{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:08:46Z","timestamp":1783555726844,"version":"3.55.0"},"reference-count":26,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[1997,10,1]],"date-time":"1997-10-01T00:00:00Z","timestamp":875664000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[1997,10,1]],"date-time":"1997-10-01T00:00:00Z","timestamp":875664000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["molpharm.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Pharmacology"],"published-print":{"date-parts":[[1997,10]]},"DOI":"10.1124\/mol.52.4.749","type":"journal-article","created":{"date-parts":[[2018,1,8]],"date-time":"2018-01-08T20:28:07Z","timestamp":1515443287000},"page":"749-753","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":39,"title":["21-Hydroxy-6,19-oxidoprogesterone: A Novel Synthetic Steroid with Specific Antiglucocorticoid Properties in the Rat"],"prefix":"10.1016","volume":"52","author":[{"given":"G.P.","family":"Vicent","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.C.","family":"Monteser\u00edn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.S.","family":"Veleiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Burton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.P.","family":"Lantos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.D.","family":"Galigniana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1124\/mol.52.4.749_bib1","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1038\/318635a0","article-title":"Primary structure and expression of a functional human glucocorticoid receptor cDNA.","volume":"318","author":"Hollemberg","year":"1985","journal-title":"Nature (Lond.)"},{"key":"10.1124\/mol.52.4.749_bib2","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/j.1749-6632.1995.tb31366.x","article-title":"Nuclear hormone receptors activate direct, inverted, and everted repeats.","volume":"761","author":"Forman","year":"1995","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1124\/mol.52.4.749_bib3","series-title":"Physiopathology of Endocrine Diseases and Mechanisms of Hormone Action","first-page":"477","article-title":"Structure-activity relationship in certain glucocorticoids and mineralocorticoids","author":"Lantos","year":"1981"},{"key":"10.1124\/mol.52.4.749_bib4","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1080\/15287397809529658","article-title":"Molecular conformation and protein binding affinity of progestins.","volume":"4","author":"Duax","year":"1978","journal-title":"J. Toxicol. Environ. Health"},{"key":"10.1124\/mol.52.4.749_bib5","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/S0026-895X(25)08573-6","article-title":"Sodium-retaining activity of some natural and synthetic 21-deoxysteroids.","volume":"47","author":"Burton","year":"1995","journal-title":"Mol. Pharmacol."},{"key":"10.1124\/mol.52.4.749_bib6","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1126\/science.3037703","article-title":"Cloning of human mineralocorticoid receptor complementary DNA: structural and functional kinship with the glucocorticoid receptor.","volume":"237","author":"Arriza","year":"1987","journal-title":"Science (Washington D. C.)"},{"key":"10.1124\/mol.52.4.749_bib7","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/j.1749-6632.1995.tb31365.x","article-title":"General structure-activity correlations of antihormones.","volume":"761","author":"Teutsch","year":"1995","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1124\/mol.52.4.749_bib8","doi-asserted-by":"crossref","unstructured":"Grill, H. J., K. Nickisch, P. E. Schulze, H. Laurent, W. Elger, A. Heubner, and K. Pollow.3H-ZK91587: a new synthetic, highly specific ligand for mineralocorticoid receptor determination. J. Steroid Biochem. 23(suppl): 19S (1985).","DOI":"10.1016\/0022-4731(85)90332-2"},{"key":"10.1124\/mol.52.4.749_bib9","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1016\/0024-3205(88)90402-X","article-title":"ZK91587: a novel synthetic antimineralocorticoid displays high affinity for corticosterone (Type I) receptors in the rat hippocampus.","volume":"43","author":"Sutanto","year":"1988","journal-title":"Life Sci"},{"key":"10.1124\/mol.52.4.749_bib10","unstructured":"Antiprogestins\/antiglucocorticoids, in Endocrinology at Roussel-Udaf. 64 (1993)."},{"key":"10.1124\/mol.52.4.749_bib11","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1056\/NEJM199308053290607","article-title":"Mefiprestone (RU486): a modulator of progestin and glucocorticoid action.","volume":"329","author":"Spitz","year":"1993","journal-title":"N. Engl. J. Med."},{"key":"10.1124\/mol.52.4.749_bib12","first-page":"711","article-title":"An improved preparation of 11,19-oxidopregn-4-ene-3,20-dione and 6,19-oxidopregnan-4-ene-3,11,20-trione.","volume":"45","author":"Brachet-Cota","year":"1990","journal-title":"Z. Naturforsch. Teil B Anorg. Chem. Org. Chem."