{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:03:19Z","timestamp":1791266599717,"version":"4.1.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["molpharm.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Pharmacology"],"published-print":{"date-parts":[[2015,7]]},"DOI":"10.1124\/mol.115.098277","type":"journal-article","created":{"date-parts":[[2015,5,8]],"date-time":"2015-05-08T02:12:19Z","timestamp":1431051139000},"page":"131-138","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["The Pore Loop Domain of TRPV1 Is Required for Its Activation by the Volatile Anesthetics Chloroform and Isoflurane"],"prefix":"10.1016","volume":"88","author":[{"given":"Corinna","family":"Kimball","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialie","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shijin","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongzhen","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajay","family":"Dhaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1124\/mol.115.098277_bib1","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/j.cell.2006.02.023","article-title":"TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents","volume":"124","author":"Bautista","year":"2006","journal-title":"Cell"},{"key":"10.1124\/mol.115.098277_bib2","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1152\/jn.1984.52.4.762","article-title":"Halothane sensitizes cutaneous nociceptors in monkeys","volume":"52","author":"Campbell","year":"1984","journal-title":"J Neurophysiol"},{"key":"10.1124\/mol.115.098277_bib3","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.neuron.2012.12.016","article-title":"TRPV1 channels are intrinsically heat sensitive and negatively regulated by phosphoinositide lipids","volume":"77","author":"Cao","year":"2013","journal-title":"Neuron"},{"key":"10.1124\/mol.115.098277_bib4","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/nature12823","article-title":"TRPV1 structures in distinct conformations reveal activation mechanisms","volume":"504","author":"Cao","year":"2013","journal-title":"Nature"},{"key":"10.1124\/mol.115.098277_bib5","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1126\/science.288.5464.306","article-title":"Impaired nociception and pain sensation in mice lacking the capsaicin receptor","volume":"288","author":"Caterina","year":"2000","journal-title":"Science"},{"key":"10.1124\/mol.115.098277_bib6","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/nature02196","article-title":"TRP channels as cellular sensors","volume":"426","author":"Clapham","year":"2003","journal-title":"Nature"},{"key":"10.1124\/mol.115.098277_bib7","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1124\/mol.108.049684","article-title":"General anesthetics sensitize the capsaicin receptor transient receptor potential V1","volume":"74","author":"Cornett","year":"2008","journal-title":"Mol Pharmacol"},{"key":"10.1124\/mol.115.098277_bib8","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1523\/JNEUROSCI.3976-07.2008","article-title":"Visualizing cold spots: TRPM8-expressing sensory neurons and their projections","volume":"28","author":"Dhaka","year":"2008","journal-title":"J Neurosci"},{"key":"10.1124\/mol.115.098277_bib9","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1523\/JNEUROSCI.4901-08.2009","article-title":"TRPV1 is activated by both acidic and basic pH","volume":"29","author":"Dhaka","year":"2009","journal-title":"J Neurosci"},{"key":"10.1124\/mol.115.098277_bib10","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1146\/annurev.neuro.29.051605.112958","article-title":"Trp ion channels and temperature sensation","volume":"29","author":"Dhaka","year":"2006","journal-title":"Annu Rev Neurosci"},{"key":"10.1124\/mol.115.098277_bib11","doi-asserted-by":"crossref","first-page":"602870","DOI":"10.1155\/2008\/602870","article-title":"Molecular processes in biological thermosensation","volume":"2008","author":"Digel","year":"2008","journal-title":"J Biophys"},{"key":"10.1124\/mol.115.098277_bib12","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1097\/00004311-199500000-00004","article-title":"New drugs in anesthesia","volume":"33","author":"Eger","year":"1995","journal-title":"Int Anesthesiol Clin"},{"key":"10.1124\/mol.115.098277_bib13","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1097\/ALN.0b013e3181d94e00","article-title":"Pungent general anesthetics activate transient receptor potential-A1 to produce hyperalgesia and neurogenic bronchoconstriction","volume":"112","author":"Eilers","year":"2010","journal-title":"Anesthesiology"},{"key":"10.1124\/mol.115.098277_bib14","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1038\/nrn2372","article-title":"General anaesthesia: from molecular targets to neuronal pathways of sleep and arousal","volume":"9","author":"Franks","year":"2008","journal-title":"Nat Rev Neurosci"},{"key":"10.1124\/mol.115.098277_bib15","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1038\/367607a0","article-title":"Molecular and cellular mechanisms of general anaesthesia","volume":"367","author":"Franks","year":"1994","journal-title":"Nature"},{"key":"10.1124\/mol.115.098277_bib16","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1124\/jpet.104.079855","article-title":"AMG 9810 [(E)-3-(4-t-butylphenyl)-N-(2,3-dihydrobenzo[b][1,4] dioxin-6-yl)acrylamide], a novel vanilloid receptor 1 (TRPV1) antagonist with antihyperalgesic properties","volume":"313","author":"Gavva","year":"2005","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/mol.115.098277_bib17","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1038\/nn.2169","article-title":"Pore region of TRPV3 ion channel is specifically required for heat activation","volume":"11","author":"Grandl","year":"2008","journal-title":"Nat Neurosci"},{"key":"10.1124\/mol.115.098277_bib18","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1038\/nn.2552","article-title":"Temperature-induced opening of TRPV1 ion channel is stabilized by the pore domain","volume":"13","author":"Grandl","year":"2010","journal-title":"Nat Neurosci"},{"key":"10.1124\/mol.115.098277_bib19","doi-asserted-by":"crossref","first-page":"35741","DOI":"10.1074\/jbc.M404164200","article-title":"2-Aminoethoxydiphenyl borate is a common activator of TRPV1, TRPV2, and