{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T22:16:29Z","timestamp":1762899389262,"version":"3.37.3"},"reference-count":104,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2017,5,1]],"date-time":"2017-05-01T00:00:00Z","timestamp":1493596800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,5,1]],"date-time":"2017-05-01T00:00:00Z","timestamp":1493596800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["molpharm.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Pharmacology"],"published-print":{"date-parts":[[2017,5]]},"DOI":"10.1124\/mol.116.106906","type":"journal-article","created":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T01:30:23Z","timestamp":1488331823000},"page":"482-498","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["AEE788 Inhibits Basal Body Assembly and Blocks DNA Replication in the African Trypanosome"],"prefix":"10.1016","volume":"91","author":[{"given":"Catherine","family":"Sullenberger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Piqu\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuko","family":"Ogata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kojo","family":"Mensa-Wilmot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1124\/mol.116.106906_bib1","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1007\/s00436-015-4346-x","article-title":"A cultivation method for growing bloodstream forms of Trypanosoma brucei to higher cell density and for longer time","volume":"114","author":"Ajoko","year":"2015","journal-title":"Parasitol Res"},{"key":"10.1124\/mol.116.106906_bib2","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1074\/jbc.M113.509521","article-title":"An alternative model for the role of RP2 protein in flagellum assembly in the African trypanosome","volume":"289","author":"Andre","year":"2014","journal-title":"J Biol Chem"},{"key":"10.1124\/mol.116.106906_bib3","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0018425","article-title":"The cell cycle regulated transcriptome of Trypanosoma brucei","volume":"6","author":"Archer","year":"2011","journal-title":"PLoS One"},{"key":"10.1124\/mol.116.106906_bib4","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1179\/2047773213Y.0000000105","article-title":"A current analysis of chemotherapy strategies for the treatment of human African trypanosomiasis","volume":"107","author":"Babokhov","year":"2013","journal-title":"Pathog Glob Health"},{"key":"10.1124\/mol.116.106906_bib5","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1111\/j.1365-2958.2011.07900.x","article-title":"Replication of the ERES:Golgi junction in bloodstream-form African trypanosomes","volume":"82","author":"Bangs","year":"2011","journal-title":"Mol Microbiol"},{"key":"10.1124\/mol.116.106906_bib6","doi-asserted-by":"crossref","first-page":"2202","DOI":"10.1128\/AAC.01691-13","article-title":"New chemical scaffolds for human african trypanosomiasis lead discovery from a screen of tyrosine kinase inhibitor drugs","volume":"58","author":"Behera","year":"2014","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1124\/mol.116.106906_bib7","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.ijpara.2009.10.015","article-title":"Depletion of 14-3-3 proteins in bloodstream-form Trypanosoma brucei inhibits variant surface glycoprotein recycling","volume":"40","author":"Benz","year":"2010","journal-title":"Int J Parasitol"},{"key":"10.1124\/mol.116.106906_bib8","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1126\/science.1112642","article-title":"The genome of the African trypanosome Trypanosoma brucei","volume":"309","author":"Berriman","year":"2005","journal-title":"Science"},{"key":"10.1124\/mol.116.106906_bib9","doi-asserted-by":"crossref","first-page":"e105","DOI":"10.1371\/journal.pbio.0060105","article-title":"Biogenesis of the trypanosome endo-exocytotic organelle is cytoskeleton mediated","volume":"6","author":"Bonhivers","year":"2008","journal-title":"PLoS Biol"},{"key":"10.1124\/mol.116.106906_bib10","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/0166-6851(82)90049-4","article-title":"On the DNA content and ploidy of trypanosomes","volume":"6","author":"Borst","year":"1982","journal-title":"Mol Biochem Parasitol"},{"key":"10.1124\/mol.116.106906_bib11","doi-asserted-by":"crossref","first-page":"7980","DOI":"10.3390\/molecules16097980","article-title":"Thymidine