{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T07:52:30Z","timestamp":1792309950031,"version":"4.4.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[1998,7,1]],"date-time":"1998-07-01T00:00:00Z","timestamp":899251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[1998,7,1]],"date-time":"1998-07-01T00:00:00Z","timestamp":899251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["molpharm.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Pharmacology"],"published-print":{"date-parts":[[1998,7]]},"DOI":"10.1124\/mol.54.1.197","type":"journal-article","created":{"date-parts":[[2018,1,8]],"date-time":"2018-01-08T20:30:44Z","timestamp":1515443444000},"page":"197-206","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"title":["The Biophysical and Pharmacological Characteristics of Skeletal Muscle ATP-Sensitive K+ Channels Are Modified in K+-Depleted Rat, an Animal Model of Hypokalemic Periodic Paralysis"],"prefix":"10.1016","volume":"54","author":[{"given":"Domenico","family":"Tricarico","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabata","family":"Pierno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosanna","family":"Mallamaci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni Siro","family":"Brigiani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaele","family":"Capriulo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Santoro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana Conte","family":"Camerino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1124\/mol.54.1.197_bib1","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/BF00370419","article-title":"Nucleotide diphosphates activate the ATP-sensitive potassium channel in mouse skeletal muscle.","volume":"422","author":"Allard","year":"1992","journal-title":"Pflueg Arch Eur J Physiol"},{"key":"10.1124\/mol.54.1.197_bib2","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/0898-6568(90)90048-F","article-title":"Properties and functions of ATP-sensitive K-channels.","volume":"2\/3","author":"Ashcroft","year":"1990","journal-title":"Cell Signal"},{"key":"10.1124\/mol.54.1.197_bib3","doi-asserted-by":"crossref","first-page":"C257","DOI":"10.1152\/ajpcell.1993.265.1.C257","article-title":"Insulin-induced membrane changes in K+-depleted rat skeletal muscle.","volume":"265","author":"Bond","year":"1993","journal-title":"Am J Physiol"},{"key":"10.1124\/mol.54.1.197_bib4","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/0166-2236(96)81859-5","article-title":"Ion-channel defects and aberrant excitability in myotonia and periodic paralysis.","volume":"19","author":"Cannon","year":"1996","journal-title":"Trends Neurosci"},{"key":"10.1124\/mol.54.1.197_bib5","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/S0896-6273(00)80321-9","article-title":"Association and stoichiometry of KATP channel subunits.","volume":"18","author":"Clement","year":"1997","journal-title":"Neuron"},{"key":"10.1124\/mol.54.1.197_bib6","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1136\/jnnp.42.9.818","article-title":"Effects of potassium depletion and insulin on resting and stimulated skeletal rat muscle.","volume":"42","author":"Dengler","year":"1979","journal-title":"J Neurol Neurosurg Psychiatr"},{"key":"10.1124\/mol.54.1.197_bib7","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/0005-2736(95)00249-9","article-title":"A possible role of the ATP-sensitive potassium ion channel in determining the duration of spike-burst in mouse pancreatic \u03b2-cells.","volume":"1279","author":"Ding","year":"1996","journal-title":"Biochem Biophys Acta"},{"key":"10.1124\/mol.54.1.197_bib8","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/BF02505761","article-title":"Cytoplasmic acidosis induces multiple conductance states in ATP-sensitive potassium channels of cardiac myocytes.","volume":"136","author":"Fan","year":"1993","journal-title":"J Membr Biol"},{"key":"10.1124\/mol.54.1.197_bib9","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/ng0394-267","article-title":"Mapping of hypokalemic periodic paralysis to chromosome 1q31\u2013q32 by a genoma-wide search in three European families.","volume":"6","author":"Fontaine","year":"1994","journal-title":"Nat Genet"},{"key":"10.1124\/mol.54.1.197_bib10","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0960-8966(96)00401-4","article-title":"Genotype-phenotype