{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T19:49:16Z","timestamp":1770752956975,"version":"3.50.0"},"reference-count":27,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2012,3,1]],"date-time":"2012-03-01T00:00:00Z","timestamp":1330560000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,3,1]],"date-time":"2012-03-01T00:00:00Z","timestamp":1330560000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["molpharm.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Pharmacology"],"published-print":{"date-parts":[[2012,3]]},"DOI":"10.1124\/mol.111.076166","type":"journal-article","created":{"date-parts":[[2011,12,16]],"date-time":"2011-12-16T05:56:32Z","timestamp":1324014992000},"page":"292-298","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":44,"title":["MicroRNA 335 Is Required for Differentiation of Malignant Glioma Cells Induced by Activation of cAMP\/Protein Kinase A Pathway"],"prefix":"10.1016","volume":"81","author":[{"given":"Minfeng","family":"Shu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuehan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenbo","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haipeng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sihan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingkao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangmei","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1124\/mol.111.076166_bib1","doi-asserted-by":"crossref","first-page":"7015","DOI":"10.1128\/MCB.22.20.7015-7023.2002","article-title":"v-Crk activates the phosphoinositide 3-kinase\/AKT pathway by utilizing focal adhesion kinase and H-Ras","volume":"22","author":"Akagi","year":"2002","journal-title":"Mol Cell Biol"},{"key":"10.1124\/mol.111.076166_bib2","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1038\/nature05236","article-title":"Glioma stem cells promote radioresistance by preferential activation of the DNA damage response","volume":"444","author":"Bao","year":"2006","journal-title":"Nature"},{"key":"10.1124\/mol.111.076166_bib3","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.jhep.2008.09.015","article-title":"The role of microRNA expression pattern in human intrahepatic cholangiocarcinoma","volume":"50","author":"Chen","year":"2009","journal-title":"J Hepatol"},{"key":"10.1124\/mol.111.076166_bib4","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1093\/jnci\/85.9.704","article-title":"Recursive partitioning analysis of prognostic factors in three Radiation Therapy Oncology Group malignant glioma trials","volume":"85","author":"Curran","year":"1993","journal-title":"J Nat Cancer Inst"},{"key":"10.1124\/mol.111.076166_bib5","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1056\/NEJM200101113440207","article-title":"Brain tumors","volume":"344","author":"DeAngelis","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1124\/mol.111.076166_bib6","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/nrc1840","article-title":"Oncomirs - microRNAs with a role in cancer","volume":"6","author":"Esquela-Kerscher","year":"2006","journal-title":"Nat Rev Cancer"},{"key":"10.1124\/mol.111.076166_bib7","doi-asserted-by":"crossref","first-page":"3029","DOI":"10.1007\/s11033-010-9969-5","article-title":"Clinical significance of miR-221 and its inverse correlation with p27Kip1 in hepatocellular carcinoma","volume":"38","author":"Fu","year":"2011","journal-title":"Mol Biol Rep"},{"key":"10.1124\/mol.111.076166_bib8","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1002\/bip.20005","article-title":"In situ synthesis of oligonucleotide microarrays","volume":"73","author":"Gao","year":"2004","journal-title":"Biopolymers"},{"key":"10.1124\/mol.111.076166_bib9","doi-asserted-by":"crossref","first-page":"9655","DOI":"10.1073\/pnas.91.20.9655","article-title":"Role of platelet activating factor in the intestinal epithelial secretory and Chinese hamster ovary cell cytoskeletal responses to cholera toxin","volume":"91","author":"Guerrant","year":"1994","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/mol.111.076166_bib10","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.1002\/jcb.23140","article-title":"Transcriptional and post-transcriptional down-regulation of cyclin D1 contributes to C6 glioma cell differentiation induced by forskolin","volume":"112","author":"He","year":"2011","journal-title":"J Cell Biochem"},{"key":"10.1124\/mol.111.076166_bib11","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1182\/blood.V72.2.567.567","article-title":"Use of all-trans retinoic acid in the treatment of acute promyelocytic leukemia","volume":"72","author":"Huang","year":"1988","journal-title":"Blood"},{"key":"10.1124\/mol.111.076166_bib12","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1093\/nar\/gkp002","article-title":"Functional links between clustered microRNAs: suppression of cell-cycle inhibitors by microRNA clusters in gastric cancer","volume":"37","author":"Kim","year":"2009","journal-title":"Nucleic Acids Res"},{"key":"10.1124\/mol.111.076166_bib13","doi-asserted-by":"crossref","first-page":"13438","DOI":"10.1073\/pnas.0701990104","article-title":"Cholera toxin induces malignant glioma cell differentiation via the PKA\/CREB pathway","volume":"104","author":"Li","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/mol.111.076166_bib14","doi-asserted-by":"crossref","first-page":"7291","DOI":"10.1111\/j.1742-4658.2009.07441.x","article-title":"Hypoxia-inducible factor-1alpha blocks differentiation of malignant