{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T20:46:42Z","timestamp":1784666802914,"version":"3.55.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T00:00:00Z","timestamp":1314835200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T00:00:00Z","timestamp":1314835200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["molpharm.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Pharmacology"],"published-print":{"date-parts":[[2011,9]]},"DOI":"10.1124\/mol.111.073304","type":"journal-article","created":{"date-parts":[[2011,6,14]],"date-time":"2011-06-14T03:00:27Z","timestamp":1308020427000},"page":"416-425","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":177,"title":["Functional Interaction between Trace Amine-Associated Receptor 1 and Dopamine D2 Receptor"],"prefix":"10.1016","volume":"80","author":[{"given":"Stefano","family":"Espinoza","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Salahpour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Masri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatyana D.","family":"Sotnikova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirko","family":"Messa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larry S.","family":"Barak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc G.","family":"Caron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raul R.","family":"Gainetdinov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1124\/mol.111.073304_bib1","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1146\/annurev.pharmtox.42.091701.082314","article-title":"Dimerization: an emerging concept for G protein-coupled receptor ontogeny and function","volume":"42","author":"Angers","year":"2002","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"10.1124\/mol.111.073304_bib2","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/0006-2952(78)90495-1","article-title":"Trace amines and alternative neurotransmitters in the central nervous system","volume":"27","author":"Baldessarini","year":"1978","journal-title":"Biochem Pharmacol"},{"key":"10.1124\/mol.111.073304_bib3","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1124\/mol.108.048884","article-title":"Pharmacological characterization of membrane-expressed human trace amine-associated receptor 1 (TAAR1) by a bioluminescence resonance energy transfer cAMP biosensor","volume":"74","author":"Barak","year":"2008","journal-title":"Mol Pharmacol"},{"key":"10.1124\/mol.111.073304_bib4","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1124\/pr.110.002642","article-title":"The physiology, signaling, and pharmacology of dopamine receptors","volume":"63","author":"Beaulieu","year":"2011","journal-title":"Pharmacol Rev"},{"key":"10.1124\/mol.111.073304_bib5","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1111\/j.1471-4159.2004.02501.x","article-title":"Mammalian central nervous system trace amines. Pharmacologic amphetamines, physiologic neuromodulators","volume":"90","author":"Berry","year":"2004","journal-title":"J Neurochem"},{"key":"10.1124\/mol.111.073304_bib6","doi-asserted-by":"crossref","first-page":"8966","DOI":"10.1073\/pnas.151105198","article-title":"Trace amines: identification of a family of mammalian G protein-coupled receptors","volume":"98","author":"Borowsky","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/mol.111.073304_bib7","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1038\/35067575","article-title":"Oligomerization of G-protein-coupled transmitter receptors","volume":"2","author":"Bouvier","year":"2001","journal-title":"Nat Rev Neurosci"},{"key":"10.1124\/mol.111.073304_bib8","doi-asserted-by":"crossref","first-page":"20081","DOI":"10.1073\/pnas.0906522106","article-title":"The selective antagonist EPPTB reveals TAAR1-mediated regulatory mechanisms in dopaminergic neurons of the mesolimbic system","volume":"106","author":"Bradaia","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/mol.111.073304_bib9","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1073\/pnas.94.6.2569","article-title":"Schizophrenia is associated with elevated amphetamine-induced synaptic dopamine concentrations: evidence from a novel positron emission tomography method","volume":"94","author":"Breier","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/mol.111.073304_bib10","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1124\/mol.60.6.1181","article-title":"Amphetamine, 3,4-methylenedioxymethamphetamine, lysergic acid diethylamide, and metabolites of the catecholamine neurotransmitters are agonists of a rat trace amine receptor","volume":"60","author":"Bunzow","year":"2001","journal-title":"Mol Pharmacol"},{"key":"10.1124\/mol.111.073304_bib11","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1126\/science.3854","article-title":"Dopamine receptor binding predicts clinical and pharmacological potencies of antischizophrenic drugs","volume":"192","author":"Creese","year":"1976","journal-title":"Science"},{"key":"10.1124\/mol.111.073304_bib12","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.pharmthera.2008.03.004","article-title":"G