{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T18:10:06Z","timestamp":1791051006233,"version":"4.1.0"},"reference-count":25,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2003,8,1]],"date-time":"2003-08-01T00:00:00Z","timestamp":1059696000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2003,8,1]],"date-time":"2003-08-01T00:00:00Z","timestamp":1059696000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["molpharm.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Pharmacology"],"published-print":{"date-parts":[[2003,8]]},"DOI":"10.1124\/mol.64.2.316","type":"journal-article","created":{"date-parts":[[2003,7,17]],"date-time":"2003-07-17T21:32:25Z","timestamp":1058477545000},"page":"316-324","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":147,"title":["Identification of Constitutive Androstane Receptor and Glucocorticoid Receptor Binding Sites in the CYP2C19 Promoter"],"prefix":"10.1016","volume":"64","author":[{"given":"Yuping","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen S","family":"Ferguson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiko","family":"Negishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joyce A","family":"Goldstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1124\/mol.64.2.316_bib1","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1124\/mol.62.3.737","article-title":"Regulation of human CYP2C9 by the constitutive androstane receptor: discovery of a new distal binding site","volume":"62","author":"Ferguson","year":"2002","journal-title":"Mol Pharmacol"},{"key":"10.1124\/mol.64.2.316_bib2","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.7326\/0003-4819-129-12-199812150-00006","article-title":"Effect of genetic differences in omeprazole metabolism on cure rates for Helicobacter pylori infection and peptic ulcer","volume":"129","author":"Furuta","year":"1998","journal-title":"Ann Intern Med"},{"key":"10.1124\/mol.64.2.316_bib3","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1074\/jbc.M107228200","article-title":"Transcriptional regulation of CYP2C9 gene. Role of glucocorticoid receptor and constitutive androstane receptor","volume":"277","author":"Gerbal-Chaloin","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1124\/mol.64.2.316_bib4","first-page":"242","article-title":"Induction of CYP2C genes in human hepatocytes in primary culture","volume":"29","author":"Gerbal-Chaloin","year":"2001","journal-title":"Drug Metab Dispos"},{"key":"10.1124\/mol.64.2.316_bib5","series-title":"The Genetic Basis of CYP2C9 and CYP2C19 Polymorphisms.","author":"Goldstein","year":"1996"},{"key":"10.1124\/mol.64.2.316_bib6","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1097\/00008571-199412000-00001","article-title":"Biochemistry and molecular biology of the human CYP2C subfamily","volume":"4","author":"Goldstein","year":"1994","journal-title":"Pharmacogenetics"},{"key":"10.1124\/mol.64.2.316_bib7","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1021\/bi00173a017","article-title":"Evidence that CYP2C19 is the major (S)mephenytoin 4\u2032-hydroxylase in humans","volume":"33","author":"Goldstein","year":"1994","journal-title":"Biochemistry"},{"key":"10.1124\/mol.64.2.316_bib8","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1124\/mol.62.2.359","article-title":"Transcriptional regulation of the human CYP3A4 gene by the constitutive androstane receptor","volume":"62","author":"Goodwin","year":"2002","journal-title":"Mol Pharmacol"},{"key":"10.1124\/mol.64.2.316_bib9","first-page":"1329","article-title":"The orphan human pregnane X receptor mediates the transcriptional activation of CYP3A4 by rifampicin through a distal enhancer module","volume":"56","author":"Goodwin","year":"1999","journal-title":"Mol Pharmacol"},{"key":"10.1124\/mol.64.2.316_bib10","doi-asserted-by":"crossref","first-page":"14943","DOI":"10.1074\/jbc.272.23.14943","article-title":"Characterization of a phenobarbital-responsive enhancer module in mouse P450 Cyp2b10 gene","volume":"272","author":"Honkakoski","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1124\/mol.64.2.316_bib11","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/(SICI)1099-0461(1998)12:1<3::AID-JBT2>3.0.CO;2-P","article-title":"Regulatory DNA elements of phenobarbital-responsive cytochrome P450 CYP2B genes","volume":"12","author":"Honkakoski","year":"1998","journal-title":"J Biochem Mol Toxicol"},{"key":"10.1124\/mol.64.2.316_bib12","doi-asserted-by":"crossref","first-page":"6318","DOI":"10.1128\/MCB.19.9.6318","article-title":"Phenobarbital-responsive nuclear translocation of the receptor CAR in induction of the CYP2B gene","volume":"19","author":"Kawamoto","year":"1999","journal-title":"Mol Cell Biol"},{"key":"10.1124\/mol.64.2.316_bib13","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1124\/mol.63.3.524","article-title":"Molecular mechanism of nuclear translocation of an orphan nuclear receptor, SXR","volume":"63","author":"Kawana","year":"2003","journal-title":"Mol