{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T23:28:59Z","timestamp":1768433339407,"version":"3.49.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["molpharm.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Pharmacology"],"published-print":{"date-parts":[[2014,5]]},"DOI":"10.1124\/mol.114.091835","type":"journal-article","created":{"date-parts":[[2014,3,1]],"date-time":"2014-03-01T03:25:20Z","timestamp":1393644320000},"page":"769-776","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"title":["Kinetics of Drug Interaction with the Kv11.1 Potassium Channel"],"prefix":"10.1016","volume":"85","author":[{"given":"Adam P.","family":"Hill","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark J.","family":"Perrin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliane","family":"Heide","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terence J.","family":"Campbell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan A.","family":"Mann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jamie I.","family":"Vandenberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1124\/mol.114.091835_bib1","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.ejps.2008.09.013","article-title":"Multiscale modelling of drug-induced effects on cardiac electrophysiological activity","volume":"36","author":"Brennan","year":"2009","journal-title":"Eur J Pharm Sci"},{"key":"10.1124\/mol.114.091835_bib2","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/S0022-3565(25)10827-6","article-title":"Voltage- and time-dependent block of the delayed K+ current in cardiac myocytes by dofetilide","volume":"262","author":"Carmeliet","year":"1992","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/mol.114.091835_bib3","doi-asserted-by":"crossref","first-page":"3510","DOI":"10.1529\/biophysj.103.038679","article-title":"How to impose microscopic reversibility in complex reaction mechanisms","volume":"86","author":"Colquhoun","year":"2004","journal-title":"Biophys J"},{"key":"10.1124\/mol.114.091835_bib4","doi-asserted-by":"crossref","unstructured":"Di Veroli GY, Davies MR, Zhang H, Abi-Gerges N, Boyett MR (2013a) hERG inhibitors with similar potency but different binding kinetics do not pose the same proarrhythmic risk: Implications for drug safety assessment. J Cardiovasc Electrophysiol. DOI: 10.1111\/jce.12289 [published ahead of print]","DOI":"10.1111\/jce.12289"},{"key":"10.1124\/mol.114.091835_bib5","doi-asserted-by":"crossref","first-page":"H104","DOI":"10.1152\/ajpheart.00511.2012","article-title":"High-throughput screening of drug-binding dynamics to HERG improves early drug safety assessment","volume":"304","author":"Di Veroli","year":"2013","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1124\/mol.114.091835_bib6","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1161\/01.RES.82.3.386","article-title":"Molecular determinants of dofetilide block of HERG K+ channels","volume":"82","author":"Ficker","year":"1998","journal-title":"Circ Res"},{"key":"10.1124\/mol.114.091835_bib7","series-title":"Ionic Channels of excitable membranes, 3rd ed","first-page":"503","article-title":"Classical mechanisms of block","author":"Hille","year":"2001"},{"key":"10.1124\/mol.114.091835_bib8","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1254\/jphs.08102FP","article-title":"Molecular determinants of hERG channel block by terfenadine and cisapride","volume":"108","author":"Kamiya","year":"2008","journal-title":"J Pharmacol Sci"},{"key":"10.1124\/mol.114.091835_bib9","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.vascn.2004.06.003","article-title":"Variability in the measurement of hERG potassium channel inhibition: effects of temperature and stimulus pattern","volume":"50","author":"Kirsch","year":"2004","journal-title":"J Pharmacol Toxicol Methods"},{"key":"10.1124\/mol.114.091835_bib10","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/sj.bjp.0706744","article-title":"Blockade of HERG human K+ channels and IKr of guinea-pig cardiomyocytes by the antipsychotic drug clozapine","volume":"148","author":"Lee","year":"2006","journal-title":"Br J Pharmacol"},{"key":"10.1124\/mol.114.091835_bib11","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1056\/NEJMoa051688","article-title":"Effectiveness of antipsychotic drugs in patients with chronic schizophrenia","volume":"353","author":"Lieberman","year":"2005","journal-title":"N Engl J Med"},{"key":"10.1124\/mol.114.091835_bib12","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1113\/jphysiol.2001.012690","article-title":"Effects of premature stimulation on HERG K(+) channels","volume":"537","author":"Lu","year":"2001","journal-title":"J Physiol"},{"key":"10.1124\/mol.114.091835_bib13","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1038\/sj.bjp.0705335","article-title":"Blockade of HERG potassium currents by fluvoxamine: incomplete attenuation by S6 mutations at F656 or Y652","volume":"139","author":"Milnes","year":"2003","journal-title":"Br J Pharmacol"},{"key":"10.1124\/mol.114.091835_bib14","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.vascn.2010.02.007","article-title":"Investigating dynamic protocol-dependence of hERG potassium channel inhibition at 37 degrees C: Cisapride versus dofetilide","volume":"61","author":"Milnes","year":"2010","journal-title":"J Pharmacol Toxicol Methods"},{"key":"10.1124\/mol.114.091835_bib15","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1085\/jgp.115.3.229","article-title":"Trapping of a methanesulfonanilide by closure of the HERG potassium channel activation gate","volume":"115","author":"Mitcheson","year":"2000","journal-title":"J Gen Physiol"},{"key":"10.1124\/mol.114.091835_bib16","doi-asserted-by":"crossref","first-page":"4968","DOI":"10.1021\/ac035527j","article-title":"A microfluidics approach to the problem of creating separate