analogues for tracking DNA synthesis","volume":"16","author":"Cavanagh","year":"2011","journal-title":"Molecules"},{"key":"10.1124\/mol.116.106906_bib12","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1002\/pmic.201400189","article-title":"Quantitative phosphoproteomics of Alzheimer\u2019s disease reveals cross-talk between kinases and small heat shock proteins","volume":"15","author":"Dammer","year":"2015","journal-title":"Proteomics"},{"key":"10.1124\/mol.116.106906_bib13","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1146\/annurev-biochem-090308-173656","article-title":"The evolution of protein kinase inhibitors from antagonists to agonists of cellular signaling","volume":"80","author":"Dar","year":"2011","journal-title":"Annu Rev Biochem"},{"key":"10.1124\/mol.116.106906_bib14","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1091\/mbc.e12-12-0911","article-title":"Polo-like kinase phosphorylation of bilobe-resident TbCentrin2 facilitates flagellar inheritance in Trypanosoma brucei","volume":"24","author":"de Graffenried","year":"2013","journal-title":"Mol Biol Cell"},{"key":"10.1124\/mol.116.106906_bib15","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0167-6296(02)00126-1","article-title":"The price of innovation: new estimates of drug development costs","volume":"22","author":"DiMasi","year":"2003","journal-title":"J Health Econ"},{"key":"10.1124\/mol.116.106906_bib16","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/1044-0305(94)80016-2","article-title":"An approach to correlate tandem mass spectral data of peptides with amino acid sequences in a protein database","volume":"5","author":"Eng","year":"1994","journal-title":"J Am Soc Mass Spectrom"},{"key":"10.1124\/mol.116.106906_bib17","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1128\/EC.05287-11","article-title":"Morphology of the trypanosome bilobe, a novel cytoskeletal structure","volume":"11","author":"Esson","year":"2012","journal-title":"Eukaryot Cell"},{"key":"10.1124\/mol.116.106906_bib18","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1017\/S1431927604040942","article-title":"New approaches to the microscopic imaging of Trypanosoma brucei","volume":"10","author":"Field","year":"2004","journal-title":"Microsc Microanal"},{"key":"10.1124\/mol.116.106906_bib19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1937-6448(09)78001-3","article-title":"Macromolecular trafficking and immune evasion in African trypanosomes","volume":"278","author":"Field","year":"2009","journal-title":"Int Rev Cell Mol Biol"},{"key":"10.1124\/mol.116.106906_bib20","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.molbiopara.2008.12.008","article-title":"Hydroxyurea-induced synchronisation of bloodstream stage Trypanosoma brucei","volume":"164","author":"Forsythe","year":"2009","journal-title":"Mol Biochem Parasitol"},{"key":"10.1124\/mol.116.106906_bib21","first-page":"4423","article-title":"Cell cycle regulation by the NEK family of protein kinases","volume":"125","author":"Fry","year":"2012","journal-title":"J Cell Sci"},{"key":"10.1124\/mol.116.106906_bib22","doi-asserted-by":"crossref","unstructured":"Garner DL, Pinkel D, Johnson LA, Pace MM (1986) Assessment of spermatozoal function using dual fluorescent staining and flow cytometric analyses. Biol Reprod 34:127\u2013138.","DOI":"10.1095\/biolreprod34.1.127"},{"key":"10.1124\/mol.116.106906_bib23","doi-asserted-by":"crossref","first-page":"3489","DOI":"10.1074\/jbc.M112.417428","article-title":"Biochemical characterization of the bi-lobe reveals a continuous structural network linking the bi-lobe to other single-copied organelles in Trypanosoma brucei","volume":"288","author":"Gheiratmand","year":"2013","journal-title":"J Biol Chem"},{"key":"10.1124\/mol.116.106906_bib24","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1111\/j.1742-4658.2010.07987.x","article-title":"Serine-arginine protein kinases: a small protein kinase family with a large cellular presence","volume":"278","author":"Giannakouros","year":"2011","journal-title":"FEBS J"},{"key":"10.1124\/mol.116.106906_bib25","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1128\/MCB.01176-10","article-title":"The kinetoplast duplication cycle in Trypanosoma brucei is orchestrated by cytoskeleton-mediated cell