plexus","volume":"27","author":"Spector","year":"2010","journal-title":"Pharm Res"},{"key":"10.1124\/mol.111.072421_bib32","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1080\/00498250801927435","article-title":"Physiology, structure, and regulation of the cloned organic anion transporters","volume":"38","author":"Srimaroeng","year":"2008","journal-title":"Xenobiotica"},{"key":"10.1124\/mol.111.072421_bib33","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1055\/s-2006-942257","article-title":"Antiepileptic treatment in paediatric oncology\u2014an interdisciplinary challenge","volume":"218","author":"Tibussek","year":"2006","journal-title":"Klin Padiatr"},{"key":"10.1124\/mol.111.072421_bib34","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1002\/(SICI)1097-0215(20000301)85:5<683::AID-IJC14>3.0.CO;2-U","article-title":"Resistance to methotrexate in SKOV-3 cell lines after chronic exposure to carbamazepine is associated with a decreased expression of folate receptor","volume":"85","author":"Toffoli","year":"2000","journal-title":"Int J Cancer"},{"key":"10.1124\/mol.111.072421_bib35","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/BF02977789","article-title":"Induction of phase I, II and III drug metabolism\/transport by xenobiotics","volume":"28","author":"Xu","year":"2005","journal-title":"Arch Pharm Res"},{"key":"10.1124\/mol.111.072421_bib36","first-page":"7225","article-title":"Transport of methotrexate (MTX) and folates by multidrug resistance protein (MRP) 3 and MRP1: effect of polyglutamylation on MTX transport","volume":"61","author":"Zeng","year":"2001","journal-title":"Cancer Res"},{"key":"10.1124\/mol.111.072421_bib37","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1124\/mol.108.045443","article-title":"The proton-coupled folate transporter: impact on pemetrexed transport and on antifolates activities compared with the reduced folate carrier","volume":"74","author":"Zhao","year":"2008","journal-title":"Mol Pharmacol"},{"key":"10.1124\/mol.111.072421_bib38","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/S0006-8993(02)03683-1","article-title":"Establishment and characterization of an immortalized Z310 choroidal epithelial cell line from murine choroid plexus","volume":"958","author":"Zheng","year":"2002","journal-title":"Brain Res"}],"container-title":["Molecular Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026895X24033005?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026895X24033005?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/mol.111.072421","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T10:37:42Z","timestamp":1739961462000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0026895X24033005"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10]]},"references-count":38,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011,10]]}},"alternative-id":["S0026895X24033005"],"URL":"https:\/\/doi.org\/10.1124\/mol.111.072421","relation":{},"ISSN":["0026-895X"],"issn-type":[{"value":"0026-895X","type":"print"}],"subject":[],"published":{"date-parts":[[2011,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Antiepileptic Drugs Phenobarbital and Carbamazepine Reduce Transport of Methotrexate in Rat Choroid Plexus by Down-Regulation of the Reduced Folate Carrier","name":"articletitle","label":"Article Title"},{"value":"Molecular Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/mol.111.072421","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2011 The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}