protein-coupled receptor dimers: functional consequences, disease states and drug targets","volume":"118","author":"Dalrymple","year":"2008","journal-title":"Pharmacol Ther"},{"key":"10.1124\/mol.111.073304_bib13","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0278-5846(94)90022-1","article-title":"The trace amines and their acidic metabolites in depression\u2014an overview","volume":"18","author":"Davis","year":"1994","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1124\/mol.111.073304_bib14","doi-asserted-by":"crossref","first-page":"16513","DOI":"10.1073\/pnas.0405973101","article-title":"Fluorescent indicators of cAMP and Epac activation reveal differential dynamics of cAMP signaling within discrete subcellular compartments","volume":"101","author":"DiPilato","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/mol.111.073304_bib15","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/j.bbamem.2006.09.008","article-title":"Regulation of G protein-coupled receptor export trafficking","volume":"1768","author":"Dong","year":"2007","journal-title":"Biochim Biophys Acta"},{"key":"10.1124\/mol.111.073304_bib16","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.pharmthera.2007.06.007","article-title":"Trace amine-associated receptor 1-Family archetype or iconoclast?","volume":"116","author":"Grandy","year":"2007","journal-title":"Pharmacol Ther"},{"key":"10.1124\/mol.111.073304_bib17","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1038\/25348","article-title":"GABA(B) receptors function as a heteromeric assembly of the subunits GABA(B)R1 and GABA(B)R2","volume":"396","author":"Jones","year":"1998","journal-title":"Nature"},{"key":"10.1124\/mol.111.073304_bib18","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1038\/25360","article-title":"GABA(B)-receptor subtypes assemble into functional heteromeric complexes","volume":"396","author":"Kaupmann","year":"1998","journal-title":"Nature"},{"key":"10.1124\/mol.111.073304_bib19","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.tips.2005.03.007","article-title":"A renaissance in trace amines inspired by a novel GPCR family","volume":"26","author":"Lindemann","year":"2005","journal-title":"Trends Pharmacol Sci"},{"key":"10.1124\/mol.111.073304_bib20","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1124\/jpet.107.132647","article-title":"Trace amine-associated receptor 1 modulates dopaminergic activity","volume":"324","author":"Lindemann","year":"2008","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/mol.111.073304_bib21","doi-asserted-by":"crossref","first-page":"13656","DOI":"10.1073\/pnas.0803522105","article-title":"Antagonism of dopamine D2 receptor\/beta-arrestin 2 interaction is a common property of clinically effective antipsychotics","volume":"105","author":"Masri","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/mol.111.073304_bib22","first-page":"178","article-title":"Dietary consideration in MAO inhibitor regimens","volume":"43","author":"McCabe","year":"1982","journal-title":"J Clin Psychiatry"},{"key":"10.1124\/mol.111.073304_bib23","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1124\/jpet.105.084459","article-title":"Primate trace amine receptor 1 modulation by the dopamine transporter","volume":"313","author":"Miller","year":"2005","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/mol.111.073304_bib24","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/j.1476-5381.2009.00169.x","article-title":"G protein-coupled receptor hetero-dimerization: contribution to pharmacology and function","volume":"158","author":"Milligan","year":"2009","journal-title":"Br J Pharmacol"},{"key":"10.1124\/mol.111.073304_bib25","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1016\/j.pnpbp.2003.09.006","article-title":"Amisulpride: limbic specificity and the mechanism of antipsychotic atypicality","volume":"27","author":"M\u00f6ller","year":"2003","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1124\/mol.111.073304_bib26","doi-asserted-by":"crossref","first-page":"4270","DOI":"10.1073\/pnas.89.10.4270","article-title":"Differential expression of c-fos and zif268 in rat striatum after haloperidol, clozapine, and amphetamine","volume":"89","author":"Nguyen","year":"1992","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/mol.111.073304_bib27","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1038\/nmeth841","article-title":"Illuminating insights into protein-protein interactions using bioluminescence resonance energy transfer (BRET)","volume":"3","author":"Pfleger","year":"2006","journal-title":"Nat Methods"},{"key":"10.1124\/mol.111.073304_bib28","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1038\/sj.embor.7400290","article-title":"Detecting cAMP-induced Epac activation by fluorescence resonance energy transfer: Epac as a novel cAMP indicator","volume":"5","author":"Ponsioen","year":"2004","journal-title":"EMBO