{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T11:40:15Z","timestamp":1739965215794,"version":"3.37.3"},"reference-count":49,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2013,9,1]],"date-time":"2013-09-01T00:00:00Z","timestamp":1377993600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,9,1]],"date-time":"2013-09-01T00:00:00Z","timestamp":1377993600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["molpharm.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Pharmacology"],"published-print":{"date-parts":[[2013,9]]},"DOI":"10.1124\/mol.113.087312","type":"journal-article","created":{"date-parts":[[2013,6,19]],"date-time":"2013-06-19T01:42:38Z","timestamp":1371606158000},"page":"372-383","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Connective Tissue Growth Factor\/CCN2 Attenuates \u03b2-Adrenergic Receptor Responsiveness and Cardiotoxicity by Induction of G Protein\u2013Coupled Receptor Kinase-5 in Cardiomyocytes"],"prefix":"10.1016","volume":"84","author":[{"given":"J\u00f8rgen","family":"Gravning","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Shakil","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eirik","family":"Qvigstad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kurt","family":"Krobert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thor","family":"Edvardsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingvild Tronstad","family":"Moe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Else Marie V.","family":"Hagelin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Sagave","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guro","family":"Valen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Finn Olav","family":"Levy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan-Bj\u00f8rn","family":"Osnes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tor","family":"Skomedal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e5vard","family":"Attramadal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1124\/mol.113.087312_bib1","doi-asserted-by":"crossref","first-page":"5038","DOI":"10.1074\/jbc.274.8.5038","article-title":"Oxidative damage of cardiomyocytes is limited by extracellular regulated kinases 1\/2-mediated induction of cyclooxygenase-2","volume":"274","author":"Adderley","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1124\/mol.113.087312_bib2","doi-asserted-by":"crossref","first-page":"H1291","DOI":"10.1152\/ajpheart.00604.2010","article-title":"Mechanisms of novel cardioprotective functions of CCN2\/CTGF in myocardial ischemia-reperfusion injury","volume":"300","author":"Ahmed","year":"2011","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1124\/mol.113.087312_bib3","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.yjmcc.2003.12.004","article-title":"Connective tissue growth factor\u2014a novel mediator of angiotensin II-stimulated cardiac fibroblast activation in heart failure in rats","volume":"36","author":"Ahmed","year":"2004","journal-title":"J Mol Cell Cardiol"},{"key":"10.1124\/mol.113.087312_bib4","doi-asserted-by":"crossref","first-page":"H1354","DOI":"10.1152\/ajpheart.00549.2003","article-title":"Alpha1-AR-mediated activation of NKCC in rat cardiomyocytes involves ERK-dependent phosphorylation of the cotransporter","volume":"286","author":"Andersen","year":"2004","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1124\/mol.113.087312_bib5","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1161\/01.CIR.101.5.558","article-title":"beta-adrenergic receptor blockade in chronic heart failure","volume":"101","author":"Bristow","year":"2000","journal-title":"Circulation"},{"key":"10.1124\/mol.113.087312_bib6","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1056\/NEJM198207223070401","article-title":"Decreased catecholamine sensitivity and beta-adrenergic-receptor density in failing human hearts","volume":"307","author":"Bristow","year":"1982","journal-title":"N Engl J Med"},{"key":"10.1124\/mol.113.087312_bib7","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/0163-7258(93)90030-H","article-title":"Beta-adrenoceptors in cardiac disease","volume":"60","author":"Brodde","year":"1993","journal-title":"Pharmacol Ther"},{"key":"10.1124\/mol.113.087312_bib8","doi-asserted-by":"crossref","first-page":"35040","DOI":"10.1074\/jbc.M109.047456","article-title":"G Protein-coupled receptor kinases phosphorylate LRP6 in the Wnt pathway","volume":"284","author":"Chen","year":"2009","journal-title":"J Biol Chem"},{"key":"10.1124\/mol.113.087312_bib9","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1006\/jmcc.2000.1215","article-title":"CTGF expression is induced by TGF- beta in cardiac fibroblasts and cardiac myocytes: a potential role in