{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T14:05:11Z","timestamp":1765807511201,"version":"3.41.0"},"reference-count":40,"publisher":"Elsevier BV","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol Pharmacol"],"published-print":{"date-parts":[[2000,3,1]]},"DOI":"10.1124\/mol.57.3.474","type":"journal-article","created":{"date-parts":[[2018,1,8]],"date-time":"2018-01-08T20:38:07Z","timestamp":1515443887000},"page":"474-484","source":"Crossref","is-referenced-by-count":241,"title":["A Single Glycine Residue at the Entrance to the First Membrane-Spanning Domain of the \u03b3-Aminobutyric Acid Type A Receptor \u03b2<sub>2<\/sub>Subunit Affects Allosteric Sensitivity to GABA and Anesthetics"],"prefix":"10.1016","volume":"57","author":[{"given":"Berit X.","family":"Carlson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. Christine","family":"Engblom","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uffe","family":"Kristiansen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arne","family":"Schousboe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard W.","family":"Olsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","published-online":{"date-parts":[[2000,3,1]]},"reference":[{"key":"2019092417192126000_57.3.474.1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00039a002"},{"key":"2019092417192126000_57.3.474.2","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S0026-895X(24)12165-7","article-title":"A single hydrophobic residue confers barbiturate sensitivity to \u03b3-aminobutyric acid type C receptor.","volume":"55","author":"Amin","year":"1999","journal-title":"Mol Pharmacol"},{"key":"2019092417192126000_57.3.474.3","doi-asserted-by":"publisher","DOI":"10.1124\/mol.51.5.833"},{"key":"2019092417192126000_57.3.474.4","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.1996.0042"},{"key":"2019092417192126000_57.3.474.5","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S0031-6997(24)01363-2","article-title":"International Union of Pharmacology. XV. Subtypes of \u03b3-aminobutyric acidA receptors: Classification on the basis of subunit structure and receptor function.","volume":"50","author":"Barnard","year":"1998","journal-title":"Pharmacol Rev"},{"key":"2019092417192126000_57.3.474.6","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.20.11031"},{"key":"2019092417192126000_57.3.474.7","doi-asserted-by":"publisher","DOI":"10.1007\/s002329900167"},{"key":"2019092417192126000_57.3.474.8","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1016\/S0026-895X(25)08998-9","article-title":"Point mutations of the \u03b11\u03b22\u03b32 \u03b3-aminobutyric acidA receptor affecting modulation of the channel ligands of the benzodiazepine binding site.","volume":"49","author":"Buhr","year":"1996","journal-title":"Mol Pharmacol"},{"key":"2019092417192126000_57.3.474.9","unstructured":"Carlson BX Hales TG Olsen RW (1997) GABAA receptors and anesthesia. in Anesthesia, Biologic Foundations, ed Yaksh TL (Lippincott-Raven, Philadelphia, PA), pp 259\u2013275."},{"key":"2019092417192126000_57.3.474.10","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1097\/00001756-199603220-00023","article-title":"The agonistic action of pentobarbital on GABAA \u03b2-subunit homomeric receptors.","volume":"7","author":"Cestari","year":"1996","journal-title":"Neuroreport"},{"key":"2019092417192126000_57.3.474.11","doi-asserted-by":"crossref","first-page":"5415","DOI":"10.1523\/JNEUROSCI.16-17-05415.1996","article-title":"Stoichiometry of a recombinant GABAA receptor.","volume":"16","author":"Chang","year":"1996","journal-title":"J Neurosci"},{"key":"2019092417192126000_57.3.474.12","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.7.2673"},{"key":"2019092417192126000_57.3.474.13","doi-asserted-by":"publisher","DOI":"10.1038\/385820a0"},{"key":"2019092417192126000_57.3.474.14","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0701441"},{"key":"2019092417192126000_57.3.474.15","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/S0026-895X(24)13060-X","article-title":"Do specific or nonspecific interactions with proteins underlie inhalational anesthetic action?","volume":"54","author":"Eckenhoff","year":"1998","journal-title":"Mol Pharmacol"},{"key":"2019092417192126000_57.3.474.16","doi-asserted-by":"publisher","DOI":"10.1126\/science.1925602"},{"key":"2019092417192126000_57.3.474.17","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1002\/j.1460-2075.1990.tb08172.x","article-title":"Alpha subunit variants of the human glycine receptor: Primary structures, functional expression and chromosomal localization of the corresponding genes.","volume":"9","author":"Grenningloh","year":"1990","journal-title":"EMBO J"},{"key":"2019092417192126000_57.3.474.18","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1111\/j.1476-5381.1991.tb12479.x","article-title":"The actions of propofol on inhibitory amino acid receptors of bovine adrenomedullary chromaffin cells and rodent central neurones.","volume":"104","author":"Hales","year":"1991","journal-title":"Br J Pharmacol"},{"key":"2019092417192126000_57.3.474.19","unstructured":"Hales TG Olsen RW (1994) Basic pharmacology of intravenous induction agents. in The Pharmacological Basis of Anesthesiology: Basic Science and Practical Applications, eds Bowdle TA Horita A Kharasch ED (Churchill Livingstone, New York), pp 295\u2013306."