{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:14:51Z","timestamp":1783556091760,"version":"3.55.0"},"reference-count":28,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2003,4,1]],"date-time":"2003-04-01T00:00:00Z","timestamp":1049155200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2003,4,1]],"date-time":"2003-04-01T00:00:00Z","timestamp":1049155200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["molpharm.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Pharmacology"],"published-print":{"date-parts":[[2003,4]]},"DOI":"10.1124\/mol.63.4.791","type":"journal-article","created":{"date-parts":[[2003,3,18]],"date-time":"2003-03-18T18:52:52Z","timestamp":1048013572000},"page":"791-798","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Mutation of the Androgen Receptor at Amino Acid 708 (Gly\u2192Ala) Abolishes Partial Agonist Activity of Steroidal Antiandrogens"],"prefix":"10.1016","volume":"63","author":[{"given":"B\u00e9atrice","family":"Terouanne","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Nird\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanja","family":"Rabenoelina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Bourguet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Sultan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"Auzou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1124\/mol.63.4.791_bib1","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/S0022-3476(97)80063-7","article-title":"Etiologic classification of severe hypospadias: implications for prognosis and management","volume":"131","author":"Albers","year":"1997","journal-title":"J Pediatr"},{"key":"10.1124\/mol.63.4.791_bib2","unstructured":"Auchus RJ, Mc Phaul MJ, Fuqua SAW (1995) Characterization of a novel androgen receptor mutation in the amino terminal portion of the hormone binding domain from a kindred with complete androgen resistance. 77th US Endocrine Society Meeting; 1995 Jun 14\u201317; Washington DC. The Endocrine Society, Bethesda, MD, abstract P1-508."},{"key":"10.1124\/mol.63.4.791_bib3","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/S0026-895X(24)23099-6","article-title":"A single amino acid mutation of Ala773 in the mineralocorticoid receptor confers agonist properties to 11\u03b2-substituted spirolactones","volume":"58","author":"Auzou","year":"2000","journal-title":"Mol Pharmacol"},{"key":"10.1124\/mol.63.4.791_bib4","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1093\/nar\/28.1.235","article-title":"The Protein Data Bank","volume":"28","author":"Berman","year":"2000","journal-title":"Nucleic Acids Res"},{"key":"10.1124\/mol.63.4.791_bib5","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/S0022-2836(77)80200-3","article-title":"The Protein Data Bank: a computer-based archival file for macromolecular structures","volume":"112","author":"Bernstein","year":"1977","journal-title":"J Mol Biol"},{"key":"10.1124\/mol.63.4.791_bib6","doi-asserted-by":"crossref","first-page":"2404","DOI":"10.1021\/jm00068a018","article-title":"Synthesis of new 11\u03b2-substituted spirolactone derivatives. Relationship with affinity for mineralocorticoid and glucocorticoid receptors","volume":"36","author":"Claire","year":"1993","journal-title":"J Med Chem"},{"key":"10.1124\/mol.63.4.791_bib7","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1126\/science.3283939","article-title":"The steroid and thyroid hormone superfamily","volume":"240","author":"Evans","year":"1988","journal-title":"Science (Wash DC)"},{"key":"10.1124\/mol.63.4.791_bib8","doi-asserted-by":"crossref","first-page":"3317","DOI":"10.1093\/emboj\/17.12.3317","article-title":"Antagonism in the human mineralocorticoid receptor","volume":"17","author":"Fagart","year":"1998","journal-title":"EMBO (Eur Mol Biol Organ) J"},{"key":"10.1124\/mol.63.4.791_bib9","doi-asserted-by":"crossref","first-page":"3045","DOI":"10.1039\/P19900003045","article-title":"Synthesis of new steroidal 11\u03b2-substituted spirolactones","volume":"1","author":"Faraj","year":"1990","journal-title":"J Chem Soc Perkin Trans"},{"key":"10.1124\/mol.63.4.791_bib10","doi-asserted-by":"crossref","first-page":"11824","DOI":"10.1021\/bi0259150","article-title":"Mechanism of antiandrogen action: key role of hsp90 in conformational change and transcriptional activity of the androgen receptor","volume":"41","author":"Georget","year":"2002","journal-title":"Biochemistry"},{"key":"10.1124\/mol.63.4.791_bib11","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1093\/nar\/26.1.234","article-title":"The androgen receptor gene mutations database","volume":"26","author":"Gotlieb","year":"1998","journal-title":"Nucleic Acids Res"},{"key":"10.1124\/mol.63.4.791_bib12","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1093\/nar\/19.7.1563","article-title":"Cooperation between structural elements in hormono-regulated transcription from the mouse mammary tumors virus promoter","volume":"19","author":"Gouilleux","year":"1991","journal-title":"Nucleic Acids Res"},{"key":"10.1124\/mol.63.4.791_bib13","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/BF01956409","article-title":"Molecular characterisation of the androgen receptor gene in boy hypospadias","volume":"153","author":"Hiort","year":"1994","journal-title":"Eur J Pediatr"},{"key":"10.1124\/mol.63.4.791_bib14","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1210\/mend.13.3.0255","article-title":"Distinguishing androgen receptor agonists and antagonists: distinct mechanisms of activation by medroxyprogesterone acetate and dihydrotestosterone","volume":"13","author":"Kemppainen","year":"1999","journal-title":"Mol