{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T15:06:41Z","timestamp":1780412801366,"version":"3.54.1"},"reference-count":29,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["molpharm.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Pharmacology"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1124\/mol.119.117382","type":"journal-article","created":{"date-parts":[[2019,11,9]],"date-time":"2019-11-09T03:55:12Z","timestamp":1573271712000},"page":"2-8","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Thyrotropin Causes Dose-dependent Biphasic Regulation of cAMP Production Mediated by Gs and Gi\/o Proteins"],"prefix":"10.1016","volume":"97","author":[{"given":"Susanne","family":"Neumann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah S.","family":"Malik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernice","family":"Marcus-Samuels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Eliseeva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daesong","family":"Jang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Klubo-Gwiezdzinska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine C.","family":"Krieger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marvin C.","family":"Gershengorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1124\/mol.119.117382_bib1","doi-asserted-by":"crossref","first-page":"3687","DOI":"10.1096\/fj.11-188961","article-title":"Occupancy of both sites on the thyrotropin (TSH) receptor dimer is necessary for phosphoinositide signaling","volume":"25","author":"Allen","year":"2011","journal-title":"FASEB J"},{"key":"10.1124\/mol.119.117382_bib2","doi-asserted-by":"crossref","first-page":"13733","DOI":"10.1016\/S0021-9258(17)36705-4","article-title":"The human thyrotropin receptor activates G-proteins Gs and Gq\/11","volume":"269","author":"Allgeier","year":"1994","journal-title":"J Biol Chem"},{"key":"10.1124\/mol.119.117382_bib3","doi-asserted-by":"crossref","first-page":"3446","DOI":"10.1096\/fj.14-251124","article-title":"\u03b2-Arrestin-1 mediates thyrotropin-enhanced osteoblast differentiation","volume":"28","author":"Boutin","year":"2014","journal-title":"FASEB J"},{"key":"10.1124\/mol.119.117382_bib4","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.envpol.2013.07.046","article-title":"Biphasic dose responses in biology, toxicology and medicine: accounting for their generalizability and quantitative features","volume":"182","author":"Calabrese","year":"2013","journal-title":"Environ Pollut"},{"key":"10.1124\/mol.119.117382_bib5","doi-asserted-by":"crossref","first-page":"E2871","DOI":"10.3390\/ijms19102871","article-title":"Hormesis: path and progression to significance","volume":"19","author":"Calabrese","year":"2018","journal-title":"Int J Mol Sci"},{"key":"10.1124\/mol.119.117382_bib6","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1016\/S0021-9258(19)39988-0","article-title":"Gz, a guanine nucleotide-binding protein with unique biochemical properties","volume":"265","author":"Casey","year":"1990","journal-title":"J Biol Chem"},{"key":"10.1124\/mol.119.117382_bib7","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1093\/toxsci\/kfh007","article-title":"Nonmonotonic dose-response relationships: mechanistic basis, kinetic modeling, and implications for risk assessment","volume":"77","author":"Conolly","year":"2004","journal-title":"Toxicol Sci"},{"key":"10.1124\/mol.119.117382_bib8","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/36362","article-title":"Switching of the coupling of the beta2-adrenergic receptor to different G proteins by protein kinase A","volume":"390","author":"Daaka","year":"1997","journal-title":"Nature"},{"key":"10.1124\/mol.119.117382_bib9","doi-asserted-by":"crossref","first-page":"15795","DOI":"10.1016\/S0021-9258(19)49605-1","article-title":"Simultaneous coupling of alpha 2-adrenergic receptors to two G-proteins with opposing effects. Subtype-selective coupling of alpha 2C10, alpha 2C4, and alpha 2C2 adrenergic receptors to Gi and Gs","volume":"267","author":"Eason","year":"1992","journal-title":"J Biol Chem"},{"key":"10.1124\/mol.119.117382_bib10","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1089\/thy.1995.5.55","article-title":"A novel, nonradioactive in vivo bioassay of thyrotropin (TSH)","volume":"5","author":"East-Palmer","year":"1995","journal-title":"Thyroid"},{"key":"10.1124\/mol.119.117382_bib11","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/0006-8993(83)91045-4","article-title":"Inhibition of brain adenylate cyclase by A1 adenosine receptors: pharmacological characteristics and locations","volume":"267","author":"Ebersolt","year":"1983","journal-title":"Brain Res"},{"key":"10.1124\/mol.119.117382_bib12","doi-asserted-by":"crossref","first-page":"3114","DOI":"10.1210\/en.2005-0687","article-title":"The human thyrotropin receptor is predominantly internalized by beta-arrestin 2","volume":"147","author":"Frenzel","year":"2006","journal-title":"Endocrinology"},{"key":"10.1124\/mol.119.117382_bib13","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/j.bbamcr.2013.01.019","article-title":"Biphasic Erk1\/2 activation sequentially involving Gs and Gi signaling is required in beta3-adrenergic receptor-induced primary smooth muscle cell proliferation","volume":"1833","author":"Hadi","year":"2013","journal-title":"Biochim Biophys Acta"},{"key":"10.1124\/mol.119.117382_bib14","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1210\/endo.140.4.6619","article-title":"Thyrotropin regulates c-Jun N-terminal kinase (JNK) activity through two distinct signal pathways in human thyroid cells","volume":"140","author":"Hara","year":"1999","journal-title":"Endocrinology"},{"key":"10.1124\/mol.119.117382_bib15","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1124\/jpet.115.225896","article-title":"Functional