{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T05:16:21Z","timestamp":1740114981715,"version":"3.37.3"},"reference-count":42,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["molpharm.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Pharmacology"],"published-print":{"date-parts":[[2013,1]]},"DOI":"10.1124\/mol.112.080440","type":"journal-article","created":{"date-parts":[[2012,10,12]],"date-time":"2012-10-12T00:33:31Z","timestamp":1350002011000},"page":"129-141","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["\u03b2-Adrenergic Agonists Mediate Enhancement of \u03b21-Adrenergic Receptor N-terminal Cleavage and Stabilization In Vivo and In Vitro"],"prefix":"10.1016","volume":"83","author":[{"given":"Anna E.","family":"Hakalahti","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamayun","family":"Khan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miia M.","family":"Vierimaa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilia H.","family":"Pekkala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jarkko J.","family":"Lackman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johanna","family":"Ulvila","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Risto","family":"Kerkel\u00e4","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulla E.","family":"Pet\u00e4j\u00e4-Repo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1124\/mol.112.080440_bib1","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/S0022-3565(25)33079-X","article-title":"Changes in the density of beta adrenergic receptors in rat lymphocytes, heart and lung after chronic treatment with propranolol","volume":"221","author":"Aarons","year":"1982","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/mol.112.080440_bib2","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/sj.bjp.0706048","article-title":"The selectivity of \u03b2-adrenoceptor antagonists at the human \u03b21, \u03b22 and \u03b23 adrenoceptors","volume":"144","author":"Baker","year":"2005","journal-title":"Br J Pharmacol"},{"key":"10.1124\/mol.112.080440_bib3","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1124\/mol.63.6.1312","article-title":"Agonist actions of \u201c\u03b2-blockers\u201d provide evidence for two agonist activation sites or conformations of the human \u03b21-adrenoceptor","volume":"63","author":"Baker","year":"2003","journal-title":"Mol Pharmacol"},{"key":"10.1124\/mol.112.080440_bib4","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1161\/01.CIR.101.5.558","article-title":"\u03b2-adrenergic receptor blockade in chronic heart failure","volume":"101","author":"Bristow","year":"2000","journal-title":"Circulation"},{"key":"10.1124\/mol.112.080440_bib5","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1161\/01.RES.59.3.297","article-title":"Beta 1- and beta 2-adrenergic-receptor subpopulations in nonfailing and failing human ventricular myocardium: coupling of both receptor subtypes to muscle contraction and selective beta 1-receptor down-regulation in heart failure","volume":"59","author":"Bristow","year":"1986","journal-title":"Circ Res"},{"key":"10.1124\/mol.112.080440_bib6","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1002\/(SICI)1522-2675(19990804)82:8<1211::AID-HLCA1211>3.0.CO;2-K","article-title":"Structure-lipophilicity relationships of neutral and protonated \u03b2-blockers. Part I. Intra- and intermolecular effects in isotropic solvent systems","volume":"82","author":"Caron","year":"1999","journal-title":"Helv Chim Acta"},{"key":"10.1124\/mol.112.080440_bib7","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1124\/jpet.106.107987","article-title":"Ligands regulate cell surface level of the human \u03ba opioid receptor by activation-induced down-regulation and pharmacological chaperone-mediated enhancement: differential effects of nonpeptide and peptide agonists","volume":"319","author":"Chen","year":"2006","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/mol.112.080440_bib8","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/S0026-895X(24)12297-3","article-title":"Constitutive activity of the human \u03b21-adrenergic receptor in \u03b21-receptor transgenic mice","volume":"60","author":"Engelhardt","year":"2001","journal-title":"Mol Pharmacol"},{"key":"10.1124\/mol.112.080440_bib9","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1124\/mol.106.026716","article-title":"Distinct signaling profiles of \u03b21 and \u03b22 adrenergic receptor ligands toward adenylyl cyclase and mitogen-activated protein kinase reveals the pluridimensionality of efficacy","volume":"70","author":"Galandrin","year":"2006","journal-title":"Mol Pharmacol"},{"key":"10.1124\/mol.112.080440_bib10","doi-asserted-by":"crossref","first-page":"28850","DOI":"10.1074\/jbc.M110.149989","article-title":"Human \u03b21-adrenergic receptor is subject to constitutive and regulated N-terminal cleavage","volume":"285","author":"Hakalahti","year":"2010","journal-title":"J Biol Chem"},{"key":"10.1124\/mol.112.080440_bib11","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/BF00501161","article-title":"Measurement of hydrophobicity, surface activity, local anaesthesia, and myocardial conduction velocity as quantitative parameters of the non-specific membrane affinity of nine \u03b2-adrenergic blocking agents","volume":"277","author":"Hellenbrecht","year":"1973","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"10.1124\/mol.112.080440_bib12","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1111\/j.1600-0854.2010.01145.x","article-title":"The