{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T01:45:58Z","timestamp":1790214358829,"version":"4.1.0"},"reference-count":24,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["molpharm.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Pharmacology"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1124\/mol.119.116475","type":"journal-article","created":{"date-parts":[[2019,7,23]],"date-time":"2019-07-23T19:09:00Z","timestamp":1563908940000},"page":"401-407","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["Dantrolene Requires Mg2+ and ATP To Inhibit the Ryanodine Receptor"],"prefix":"10.1016","volume":"96","author":[{"given":"Gyula","family":"Diszh\u00e1zi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zsuzsanna \u00c9dua","family":"Magyar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e1nos Andr\u00e1s","family":"M\u00f3ty\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e1szl\u00f3","family":"Csernoch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Istv\u00e1n","family":"J\u00f3na","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e9ter P\u00e1l","family":"N\u00e1n\u00e1si","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e1nos","family":"Alm\u00e1ssy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1124\/mol.119.116475_bib1","doi-asserted-by":"crossref","first-page":"4576","DOI":"10.1073\/pnas.1704103114","article-title":"Mind the magnesium, in dantrolene suppression of malignant hyperthermia","volume":"114","author":"Cannon","year":"2017","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/mol.119.116475_bib2","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1124\/mol.107.043299","article-title":"Enhanced excitation-coupled calcium entry in myotubes expressing malignant hyperthermia mutation R163C is attenuated by dantrolene","volume":"73","author":"Cherednichenko","year":"2008","journal-title":"Mol Pharmacol"},{"key":"10.1124\/mol.119.116475_bib3","doi-asserted-by":"crossref","first-page":"4811","DOI":"10.1073\/pnas.1619835114","article-title":"Dantrolene requires Mg2+ to arrest malignant hyperthermia","volume":"114","author":"Choi","year":"2017","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/mol.119.116475_bib8","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.cell.2016.08.075","article-title":"Structural basis for gating and activation of RyR1","volume":"167","author":"des Georges","year":"2016","journal-title":"Cell"},{"key":"10.1124\/mol.119.116475_bib4","doi-asserted-by":"crossref","first-page":"C1103","DOI":"10.1152\/ajpcell.90642.2007","article-title":"Halothane modulation of skeletal muscle ryanodine receptors: dependence on Ca2+, Mg2+, and ATP","volume":"294","author":"Diaz-Sylvester","year":"2008","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1124\/mol.119.116475_bib5","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/nature13916","article-title":"Architecture and conformational switch mechanism of the ryanodine receptor","volume":"517","author":"Efremov","year":"2015","journal-title":"Nature"},{"key":"10.1124\/mol.119.116475_bib6","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1152\/physrev.00013.2002","article-title":"Ryanodine receptor calcium release channels","volume":"82","author":"Fill","year":"2002","journal-title":"Physiol Rev"},{"key":"10.1124\/mol.119.116475_bib7","doi-asserted-by":"crossref","first-page":"26965","DOI":"10.1074\/jbc.272.43.26965","article-title":"Dantrolene inhibition of sarcoplasmic reticulum Ca2+ release by direct and specific action at skeletal muscle ryanodine receptors","volume":"272","author":"Fruen","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1124\/mol.119.116475_bib9","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.ceca.2015.03.009","article-title":"Bile acids activate ryanodine receptors in pancreatic acinar cells via a direct allosteric mechanism","volume":"58","author":"Geyer","year":"2015","journal-title":"Cell Calcium"},{"key":"10.1124\/mol.119.116475_bib10","doi-asserted-by":"crossref","first-page":"d671","DOI":"10.2741\/ikemoto","article-title":"Regulation of calcium release by interdomain interaction within ryanodine receptors","volume":"7","author":"Ikemoto","year":"2002","journal-title":"Front Biosci"},{"key":"10.1124\/mol.119.116475_bib11","doi-asserted-by":"crossref","first-page":"6580","DOI":"10.1074\/jbc.M408375200","article-title":"Dantrolene stabilizes domain interactions within the ryanodine receptor","volume":"280","author":"Kobayashi","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1124\/mol.119.116475_bib12","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1042\/bj20040112","article-title":"Antibody probe study of Ca2+ channel regulation by interdomain interaction within