selectivity of kappa opioid receptor agonists in peripheral sensory neurons","volume":"355","author":"Jamshidi","year":"2015","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/mol.119.117382_bib16","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1515\/enr-2017-0012","article-title":"The role of thyrostimulin and its potential clinical significance","volume":"51","author":"Karponis","year":"2017","journal-title":"Endocr Regul"},{"key":"10.1124\/mol.119.117382_bib17","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1073\/pnas.93.1.116","article-title":"The human thyrotropin receptor: a heptahelical receptor capable of stimulating members of all four G protein families","volume":"93","author":"Laugwitz","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/mol.119.117382_bib18","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1124\/jpet.113.206896","article-title":"Comparative pharmacology of bombesin receptor subtype-3, nonpeptide agonist MK-5046, a universal peptide agonist, and peptide antagonist Bantag-1 for human bombesin receptors","volume":"347","author":"Moreno","year":"2013","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/mol.119.117382_bib19","doi-asserted-by":"crossref","first-page":"16317","DOI":"10.1074\/jbc.M109.005710","article-title":"The superagonistic activity of bovine thyroid-stimulating hormone (TSH) and the human TR1401 TSH analog is determined by specific amino acids in the hinge region of the human TSH receptor","volume":"284","author":"Mueller","year":"2009","journal-title":"J Biol Chem"},{"key":"10.1124\/mol.119.117382_bib20","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1172\/JCI0214340","article-title":"Thyrostimulin, a heterodimer of two new human glycoprotein hormone subunits, activates the thyroid-stimulating hormone receptor","volume":"109","author":"Nakabayashi","year":"2002","journal-title":"J Clin Invest"},{"key":"10.1124\/mol.119.117382_bib21","doi-asserted-by":"crossref","first-page":"5945","DOI":"10.1210\/en.2008-0836","article-title":"A low-molecular-weight antagonist for the human thyrotropin receptor with therapeutic potential for hyperthyroidism","volume":"149","author":"Neumann","year":"2008","journal-title":"Endocrinology"},{"key":"10.1124\/mol.119.117382_bib22","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1056\/NEJM199712043372307","article-title":"The thyrotropin receptor in thyroid diseases","volume":"337","author":"Paschke","year":"1997","journal-title":"N Engl J Med"},{"key":"10.1124\/mol.119.117382_bib23","doi-asserted-by":"crossref","first-page":"2645","DOI":"10.1210\/en.2004-0052","article-title":"Minireview: diversity and complexity of signaling through peptidergic G protein-coupled receptors","volume":"145","author":"Rashid","year":"2004","journal-title":"Endocrinology"},{"key":"10.1124\/mol.119.117382_bib24","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1111\/ejn.12429","article-title":"Inverted-U shaped effects of D1 dopamine receptor stimulation in the medial preoptic nucleus on sexually motivated song in male European starlings","volume":"39","author":"Riters","year":"2014","journal-title":"Eur J Neurosci"},{"key":"10.1124\/mol.119.117382_bib25","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.1091\/mbc.e04-01-0015","article-title":"An assembly-incompetent mutant establishes a requirement for dynamin self-assembly in clathrin-mediated endocytosis in vivo","volume":"15","author":"Song","year":"2004","journal-title":"Mol Biol Cell"},{"key":"10.1124\/mol.119.117382_bib26","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1210\/endo-128-1-341","article-title":"Biological activity and metabolic clearance of a recombinant human thyrotropin produced in Chinese hamster ovary cells","volume":"128","author":"Thotakura","year":"1991","journal-title":"Endocrinology"},{"key":"10.1124\/mol.119.117382_bib27","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1210\/er.2011-1050","article-title":"Hormones and endocrine-disrupting chemicals: low-dose effects and nonmonotonic dose responses","volume":"33","author":"Vandenberg","year":"2012","journal-title":"Endocr Rev"},{"key":"10.1124\/mol.119.117382_bib28","doi-asserted-by":"crossref","first-page":"237","DOI":"10.2174\/1874467210902030237","article-title":"G protein--mediated signaling: same receptor, multiple effectors","volume":"2","author":"Woehler","year":"2009","journal-title":"Curr Mol Pharmacol"},{"key":"10.1124\/mol.119.117382_bib29","first-page":"473","article-title":"Potent thyrotropic activity of human chorionic gonadotropin variants in terms of 125I incorporation and de novo synthesized thyroid hormone release in human thyroid follicles","volume":"80","author":"Yamazaki","year":"1995","journal-title":"J Clin Endocrinol Metab"}],"container-title":["Molecular Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026895X24009647?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026895X24009647?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/mol.119.117382","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T10:31:29Z","timestamp":1739961089000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0026895X24009647"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["S0026895X24009647"],"URL":"https:\/\/doi.org\/10.1124\/mol.119.117382","relation":{},"ISSN":["0026-895X"],"issn-type":[{"value":"0026-895X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Thyrotropin Causes Dose-dependent Biphasic Regulation of cAMP Production Mediated by Gs and Gi\/o Proteins","name":"articletitle","label":"Article Title"},{"value":"Molecular Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/mol.119.117382","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"U.S. Government work not protected by U.S. copyright","name":"copyright","label":"Copyright"}]}}