morphogenesis","volume":"31","author":"Gluenz","year":"2011","journal-title":"Mol Cell Biol"},{"key":"10.1124\/mol.116.106906_bib26","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1091\/mbc.e10-11-0901","article-title":"Sas-4 proteins are required during basal body duplication in Paramecium","volume":"22","author":"Gogendeau","year":"2011","journal-title":"Mol Biol Cell"},{"key":"10.1124\/mol.116.106906_bib27","doi-asserted-by":"crossref","first-page":"28922","DOI":"10.1074\/jbc.M111.272526","article-title":"Active site inhibitors protect protein kinase C from dephosphorylation and stabilize its mature form","volume":"286","author":"Gould","year":"2011","journal-title":"J Biol Chem"},{"key":"10.1124\/mol.116.106906_bib28","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1021\/acsinfecdis.6b00077","article-title":"Glycogen synthase kinase 3\u03b2 promotes the endocytosis of transferrin in the African trypanosome","volume":"2","author":"Guyett","year":"2016","journal-title":"ACS Infect Dis"},{"key":"10.1124\/mol.116.106906_bib29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.molbiopara.2007.01.017","article-title":"Cell cycle regulation in Trypanosoma brucei","volume":"153","author":"Hammarton","year":"2007","journal-title":"Mol Biochem Parasitol"},{"key":"10.1124\/mol.116.106906_bib30","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1126\/science.1119969","article-title":"Golgi duplication in Trypanosoma brucei requires Centrin2","volume":"310","author":"He","year":"2005","journal-title":"Science"},{"key":"10.1124\/mol.116.106906_bib31","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/0166-6851(95)00027-X","article-title":"A novel cultivation technique for long-term maintenance of bloodstream form trypanosomes in vitro","volume":"70","author":"Hesse","year":"1995","journal-title":"Mol Biochem Parasitol"},{"key":"10.1124\/mol.116.106906_bib32","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/0169-4758(94)90402-2","article-title":"Axenic culture of African trypanosome bloodstream forms","volume":"10","author":"Hirumi","year":"1994","journal-title":"Parasitol Today"},{"key":"10.1124\/mol.116.106906_bib33","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1242\/jcs.064873","article-title":"Reconstructing the evolutionary history of the centriole from protein components","volume":"123","author":"Hodges","year":"2010","journal-title":"J Cell Sci"},{"key":"10.1124\/mol.116.106906_bib34","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/j.ccr.2013.03.033","article-title":"RAF inhibitors activate the MAPK pathway by relieving inhibitory autophosphorylation","volume":"23","author":"Holderfield","year":"2013","journal-title":"Cancer Cell"},{"key":"10.1124\/mol.116.106906_bib35","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1128\/EC.00083-15","article-title":"The centriole cartwheel protein SAS-6 in Trypanosoma brucei is required for probasal body biogenesis and flagellum assembly","volume":"14","author":"Hu","year":"2015","journal-title":"Eukaryot Cell"},{"key":"10.1124\/mol.116.106906_bib36","doi-asserted-by":"crossref","first-page":"30453","DOI":"10.1074\/jbc.M115.694109","article-title":"SAS-4 protein in Trypanosoma brucei controls life cycle transitions by modulating the length of the flagellum attachment zone filament","volume":"290","author":"Hu","year":"2015","journal-title":"J Biol Chem"},{"key":"10.1124\/mol.116.106906_bib37","first-page":"3173","article-title":"Polo-like kinase is necessary for flagellum inheritance in Trypanosoma brucei","volume":"125","author":"Ikeda","year":"2012","journal-title":"J Cell Sci"},{"key":"10.1124\/mol.116.106906_bib38","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1093\/jb\/mvv018","article-title":"Identification and characterization of a cell division-regulating kinase AKB1 (associated kinase of Trypanosoma brucei 14-3-3) through proteomics study of the Tb14-3-3 binding proteins","volume":"158","author":"Inoue","year":"2015","journal-title":"J Biochem"},{"key":"10.1124\/mol.116.106906_bib39","doi-asserted-by":"crossref","first-page":"25146","DOI":"10.1074\/jbc.M001144200","article-title":"Phosphorylation at serine 10, a major phosphorylation site of p27(Kip1), increases its protein