Rep"},{"key":"10.1124\/mol.111.073304_bib29","doi-asserted-by":"crossref","first-page":"8485","DOI":"10.1073\/pnas.1103029108","article-title":"TAAR1 activation modulates monoaminergic neurotransmission, preventing hyperdopaminergic and hypoglutamatergic activity","volume":"108","author":"Revel","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/mol.111.073304_bib30","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1176\/ajp.131.6.695","article-title":"Phenylethylamine hypothesis of affective behavior","volume":"131","author":"Sabelli","year":"1974","journal-title":"Am J Psychiatry"},{"key":"10.1124\/mol.111.073304_bib31","doi-asserted-by":"crossref","first-page":"33390","DOI":"10.1074\/jbc.M403363200","article-title":"Homodimerization of the beta2-adrenergic receptor as a prerequisite for cell surface targeting","volume":"279","author":"Salahpour","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1124\/mol.111.073304_bib32","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/nmeth0807-599","article-title":"Experimental challenge to a \u2018rigorous\u2019 BRET analysis of GPCR oligomerization","volume":"4","author":"Salahpour","year":"2007","journal-title":"Nat Methods"},{"key":"10.1124\/mol.111.073304_bib33","doi-asserted-by":"crossref","first-page":"e271","DOI":"10.1371\/journal.pbio.0030271","article-title":"Dopamine-independent locomotor actions of amphetamines in a novel acute mouse model of Parkinson disease","volume":"3","author":"Sotnikova","year":"2005","journal-title":"PLoS Biol"},{"key":"10.1124\/mol.111.073304_bib34","doi-asserted-by":"crossref","first-page":"e13452","DOI":"10.1371\/journal.pone.0013452","article-title":"The dopamine metabolite 3-methoxytyramine is a neuromodulator","volume":"5","author":"Sotnikova","year":"2010","journal-title":"PLoS One"},{"key":"10.1124\/mol.111.073304_bib35","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1111\/j.1471-4159.2004.02721.x","article-title":"Dopamine transporter-dependent and -independent actions of trace amine beta-phenylethylamine","volume":"91","author":"Sotnikova","year":"2004","journal-title":"J Neurochem"},{"key":"10.1124\/mol.111.073304_bib36","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1124\/mol.109.055970","article-title":"Trace amine-associated receptors as emerging therapeutic targets","volume":"76","author":"Sotnikova","year":"2009","journal-title":"Mol Pharmacol"},{"issue":"Suppl 2","key":"10.1124\/mol.111.073304_bib37","doi-asserted-by":"crossref","first-page":"S99","DOI":"10.1016\/j.parkreldis.2008.04.006","article-title":"Trace amine associated receptor 1 and movement control","volume":"14","author":"Sotnikova","year":"2008","journal-title":"Parkinsonism Relat Disord"},{"key":"10.1124\/mol.111.073304_bib38","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0031-6997(24)01483-2","article-title":"Antipsychotic drugs: importance of dopamine receptors for mechanisms of therapeutic actions and side effects","volume":"53","author":"Strange","year":"2001","journal-title":"Pharmacol Rev"},{"key":"10.1124\/mol.111.073304_bib39","doi-asserted-by":"crossref","first-page":"2949","DOI":"10.1074\/jbc.M707009200","article-title":"beta2-adrenergic receptor signaling and desensitization elucidated by quantitative modeling of real time cAMP dynamics","volume":"283","author":"Violin","year":"2008","journal-title":"J Biol Chem"},{"key":"10.1124\/mol.111.073304_bib40","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/25354","article-title":"Heterodimerization is required for the formation of a functional GABA(B) receptor","volume":"396","author":"White","year":"1998","journal-title":"Nature"},{"key":"10.1124\/mol.111.073304_bib41","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1111\/j.1601-183X.2006.00292.x","article-title":"The Trace Amine 1 receptor knockout mouse: an animal model with relevance to schizophrenia","volume":"6","author":"Wolinsky","year":"2007","journal-title":"Genes Brain Behav"}],"container-title":["Molecular Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026895X24032759?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026895X24032759?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/mol.111.073304","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T10:12:21Z","timestamp":1739959941000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0026895X24032759"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9]]},"references-count":41,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,9]]}},"alternative-id":["S0026895X24032759"],"URL":"https:\/\/doi.org\/10.1124\/mol.111.073304","relation":{},"ISSN":["0026-895X"],"issn-type":[{"value":"0026-895X","type":"print"}],"subject":[],"published":{"date-parts":[[2011,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Functional Interaction between Trace Amine-Associated Receptor 1 and Dopamine D2 Receptor","name":"articletitle","label":"Article Title"},{"value":"Molecular Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/mol.111.073304","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2011 The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}