heart fibrosis","volume":"32","author":"Chen","year":"2000","journal-title":"J Mol Cell Cardiol"},{"key":"10.1124\/mol.113.087312_bib10","doi-asserted-by":"crossref","first-page":"12823","DOI":"10.1074\/jbc.M109.094243","article-title":"G-protein-coupled receptor kinase 5 phosphorylates p53 and inhibits DNA damage-induced apoptosis","volume":"285","author":"Chen","year":"2010","journal-title":"J Biol Chem"},{"key":"10.1124\/mol.113.087312_bib11","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.ejphar.2004.03.015","article-title":"Differential functional expression of human myocardial G protein receptor kinases in left ventricular cardiac diseases","volume":"489","author":"Dzimiri","year":"2004","journal-title":"Eur J Pharmacol"},{"key":"10.1124\/mol.113.087312_bib12","doi-asserted-by":"crossref","first-page":"7059","DOI":"10.1073\/pnas.96.12.7059","article-title":"Progressive hypertrophy and heart failure in beta1-adrenergic receptor transgenic mice","volume":"96","author":"Engelhardt","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/mol.113.087312_bib13","doi-asserted-by":"crossref","first-page":"17953","DOI":"10.1074\/jbc.270.30.17953","article-title":"Phosphorylation and desensitization of the human beta 1-adrenergic receptor. Involvement of G protein-coupled receptor kinases and cAMP-dependent protein kinase","volume":"270","author":"Freedman","year":"1995","journal-title":"J Biol Chem"},{"key":"10.1124\/mol.113.087312_bib14","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/S0896-6273(00)81048-X","article-title":"Muscarinic supersensitivity and impaired receptor desensitization in G protein-coupled receptor kinase 5-deficient mice","volume":"24","author":"Gainetdinov","year":"1999","journal-title":"Neuron"},{"key":"10.1124\/mol.113.087312_bib15","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1161\/CIRCRESAHA.112.273367","article-title":"Determining the absolute requirement of G protein-coupled receptor kinase 5 for pathological cardiac hypertrophy: short communication","volume":"111","author":"Gold","year":"2012","journal-title":"Circ Res"},{"key":"10.1124\/mol.113.087312_bib16","doi-asserted-by":"crossref","unstructured":"Gravning J, Ahmed MS, von Lueder TG, Edvardsen T, Attramadal H (2013) CCN2\/CTGF attenuates myocardial hypertrophy and cardiac dysfunction upon chronic pressure-overload. Int J Cardiol pii: S0167-5273(13)00224-6.","DOI":"10.1016\/j.ijcard.2013.01.165"},{"key":"10.1124\/mol.113.087312_bib17","doi-asserted-by":"crossref","first-page":"5809","DOI":"10.1073\/pnas.091102398","article-title":"Cardiac beta ARK1 inhibition prolongs survival and augments beta blocker therapy in a mouse model of severe heart failure","volume":"98","author":"Harding","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/mol.113.087312_bib18","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1161\/01.CIR.80.3.658","article-title":"Isoproterenol-induced alterations in myocardial blood flow, systolic and diastolic function in conscious dogs with heart failure","volume":"80","author":"Hittinger","year":"1989","journal-title":"Circulation"},{"key":"10.1124\/mol.113.087312_bib19","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1089\/154065803321204484","article-title":"Transgenic mice targeting the heart unveil G protein-coupled receptor kinases as therapeutic targets","volume":"1","author":"Iaccarino","year":"2003","journal-title":"Assay Drug Dev Technol"},{"key":"10.1124\/mol.113.087312_bib20","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1161\/01.CIR.98.17.1783","article-title":"Reciprocal in vivo regulation of myocardial G protein-coupled receptor kinase expression by beta-adrenergic receptor stimulation and blockade","volume":"98","author":"Iaccarino","year":"1998","journal-title":"Circulation"},{"key":"10.1124\/mol.113.087312_bib21","doi-asserted-by":"crossref","first-page":"12771","DOI":"10.1074\/jbc.M111.324566","article-title":"Involvement of nuclear factor \u03baB (NF-\u03baB) signaling pathway in regulation of cardiac G protein-coupled receptor kinase 5 (GRK5) expression","volume":"287","author":"Islam","year":"2012","journal-title":"J Biol Chem"},{"key":"10.1124\/mol.113.087312_bib22","doi-asserted-by":"crossref","first-page":"10169","DOI":"10.1128\/MCB.24.23.10169-10179.2004","article-title":"G protein-coupled receptor kinase 5 contains a DNA-binding nuclear localization sequence","volume":"24","author":"Johnson","year":"2004","journal-title":"Mol Cell Biol"},{"key":"10.1124\/mol.113.087312_bib23","doi-asserted-by":"crossref","first-page":"14555","DOI":"10.1073\/pnas.0804745105","article-title":"Beta-blockers alprenolol and carvedilol stimulate beta-arrestin-mediated EGFR