{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T08:43:37Z","timestamp":1747125817388,"version":"3.37.3"},"reference-count":51,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["molpharm.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Pharmacology"],"published-print":{"date-parts":[[2014,4]]},"DOI":"10.1124\/mol.113.089342","type":"journal-article","created":{"date-parts":[[2014,1,15]],"date-time":"2014-01-15T06:18:05Z","timestamp":1389766685000},"page":"564-575","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Eudistomin D and Penaresin Derivatives as Modulators of Ryanodine Receptor Channels and Sarcoplasmic Reticulum Ca2+ ATPase in Striated Muscle"],"prefix":"10.1016","volume":"85","author":[{"given":"Paula L.","family":"Diaz-Sylvester","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maura","family":"Porta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa V.","family":"Juettner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanzhao","family":"Lv","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sidney","family":"Fleischer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julio A.","family":"Copello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1124\/mol.113.089342_bib1","doi-asserted-by":"crossref","first-page":"C1726","DOI":"10.1152\/ajpcell.1997.272.5.C1726","article-title":"Different interactions of cardiac and skeletal muscle ryanodine receptors with FK-506 binding protein isoforms","volume":"272","author":"Barg","year":"1997","journal-title":"Am J Physiol"},{"key":"10.1124\/mol.113.089342_bib2","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1096\/fj.02-0481fje","article-title":"Ryanodine receptors of pancreatic beta-cells mediate a distinct context-dependent signal for insulin secretion","volume":"17","author":"Bruton","year":"2003","journal-title":"FASEB J"},{"key":"10.1124\/mol.113.089342_bib3","doi-asserted-by":"crossref","first-page":"6602","DOI":"10.1016\/S0021-9258(18)32455-4","article-title":"Isolation and characterization of canine cardiac sarcoplasmic reticulum with improved Ca2+ transport properties","volume":"258","author":"Chamberlain","year":"1983","journal-title":"J Biol Chem"},{"key":"10.1124\/mol.113.089342_bib4","doi-asserted-by":"crossref","first-page":"7540","DOI":"10.1016\/S0021-9258(17)42824-9","article-title":"Calcium-induced calcium release from purified cardiac sarcoplasmic reticulum vesicles. General characteristics","volume":"259","author":"Chamberlain","year":"1984","journal-title":"J Biol Chem"},{"key":"10.1124\/mol.113.089342_bib5","doi-asserted-by":"crossref","first-page":"7547","DOI":"10.1016\/S0021-9258(17)42825-0","article-title":"Inhibition of calcium-induced calcium release from purified cardiac sarcoplasmic reticulum vesicles","volume":"259","author":"Chamberlain","year":"1984","journal-title":"J Biol Chem"},{"key":"10.1124\/mol.113.089342_bib6","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/0076-6879(88)57066-0","article-title":"Isolation of sarcoplasmic reticulum fractions referable to longitudinal tubules and junctional terminal cisternae from rabbit skeletal muscle","volume":"157","author":"Chu","year":"1988","journal-title":"Methods Enzymol"},{"key":"10.1124\/mol.113.089342_bib7","unstructured":"Conley EC and Brammar WJ, editors (1996) The Ion Channel Factsbook, vol II, Intracellular Ligand-Gated Channels. Academic Press, San Diego, CA."},{"key":"10.1124\/mol.113.089342_bib8","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0006-3495(97)78055-X","article-title":"Heterogeneity of Ca2+ gating of skeletal muscle and cardiac ryanodine receptors","volume":"73","author":"Copello","year":"1997","journal-title":"Biophys J"},{"key":"10.1124\/mol.113.089342_bib9","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s00232-001-0150-x","article-title":"Differential activation by Ca2+, ATP and caffeine of cardiac and skeletal muscle ryanodine receptors after block by Mg2+","volume":"187","author":"Copello","year":"2002","journal-title":"J Membr Biol"},{"key":"10.1124\/mol.113.089342_bib10","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1039\/p19810001679","article-title":"Structure and synthesis of a new bromoindole from a marine sponge","volume":"1","author":"Dellar","year":"1981","journal-title":"J Chem Soc Perkin Trans"},{"key":"10.1124\/mol.113.089342_bib11","doi-asserted-by":"crossref","first-page":"e26693","DOI":"10.1371\/journal.pone.0026693","article-title":"Modulation of cardiac ryanodine receptor channels by