},{"key":"2019092417192126000_57.3.474.20","doi-asserted-by":"publisher","DOI":"10.1007\/BF00656997"},{"key":"2019092417192126000_57.3.474.21","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/S0026-895X(25)08548-7","article-title":"Different subunit requirements for volatile and nonvolatile anesthetics at \u03b3-aminobutyric acid type A receptors.","volume":"47","author":"Harris","year":"1995","journal-title":"Mol Pharmacol"},{"key":"2019092417192126000_57.3.474.22","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1016\/S0022-3565(25)10677-0","article-title":"Modulation of the GABAA receptor by propofol is independent of the \u03b3 subunit.","volume":"274","author":"Jones","year":"1995","journal-title":"J Pharmacol Exp Ther"},{"key":"2019092417192126000_57.3.474.23","doi-asserted-by":"publisher","DOI":"10.1124\/mol.53.3.530"},{"key":"2019092417192126000_57.3.474.24","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3908(96)00070-6"},{"key":"2019092417192126000_57.3.474.25","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S0022-3565(25)12838-3","article-title":"Inhibition of \u03c11 receptor GABAergic currents by alcohols and volatile anesthetics.","volume":"277","author":"Mihic","year":"1996","journal-title":"J Pharmacol Exp Ther"},{"key":"2019092417192126000_57.3.474.26","doi-asserted-by":"publisher","DOI":"10.1038\/38738"},{"key":"2019092417192126000_57.3.474.27","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1046\/j.1471-4159.1997.69031310.x","article-title":"Distinct loci mediate the direct and indirect actions of the anesthetic etomidate at GABAA receptors.","volume":"69","author":"Moody","year":"1997","journal-title":"J Neurochem"},{"key":"2019092417192126000_57.3.474.28","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1111\/j.1749-6632.1991.tb33838.x","article-title":"Allosteric actions of CNS depressants including anesthetics on subtypes of the inhibitory GABAA receptor-chloride channel complex.","volume":"625","author":"Olsen","year":"1991","journal-title":"Ann NY Acad Sci"},{"key":"2019092417192126000_57.3.474.29","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.4.1421"},{"key":"2019092417192126000_57.3.474.30","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.19.13370"},{"key":"2019092417192126000_57.3.474.31","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/S0022-3565(25)10610-1","article-title":"Actions of the general anesthetic propofol on recombinant human GABAA receptors: Influence of receptor subunits.","volume":"274","author":"Sanna","year":"1995","journal-title":"J Pharmacol Exp Ther"},{"key":"2019092417192126000_57.3.474.32","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/S0026-895X(24)13490-6","article-title":"Differential subunit dependence of the actions of the general anesthetics alphaxalone and etomidate at \u03b3-aminobutyric type A receptors expressed in Xenopus laevis oocytes.","volume":"51","author":"Sanna","year":"1997","journal-title":"Mol Pharmacol"},{"key":"2019092417192126000_57.3.474.33","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.38.26633"},{"key":"2019092417192126000_57.3.474.34","doi-asserted-by":"publisher","DOI":"10.1124\/mol.55.6.993"},{"key":"2019092417192126000_57.3.474.35","first-page":"113","article-title":"Two threonine residues in the M2 segment of the \u03b11\u03b21 GABAA receptor are critical for ion channel function.","volume":"5","author":"Tierney","year":"1998","journal-title":"Receptors Channels"},{"key":"2019092417192126000_57.3.474.36","doi-asserted-by":"crossref","first-page":"2728","DOI":"10.1523\/JNEUROSCI.17-08-02728.1997","article-title":"Stoichiometry and assembly of a recombinant GABAA receptor subtype.","volume":"17","author":"Tretter","year":"1997","journal-title":"J Neurosci"},{"key":"2019092417192126000_57.3.474.37","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3908(97)00180-9"},{"key":"2019092417192126000_57.3.474.38","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1016\/S0021-9258(18)45961-3","article-title":"A single histidine in GABAA receptors is essential for benzodiazepine agonist binding.","volume":"267","author":"Wieland","year":"1992","journal-title":"J Biol Chem"},{"key":"2019092417192126000_57.3.474.39","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/S0378-4274(98)00205-7","article-title":"Unifying characteristics of sites of anesthetic action.","volume":"100\u2013101","author":"Xu","year":"1998","journal-title":"Toxicol Lett"},{"key":"2019092417192126000_57.3.474.40","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(96)00066-0"}],"container-title":["Molecular Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/mol.57.3.474","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,29]],"date-time":"2025-06-29T14:05:50Z","timestamp":1751205950000},"score":1,"resource":{"primary":{"URL":"http:\/\/molpharm.aspetjournals.org\/lookup\/doi\/10.1124\/mol.57.3.474"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,3,1]]},"references-count":40,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2000,3,1]]},"published-print":{"date-parts":[[2000,3,1]]}},"alternative-id":["10.1124\/mol.57.3.474"],"URL":"https:\/\/doi.org\/10.1124\/mol.57.3.474","relation":{},"ISSN":["0026-895X","1521-0111"],"issn-type":[{"type":"print","value":"0026-895X"},{"type":"electronic","value":"1521-0111"}],"subject":[],"published":{"date-parts":[[2000,3,1]]}}}