{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T17:40:50Z","timestamp":1790185250595,"version":"4.1.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2003,8,1]],"date-time":"2003-08-01T00:00:00Z","timestamp":1059696000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2003,8,1]],"date-time":"2003-08-01T00:00:00Z","timestamp":1059696000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["molpharm.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Pharmacology"],"published-print":{"date-parts":[[2003,8]]},"DOI":"10.1124\/mol.64.2.521","type":"journal-article","created":{"date-parts":[[2003,7,17]],"date-time":"2003-07-17T21:32:25Z","timestamp":1058477545000},"page":"521-532","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":54,"title":["cGMP\/Protein Kinase G-Dependent Potentiation of Glutamatergic Transmission Induced by Nitric Oxide in Immature Rat Rostral Ventrolateral Medulla Neurons in Vitro"],"prefix":"10.1016","volume":"64","author":[{"given":"Chiung-Chun","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel H. H","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuei-Sen","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1124\/mol.64.2.521_bib1","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/376074a0","article-title":"Activity-dependent long-term enhancement of transmitter release by presynaptic 3\u2032,5\u2032-cyclic GMP in cultured hippocampal neurons","volume":"376","author":"Arancio","year":"1995","journal-title":"Nature (Lond)"},{"key":"10.1124\/mol.64.2.521_bib2","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1046\/j.0953-816x.2001.01680.x","article-title":"Exogenous nitric oxide causes potentiation of hippocampal synaptic transmission during low-frequency stimulation via the endogenous nitric oxide-cGMP pathway","volume":"14","author":"Bon","year":"2001","journal-title":"Eur J Neurosci"},{"key":"10.1124\/mol.64.2.521_bib3","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1111\/j.1460-9568.1994.tb00543.x","article-title":"The nitric oxide-cyclic GMP pathway and synaptic depression in rat hippocampal slices","volume":"6","author":"Boulton","year":"1994","journal-title":"Eur J Neurosci"},{"key":"10.1124\/mol.64.2.521_bib4","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1038\/sj.bjp.0704105","article-title":"Differential cardiovascular responses to blockade of nNOS or iNOS in rostral ventrolateral medulla of the rat","volume":"133","author":"Chan","year":"2001","journal-title":"Br J Pharmacol"},{"key":"10.1124\/mol.64.2.521_bib5","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1007\/BF02256610","article-title":"Engagement of inducible nitric oxide synthase at the rostral ventrolateral medulla during mevinphos intoxication in the rat","volume":"8","author":"Chang","year":"2001","journal-title":"J Biomed Sci"},{"key":"10.1124\/mol.64.2.521_bib6","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/0301-0082(94)90064-7","article-title":"The subretrofacial vasomotor nucleus: anatomical, chemical and pharmacological properties and role in cardiovascular regulation","volume":"42","author":"Dampney","year":"1994","journal-title":"Prog Neurobiol"},{"key":"10.1124\/mol.64.2.521_bib7","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1113\/jphysiol.1995.sp020892","article-title":"Medullary-evoked EPSPs in neonatal rat sympathetic preganglionic neurones in vitro","volume":"487","author":"Deuchars","year":"1995","journal-title":"J Physiol"},{"key":"10.1124\/mol.64.2.521_bib8","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1038\/313310a0","article-title":"Induction by cyclic GMP of cationic conductance in plasma membrane of retinal rod outer segment","volume":"313","author":"Fesenko","year":"1985","journal-title":"Nature (Lond)"},{"key":"10.1124\/mol.64.2.521_bib9","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/0166-2236(91)90022-M","article-title":"Glutamate, nitric oxide and cell-cell signalling in the nervous system","volume":"14","author":"Garthwaite","year":"1991","journal-title":"Trends Neurosci"},{"key":"10.1124\/mol.64.2.521_bib10","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0079-6123(08)61862-2","article-title":"Role of medulla oblongata in generation of sympathetic and vagal outflows","volume":"107","author":"Guyenet","year":"1996","journal-title":"Prog Brain Res"},{"key":"10.1124\/mol.64.2.521_bib11","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1113\/jphysiol.1995.sp020527","article-title":"Evidence for a critical role of nitric oxide in the tonic excitation of rabbit renal sympathetic preganglionic neurons","volume":"482","author":"Hakim","year":"1995","journal-title":"J Physiol"},{"key":"10.1124\/mol.64.2.521_bib12","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1152\/jn.2000.83.1.198","article-title":"Calcium channel activation facilitated by nitric oxide in retinal ganglion cells","volume":"83","author":"Hirooka","year":"2000","journal-title":"J Neurophysiol"},{"key":"10.1124\/mol.64.2.521_bib13","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1097\/00004872-199611000-00010","article-title":"Pressor