alkaline earth cations","volume":"6","author":"Diaz-Sylvester","year":"2011","journal-title":"PLoS One"},{"key":"10.1124\/mol.113.089342_bib12","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1152\/physrev.00013.2002","article-title":"Ryanodine receptor calcium release channels","volume":"82","author":"Fill","year":"2002","journal-title":"Physiol Rev"},{"key":"10.1124\/mol.113.089342_bib13","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.bbrc.2007.12.119","article-title":"Personal recollections on the discovery of the ryanodine receptors of muscle","volume":"369","author":"Fleischer","year":"2008","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1124\/mol.113.089342_bib14","series-title":"Methylxanthines","first-page":"93","article-title":"Inhibition of cyclic nucleotide phosphodiesterases by methylxanthines and related compounds","author":"Francis","year":"2011"},{"key":"10.1124\/mol.113.089342_bib15","series-title":"The Alkaloids: Chemistry and Biology","first-page":"1","article-title":"Occurrence of halogenated alkaloids","author":"Gribble","year":"2012"},{"key":"10.1124\/mol.113.089342_bib16","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1126\/science.8387229","article-title":"Ryanodine receptor adaptation: control mechanism of Ca(2+)-induced Ca2+ release in heart","volume":"260","author":"Gy\u00f6rke","year":"1993","journal-title":"Science"},{"key":"10.1124\/mol.113.089342_bib17","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1023\/A:1005496708505","article-title":"Caffeine and excitation-contraction coupling in skeletal muscle: a stimulating story","volume":"20","author":"Herrmann-Frank","year":"1999","journal-title":"J Muscle Res Cell Motil"},{"key":"10.1124\/mol.113.089342_bib18","doi-asserted-by":"crossref","first-page":"3825","DOI":"10.1016\/j.bmc.2008.01.041","article-title":"Synthesis of eudistomin D analogues and its effects on adenosine receptors","volume":"16","author":"Ishiyama","year":"2008","journal-title":"Bioorg Med Chem"},{"key":"10.1124\/mol.113.089342_bib19","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.3987\/COM-90-5589","article-title":"Penaresin, a new sarcoplasmic reticulum Ca-inducer from the Okinawan marine sponge Penares sp","volume":"31","author":"Kobayashi","year":"1990","journal-title":"Heterocycles"},{"key":"10.1124\/mol.113.089342_bib20","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1021\/ja00317a080","article-title":"Eudistomins A, D, G, H, I, J, M, N, O, P, and Q, bromo, hydroxy, pyrrolyl and iminoazepino .beta.-carbolines from the antiviral Caribbean tunicate Eudistoma olivaceum","volume":"106","author":"Kobayashi","year":"1984","journal-title":"J Am Chem Soc"},{"key":"10.1124\/mol.113.089342_bib21","doi-asserted-by":"crossref","first-page":"a003996","DOI":"10.1101\/cshperspect.a003996","article-title":"Ryanodine receptors: structure, expression, molecular details, and function in calcium release","volume":"2","author":"Lanner","year":"2010","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"10.1124\/mol.113.089342_bib22","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1159\/000139480","article-title":"Structure-activity relationship of xanthines and skeletal muscle ryanodine receptor\/Ca2+ release channel","volume":"54","author":"Liu","year":"1997","journal-title":"Pharmacology"},{"key":"10.1124\/mol.113.089342_bib23","doi-asserted-by":"crossref","first-page":"446a","DOI":"10.1016\/j.bpj.2012.11.2475","article-title":"Benzodiazepines and benzothiazepines as modulators of the sarcoplasmic reticulum calcium ATP-ase and ryanodine receptors in striated muscle (Abstract)","volume":"104","author":"Lv","year":"2013","journal-title":"Biophys J"},{"key":"10.1124\/mol.113.089342_bib24","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.ceca.2004.01.015","article-title":"Molecular regulation of cardiac ryanodine receptor ion channel","volume":"35","author":"Meissner","year":"2004","journal-title":"Cell Calcium"},{"key":"10.1124\/mol.113.089342_bib25","series-title":"Methylxanthines","first-page":"151","article-title":"Xanthines as adenosine receptor antagonists","author":"M\u00fcller","year":"2011"},{"key":"10.1124\/mol.113.089342_bib26","doi-asserted-by":"crossref","first-page":"4139","DOI":"10.1016\/S0021-9258(17)35636-3","article-title":"Bromo-eudistomin D, a novel inducer of calcium release from fragmented sarcoplasmic reticulum that causes contractions of skinned muscle fibers","volume":"261","author":"Nakamura","year":"1986","journal-title":"J