transactivation","volume":"105","author":"Kim","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/mol.113.087312_bib24","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1126\/science.7761854","article-title":"Cardiac function in mice overexpressing the beta-adrenergic receptor kinase or a beta ARK inhibitor","volume":"268","author":"Koch","year":"1995","journal-title":"Science"},{"key":"10.1124\/mol.113.087312_bib25","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.2217\/pgs.09.92","article-title":"GRK5 Gln41Leu polymorphism is not associated with sensitivity to beta(1)-adrenergic blockade in humans","volume":"10","author":"Kurnik","year":"2009","journal-title":"Pharmacogenomics"},{"key":"10.1124\/mol.113.087312_bib26","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/0003-2697(81)90081-6","article-title":"A simplified method for quantitation of the relative amounts of type I and type III collagen in small tissue samples","volume":"113","author":"Laurent","year":"1981","journal-title":"Anal Biochem"},{"key":"10.1124\/mol.113.087312_bib27","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1038\/nm1750","article-title":"A GRK5 polymorphism that inhibits beta-adrenergic receptor signaling is protective in heart failure","volume":"14","author":"Liggett","year":"2008","journal-title":"Nat Med"},{"key":"10.1124\/mol.113.087312_bib28","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1161\/01.CIR.0000127126.73759.23","article-title":"MEK1-ERK2 signaling pathway protects myocardium from ischemic injury in vivo","volume":"109","author":"Lips","year":"2004","journal-title":"Circulation"},{"key":"10.1124\/mol.113.087312_bib29","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1161\/01.RES.0000102042.83024.CA","article-title":"What is the role of beta-adrenergic signaling in heart failure?","volume":"93","author":"Lohse","year":"2003","journal-title":"Circ Res"},{"key":"10.1124\/mol.113.087312_bib30","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1159\/000129389","article-title":"JAK\/STAT and PI3K\/AKT pathways form a mutual transactivation loop and afford resistance to oxidative stress-induced apoptosis in cardiomyocytes","volume":"21","author":"Lu","year":"2008","journal-title":"Cell Physiol Biochem"},{"key":"10.1124\/mol.113.087312_bib31","doi-asserted-by":"crossref","first-page":"12457","DOI":"10.1073\/pnas.0803153105","article-title":"Uncovering G protein-coupled receptor kinase-5 as a histone deacetylase kinase in the nucleus of cardiomyocytes","volume":"105","author":"Martini","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/mol.113.087312_bib32","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s12079-012-0183-1","article-title":"CCN2 exerts direct cytoprotective actions in adult cardiac myocytes by activation of the PI3-kinase\/Akt\/GSK-3\u03b2 signaling pathway","volume":"7","author":"Moe","year":"2013","journal-title":"J Cell Commun Signal"},{"key":"10.1124\/mol.113.087312_bib33","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.1172\/JCI31901","article-title":"Beta-arrestin-mediated beta1-adrenergic receptor transactivation of the EGFR confers cardioprotection","volume":"117","author":"Noma","year":"2007","journal-title":"J Clin Invest"},{"key":"10.1124\/mol.113.087312_bib34","first-page":"271","article-title":"Isolation and culture of adult mouse cardiac myocytes","volume":"357","author":"O\u2019Connell","year":"2007","journal-title":"Methods Mol Biol"},{"key":"10.1124\/mol.113.087312_bib35","doi-asserted-by":"crossref","first-page":"2411","DOI":"10.1006\/jmcc.1998.0799","article-title":"Increased expression of connective tissue growth factor in the infarct zone of experimentally induced myocardial infarction in rats","volume":"30","author":"Ohnishi","year":"1998","journal-title":"J Mol Cell Cardiol"},{"key":"10.1124\/mol.113.087312_bib36","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1253\/circj.69.987","article-title":"Chronic beta-adrenergic receptor stimulation enhances the expression of G-Protein coupled receptor kinases, GRK2 and GRK5, in both the heart and peripheral lymphocytes","volume":"69","author":"Oyama","year":"2005","journal-title":"Circ J"},{"key":"10.1124\/mol.113.087312_bib37","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1161\/01.CIR.77.4.721","article-title":"Neurohormonal interactions and adaptations in congestive heart failure","volume":"77","author":"Packer","year":"1988","journal-title":"Circulation"},{"key":"10.1124\/mol.113.087312_bib38","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.cardiores.2005.09.011","article-title":"Mechanisms of regulation of G protein-coupled receptor kinases (GRKs) and cardiovascular disease","volume":"69","author":"Penela","year":"2006","journal-title":"Cardiovasc