Pharmacol"},{"key":"10.1124\/mol.64.2.316_bib14","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1172\/JCI3703","article-title":"The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions","volume":"102","author":"Lehmann","year":"1998","journal-title":"J Clin Investig"},{"key":"10.1124\/mol.64.2.316_bib15","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S0026-895X(24)12072-X","article-title":"Dexamethasone induces pregnane X receptor and retinoid X receptor-alpha expression in human hepatocytes: synergistic increase of CYP3A4 induction by pregnane X receptor activators","volume":"58","author":"Pascussi","year":"2000","journal-title":"Mol Pharmacol"},{"key":"10.1124\/mol.64.2.316_bib16","doi-asserted-by":"crossref","first-page":"6346","DOI":"10.1046\/j.0014-2956.2001.02540.x","article-title":"Dual effect of dexamethasone on CYP3A4 gene expression in human hepatocytes. Sequential role of glucocorticoid receptor and pregnane X receptor","volume":"268","author":"Pascussi","year":"2001","journal-title":"Eur J Biochem"},{"key":"10.1124\/mol.64.2.316_bib17","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0304-4165(02)00483-X","article-title":"The expression of CYP2B6, CYP2C9 and CYP3A4 genes: a tangle of networks of nuclear and steroid receptors","volume":"1619","author":"Pascussi","year":"2003","journal-title":"Biochim Biophys Acta"},{"key":"10.1124\/mol.64.2.316_bib18","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1006\/abbi.1997.0467","article-title":"Characterization of DNA-binding proteins required for glucocorticoid induction of CYP3A23","volume":"349","author":"Quattrochi","year":"1998","journal-title":"Arch Biochem Biophys"},{"key":"10.1124\/mol.64.2.316_bib19","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1124\/jpet.102.033837","article-title":"Expression and induction of CYP2C P450 enzymes in primary cultures of human hepatocytes","volume":"302","author":"Raucy","year":"2002","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/mol.64.2.316_bib20","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/S0304-4165(02)00484-1","article-title":"Transcriptional analysis in vivo of the hepatic genes, Cyp2b9 and Cyp2b10, by intravenous administration of plasmid DNA in mice","volume":"1619","author":"Rivera-Rivera","year":"2003","journal-title":"Biochim Biophys Acta"},{"key":"10.1124\/mol.64.2.316_bib21","doi-asserted-by":"crossref","first-page":"6043","DOI":"10.1074\/jbc.274.10.6043","article-title":"The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene","volume":"274","author":"Sueyoshi","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1124\/mol.64.2.316_bib22","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1038\/nm815","article-title":"The orphan nuclear receptor HNF4alpha determines PXR- and CAR-mediated xenobiotic induction of CYP3A4","volume":"9","author":"Tirona","year":"2003","journal-title":"Nat Med"},{"key":"10.1124\/mol.64.2.316_bib23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1124\/mol.61.1.1","article-title":"Diverse roles of the nuclear orphan receptor CAR in regulating hepatic genes in response to phenobarbital","volume":"61","author":"Ueda","year":"2002","journal-title":"Mol Pharmacol"},{"key":"10.1124\/mol.64.2.316_bib24","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1038\/35038112","article-title":"The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism","volume":"407","author":"Wei","year":"2000","journal-title":"Nature (Lond)"},{"key":"10.1124\/mol.64.2.316_bib25","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1111\/j.1365-2125.1990.tb03799.x","article-title":"Induction of polymorphic 4\u2032-hydroxylation of S-mephenytoin by rifampicin","volume":"30","author":"Zhou","year":"1990","journal-title":"Br J Clin Pharmacol"}],"container-title":["Molecular Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026895X24055615?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026895X24055615?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/mol.64.2.316","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T08:42:15Z","timestamp":1740040935000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0026895X24055615"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,8]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2003,8]]}},"alternative-id":["S0026895X24055615"],"URL":"https:\/\/doi.org\/10.1124\/mol.64.2.316","relation":{},"ISSN":["0026-895X"],"issn-type":[{"value":"0026-895X","type":"print"}],"subject":[],"published":{"date-parts":[[2003,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Identification of Constitutive Androstane Receptor and Glucocorticoid Receptor Binding Sites in the CYP2C19 Promoter","name":"articletitle","label":"Article Title"},{"value":"Molecular Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/mol.64.2.316","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2003 The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}