Biol Chem"},{"key":"10.1124\/mol.113.089342_bib27","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1124\/mol.111.071167","article-title":"Cross-reactivity of ryanodine receptors with plasma membrane ion channel modulators","volume":"80","author":"Neumann","year":"2011","journal-title":"Mol Pharmacol"},{"key":"10.1124\/mol.113.089342_bib28","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1124\/mol.110.067165","article-title":"CGP-37157 inhibits the sarcoplasmic reticulum Ca\u00b2+ ATPase and activates ryanodine receptor channels in striated muscle","volume":"79","author":"Neumann","year":"2011","journal-title":"Mol Pharmacol"},{"key":"10.1124\/mol.113.089342_bib29","doi-asserted-by":"crossref","first-page":"229","DOI":"10.3109\/10409239409083482","article-title":"Role of ryanodine receptors","volume":"29","author":"Ogawa","year":"1994","journal-title":"Crit Rev Biochem Mol Biol"},{"key":"10.1124\/mol.113.089342_bib30","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1254\/jjp.85.382","article-title":"Imaging of Ca2+ release by caffeine and 9-methyl-7-bromoeudistomin D and the associated activation of large conductance Ca2+-dependent K+ channels in urinary bladder smooth muscle cells of the guinea pig","volume":"85","author":"Ohi","year":"2001","journal-title":"Jpn J Pharmacol"},{"key":"10.1124\/mol.113.089342_bib31","doi-asserted-by":"crossref","first-page":"2469","DOI":"10.1016\/j.bbamem.2008.07.024","article-title":"Ryanoids and imperatoxin affect the modulation of cardiac ryanodine receptors by dihydropyridine receptor Peptide A","volume":"1778","author":"Porta","year":"2008","journal-title":"Biochim Biophys Acta"},{"key":"10.1124\/mol.113.089342_bib32","doi-asserted-by":"crossref","first-page":"C682","DOI":"10.1152\/ajpcell.00150.2012","article-title":"Coupled gating of skeletal muscle ryanodine receptors is modulated by Ca2+, Mg2+, and ATP","volume":"303","author":"Porta","year":"2012","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1124\/mol.113.089342_bib33","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/j.bpj.2011.01.017","article-title":"Single ryanodine receptor channel basis of caffeine\u2019s action on Ca2+ sparks","volume":"100","author":"Porta","year":"2011","journal-title":"Biophys J"},{"key":"10.1124\/mol.113.089342_bib34","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1111\/apha.12027","article-title":"Energetic study of cardioplegic hearts under ischaemia\/reperfusion and [Ca(2+)] changes in cardiomyocytes of guinea-pig: mitochondrial role","volume":"207","author":"Ragone","year":"2013","journal-title":"Acta Physiol (Oxf)"},{"key":"10.1124\/mol.113.089342_bib35","series-title":"Methylxanthines","first-page":"413","article-title":"The cardiovascular effects of methylxanthines","author":"Riksen","year":"2011"},{"key":"10.1124\/mol.113.089342_bib36","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1085\/jgp.200308868","article-title":"Calcium regulation of single ryanodine receptor channel gating analyzed using HMM\/MCMC statistical methods","volume":"123","author":"Rosales","year":"2004","journal-title":"J Gen Physiol"},{"key":"10.1124\/mol.113.089342_bib37","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/0003-9861(88)90010-0","article-title":"Activation of the Ca2+ release channel of skeletal muscle sarcoplasmic reticulum by caffeine and related compounds","volume":"267","author":"Rousseau","year":"1988","journal-title":"Arch Biochem Biophys"},{"key":"10.1124\/mol.113.089342_bib38","first-page":"H328","article-title":"Single cardiac sarcoplasmic reticulum Ca2+-release channel: activation by caffeine","volume":"256","author":"Rousseau","year":"1989","journal-title":"Am J Physiol"},{"key":"10.1124\/mol.113.089342_bib39","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1083\/jcb.99.3.875","article-title":"Preparation and morphology of sarcoplasmic reticulum terminal cisternae from rabbit skeletal muscle","volume":"99","author":"Saito","year":"1984","journal-title":"J Cell Biol"},{"key":"10.1124\/mol.113.089342_bib40","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/S0022-3565(25)23009-9","article-title":"9-Methyl-7-bromoeudistomin D, a powerful radio-labelable Ca++ releaser having caffeine-like properties, acts on Ca(++)-induced Ca++ release channels of sarcoplasmic reticulum","volume":"256","author":"Seino","year":"1991","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/mol.113.089342_bib41","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S0014-2999(98)00589-5","article-title":"9-Methyl-7-bromoeudistomin