{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T05:14:58Z","timestamp":1789190098847,"version":"build-2803163510"},"reference-count":36,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["molpharm.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Pharmacology"],"published-print":{"date-parts":[[2002,1]]},"DOI":"10.1124\/mol.61.1.239","type":"journal-article","created":{"date-parts":[[2003,1,15]],"date-time":"2003-01-15T23:40:38Z","timestamp":1042674038000},"page":"239-245","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"title":["Presynaptic H3 Autoreceptors Modulate Histamine Synthesis through cAMP Pathway"],"prefix":"10.1016","volume":"61","author":[{"given":"Jordi","family":"Gomez-Ramirez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordi","family":"Ortiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isaac","family":"Blanco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1124\/mol.61.1.239_B1","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0006-8993(86)90392-6","article-title":"Adenosine 3\u2032,5\u2032-cyclic monophosphate stimulates dopamine biosynthesis in the median eminence of rat hypothalamic slices.","volume":"374","author":"Arita","year":"1986","journal-title":"Brain Res"},{"key":"10.1124\/mol.61.1.239_B2","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/327117a0","article-title":"Highly potent and selective ligands for histamine H3-receptors.","volume":"327","author":"Arrang","year":"1987","journal-title":"Nature (Lond)"},{"key":"10.1124\/mol.61.1.239_B3","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1038\/302832a0","article-title":"Auto-inhibition of brain histamine release mediated by a novel class (H3) of histamine receptor.","volume":"302","author":"Arrang","year":"1983","journal-title":"Nature (Lond)"},{"key":"10.1124\/mol.61.1.239_B4","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/0306-4522(87)90279-X","article-title":"Autoinhibition of histamine synthesis mediated by presynaptic H3-receptors.","volume":"23","author":"Arrang","year":"1987","journal-title":"Neuroscience"},{"key":"10.1124\/mol.61.1.239_B5","first-page":"427","article-title":"Receptors mediating some actions of histamine.","volume":"27","author":"Ash","year":"1966","journal-title":"Br J Pharmacol"},{"key":"10.1124\/mol.61.1.239_B6","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/0165-6147(90)90066-H","article-title":"Primary sequence of cyclic nucleotide phosphodiesterase isozymes and the design of selective inhibitors.","volume":"11","author":"Beavo","year":"1990","journal-title":"Trends Pharmacol Sci"},{"key":"10.1124\/mol.61.1.239_B7","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/236385a0","article-title":"Definition and antagonism of histamine H2-receptors.","volume":"236","author":"Black","year":"1972","journal-title":"Nature (Lond)"},{"key":"10.1124\/mol.61.1.239_B8","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s002100000351","article-title":"H3-receptor-mediated inhibition of intestinal acetylcholine release: pharmacological characterization of signal transduction pathways.","volume":"363","author":"Blandizzi","year":"2001","journal-title":"Naunyn-Schmiedeberg's Arch Pharmacol"},{"key":"10.1124\/mol.61.1.239_B9","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/0076-6879(88)59017-1","article-title":"cAMP analog antagonists of cAMP action.","volume":"159","author":"Botelho","year":"1988","journal-title":"Methods Enzymol"},{"key":"10.1124\/mol.61.1.239_B10","doi-asserted-by":"crossref","first-page":"25315","DOI":"10.1016\/S0021-9258(19)74042-3","article-title":"Purification of a histamine H3 receptor negatively coupled to phosphoinositide turnover in the human gastric cell line HGT1.","volume":"267","author":"Cherify","year":"1992","journal-title":"J Biol Chem"},{"key":"10.1124\/mol.61.1.239_B11","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/0014-2999(95)00800-4","article-title":"Sensitivity of histamine H3 receptor agonist-stimulated [35S]GTP\u03b3[S] binding to pertussis toxin.","volume":"296","author":"Clark","year":"1996","journal-title":"Eur J Pharmacol"},{"key":"10.1124\/mol.61.1.239_B12","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1111\/j.1471-4159.1982.tb08660.x","article-title":"Activation of cyclic AMP-generating systems in brain membranes