and sympathoexcitatory effects of nitric oxide in the rostral ventrolateral medulla","volume":"14","author":"Hirooka","year":"1996","journal-title":"J Hypertens"},{"key":"10.1124\/mol.64.2.521_bib14","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0014-2999(98)00009-0","article-title":"Radical releasing properties of nitric oxide donors GEA 3162, SIN-1, and S-nitroso-N-acetylpenicillamine","volume":"346","author":"Holm","year":"1998","journal-title":"Eur J Pharmacol"},{"key":"10.1124\/mol.64.2.521_bib15","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1111\/j.1469-7793.2001.0731e.x","article-title":"Presynaptic mechanisms underlying cannabinoid inhibition of excitatory synaptic transmission in rat striatal neurons","volume":"532","author":"Huang","year":"2001","journal-title":"J Physiol"},{"key":"10.1124\/mol.64.2.521_bib16","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1152\/jn.1998.80.3.1033","article-title":"5-Hydroxytryptamine responses in immature rat rostral ventrolateral medulla neurons in vitro","volume":"80","author":"Hwang","year":"1998","journal-title":"J Neurophysiol"},{"key":"10.1124\/mol.64.2.521_bib17","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/0006-2952(91)90618-F","article-title":"Signal transduction mechanisms involving nitric oxide","volume":"41","author":"Ignarro","year":"1991","journal-title":"Biochem Pharmacol"},{"key":"10.1124\/mol.64.2.521_bib18","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0006-8993(97)00336-3","article-title":"Cardiovascular effects of nitric oxide in the rostral ventrolateral medulla of rats","volume":"757","author":"Kagiyama","year":"1997","journal-title":"Brain Res"},{"key":"10.1124\/mol.64.2.521_bib19","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/0168-0102(87)90014-9","article-title":"Presynaptic Ca-antagonist omega-conotoxin irreversibly blocks N-type Ca-channels in chick sensory neurons","volume":"4","author":"Kasai","year":"1987","journal-title":"Neurosci Res"},{"key":"10.1124\/mol.64.2.521_bib20","series-title":"The Release of Neural Transmitter Substances","author":"Katz","year":"1969"},{"key":"10.1124\/mol.64.2.521_bib21","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1038\/31255","article-title":"A family of hyperpolarization-activated mammalian cation channels","volume":"393","author":"Ludwig","year":"1998","journal-title":"Nature (Lond)"},{"key":"10.1124\/mol.64.2.521_bib22","doi-asserted-by":"crossref","first-page":"11285","DOI":"10.1073\/pnas.88.24.11285","article-title":"Tests of the roles of two diffusible substances in long-term potentiation: evidence for nitric oxide as a possible early retrograde messenger","volume":"88","author":"O\u2019Dell","year":"1991","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/mol.64.2.521_bib23","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/358676a0","article-title":"Nitric oxide release from a single cell measured in situ by a porphyrinic-based microsensor","volume":"358","author":"Malinski","year":"1992","journal-title":"Nature (Lond)"},{"key":"10.1124\/mol.64.2.521_bib24","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/0006-8993(91)91196-8","article-title":"Rostral ventrolateral medulla: a source of the glutamatergic innervation of the sympathetic intermediolateral nucleus","volume":"562","author":"Morrison","year":"1991","journal-title":"Brain Res"},{"key":"10.1124\/mol.64.2.521_bib25","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1002\/cne.903510103","article-title":"Medullary visceral reflex circuits: local afferents to nucleus tractus solitarii synthesize catecholamines and project to thoracic spinal cord","volume":"351","author":"Mtui","year":"1995","journal-title":"J Comp Neurol"},{"key":"10.1124\/mol.64.2.521_bib26","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/0165-6147(91)90484-A","article-title":"Differential modulation of tissue function and therapeutic potential of selective inhibitors of cyclic nucleotide phosphodiesterase isoenzymes","volume":"12","author":"Nicholson","year":"1991","journal-title":"Trends Pharmacol Sci"},{"key":"10.1124\/mol.64.2.521_bib27","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1038\/327524a0","article-title":"Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor","volume":"327","author":"Palmer","year":"1987","journal-title":"Nature (Lond)"},{"key":"10.1124\/mol.64.2.521_bib28","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1038\/323812a0","article-title":"cGMP-dependent protein kinase enhances Ca2+ current and potentiates the serotonin-induced Ca2+ current increase in snail neurons","volume":"323","author":"Paupardin-Tritsch","year":"1986","journal-title":"Nature (Lond)"},{"key":"10.1124\/mol.64.2.521_bib29","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1523\/JNEUROSCI.16-04-01389.1996","article-title":"Nitric oxide and carbon monoxide activate locus coeruleus neurons through a cGMP-dependent protein kinase: involvement of a nonselective cationic channel","volume":"16","author":"Pineda","year":"1996","journal-title":"J Neurosci"},{"key":"10.1124\/mol.64.2.521_bib30","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.1111\/j.1460-9568.1995.tb00709.x","article-title":"Extracellular activation of unitary excitatory synapses between hippocampal CA3 and CA1 pyramidal cells","volume":"7","author":"Raastad","year":"1995","journal-title":"Eur J Neurosci"},{"key":"10.1124\/mol.64.2.521_bib31","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1021\/tx960183w","article-title":"Measurement and modeling of nitric oxide release rates for nitric oxide donors","volume":"10","author":"Ramamurthi","year":"1997","journal-title":"Chem Res Toxicol"},{"key":"10.1124\/mol.64.2.521_bib32","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1523\/JNEUROSCI.04-02-00474.1984","article-title":"Tonic vasomotor control by the rostral ventrolateral medulla: effect of electrical or chemical stimulation of the area containing C1 adrenaline neurons on arterial pressure, heart rate and plasma catecholamines and vasopressin","volume":"4","author":"Ross","year":"1984","journal-title":"J Neurosci"},{"key":"10.1124\/mol.64.2.521_bib33","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/0896-6273(92)90244-8","article-title":"Presynaptic inhibition of miniature excitatory synaptic currents by baclofen and adenosine in the hippocampus","volume":"9","author":"Scanziani","year":"1992","journal-title":"Neuron"},{"key":"10.1124\/mol.64.2.521_bib34","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1038\/349326a0","article-title":"Endogenous nitric oxide release required for long-term synaptic depression in the cerebellum","volume":"349","author":"Shibuki","year":"1991","journal-title":"Nature (Lond)"},{"key":"10.1124\/mol.64.2.521_bib35","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1038\/371704a0","article-title":"Changes in reliability of synaptic function as a mechanism for plasticity","volume":"371","author":"Stevens","year":"1994","journal-title":"Nature (Lond)"},{"key":"10.1124\/mol.64.2.521_bib36","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1111\/j.1749-6632.2001.tb03681.x","article-title":"Excitatory inputs to the RVLM in the context of the baroreceptor reflex","volume":"940","author":"Sved","year":"2001","journal-title":"Ann NY Acad Sci"},{"key":"10.1124\/mol.64.2.521_bib37","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1046\/j.1471-4159.2001.00584.x","article-title":"SIN-1-induced cytotoxicity in mixed cortical cell culture: peroxynitrite-dependent and -independent induction of excitotoxic cell death","volume":"79","author":"Trackey","year":"2001","journal-title":"J Neurochem"},{"key":"10.1124\/mol.64.2.521_bib38","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/0306-4522(92)90184-4","article-title":"Histochemical mapping of nitric oxide synthase in the rat brain","volume":"46","author":"Vincent","year":"1992","journal-title":"Neuroscience"},{"key":"10.1124\/mol.64.2.521_bib39","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1126\/science.7832825","article-title":"Roles of N-type and Q-type Ca2+ channels in supporting hippocampal synaptic transmission","volume":"264","author":"Wheeler","year":"1994","journal-title":"Science (Wash DC)"},{"key":"10.1124\/mol.64.2.521_bib40","first-page":"R958","article-title":"Inhibition of basal and reflex-mediated sympathetic activity in the RVLM by nitric oxide","volume":"268","author":"Zanzinger","year":"1995","journal-title":"Am J Physiol"},{"key":"10.1124\/mol.64.2.521_bib41","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1146\/annurev.ne.12.030189.000305","article-title":"Short-term synaptic plasticity","volume":"12","author":"Zucker","year":"1989","journal-title":"Annu Rev Neurosci"}],"container-title":["Molecular Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026895X24055834?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026895X24055834?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/mol.64.2.521","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T08:44:19Z","timestamp":1740041059000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0026895X24055834"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,8]]},"references-count":41,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2003,8]]}},"alternative-id":["S0026895X24055834"],"URL":"https:\/\/doi.org\/10.1124\/mol.64.2.521","relation":{},"ISSN":["0026-895X"],"issn-type":[{"value":"0026-895X","type":"print"}],"subject":[],"published":{"date-parts":[[2003,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"cGMP\/Protein Kinase G-Dependent Potentiation of Glutamatergic Transmission Induced by Nitric Oxide in Immature Rat Rostral Ventrolateral Medulla Neurons in Vitro","name":"articletitle","label":"Article Title"},{"value":"Molecular Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/mol.64.2.521","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2003 The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}