correlations of DHP receptor \u03b11-subunit gene mutations causing hypokalemic periodic paralysis.","volume":"7","author":"Fouad","year":"1997","journal-title":"Neurol Disord"},{"key":"10.1124\/mol.54.1.197_bib11","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1002\/mus.880130513","article-title":"Enhancement of K+ conductance improves in vitro the contraction force of skeletal muscle in hypokalemic periodic paralysis.","volume":"13","author":"Grafe","year":"1990","journal-title":"Muscle Nerve"},{"key":"10.1124\/mol.54.1.197_bib12","first-page":"F760","article-title":"Na+ pump inhibition downregulates an ATP-sensitive K+ channel in rabbit proximal convoluted tubule.","volume":"264","author":"Hurst","year":"1993","journal-title":"Am J Physiol"},{"key":"10.1124\/mol.54.1.197_bib13","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/BF00235135","article-title":"Rundown and reactivation of ATP-sensitive potassium channels (KATP) in mouse skeletal muscle.","volume":"141","author":"Hussain","year":"1994","journal-title":"J Membr Biol"},{"key":"10.1124\/mol.54.1.197_bib14","doi-asserted-by":"crossref","first-page":"C368","DOI":"10.1152\/ajpcell.1989.256.2.C368","article-title":"Insulin-induced hyperpolarization in mammalian skeletal muscle.","volume":"256","author":"Iannaccone","year":"1989","journal-title":"Am J Physiol"},{"key":"10.1124\/mol.54.1.197_bib15","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/S0014-5793(97)00488-2","article-title":"Subunit stoichiometry of the pancreatic \u03b2-cell ATP-sensitive K+ channel.","volume":"409","author":"Inagaki","year":"1997","journal-title":"FEBS Lett"},{"key":"10.1124\/mol.54.1.197_bib16","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1093\/hmg\/3.8.1415","article-title":"A calcium channel mutation causing hypokalemic periodic paralysis.","volume":"3","author":"Jurkat-Rott","year":"1994","journal-title":"Hum Mol Genet"},{"key":"10.1124\/mol.54.1.197_bib17","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/0014-5793(96)00173-1","article-title":"Electrophysiological properties of the hypokalaemic periodic paralysis mutation (R528) of the skeletal muscle a1S subunit as expressed in mouse L cells.","volume":"382","author":"Lapie","year":"1996","journal-title":"FEBS Lett"},{"key":"10.1124\/mol.54.1.197_bib18","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/S0960-8966(97)00435-5","article-title":"Hypokalemic periodic paralysis: an autosomal dominant muscle disorder caused by mutations in a voltage-gated calcium channel.","volume":"7","author":"Lapie","year":"1997","journal-title":"Neuromuscular Disord"},{"key":"10.1124\/mol.54.1.197_bib19","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/3-540-61343-9_9","article-title":"Molecular pathophysiology of voltage-gated ion channels.","volume":"128","author":"Lehmann-Horn","year":"1996","journal-title":"Rev Physiol Bioch Pharmacol"},{"key":"10.1124\/mol.54.1.197_bib20","first-page":"1303","article-title":"The periodic paralyses and paramyotonia congenita.","volume":"50","author":"Lehmann-Horn","year":"1994","journal-title":"Myology"},{"key":"10.1124\/mol.54.1.197_bib21","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1042\/cs0910583","article-title":"Normal insulin release during sustained hyperglycaemia in hypokalaemic periodic paralysis: role of the potassium channel opener pinacidil in impaired muscle strength.","volume":"91","author":"Ligtenberg","year":"1996","journal-title":"Clin Sci"},{"key":"10.1124\/mol.54.1.197_bib22","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1042\/cs0850319","article-title":"Potassium channels in hypokalaemic periodic paralysis: a key to the pathogenesis?","volume":"85","author":"Links","year":"1993","journal-title":"Clin Sci"},{"key":"10.1124\/mol.54.1.197_bib23","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/0092-8674(94)90135-X","article-title":"Dihydropyridine receptor mutations cause hypokalemic periodic paralysis.","volume":"77","author":"Ptacek","year":"1994","journal-title":"Cell"},{"key":"10.1124\/mol.54.1.197_bib24","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1002\/mus.880070205","article-title":"Hypokalemic periodic paralysis: in vitro investigation of muscle fiber membrane parameters.","volume":"7","author":"R\u00fcdel","year":"1984","journal-title":"Muscle