and slices by the diterpene forskolin: augmentation of receptor-mediated responses.","volume":"38","author":"Daly","year":"1982","journal-title":"J Neurochem"},{"key":"10.1124\/mol.61.1.239_B13","doi-asserted-by":"crossref","first-page":"28380","DOI":"10.1074\/jbc.M003571200","article-title":"Selective coupling of G-protein \u03b2\u03b3 complexes to inhibition of Ca2+ channels.","volume":"275","author":"Diverse-Pierluissi","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1124\/mol.61.1.239_B14","doi-asserted-by":"crossref","first-page":"5417","DOI":"10.1073\/pnas.94.10.5417","article-title":"Novel form of crosstalk between G protein and tyrosine kinase pathway.","volume":"94","author":"Diverse-Pierluissi","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/mol.61.1.239_B15","first-page":"1","article-title":"Identification of rat H3 receptor isoforms with different brain expression and signaling properties.","volume":"59","author":"Drutel","year":"2001","journal-title":"Mol Pharmacol"},{"issue":"1","key":"10.1124\/mol.61.1.239_B16","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1111\/j.1471-4159.1985.tb05490.x","article-title":"Characteristics of tyrosine hydroxylase activation by K+-induced depolarization and\/or forskolin in rat striatal slices.","volume":"45","author":"El Mestikawy","year":"1985","journal-title":"J Neurochem"},{"key":"10.1124\/mol.61.1.239_B17","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/S0022-3565(25)10340-6","article-title":"S-[2-(4-Imidazolyl)ethyl]Isothiourea, a highly specific and potent histamine H3 receptor agonist.","volume":"263","author":"Garbarg","year":"1992","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/mol.61.1.239_B18","doi-asserted-by":"crossref","first-page":"8802","DOI":"10.1016\/S0021-9258(18)81864-6","article-title":"Primary structural determinants essential for potent inhibition of cAMP-dependent protein kinase by inhibitory peptides corresponding to the active portion of the heat-stable inhibitor protein.","volume":"264","author":"Glass","year":"1989","journal-title":"J Biol Chem"},{"key":"10.1124\/mol.61.1.239_B19","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/j.1432-1033.1991.tb15898.x","article-title":"Possible regulation of hypothalamus and lung histidine decarboxylase activity by cAMP-dependent protein kinase.","volume":"197","author":"Huszti","year":"1991","journal-title":"Eur J Biochem"},{"key":"10.1124\/mol.61.1.239_B20","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1073\/pnas.87.2.733","article-title":"Characterization and expression of the complementary DNA encoding rat histidine decarboxylase.","volume":"87","author":"Joseph","year":"1990","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/mol.61.1.239_B21","first-page":"498","article-title":"Nordimaprit, homodimaprit, clobenpropit, and imetit: Affinities for H3 binding sites and potencies in a functional H3 receptor model.","volume":"348","author":"Kathman","year":"1993","journal-title":"Naunyn-Schmiederg's Arch Pharmacol"},{"key":"10.1124\/mol.61.1.239_B22","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/S0165-6147(89)80008-2","article-title":"Forskolin: a specific stimulator of adenylyl cyclase or a diterpene with multiple sites of action?","volume":"10","author":"Laurenza","year":"1989","journal-title":"Trends Pharmacol Sci"},{"key":"10.1124\/mol.61.1.239_B23","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/S0022-3565(24)39297-3","article-title":"Cloning of rat histamine H3 receptor reveals distinct species pharmacological profiles.","volume":"293","author":"Lovenberg","year":"2000","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/mol.61.1.239_B24","first-page":"1101","article-title":"Cloning and functional expression of the human histamine H3 receptor.","volume":"55","author":"Lovenberg","year":"1999","journal-title":"Mol Pharmacol"},{"key":"10.1124\/mol.61.1.239_B25","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurements with the Folin phenol reagent.","volume":"193","author":"Lowry","year":"1951","journal-title":"J Biol Chem"},{"key":"10.1124\/mol.61.1.239_B26","doi-asserted-by":"crossref","first-page":"2373","DOI":"10.1016\/0006-2952(93)90216-J","article-title":"Comparison of the Effect of Isobutylmethylxanthine and Phosphodiesterase-Selective