Endocrinol"},{"key":"10.1124\/mol.63.4.791_bib15","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1210\/endo.140.1.6418","article-title":"Transcriptional interferences between normal or mutant androgen receptors and the activator protein 1-dissection of the androgen receptor functional domains","volume":"140","author":"Lobaccaro","year":"1999","journal-title":"Endocrinology"},{"key":"10.1124\/mol.63.4.791_bib16","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/0092-8674(95)90199-X","article-title":"The nuclear receptor super family: the second decade","volume":"83","author":"Mangelsdorf","year":"1995","journal-title":"Cell"},{"key":"10.1124\/mol.63.4.791_bib17","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1021\/jm0005353","article-title":"Homology modeling using molecular dynamics simulations and docking studies of the human androgen receptor ligand binding domain bound to testosterone and nonsteroidal ligands","volume":"44","author":"Marhefka","year":"2001","journal-title":"J Med Chem"},{"key":"10.1124\/mol.63.4.791_bib18","doi-asserted-by":"crossref","first-page":"26164","DOI":"10.1074\/jbc.M004571200","article-title":"Structural evidence for ligand specificity in the binding domain of the human Androgen receptor: implications for pathogenic gene mutations","volume":"275","author":"Matias","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1124\/mol.63.4.791_bib19","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1002\/1097-0142(19930201)71:3+<1046::AID-CNCR2820711424>3.0.CO;2-M","article-title":"Antiandrogenic drugs","volume":"71","author":"McLeod","year":"1993","journal-title":"Cancer"},{"key":"10.1124\/mol.63.4.791_bib20","unstructured":"Nickisch K, Annen K, Laurent H, Wiechert R, Beier S, Elger W (1985) inventors; Schering AG, assignee. 17-Substituted estradienes and estratrienes. German Patent P34 10 880."},{"key":"10.1124\/mol.63.4.791_bib21","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1016\/S0026-895X(24)12592-8","article-title":"11\u03b2-spirolactone derivatives, antimineralocorticoid, exhibit also androgenic transcriptional activity","volume":"59","author":"Nird\u00e9","year":"2001","journal-title":"Mol Pharmacol"},{"key":"10.1124\/mol.63.4.791_bib22","doi-asserted-by":"crossref","first-page":"24022","DOI":"10.1074\/jbc.M001999200","article-title":"Specific recognition of androgens by their nuclear receptor: a structure-function study","volume":"275","author":"Poujol","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1124\/mol.63.4.791_bib23","first-page":"271","article-title":"Androgen receptor defects: historical, clinical and molecular perspectives","volume":"16","author":"Quigley","year":"1995","journal-title":"Endocrine Rev"},{"key":"10.1124\/mol.63.4.791_bib24","first-page":"176","article-title":"Threonine on amino acid position 868 in the human androgen receptor is essential for androgen binding specificity and functional activity","volume":"196","author":"Ris-Stalpers","year":"1993","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1124\/mol.63.4.791_bib25","doi-asserted-by":"crossref","first-page":"4904","DOI":"10.1073\/pnas.081565498","article-title":"Crystallographic structures of the ligand-binding domains of the androgen receptor and its T877A mutant complexed with the natural agonist dihydrotestosterone","volume":"98","author":"Sack","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/mol.63.4.791_bib26","doi-asserted-by":"crossref","first-page":"3839","DOI":"10.1002\/j.1460-2075.1991.tb04953.x","article-title":"Cell-specific inhibitory and stimulatory effects of Fos and Jun on transcription activation by nuclear receptors","volume":"10","author":"Shemshedini","year":"1991","journal-title":"EMBO (Eur Mol Biol Organ) J"},{"key":"10.1124\/mol.63.4.791_bib27","first-page":"359","article-title":"Structural characterization of a subtype-selective ligand reveals a novel mode of estrogen receptor antagonism","volume":"9","author":"Shiau","year":"2002","journal-title":"Nat Struct Biol"},{"key":"10.1124\/mol.63.4.791_bib28","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/S0006-291X(05)80067-1","article-title":"A mutation in the ligand binding domain of the androgen receptor of human LNCaP cells affects steroid binding characteristics and response to anti-androgens","volume":"173","author":"Veldscholte","year":"1990","journal-title":"Biochem Biophys Res Commun"}],"container-title":["Molecular Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026895X24057857?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026895X24057857?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/mol.63.4.791","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T08:52:49Z","timestamp":1740041569000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0026895X24057857"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,4]]},"references-count":28,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2003,4]]}},"alternative-id":["S0026895X24057857"],"URL":"https:\/\/doi.org\/10.1124\/mol.63.4.791","relation":{},"ISSN":["0026-895X"],"issn-type":[{"value":"0026-895X","type":"print"}],"subject":[],"published":{"date-parts":[[2003,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mutation of the Androgen Receptor at Amino Acid 708 (Gly\u2192Ala) Abolishes Partial Agonist Activity of Steroidal Antiandrogens","name":"articletitle","label":"Article Title"},{"value":"Molecular Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/mol.63.4.791","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2003 The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}