},{"key":"10.1124\/mol.52.4.749_bib13","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/0039-128X(94)00052-E","article-title":"Syntheses of 21-hydroxy-11,19-oxidopregn-4-ene-3,20-dione and 21-hydroxy-6,19-oxidopregn-4-ene-3,20-dione.","volume":"60","author":"Veleiro","year":"1995","journal-title":"Steroids"},{"key":"10.1124\/mol.52.4.749_bib14","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/S0039-128X(96)00244-9","article-title":"Features of the shuttle pair 11\u03b2-hydroxyprogesterone\/11-ketoprogesterone.","volume":"62","author":"Galigniana","year":"1997","journal-title":"Steroids"},{"key":"10.1124\/mol.52.4.749_bib15","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/0024-3205(96)00331-1","article-title":"Stability study on renal type I mineralocorticoid receptor.","volume":"59","author":"Galigniana","year":"1996","journal-title":"Life Sci."},{"key":"10.1124\/mol.52.4.749_bib16","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/0022-4731(79)90310-8","article-title":"Effect of oestradiol benzoate, tamoxifen and monohydroxytamoxifen on immature rat uterine progesterone receptor synthesis and endometrial cell division.","volume":"11","author":"Jordan","year":"1979","journal-title":"J Steroid Biochem."},{"key":"10.1124\/mol.52.4.749_bib17","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0003-2697(62)90014-3","article-title":"method for the colorimetric estimation of glycogen with iodine.","volume":"4","author":"Krisman","year":"1962","journal-title":"Anal. Biochem."},{"key":"10.1124\/mol.52.4.749_bib18","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0003-2697(76)80003-6","article-title":"The enzymatic isolation of adult rat hepatocytes in a functional and viable state.","volume":"71","author":"Fry","year":"1976","journal-title":"Anal. Biochem."},{"key":"10.1124\/mol.52.4.749_bib19","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/0076-6879(71)17252-7","article-title":"Metabolism of amino acids and amines: tyrosine amino-transferase.","volume":"17","author":"Granner","year":"1975","journal-title":"Methods Enzymol."},{"key":"10.1124\/mol.52.4.749_bib20","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1210\/endo-113-3-1004","article-title":"RU26988: a new tool for the study of the mineralocorticoid receptor.","volume":"113","author":"Gomez-Sanchez","year":"1983","journal-title":"Endocrinology"},{"key":"10.1124\/mol.52.4.749_bib21","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/0960-0760(92)90074-S","article-title":"Glucocorticoid receptors.","volume":"43","author":"Funder","year":"1992","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1124\/mol.52.4.749_bib22","first-page":"333","article-title":"Ligand properties of 11,19-oxidoprogesterone: a preliminary report.","volume":"81","author":"Galigniana","year":"1993","journal-title":"Ann. Assoc. Qu\u0131\u0301mica Argentina"},{"key":"10.1124\/mol.52.4.749_bib23","doi-asserted-by":"crossref","first-page":"6056","DOI":"10.1073\/pnas.80.19.6056","article-title":"Renal mineralocorticoid receptors and hippocampal corticosterone binding species have identical intrinsic steroid specificity.","volume":"80","author":"Krozowski","year":"1983","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1124\/mol.52.4.749_bib24","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/0960-0760(91)90399-P","article-title":"Transcortin in rat kidney: subcellular distribution of transcortin-synthesizing polyribosomes.","volume":"38","author":"Kraujelis","year":"1991","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1124\/mol.52.4.749_bib25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1749-6632.1995.tb31364.x","article-title":"Steroid hormone antagonists: an overview.","volume":"761","author":"Jensen","year":"1995","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1124\/mol.52.4.749_bib26","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/0960-0760(94)90268-2","article-title":"Design of novel antiestrogens.","volume":"49","author":"Hendry","year":"1994","journal-title":"J. Steroid Biochem. Mol. Biol."}],"container-title":["Molecular Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026895X24133809?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026895X24133809?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/mol.52.4.749","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T10:07:01Z","timestamp":1740046021000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0026895X24133809"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,10]]},"references-count":26,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1997,10]]}},"alternative-id":["S0026895X24133809"],"URL":"https:\/\/doi.org\/10.1124\/mol.52.4.749","relation":{},"ISSN":["0026-895X"],"issn-type":[{"value":"0026-895X","type":"print"}],"subject":[],"published":{"date-parts":[[1997,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"21-Hydroxy-6,19-oxidoprogesterone: A Novel Synthetic Steroid with Specific Antiglucocorticoid Properties in the Rat","name":"articletitle","label":"Article Title"},{"value":"Molecular Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/mol.52.4.749","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 1997 The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}