Inhibitors on cAMP levels in SH-SY5Y Neuroblastoma Cells.","volume":"45","author":"Morgan","year":"1993","journal-title":"Biochem Pharmacol"},{"key":"10.1124\/mol.61.1.239_B27","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/35048583","article-title":"High constitutive activity of native H3 receptors regulates histamine neurons in brain.","volume":"408","author":"Morisset","year":"2000","journal-title":"Nature (Lond)"},{"key":"10.1124\/mol.61.1.239_B28","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1006\/abio.2000.4494","article-title":"Quantitative radioisotopic determination of histidine decarboxylase using high-performance liquid chromatography","volume":"280","author":"Ortiz","year":"2000","journal-title":"Anal Biochem"},{"key":"10.1124\/mol.61.1.239_B29","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/0076-6879(74)38057-3","article-title":"The preparation of acylated derivatives of cyclic nucleotides.","volume":"38","author":"Posternak","year":"1974","journal-title":"Methods Enzymol"},{"key":"10.1124\/mol.61.1.239_B30","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1111\/j.1471-4159.1989.tb09202.x","article-title":"Dopamine autoreceptors modulate the phosphorylation of tyrosine hydroxylase in rat striatal slices.","volume":"52","author":"Salah","year":"1989","journal-title":"J Neurochem"},{"key":"10.1124\/mol.61.1.239_B31","first-page":"34","article-title":"H3 receptor-mediated inhibition of noradrenaline release: an investigation into the involvement of Ca2+ and K+ ions, G protein and adenylate cyclase.","volume":"350","author":"Schlicker","year":"1994","journal-title":"Naunyn-Schmiedeberg's Arch Pharmcol"},{"key":"10.1124\/mol.61.1.239_B32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1152\/physrev.1991.71.1.1","article-title":"Histaminergic transmission in the mammalian brain.","volume":"71","author":"Schwartz","year":"1991","journal-title":"Physiol Rev"},{"key":"10.1124\/mol.61.1.239_B33","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1021\/jm00357a021","article-title":"Structure-activity relationships for activation of adenylate cyclase by the diterpene forskolin and its derivatives.","volume":"26","author":"Seamon","year":"1983","journal-title":"J Med Chem"},{"key":"10.1124\/mol.61.1.239_B34","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/S0306-4522(98)00152-3","article-title":"Histamine modulates high-voltage-activated calcium channels in neurons dissociated from the rat tuberomammillary nucleus.","volume":"87","author":"Takeshita","year":"1998","journal-title":"Neuroscience"},{"key":"10.1124\/mol.61.1.239_B35","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1097\/00001756-200003200-00020","article-title":"Cloning and cerebral expression of the guinea pig histamine H3 receptor: evidence for two isoforms.","volume":"11","author":"Tardivel-Lacombe","year":"2000","journal-title":"Neuroreport"},{"key":"10.1124\/mol.61.1.239_B36","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1126\/science.1653455","article-title":"Regulation of Kainate receptors by cAMP-dependent protein kinase and phosphatases.","volume":"253","author":"Wang","year":"1991","journal-title":"Science (Wash DC)"}],"container-title":["Molecular Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026895X24130088?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026895X24130088?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/mol.61.1.239","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T09:55:53Z","timestamp":1740045353000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0026895X24130088"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,1]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2002,1]]}},"alternative-id":["S0026895X24130088"],"URL":"https:\/\/doi.org\/10.1124\/mol.61.1.239","relation":{},"ISSN":["0026-895X"],"issn-type":[{"value":"0026-895X","type":"print"}],"subject":[],"published":{"date-parts":[[2002,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Presynaptic H3 Autoreceptors Modulate Histamine Synthesis through cAMP Pathway","name":"articletitle","label":"Article Title"},{"value":"Molecular Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/mol.61.1.239","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2002 The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}