stability","volume":"275","author":"Ishida","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1124\/mol.116.106906_bib40","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1146\/annurev-micro-092611-150057","article-title":"Network news: the replication of kinetoplast DNA","volume":"66","author":"Jensen","year":"2012","journal-title":"Annu Rev Microbiol"},{"key":"10.1124\/mol.116.106906_bib41","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.molbiopara.2009.08.008","article-title":"Cell-cycle synchronisation of bloodstream forms of Trypanosoma brucei using Vybrant DyeCycle Violet-based sorting","volume":"169","author":"Kabani","year":"2010","journal-title":"Mol Biochem Parasitol"},{"key":"10.1124\/mol.116.106906_bib42","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1038\/nmeth1113","article-title":"Semi-supervised learning for peptide identification from shotgun proteomics datasets","volume":"4","author":"K\u00e4ll","year":"2007","journal-title":"Nat Methods"},{"key":"10.1124\/mol.116.106906_bib43","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0056150","article-title":"Lapatinib-binding protein kinases in the African trypanosome: identification of cellular targets for kinase-directed chemical scaffolds","volume":"8","author":"Katiyar","year":"2013","journal-title":"PLoS One"},{"key":"10.1124\/mol.116.106906_bib44","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/j.bbrc.2012.02.082","article-title":"Regulation and spatial organization of PCNA in Trypanosoma brucei","volume":"419","author":"Kaufmann","year":"2012","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1124\/mol.116.106906_bib45","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/S1474-4422(12)70296-X","article-title":"Clinical features, diagnosis, and treatment of human African trypanosomiasis (sleeping sickness)","volume":"12","author":"Kennedy","year":"2013","journal-title":"Lancet Neurol"},{"key":"10.1124\/mol.116.106906_bib46","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.cell.2006.01.044","article-title":"Global survey of organ and organelle protein expression in mouse: combined proteomic and transcriptomic profiling","volume":"125","author":"Kislinger","year":"2006","journal-title":"Cell"},{"key":"10.1124\/mol.116.106906_bib47","doi-asserted-by":"crossref","first-page":"5336","DOI":"10.1093\/emboj\/cdg518","article-title":"Novel roles for the flagellum in cell morphogenesis and cytokinesis of trypanosomes","volume":"22","author":"Kohl","year":"2003","journal-title":"EMBO J"},{"key":"10.1124\/mol.116.106906_bib48","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1111\/j.1550-7408.1999.tb04592.x","article-title":"Assembly of the paraflagellar rod and the flagellum attachment zone complex during the Trypanosoma brucei cell cycle","volume":"46","author":"Kohl","year":"1999","journal-title":"J Eukaryot Microbiol"},{"key":"10.1124\/mol.116.106906_bib49","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1242\/jcs.045740","article-title":"Three-dimensional cellular architecture of the flagellar pocket and associated cytoskeleton in trypanosomes revealed by electron microscope tomography","volume":"122","author":"Lacomble","year":"2009","journal-title":"J Cell Sci"},{"key":"10.1124\/mol.116.106906_bib50","doi-asserted-by":"crossref","first-page":"2884","DOI":"10.1242\/jcs.074161","article-title":"Basal body movements orchestrate membrane organelle division and cell morphogenesis in Trypanosoma brucei","volume":"123","author":"Lacomble","year":"2010","journal-title":"J Cell Sci"},{"key":"10.1124\/mol.116.106906_bib51","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0166-6851(01)00257-2","article-title":"Virulence of Trypanosoma brucei strain 427 is not affected by the absence of glycosylphosphatidylinositol phospholipase C","volume":"114","author":"Leal","year":"2001","journal-title":"Mol Biochem Parasitol"},{"key":"10.1124\/mol.116.106906_bib52","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/S1534-5807(03)00062-5","article-title":"SAS-4 is essential for centrosome duplication in C elegans and is recruited to daughter centrioles once per cell cycle","volume":"4","author":"Leidel","year":"2003","journal-title":"Dev Cell"},{"key":"10.1124\/mol.116.106906_bib53","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1111\/j.1365-3156.2005.01403.x","article-title":"Review article: cerebrospinal fluid in human African trypanosomiasis: a key to