the ryanodine receptor","volume":"380","author":"Kobayashi","year":"2004","journal-title":"Biochem J"},{"key":"10.1124\/mol.119.116475_bib13","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1124\/mol.115.097691","article-title":"Essential role of calmodulin in RyR inhibition by dantrolene","volume":"88","author":"Oo","year":"2015","journal-title":"Mol Pharmacol"},{"key":"10.1124\/mol.119.116475_bib14","doi-asserted-by":"crossref","first-page":"34918","DOI":"10.1074\/jbc.M205487200","article-title":"Identification of a dantrolene-binding sequence on the skeletal muscle ryanodine receptor","volume":"277","author":"Paul-Pletzer","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1124\/mol.119.116475_bib15","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1042\/BJ20041336","article-title":"Probing a putative dantrolene-binding site on the cardiac ryanodine receptor","volume":"387","author":"Paul-Pletzer","year":"2005","journal-title":"Biochem J"},{"key":"10.1124\/mol.119.116475_bib16","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s10974-007-9113-x","article-title":"Effect of natural phenol derivatives on skeletal type sarcoplasmic reticulum Ca2+ -ATPase and ryanodine receptor","volume":"28","author":"S\u00e1rk\u00f6zi","year":"2007","journal-title":"J Muscle Res Cell Motil"},{"key":"10.1124\/mol.119.116475_bib17","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1016\/j.bpj.2017.03.023","article-title":"Lanthanides report calcium sensor in the vestibule of ryanodine receptor","volume":"112","author":"S\u00e1rk\u00f6zi","year":"2017","journal-title":"Biophys J"},{"key":"10.1124\/mol.119.116475_bib18","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1085\/jgp.118.4.355","article-title":"Effects of dantrolene on steps of excitation-contraction coupling in mammalian skeletal muscle fibers","volume":"118","author":"Szentesi","year":"2001","journal-title":"J Gen Physiol"},{"key":"10.1124\/mol.119.116475_bib19","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/nature09471","article-title":"The amino-terminal disease hotspot of ryanodine receptors forms a cytoplasmic vestibule","volume":"468","author":"Tung","year":"2010","journal-title":"Nature"},{"key":"10.1124\/mol.119.116475_bib20","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.ceca.2014.05.004","article-title":"Characterization of ryanodine receptor type 1 single channel activity using \u201con-nucleus\u201d patch clamp","volume":"56","author":"Wagner II","year":"2014","journal-title":"Cell Calcium"},{"key":"10.1124\/mol.119.116475_bib21","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1021\/bi015581z","article-title":"Spectroscopic monitoring of local conformational changes during the intramolecular domain-domain interaction of the ryanodine receptor","volume":"41","author":"Yamamoto","year":"2002","journal-title":"Biochemistry"},{"key":"10.1124\/mol.119.116475_bib22","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/nature14063","article-title":"Structure of the rabbit ryanodine receptor RyR1 at near-atomic resolution","volume":"517","author":"Yan","year":"2015","journal-title":"Nature"},{"key":"10.1124\/mol.119.116475_bib23","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nature13950","article-title":"Structure of a mammalian ryanodine receptor","volume":"517","author":"Zalk","year":"2015","journal-title":"Nature"},{"key":"10.1124\/mol.119.116475_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0031-6997(24)01312-7","article-title":"The sarcoplasmic reticulum Ca2+ channel\/ryanodine receptor: modulation by endogenous effectors, drugs and disease states","volume":"49","author":"Zucchi","year":"1997","journal-title":"Pharmacol Rev"}],"container-title":["Molecular Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026895X24009313?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026895X24009313?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/mol.119.116475","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T05:30:11Z","timestamp":1739943011000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0026895X24009313"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":24,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["S0026895X24009313"],"URL":"https:\/\/doi.org\/10.1124\/mol.119.116475","relation":{},"ISSN":["0026-895X"],"issn-type":[{"value":"0026-895X","type":"print"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dantrolene Requires Mg2+ and ATP To Inhibit the Ryanodine Receptor","name":"articletitle","label":"Article Title"},{"value":"Molecular Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/mol.119.116475","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 by The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}