gliomas","volume":"276","author":"Lu","year":"2009","journal-title":"FEBS J"},{"key":"10.1124\/mol.111.076166_bib15","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1083\/jcb.98.1.22","article-title":"Binding and degradation of platelet thrombospondin by cultured fibroblasts","volume":"98","author":"McKeown-Longo","year":"1984","journal-title":"J Cell Biol"},{"key":"10.1124\/mol.111.076166_bib16","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1146\/annurev.bi.48.070179.003053","article-title":"Activation of adenylate cyclase by choleragen","volume":"48","author":"Moss","year":"1979","journal-title":"Annu Rev Biochem"},{"key":"10.1124\/mol.111.076166_bib17","doi-asserted-by":"crossref","first-page":"e190","DOI":"10.1097\/MPA.0b013e3181ba82e1","article-title":"Antisense inhibition of microRNA-21 or -221 arrests cell cycle, induces apoptosis, and sensitizes the effects of gemcitabine in pancreatic adenocarcinoma","volume":"38","author":"Park","year":"2009","journal-title":"Pancreas"},{"key":"10.1124\/mol.111.076166_bib18","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1101\/gad.1974211","article-title":"MicroRNA-335 inhibits tumor reinitiation and is silenced through genetic and epigenetic mechanisms in human breast cancer","volume":"25","author":"Png","year":"2011","journal-title":"Genes Dev"},{"key":"10.1124\/mol.111.076166_bib19","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/1755-8794-1-37","article-title":"An integrative genomic approach reveals coordinated expression of intronic miR-335, miR-342, and miR-561 with deregulated host genes in multiple myeloma","volume":"1","author":"Ronchetti","year":"2008","journal-title":"BMC Med Genomics"},{"key":"10.1124\/mol.111.076166_bib20","doi-asserted-by":"crossref","first-page":"6925","DOI":"10.1158\/0008-5472.CAN-10-0141","article-title":"miR-335 directly targets Rb1 (pRb\/p105) in a proximal connection to p53-dependent stress response","volume":"70","author":"Scarola","year":"2010","journal-title":"Cancer Res"},{"key":"10.1124\/mol.111.076166_bib21","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/1476-4598-10-59","article-title":"Targeting oncogenic miR-335 inhibits growth and invasion of malignant astrocytoma cells","volume":"10","author":"Shu","year":"2011","journal-title":"Mol Cancer"},{"key":"10.1124\/mol.111.076166_bib22","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.molonc.2011.03.003","article-title":"Activation of a pro-survival pathway IL-6\/JAK2\/STAT3 contributes to glial fibrillary acidic protein induction during the cholera toxin-induced differentiation of C6 malignant glioma cells","volume":"5","author":"Shu","year":"2011","journal-title":"Mol Oncol"},{"key":"10.1124\/mol.111.076166_bib23","doi-asserted-by":"crossref","first-page":"15441","DOI":"10.1074\/jbc.M311844200","article-title":"cAMP-induced astrocytic differentiation of C6 glioma cells is mediated by autocrine interleukin-6","volume":"279","author":"Takanaga","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1124\/mol.111.076166_bib24","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1038\/nature06487","article-title":"Endogenous human microRNAs that suppress breast cancer metastasis","volume":"451","author":"Tavazoie","year":"2008","journal-title":"Nature"},{"key":"10.1124\/mol.111.076166_bib25","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1038\/cdd.2010.167","article-title":"miR-335 orchestrates cell proliferation, migration and differentiation in human mesenchymal stem cells","volume":"18","author":"Tom\u00e9","year":"2011","journal-title":"Cell Death Differ"},{"key":"10.1124\/mol.111.076166_bib26","doi-asserted-by":"crossref","first-page":"2924","DOI":"10.1002\/pmic.200500587","article-title":"Is current therapy of malignant gliomas beneficial for patients? Proteomics evidence of shifts in glioma cells expression patterns under clinically relevant treatment conditions","volume":"6","author":"Trog","year":"2006","journal-title":"Proteomics"},{"key":"10.1124\/mol.111.076166_bib27","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1111\/j.1471-4159.2004.02339.x","article-title":"P2Y12 receptor stimulation inhibits beta-adrenergic receptor-induced differentiation by reversing the cyclic AMP-dependent inhibition of protein kinase B","volume":"89","author":"Van Kolen","year":"2004","journal-title":"J Neurochem"}],"container-title":["Molecular Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026895X24034011?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026895X24034011?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/mol.111.076166","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T10:46:57Z","timestamp":1739962017000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0026895X24034011"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3]]},"references-count":27,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,3]]}},"alternative-id":["S0026895X24034011"],"URL":"https:\/\/doi.org\/10.1124\/mol.111.076166","relation":{},"ISSN":["0026-895X"],"issn-type":[{"value":"0026-895X","type":"print"}],"subject":[],"published":{"date-parts":[[2012,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"MicroRNA 335 Is Required for Differentiation of Malignant Glioma Cells Induced by Activation of cAMP\/Protein Kinase A Pathway","name":"articletitle","label":"Article Title"},{"value":"Molecular Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/mol.111.076166","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2012 The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}