diagnosis, therapeutic decision and post-treatment follow-up","volume":"10","author":"Lejon","year":"2005","journal-title":"Trop Med Int Health"},{"key":"10.1124\/mol.116.106906_bib54","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1128\/EC.00145-12","article-title":"Regulation of the cell division cycle in Trypanosoma brucei","volume":"11","author":"Li","year":"2012","journal-title":"Eukaryot Cell"},{"key":"10.1124\/mol.116.106906_bib55","doi-asserted-by":"crossref","first-page":"3076","DOI":"10.1021\/ac025529o","article-title":"Automation of nanoscale microcapillary liquid chromatography-tandem mass spectrometry with a vented column","volume":"74","author":"Licklider","year":"2002","journal-title":"Anal Chem"},{"key":"10.1124\/mol.116.106906_bib56","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.pt.2005.06.008","article-title":"Fellowship of the rings: the replication of kinetoplast DNA","volume":"21","author":"Liu","year":"2005","journal-title":"Trends Parasitol"},{"key":"10.1124\/mol.116.106906_bib57","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1586\/epr.09.69","article-title":"Role of spectral counting in quantitative proteomics","volume":"7","author":"Lundgren","year":"2010","journal-title":"Expert Rev Proteomics"},{"key":"10.1124\/mol.116.106906_bib58","doi-asserted-by":"crossref","first-page":"6253","DOI":"10.1074\/jbc.R400037200","article-title":"Cellular checkpoint mechanisms monitoring proper initiation of DNA replication","volume":"280","author":"Machida","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1124\/mol.116.106906_bib59","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1593\/tlo.10163","article-title":"Dual inhibitor AEE788 reduces tumor growth in preclinical models of medulloblastoma","volume":"3","author":"Meco","year":"2010","journal-title":"Transl Oncol"},{"key":"10.1124\/mol.116.106906_bib60","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1128\/EC.00326-12","article-title":"Novel bilobe components in Trypanosoma brucei identified using proximity-dependent biotinylation","volume":"12","author":"Morriswood","year":"2013","journal-title":"Eukaryot Cell"},{"key":"10.1124\/mol.116.106906_bib61","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1128\/EC.00094-15","article-title":"A MORN repeat protein facilitates protein entry into the flagellar pocket of Trypanosoma brucei","volume":"14","author":"Morriswood","year":"2015","journal-title":"Eukaryot Cell"},{"key":"10.1124\/mol.116.106906_bib62","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/0166-6851(96)02675-8","article-title":"Effects of aphidicolin and hydroxyurea on the cell cycle and differentiation of Trypanosoma brucei bloodstream forms","volume":"80","author":"Mutomba","year":"1996","journal-title":"Mol Biochem Parasitol"},{"key":"10.1124\/mol.116.106906_bib63","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1046\/j.1365-2443.2002.00544.x","article-title":"Control of DNA replication licensing in a cell cycle","volume":"7","author":"Nishitani","year":"2002","journal-title":"Genes Cells"},{"key":"10.1124\/mol.116.106906_bib64","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1016\/S0960-9822(00)80018-4","article-title":"N-linked glycans containing linear poly-N-acetyllactosamine as sorting signals in endocytosis in Trypanosoma brucei","volume":"9","author":"Nolan","year":"1999","journal-title":"Curr Biol"},{"key":"10.1124\/mol.116.106906_bib65","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.devcel.2016.05.022","article-title":"Cdk1 phosphorylates Drosophila Sas-4 to recruit polo to daughter centrioles and convert them to centrosomes","volume":"37","author":"Novak","year":"2016","journal-title":"Dev Cell"},{"key":"10.1124\/mol.116.106906_bib66","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1091\/mbc.e02-08-0525","article-title":"A high-order trans-membrane structural linkage is responsible for mitochondrial genome positioning and segregation by flagellar basal bodies in trypanosomes","volume":"14","author":"Ogbadoyi","year":"2003","journal-title":"Mol Biol Cell"},{"key":"10.1124\/mol.116.106906_bib67","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1038\/nchembio.183","article-title":"Inhibitor hijacking of Akt activation","volume":"5","author":"Okuzumi","year":"2009","journal-title":"Nat Chem