Res"},{"key":"10.1124\/mol.113.087312_bib39","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1146\/annurev.biochem.67.1.653","article-title":"G protein-coupled receptor kinases","volume":"67","author":"Pitcher","year":"1998","journal-title":"Annu Rev Biochem"},{"key":"10.1124\/mol.113.087312_bib40","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1161\/CIRCRESAHA.107.168336","article-title":"G protein-coupled receptor kinase 2 ablation in cardiac myocytes before or after myocardial infarction prevents heart failure","volume":"103","author":"Raake","year":"2008","journal-title":"Circ Res"},{"key":"10.1124\/mol.113.087312_bib41","doi-asserted-by":"crossref","first-page":"7000","DOI":"10.1073\/pnas.95.12.7000","article-title":"Expression of a beta-adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-targeted mice","volume":"95","author":"Rockman","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/mol.113.087312_bib42","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1038\/415206a","article-title":"Seven-transmembrane-spanning receptors and heart function","volume":"415","author":"Rockman","year":"2002","journal-title":"Nature"},{"key":"10.1124\/mol.113.087312_bib43","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1074\/jbc.M506576200","article-title":"beta-arrestin-dependent, G protein-independent ERK1\/2 activation by the beta2 adrenergic receptor","volume":"281","author":"Shenoy","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1124\/mol.113.087312_bib44","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1111\/j.1600-0773.1981.tb00874.x","article-title":"Mechanical response of rat myocardium to dibutyryl cyclic AMP in relation to effects of alpha-and beta-adrenoceptor stimulators","volume":"49","author":"Skomedal","year":"1981","journal-title":"Acta Pharmacol Toxicol (Copenh)"},{"key":"10.1124\/mol.113.087312_bib45","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1161\/01.CIR.87.2.454","article-title":"Altered expression of beta-adrenergic receptor kinase and beta 1-adrenergic receptors in the failing human heart","volume":"87","author":"Ungerer","year":"1993","journal-title":"Circulation"},{"key":"10.1124\/mol.113.087312_bib46","doi-asserted-by":"crossref","first-page":"H2490","DOI":"10.1152\/ajpheart.2001.281.6.H2490","article-title":"Myocardial distribution and regulation of GRK and beta-arrestin isoforms in congestive heart failure in rats","volume":"281","author":"Vinge","year":"2001","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1124\/mol.113.087312_bib47","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1136\/hrt.37.10.1022","article-title":"Effect of chronic beta-adrenergic receptor blockade in congestive cardiomyopathy","volume":"37","author":"Waagstein","year":"1975","journal-title":"Br Heart J"},{"key":"10.1124\/mol.113.087312_bib48","doi-asserted-by":"crossref","first-page":"16657","DOI":"10.1073\/pnas.0707936104","article-title":"A unique mechanism of beta-blocker action: carvedilol stimulates beta-arrestin signaling","volume":"104","author":"Wisler","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/mol.113.087312_bib49","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1161\/01.RES.86.6.692","article-title":"Inhibition of extracellular signal-regulated kinase enhances Ischemia\/Reoxygenation-induced apoptosis in cultured cardiac myocytes and exaggerates reperfusion injury in isolated perfused heart","volume":"86","author":"Yue","year":"2000","journal-title":"Circ Res"}],"container-title":["Molecular Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026895X24037775?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026895X24037775?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/mol.113.087312","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T11:15:55Z","timestamp":1739963755000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0026895X24037775"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9]]},"references-count":49,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,9]]}},"alternative-id":["S0026895X24037775"],"URL":"https:\/\/doi.org\/10.1124\/mol.113.087312","relation":{},"ISSN":["0026-895X"],"issn-type":[{"type":"print","value":"0026-895X"}],"subject":[],"published":{"date-parts":[[2013,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Connective Tissue Growth Factor\/CCN2 Attenuates \u03b2-Adrenergic Receptor Responsiveness and Cardiotoxicity by Induction of G Protein\u2013Coupled Receptor Kinase-5 in Cardiomyocytes","name":"articletitle","label":"Article Title"},{"value":"Molecular Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/mol.113.087312","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2013 by The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}