role of ubiquitination in lysosomal trafficking of \u03b4-opioid receptors","volume":"12","author":"Henry","year":"2011","journal-title":"Traffic"},{"key":"10.1124\/mol.112.080440_bib13","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s00210-003-0860-y","article-title":"Comparative pharmacology of human \u03b2-adrenergic receptor subtypes\u2014characterization of stably transfected receptors in CHO cells","volume":"369","author":"Hoffmann","year":"2004","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"10.1124\/mol.112.080440_bib14","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.lfs.2007.06.003","article-title":"Different changes of plasma membrane \u03b2-adrenoceptors in rat heart after chronic administration of propranolol, atenolol and bevantolol","volume":"81","author":"Horinouchi","year":"2007","journal-title":"Life Sci"},{"key":"10.1124\/mol.112.080440_bib15","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1124\/jpet.110.173948","article-title":"Functional selectivity and biased receptor signaling","volume":"336","author":"Kenakin","year":"2011","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/mol.112.080440_bib16","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1111\/j.1600-0854.2009.00932.x","article-title":"Functional rescue of \u03b21-adrenoceptor dimerization and trafficking by pharmacological chaperones","volume":"10","author":"Kobayashi","year":"2009","journal-title":"Traffic"},{"key":"10.1124\/mol.112.080440_bib17","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1124\/mol.105.012419","article-title":"Nicotine acts as a pharmacological chaperone to up-regulate human \u03b14\u03b22 acetylcholine receptors","volume":"68","author":"Kuryatov","year":"2005","journal-title":"Mol Pharmacol"},{"key":"10.1124\/mol.112.080440_bib18","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/nrd2518","article-title":"Structural diversity of G protein-coupled receptors and significance for drug discovery","volume":"7","author":"Lagerstr\u00f6m","year":"2008","journal-title":"Nat Rev Drug Discov"},{"key":"10.1124\/mol.112.080440_bib19","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/S0014-5793(99)01064-9","article-title":"Constitutively active mutants of the beta1-adrenergic receptor","volume":"457","author":"Lattion","year":"1999","journal-title":"FEBS Lett"},{"key":"10.1124\/mol.112.080440_bib20","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1111\/j.1600-0854.2008.00846.x","article-title":"Phe27Cys polymorphism alters the maturation and subcellular localization of the human \u03b4 opioid receptor","volume":"10","author":"Leskel\u00e4","year":"2009","journal-title":"Traffic"},{"key":"10.1124\/mol.112.080440_bib21","doi-asserted-by":"crossref","first-page":"23171","DOI":"10.1074\/jbc.M610896200","article-title":"Opioid receptor pharmacological chaperones act by binding and stabilizing newly synthesized receptors in the endoplasmic reticulum","volume":"282","author":"Leskel\u00e4","year":"2007","journal-title":"J Biol Chem"},{"key":"10.1124\/mol.112.080440_bib22","doi-asserted-by":"crossref","first-page":"39773","DOI":"10.1074\/jbc.M304482200","article-title":"Resistance of the human \u03b21-adrenergic receptor to agonist-mediated down-regulation. Role of the C terminus in determining \u03b2-subtype degradation","volume":"278","author":"Liang","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1124\/mol.112.080440_bib23","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1161\/01.RES.60.1.108","article-title":"Propranolol treatment externalizes \u03b2-adrenergic receptors in guinea pig myocardium and prevents further externalization by ischemia","volume":"60","author":"Maisel","year":"1987","journal-title":"Circ Res"},{"key":"10.1124\/mol.112.080440_bib24","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1111\/j.1476-5381.1988.tb11576.x","article-title":"Selective regulation of beta 1- and beta 2-adrenoceptors in the human heart by chronic beta-adrenoceptor antagonist treatment","volume":"94","author":"Michel","year":"1988","journal-title":"Br J Pharmacol"},{"key":"10.1124\/mol.112.080440_bib25","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/S0165-6147(97)90685-4","article-title":"Inverse agonism and the regulation of receptor number","volume":"18","author":"Milligan","year":"1997","journal-title":"Trends Pharmacol Sci"},{"key":"10.1124\/mol.112.080440_bib26","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.yjmcc.2006.04.010","article-title":"Selective upregulation of \u03b21-adrenergic receptors and dephosphorylation of troponin I in end-stage heart failure patients supported by ventricular assist devices","volume":"41","author":"Milting","year":"2006","journal-title":"J Mol Cell Cardiol"},{"key":"10.1124\/mol.112.080440_bib27","doi-asserted-by":"crossref","first-page":"8228","DOI":"10.1073\/pnas.1100185108","article-title":"Two distinct conformations of helix 6 observed in antagonist-bound structures of a \u03b21-adrenergic receptor","volume":"108","author":"Moukhametzianov","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/mol.112.080440_bib28","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1093\/emboj\/21.7.1628","article-title":"Ligands act as pharmacological chaperones and increase the efficiency of \u03b4 opioid receptor maturation","volume":"21","author":"Pet\u00e4j\u00e4-Repo","year":"2002","journal-title":"EMBO