Biol"},{"key":"10.1124\/mol.116.106906_bib68","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1074\/mcp.M500084-MCP200","article-title":"Comparison of label-free methods for quantifying human proteins by shotgun proteomics","volume":"4","author":"Old","year":"2005","journal-title":"Mol Cell Proteomics"},{"key":"10.1124\/mol.116.106906_bib69","doi-asserted-by":"crossref","first-page":"9529","DOI":"10.1074\/jbc.M110055200","article-title":"Differential endocytic functions of Trypanosoma brucei Rab5 isoforms reveal a glycosylphosphatidylinositol-specific endosomal pathway","volume":"277","author":"Pal","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1124\/mol.116.106906_bib70","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1186\/1471-2164-6-127","article-title":"Comparative analysis of the kinomes of three pathogenic trypanosomatids: Leishmania major, Trypanosoma brucei and Trypanosoma cruzi","volume":"6","author":"Parsons","year":"2005","journal-title":"BMC Genomics"},{"key":"10.1124\/mol.116.106906_bib71","doi-asserted-by":"crossref","first-page":"3820","DOI":"10.1021\/jm400349k","article-title":"Kinase scaffold repurposing for neglected disease drug discovery: discovery of an efficacious, lapatinib-derived lead compound for trypanosomiasis","volume":"56","author":"Patel","year":"2013","journal-title":"J Med Chem"},{"key":"10.1124\/mol.116.106906_bib72","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1038\/nature05318","article-title":"Centriole assembly in Caenorhabditis elegans","volume":"444","author":"Pelletier","year":"2006","journal-title":"Nature"},{"key":"10.1124\/mol.116.106906_bib73","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.ijpara.2009.10.005","article-title":"The paraflagellar rod of kinetoplastid parasites: from structure to components and function","volume":"40","author":"Portman","year":"2010","journal-title":"Int J Parasitol"},{"key":"10.1124\/mol.116.106906_bib74","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.molbiopara.2014.03.008","article-title":"Beyond replication: division and segregation of mitochondrial DNA in kinetoplastids","volume":"196","author":"Povelones","year":"2014","journal-title":"Mol Biochem Parasitol"},{"key":"10.1124\/mol.116.106906_bib75","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1038\/352731a0","article-title":"Basal body movements as a mechanism for mitochondrial genome segregation in the trypanosome cell cycle","volume":"352","author":"Robinson","year":"1991","journal-title":"Nature"},{"key":"10.1124\/mol.116.106906_bib76","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1083\/jcb.128.6.1163","article-title":"Microtubule polarity and dynamics in the control of organelle positioning, segregation, and cytokinesis in the trypanosome cell cycle","volume":"128","author":"Robinson","year":"1995","journal-title":"J Cell Biol"},{"key":"10.1124\/mol.116.106906_bib77","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1007\/BF00931012","article-title":"Transferrin is a growth factor for the bloodstream form of Trypanosoma brucei","volume":"77","author":"Schell","year":"1991","journal-title":"Parasitol Res"},{"key":"10.1124\/mol.116.106906_bib78","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/j.cub.2009.05.016","article-title":"Control of centriole length by CPAP and CP110","volume":"19","author":"Schmidt","year":"2009","journal-title":"Curr Biol"},{"key":"10.1124\/mol.116.106906_bib79","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1098\/rstb.1989.0037","article-title":"The cell division cycle of Trypanosoma brucei brucei: timing of event markers and cytoskeletal modulations","volume":"323","author":"Sherwin","year":"1989","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"10.1124\/mol.116.106906_bib80","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.molcel.2006.07.033","article-title":"Cdc7-Dbf4 phosphorylates MCM proteins via a docking site-mediated mechanism to promote S phase progression","volume":"24","author":"Sheu","year":"2006","journal-title":"Mol Cell"},{"key":"10.1124\/mol.116.106906_bib81","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/nature08647","article-title":"The Dbf4-Cdc7 kinase promotes S phase by alleviating an inhibitory activity in