Nerve"},{"key":"10.1124\/mol.54.1.197_bib25","series-title":"Single-Channel Recording","first-page":"37","article-title":"Geometric parameters of pipettes and membrane patches","author":"Sakmann","year":"1983"},{"key":"10.1124\/mol.54.1.197_bib26","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1113\/jphysiol.1995.sp020586","article-title":"Skeletal muscle DHP receptor mutations alter calcium currents in human hypokalaemic periodic paralysis myotubes.","volume":"483","author":"Sipos","year":"1995","journal-title":"J Physiol"},{"key":"10.1124\/mol.54.1.197_bib27","first-page":"327","article-title":"Cromakalim (BRL 34915) restores in vitro the membrane potential of depolarized human skeletal muscle fibres.","volume":"339","author":"Spuler","year":"1898","journal-title":"Naunyn-Schmiedeberg\u2019s Arch Pharmacol"},{"key":"10.1124\/mol.54.1.197_bib28","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/S0026-895X(25)09809-8","article-title":"ATP-Sensitive K+ channels of skeletal muscle fibers from young adult and aged rats: possible involvement of thiol-dependent redox mechanisms in the age-dependent modifications of their biophysical and pharmacological properties.","volume":"46","author":"Tricarico","year":"1994","journal-title":"Mol Pharmacol"},{"key":"10.1124\/mol.54.1.197_bib29","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1007\/BF00374669","article-title":"Effects of ischaemia and post-ischaemic reperfusion on the passive and active electrical parameters of rat skeletal muscle fibres.","volume":"426","author":"Tricarico","year":"1994","journal-title":"Pflueg Arch Eur J Physiol"},{"key":"10.1124\/mol.54.1.197_bib30","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1006\/bbrc.1997.6320","article-title":"Modulation of ATP-sensitive K+ channel by insulin in rat skeletal muscle fibers.","volume":"232","author":"Tricarico","year":"1997","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1124\/mol.54.1.197_bib31","first-page":"A249","article-title":"Biophysical changes of skeletal muscle KATP channels in K+ depleted rats and pharmacological intervention.","volume":"72","author":"Tricarico","year":"1997","journal-title":"Biophys J"},{"key":"10.1124\/mol.54.1.197_bib32","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/S0014-2999(96)00965-X","article-title":"Different sulfonylurea and ATP sensitivity characterizes the juvenile and the adult form of KATP channel complex of rat skeletal muscle.","volume":"321","author":"Tricarico","year":"1997","journal-title":"Eur J Pharmacol"},{"key":"10.1124\/mol.54.1.197_bib33","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1113\/jphysiol.1995.sp020840","article-title":"Modification by protons of frog skeletal muscle KATP channel: effects on ion conduction and nucleotide inhibition.","volume":"486.3","author":"Vivaudou","year":"1995","journal-title":"J Physiol"},{"key":"10.1124\/mol.54.1.197_bib34","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/0005-2736(89)90225-3","article-title":"Low-conductance states of K+ channels in adult mouse skeletal muscle.","volume":"983","author":"Weik","year":"1989","journal-title":"Biochem Biophys Acta"}],"container-title":["Molecular Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026895X24131434?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026895X24131434?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/mol.54.1.197","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T10:00:03Z","timestamp":1740045603000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0026895X24131434"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,7]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1998,7]]}},"alternative-id":["S0026895X24131434"],"URL":"https:\/\/doi.org\/10.1124\/mol.54.1.197","relation":{},"ISSN":["0026-895X"],"issn-type":[{"value":"0026-895X","type":"print"}],"subject":[],"published":{"date-parts":[[1998,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Biophysical and Pharmacological Characteristics of Skeletal Muscle ATP-Sensitive K+ Channels Are Modified in K+-Depleted Rat, an Animal Model of Hypokalemic Periodic Paralysis","name":"articletitle","label":"Article Title"},{"value":"Molecular Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/mol.54.1.197","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 1998 The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}