J"},{"key":"10.1124\/mol.112.080440_bib29","doi-asserted-by":"crossref","first-page":"13727","DOI":"10.1074\/jbc.275.18.13727","article-title":"Export from the endoplasmic reticulum represents the limiting step in the maturation and cell surface expression of the human \u03b4 opioid receptor","volume":"275","author":"Pet\u00e4j\u00e4-Repo","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1124\/mol.112.080440_bib30","doi-asserted-by":"crossref","first-page":"15780","DOI":"10.1074\/jbc.M602267200","article-title":"Distinct subcellular localization for constitutive and agonist-modulated palmitoylation of the human \u03b4 opioid receptor","volume":"281","author":"Pet\u00e4j\u00e4-Repo","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1124\/mol.112.080440_bib31","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1161\/01.CIR.0000141733.55236.9D","article-title":"Effectiveness of \u03b2-blockade in experimental chronic aortic regurgitation","volume":"110","author":"Plante","year":"2004","journal-title":"Circulation"},{"key":"10.1124\/mol.112.080440_bib32","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1038\/415206a","article-title":"Seven-transmembrane-spanning receptors and heart function","volume":"415","author":"Rockman","year":"2002","journal-title":"Nature"},{"key":"10.1124\/mol.112.080440_bib33","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/S0026-895X(25)08791-7","article-title":"Distinct receptor domains determine subtype-specific coupling and desensitization phenotypes for human \u03b21- and \u03b22-adrenergic receptors","volume":"49","author":"Rousseau","year":"1996","journal-title":"Mol Pharmacol"},{"key":"10.1124\/mol.112.080440_bib34","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1177\/107424840400900404","article-title":"\u03b2-adrenergic blockers in heart failure: review of mechanisms of action and clinical outcomes","volume":"9","author":"Satwani","year":"2004","journal-title":"J Cardiovasc Pharmacol Ther"},{"key":"10.1124\/mol.112.080440_bib35","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1073\/pnas.0711253105","article-title":"Conformational thermostabilization of the \u03b21-adrenergic receptor in a detergent-resistant form","volume":"105","author":"Serrano-Vega","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/mol.112.080440_bib36","doi-asserted-by":"crossref","first-page":"29082","DOI":"10.1074\/jbc.M909757199","article-title":"Interaction with \u03b2-arrestin determines the difference in internalization behavor between \u03b21- and \u03b22-adrenergic receptors","volume":"275","author":"Shiina","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1124\/mol.112.080440_bib37","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1023\/A:1007784109255","article-title":"Beta-blocker selectivity at cloned human beta1- and beta2-adrenergic receptors","volume":"13","author":"Smith","year":"1999","journal-title":"Cardiovasc Drugs Ther"},{"key":"10.1124\/mol.112.080440_bib38","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/S0026-895X(25)08956-4","article-title":"Distinct regulation of \u03b21- and \u03b22-adrenergic receptors in Chinese hamster fibroblasts","volume":"41","author":"Suzuki","year":"1992","journal-title":"Mol Pharmacol"},{"key":"10.1124\/mol.112.080440_bib39","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/0922-4106(94)90171-6","article-title":"Basal and acidic fibroblast growth factor-induced atrial natriuretic peptide gene expression and secretion is inhibited by staurosporine","volume":"267","author":"Tokola","year":"1994","journal-title":"Eur J Pharmacol"},{"key":"10.1124\/mol.112.080440_bib40","doi-asserted-by":"crossref","first-page":"19350","DOI":"10.1074\/jbc.M414043200","article-title":"Folding efficiency is rate-limiting in dopamine D4 receptor biogenesis","volume":"280","author":"Van Craenenbroeck","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1124\/mol.112.080440_bib41","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/nature09746","article-title":"The structural basis for agonist and partial agonist action on a \u03b21-adrenergic receptor","volume":"469","author":"Warne","year":"2011","journal-title":"Nature"},{"key":"10.1124\/mol.112.080440_bib42","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1038\/nature07101","article-title":"Structure of a \u03b21-adrenergic G-protein-coupled receptor","volume":"454","author":"Warne","year":"2008","journal-title":"Nature"}],"container-title":["Molecular Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026895X24036137?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026895X24036137?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/mol.112.080440","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T07:58:52Z","timestamp":1740038332000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0026895X24036137"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["S0026895X24036137"],"URL":"https:\/\/doi.org\/10.1124\/mol.112.080440","relation":{},"ISSN":["0026-895X"],"issn-type":[{"type":"print","value":"0026-895X"}],"subject":[],"published":{"date-parts":[[2013,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"\u03b2-Adrenergic Agonists Mediate Enhancement of \u03b21-Adrenergic Receptor N-terminal Cleavage and Stabilization In Vivo and In Vitro","name":"articletitle","label":"Article Title"},{"value":"Molecular Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/mol.112.080440","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2013 by The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}