Mcm4","volume":"463","author":"Sheu","year":"2010","journal-title":"Nature"},{"key":"10.1124\/mol.116.106906_bib82","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.molbiopara.2008.04.004","article-title":"Analysis of the Trypanosoma brucei cell cycle by quantitative DAPI imaging","volume":"160","author":"Siegel","year":"2008","journal-title":"Mol Biochem Parasitol"},{"key":"10.1124\/mol.116.106906_bib83","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.stemcr.2016.07.019","article-title":"Quantitative Analysis of Human Pluripotency and Neural Specification by In-Depth (Phospho)Proteomic Profiling","volume":"7","author":"Singec","year":"2016","journal-title":"Stem Cell Rep"},{"key":"10.1124\/mol.116.106906_bib84","unstructured":"Steverding D, Stierhof YD, Chaudhri M, Ligtenberg M, Schell D, Beck-Sickinger AG, Overath P (1994) ESAG 6 and 7 products of Trypanosoma brucei form a transferrin binding protein complex. Eur J Cell Biol 64:78\u201387."},{"key":"10.1124\/mol.116.106906_bib85","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1002\/ijc.27797","article-title":"Novel prognostic protein markers of resectable pancreatic cancer identified by coupled shotgun and targeted proteomics using formalin-fixed paraffin-embedded tissues","volume":"132","author":"Takadate","year":"2013","journal-title":"Int J Cancer"},{"key":"10.1124\/mol.116.106906_bib86","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1038\/nature05465","article-title":"CDK-dependent phosphorylation of Sld2 and Sld3 initiates DNA replication in budding yeast","volume":"445","author":"Tanaka","year":"2007","journal-title":"Nature"},{"key":"10.1124\/mol.116.106906_bib87","doi-asserted-by":"crossref","first-page":"5354","DOI":"10.1021\/pr200611n","article-title":"Universal and confident phosphorylation site localization using phosphoRS","volume":"10","author":"Taus","year":"2011","journal-title":"J Proteome Res"},{"key":"10.1124\/mol.116.106906_bib88","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.pt.2013.10.009","article-title":"Nuclear DNA replication initiation in kinetoplastid parasites: new insights into an ancient process","volume":"30","author":"Tiengwe","year":"2014","journal-title":"Trends Parasitol"},{"key":"10.1124\/mol.116.106906_bib89","doi-asserted-by":"crossref","first-page":"4931","DOI":"10.1158\/0008-5472.CAN-03-3681","article-title":"AEE788: a dual family epidermal growth factor receptor\/ErbB2 and vascular endothelial growth factor receptor tyrosine kinase inhibitor with antitumor and antiangiogenic activity","volume":"64","author":"Traxler","year":"2004","journal-title":"Cancer Res"},{"key":"10.1124\/mol.116.106906_bib90","doi-asserted-by":"crossref","first-page":"4353","DOI":"10.1242\/jcs.02567","article-title":"Distinct cytoskeletal modulation and regulation of G1-S transition in the two life stages of Trypanosoma brucei","volume":"118","author":"Tu","year":"2005","journal-title":"J Cell Sci"},{"key":"10.1124\/mol.116.106906_bib91","doi-asserted-by":"crossref","first-page":"20519","DOI":"10.1074\/jbc.M312862200","article-title":"The involvement of two cdc2-related kinases (CRKs) in Trypanosoma brucei cell cycle regulation and the distinctive stage-specific phenotypes caused by CRK3 depletion","volume":"279","author":"Tu","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1124\/mol.116.106906_bib92","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1128\/EC.4.4.755-764.2005","article-title":"Pairwise knockdowns of cdc2-related kinases (CRKs) in Trypanosoma brucei identified the CRKs for G1\/S and G2\/M transitions and demonstrated distinctive cytokinetic regulations between two developmental stages of the organism","volume":"4","author":"Tu","year":"2005","journal-title":"Eukaryot Cell"},{"key":"10.1124\/mol.116.106906_bib93","doi-asserted-by":"crossref","first-page":"5131","DOI":"10.1523\/JNEUROSCI.4970-05.2006","article-title":"Regulation of DeltaFosB stability by phosphorylation","volume":"26","author":"Ulery","year":"2006","journal-title":"J Neurosci"},{"key":"10.1124\/mol.116.106906_bib94","doi-asserted-by":"crossref","first-page":"5010","DOI":"10.1128\/MCB.20.14.5010-5018.2000","article-title":"Phosphorylation of the PTEN tail regulates protein stability and function","volume":"20","author":"Vazquez","year":"2000","journal-title":"Mol Cell Biol"},{"key":"10.1124\/mol.116.106906_bib95","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1038\/sj.onc.1209990","article-title":"Rapamycin