D induces Ca2+ release from cardiac sarcoplasmic reticulum","volume":"357","author":"Seino-Umeda","year":"1998","journal-title":"Eur J Pharmacol"},{"key":"10.1124\/mol.113.089342_bib42","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1113\/jphysiol.1990.sp018031","article-title":"Mechanisms of caffeine activation of single calcium-release channels of sheep cardiac sarcoplasmic reticulum","volume":"423","author":"Sitsapesan","year":"1990","journal-title":"J Physiol"},{"key":"10.1124\/mol.113.089342_bib43","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1016\/S0006-3495(94)80622-8","article-title":"Gating of the native and purified cardiac SR Ca(2+)-release channel with monovalent cations as permeant species","volume":"67","author":"Sitsapesan","year":"1994","journal-title":"Biophys J"},{"year":"1998","series-title":"The Structure and Function of Ryanodine Receptors","author":"Sitsapesan","key":"10.1124\/mol.113.089342_bib44"},{"key":"10.1124\/mol.113.089342_bib45","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1111\/j.1476-5381.1995.tb13295.x","article-title":"4,6-Dibromo-3-hydroxycarbazole (an analogue of caffeine-like Ca2+ releaser), a novel type of inhibitor of Ca(2+)-induced Ca2+ release in skeletal muscle sarcoplasmic reticulum","volume":"114","author":"Takahashi","year":"1995","journal-title":"Br J Pharmacol"},{"key":"10.1124\/mol.113.089342_bib46","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S1063-5823(10)66007-3","article-title":"Ryanodinopathies: RyR-linked muscle diseases","volume":"66C","author":"Wei","year":"2010","journal-title":"Curr Top Membr"},{"key":"10.1124\/mol.113.089342_bib47","doi-asserted-by":"crossref","first-page":"2428","DOI":"10.2174\/138161207781368620","article-title":"Pharmacological regulators of intracellular calcium release channels","volume":"13","author":"West","year":"2007","journal-title":"Curr Pharm Des"},{"key":"10.1124\/mol.113.089342_bib48","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/0014-5793(95)01021-6","article-title":"[3H]9-Methyl-7-bromoeudistomin D, a caffeine-like powerful Ca2+ releaser, binds to caffeine-binding sites distinct from the ryanodine receptors in brain microsomes","volume":"373","author":"Yoshikawa","year":"1995","journal-title":"FEBS Lett"},{"key":"10.1124\/mol.113.089342_bib49","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/BF00374603","article-title":"Multiple effects of caffeine on calcium current in rat ventricular myocytes","volume":"424","author":"Zahradn\u00edk","year":"1993","journal-title":"Pflugers Arch"},{"key":"10.1124\/mol.113.089342_bib50","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/s004240050911","article-title":"Modal gating transitions in cardiac ryanodine receptors during increases of Ca2+ concentration produced by photolysis of caged Ca2+","volume":"438","author":"Zahradn\u00edkov\u00e1","year":"1999","journal-title":"Pflugers Arch"},{"key":"10.1124\/mol.113.089342_bib51","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.1016\/S0006-3495(95)80048-2","article-title":"Description of modal gating of the cardiac calcium release channel in planar lipid membranes","volume":"69","author":"Zahradn\u00edkov\u00e1","year":"1995","journal-title":"Biophys J"}],"container-title":["Molecular Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026895X24038999?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026895X24038999?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/mol.113.089342","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T11:20:00Z","timestamp":1739964000000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0026895X24038999"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4]]},"references-count":51,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["S0026895X24038999"],"URL":"https:\/\/doi.org\/10.1124\/mol.113.089342","relation":{},"ISSN":["0026-895X"],"issn-type":[{"type":"print","value":"0026-895X"}],"subject":[],"published":{"date-parts":[[2014,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Eudistomin D and Penaresin Derivatives as Modulators of Ryanodine Receptor Channels and Sarcoplasmic Reticulum Ca2+ ATPase in Striated Muscle","name":"articletitle","label":"Article Title"},{"value":"Molecular Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/mol.113.089342","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2014 by The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}