solution environments accessible from macroscopic volumes","volume":"76","author":"Olofsson","year":"2004","journal-title":"Anal Chem"},{"key":"10.1124\/mol.114.091835_bib17","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1038\/sj.bjp.0704784","article-title":"Inhibition of the current of heterologously expressed HERG potassium channels by flecainide and comparison with quinidine, propafenone and lignocaine","volume":"136","author":"Paul","year":"2002","journal-title":"Br J Pharmacol"},{"key":"10.1124\/mol.114.091835_bib18","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1124\/mol.108.049056","article-title":"Drug binding to the inactivated state is necessary but not sufficient for high-affinity binding to human ether-\u00e0-go-go-related gene channels","volume":"74","author":"Perrin","year":"2008","journal-title":"Mol Pharmacol"},{"key":"10.1124\/mol.114.091835_bib19","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1056\/NEJMoa0806994","article-title":"Atypical antipsychotic drugs and the risk of sudden cardiac death","volume":"360","author":"Ray","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1124\/mol.114.091835_bib20","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/S0008-6363(02)00846-5","article-title":"Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development","volume":"58","author":"Redfern","year":"2003","journal-title":"Cardiovasc Res"},{"key":"10.1124\/mol.114.091835_bib21","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1161\/01.RES.56.6.857","article-title":"Action potential prolongation and induction of abnormal automaticity by low quinidine concentrations in canine Purkinje fibers. Relationship to potassium and cycle length","volume":"56","author":"Roden","year":"1985","journal-title":"Circ Res"},{"key":"10.1124\/mol.114.091835_bib30","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1056\/NEJMra032426","article-title":"Drug-induced prolongation of the QT interval","volume":"350","author":"Roden","year":"2004","journal-title":"N Engl J Med"},{"key":"10.1124\/mol.114.091835_bib22","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1109\/TBME.2010.2077292","article-title":"Effects of the antiarrhythmic drug dofetilide on transmural dispersion of repolarization in ventriculum. A computer modeling study","volume":"58","author":"Saiz","year":"2011","journal-title":"IEEE Trans Biomed Eng"},{"key":"10.1124\/mol.114.091835_bib23","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/0092-8674(95)90340-2","article-title":"A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel","volume":"81","author":"Sanguinetti","year":"1995","journal-title":"Cell"},{"key":"10.1124\/mol.114.091835_bib24","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1038\/379833a0","article-title":"The inward rectification mechanism of the HERG cardiac potassium channel","volume":"379","author":"Smith","year":"1996","journal-title":"Nature"},{"key":"10.1124\/mol.114.091835_bib25","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1152\/physrev.00036.2011","article-title":"hERG K(+) channels: structure, function, and clinical significance","volume":"92","author":"Vandenberg","year":"2012","journal-title":"Physiol Rev"},{"key":"10.1124\/mol.114.091835_bib26","doi-asserted-by":"crossref","first-page":"C165","DOI":"10.1152\/ajpcell.00596.2005","article-title":"Temperature dependence of human ether-a-go-go-related gene K+ currents","volume":"291","author":"Vandenberg","year":"2006","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1124\/mol.114.091835_bib27","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1038\/sj.bjp.0702774","article-title":"Inhibition of the human ether-a-go-go-related gene (HERG) potassium channel by cisapride: affinity for open and inactivated states","volume":"128","author":"Walker","year":"1999","journal-title":"Br J Pharmacol"},{"key":"10.1124\/mol.114.091835_bib28","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1007\/s004240100720","article-title":"Dofetilide block involves interactions with open and inactivated states of HERG channels","volume":"443","author":"Weerapura","year":"2002","journal-title":"Pflugers Arch"},{"key":"10.1124\/mol.114.091835_bib29","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1124\/mol.104.001743","article-title":"The low-potency, voltage-dependent HERG blocker propafenone\u2014molecular determinants and drug trapping","volume":"66","author":"Witchel","year":"2004","journal-title":"Mol Pharmacol"},{"key":"10.1124\/mol.114.091835_bib31","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1007\/s10439-009-9690-5","article-title":"Identification of Ikr kinetics and drug binding in native myocytes","volume":"37","author":"Zhou","year":"2009","journal-title":"Ann Biomed Eng"}],"container-title":["Molecular Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026895X24039191?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026895X24039191?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/mol.114.091835","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T11:20:29Z","timestamp":1739964029000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0026895X24039191"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5]]},"references-count":31,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["S0026895X24039191"],"URL":"https:\/\/doi.org\/10.1124\/mol.114.091835","relation":{},"ISSN":["0026-895X"],"issn-type":[{"value":"0026-895X","type":"print"}],"subject":[],"published":{"date-parts":[[2014,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Kinetics of Drug Interaction with the Kv11.1 Potassium Channel","name":"articletitle","label":"Article Title"},{"value":"Molecular Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/mol.114.091835","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2014 by The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}