induces feedback activation of Akt signaling through an IGF-1R-dependent mechanism","volume":"26","author":"Wan","year":"2007","journal-title":"Oncogene"},{"key":"10.1124\/mol.116.106906_bib96","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1016\/j.bbamcr.2014.02.001","article-title":"Phosphorylation of p300 increases its protein degradation to enhance the lung cancer progression","volume":"1843","author":"Wang","year":"2014","journal-title":"Biochim Biophys Acta"},{"key":"10.1124\/mol.116.106906_bib97","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1242\/jcs.95.1.49","article-title":"Timing of nuclear and kinetoplast DNA replication and early morphological events in the cell cycle of Trypanosoma brucei","volume":"95","author":"Woodward","year":"1990","journal-title":"J Cell Sci"},{"key":"10.1124\/mol.116.106906_bib98","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1002\/elps.200900752","article-title":"A comparative phosphoproteomic analysis of a human tumor metastasis model using a label-free quantitative approach","volume":"31","author":"Xie","year":"2010","journal-title":"Electrophoresis"},{"key":"10.1124\/mol.116.106906_bib99","doi-asserted-by":"crossref","first-page":"10681","DOI":"10.1074\/jbc.274.16.10681","article-title":"Phosphorylation of axin, a Wnt signal negative regulator, by glycogen synthase kinase-3beta regulates its stability","volume":"274","author":"Yamamoto","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1124\/mol.116.106906_bib100","doi-asserted-by":"crossref","first-page":"2909","DOI":"10.1021\/pr0600273","article-title":"Detecting differential and correlated protein expression in label-free shotgun proteomics","volume":"5","author":"Zhang","year":"2006","journal-title":"J Proteome Res"},{"key":"10.1124\/mol.116.106906_bib101","doi-asserted-by":"crossref","first-page":"33067","DOI":"10.1074\/jbc.M212635200","article-title":"Inhibitory phosphorylation of glycogen synthase kinase-3 (GSK-3) in response to lithium. Evidence for autoregulation of GSK-3","volume":"278","author":"Zhang","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1124\/mol.116.106906_bib102","doi-asserted-by":"crossref","first-page":"e9660","DOI":"10.1371\/journal.pone.0009660","article-title":"A comparative proteomic analysis reveals a new bi-lobe protein required for bi-lobe duplication and cell division in Trypanosoma brucei","volume":"5","author":"Zhou","year":"2010","journal-title":"PLoS One"},{"key":"10.1124\/mol.116.106906_bib103","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/B978-0-12-800097-7.00004-X","article-title":"New insights into the molecular mechanisms of mitosis and cytokinesis in trypanosomes","volume":"308","author":"Zhou","year":"2014","journal-title":"Int Rev Cell Mol Biol"},{"key":"10.1124\/mol.116.106906_bib104","doi-asserted-by":"crossref","first-page":"3086","DOI":"10.1128\/MCB.20.9.3086-3096.2000","article-title":"Assembly of a complex containing Cdc45p, replication protein A, and Mcm2p at replication origins controlled by S-phase cyclin-dependent kinases and Cdc7p-Dbf4p kinase","volume":"20","author":"Zou","year":"2000","journal-title":"Mol Cell Biol"}],"container-title":["Molecular Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026895X24005911?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026895X24005911?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/mol.116.106906","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T10:18:59Z","timestamp":1739960339000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0026895X24005911"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5]]},"references-count":104,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["S0026895X24005911"],"URL":"https:\/\/doi.org\/10.1124\/mol.116.106906","relation":{},"ISSN":["0026-895X"],"issn-type":[{"type":"print","value":"0026-895X"}],"subject":[],"published":{"date-parts":[[2017,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"AEE788 Inhibits Basal Body Assembly and Blocks DNA Replication in the African Trypanosome","name":"articletitle","label":"Article Title"},{"value":"Molecular Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/mol.116.106906","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 by The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}