TRPV3","volume":"279","author":"Hu","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1124\/mol.115.098277_bib20","doi-asserted-by":"crossref","first-page":"8134","DOI":"10.1073\/pnas.100129497","article-title":"Acid potentiation of the capsaicin receptor determined by a key extracellular site","volume":"97","author":"Jordt","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/mol.115.098277_bib21","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1146\/annurev-cellbio-101011-155833","article-title":"TRP channels and pain","volume":"29","author":"Julius","year":"2013","journal-title":"Annu Rev Cell Dev Biol"},{"key":"10.1124\/mol.115.098277_bib22","first-page":"179","article-title":"Studies on the toxicity and maximum allowable concentration of chloroform","volume":"6","author":"Li","year":"1993","journal-title":"Biomed Environ Sci"},{"key":"10.1124\/mol.115.098277_bib23","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1213\/ane.0b013e3181706c7e","article-title":"Meyer and Overton revisited","volume":"107","author":"Lynch","year":"2008","journal-title":"Anesth Analg"},{"key":"10.1124\/mol.115.098277_bib24","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1097\/00000542-199006000-00012","article-title":"Volatile anesthetics excite mammalian nociceptor afferents recorded in vitro","volume":"72","author":"MacIver","year":"1990","journal-title":"Anesthesiology"},{"key":"10.1124\/mol.115.098277_bib25","first-page":"903","article-title":"Pore helix domain is critical to camphor sensitivity of transient receptor potential vanilloid 1 channel","volume":"116","author":"Marsakova","year":"2012","journal-title":"Miscellaneous Article Anesthesiology"},{"key":"10.1124\/mol.115.098277_bib26","doi-asserted-by":"crossref","first-page":"8784","DOI":"10.1073\/pnas.0711038105","article-title":"General anesthetics activate a nociceptive ion channel to enhance pain and inflammation","volume":"105","author":"Matta","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/mol.115.098277_bib27","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1038\/nature719","article-title":"Identification of a cold receptor reveals a general role for TRP channels in thermosensation","volume":"416","author":"McKemy","year":"2002","journal-title":"Nature"},{"key":"10.1124\/mol.115.098277_bib28","doi-asserted-by":"crossref","first-page":"13525","DOI":"10.1073\/pnas.0705924104","article-title":"TRPA1 mediates formalin-induced pain","volume":"104","author":"McNamara","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/mol.115.098277_bib29","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0034-5687(97)00123-0","article-title":"Responses of laryngeal capsaicin-sensitive receptors to volatile anesthetics in anesthetized dogs","volume":"111","author":"Mutoh","year":"1998","journal-title":"Respir Physiol"},{"key":"10.1124\/mol.115.098277_bib30","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/S0092-8674(02)00652-9","article-title":"A TRP channel that senses cold stimuli and menthol","volume":"108","author":"Peier","year":"2002","journal-title":"Cell"},{"key":"10.1124\/mol.115.098277_bib31","doi-asserted-by":"crossref","first-page":"2527","DOI":"10.1021\/jp110699h","article-title":"Influence of chloroform in liquid-ordered and liquid-disordered phases in lipid membranes","volume":"115","author":"Reigada","year":"2011","journal-title":"J Phys Chem B"},{"key":"10.1124\/mol.115.098277_bib32","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/S0092-8674(03)00158-2","article-title":"ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures","volume":"112","author":"Story","year":"2003","journal-title":"Cell"},{"key":"10.1124\/mol.115.098277_bib33","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1093\/bja\/85.2.305","article-title":"Which is most pungent: isoflurane, sevoflurane or desflurane?","volume":"85","author":"TerRiet","year":"2000","journal-title":"Br J Anaesth"},{"key":"10.1124\/mol.115.098277_bib34","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1124\/jpet.108.139295","volume":"326","author":"Thorneloe","year":"2008","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/mol.115.098277_bib35","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/S0896-6273(00)80564-4","article-title":"The cloned capsaicin receptor integrates multiple pain-producing stimuli","volume":"21","author":"Tominaga","year":"1998","journal-title":"Neuron"},{"key":"10.1124\/mol.115.098277_bib36","doi-asserted-by":"crossref","first-page":"4479","DOI":"10.1242\/jcs.131631","article-title":"Complex modulation of the cold receptor TRPM8 by volatile anaesthetics and its role in complications of general anaesthesia","volume":"126","author":"Vanden Abeele","year":"2013","journal-title":"J Cell Sci"},{"key":"10.1124\/mol.115.098277_bib37","doi-asserted-by":"crossref","first-page":"5068","DOI":"10.1021\/ja9011468","article-title":"Loosening and reorganization of fluid phospholipid bilayers by chloroform","volume":"131","author":"Turkyilmaz","year":"2009","journal-title":"J Am Chem Soc"},{"key":"10.1124\/mol.115.098277_bib38","doi-asserted-by":"crossref","first-page":"259","DOI":"10.3109\/01480547809105020","article-title":"Health aspects of chloroform: a review","volume":"1","author":"Winslow","year":"1978","journal-title":"Drug Chem Toxicol"}],"container-title":["Molecular Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026895X24031213?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026895X24031213?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/mol.115.098277","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T10:07:25Z","timestamp":1739959645000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0026895X24031213"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["S0026895X24031213"],"URL":"https:\/\/doi.org\/10.1124\/mol.115.098277","relation":{},"ISSN":["0026-895X"],"issn-type":[{"value":"0026-895X","type":"print"}],"subject":[],"published":{"date-parts":[[2015,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Pore Loop Domain of TRPV1 Is Required for Its Activation by the Volatile Anesthetics Chloroform and Isoflurane","name":"articletitle","label":"Article Title"},{"value":"Molecular Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/mol.115.098277","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2015 by The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}