{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T22:26:34Z","timestamp":1769552794200,"version":"3.49.0"},"reference-count":64,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["molpharm.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Pharmacology"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1124\/molpharm.120.000146","type":"journal-article","created":{"date-parts":[[2020,12,29]],"date-time":"2020-12-29T22:10:29Z","timestamp":1609279829000},"page":"197-216","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Transcriptome-Level Interactions between Budesonide and Formoterol Provide Insight into the Mechanism of Action of Inhaled Corticosteroid\/Long-Acting \u03b22-Adrenoceptor Agonist Combination Therapy in Asthma"],"prefix":"10.1016","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6377-911X","authenticated-orcid":false,"given":"Mahmoud M.","family":"Mostafa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0399-5931","authenticated-orcid":false,"given":"Christopher F.","family":"Rider","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. Dulmini","family":"Wathugala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Leigh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark A.","family":"Giembycz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4919-8498","authenticated-orcid":false,"given":"Robert","family":"Newton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"Suppl 1","key":"10.1124\/molpharm.120.000146_bib1","first-page":"S1","article-title":"THE CONCISE GUIDE TO PHARMACOLOGY 2017\/18: overview","volume":"174","author":"Alexander","year":"2017","journal-title":"Br J Pharmacol"},{"key":"10.1124\/molpharm.120.000146_bib2","doi-asserted-by":"crossref","first-page":"L358","DOI":"10.1152\/ajplung.00426.2016","article-title":"Long-acting \u03b22-agonists promote glucocorticoid-mediated repression of NF-\u03baB by enhancing expression of the feedback regulator TNFAIP3","volume":"312","author":"Altonsy","year":"2017","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1124\/molpharm.120.000146_bib3","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1165\/ajrcmb.26.4.4681","article-title":"Tumor necrosis factor-alpha-induced secretion of RANTES and interleukin-6 from human airway smooth muscle cells: modulation by glucocorticoids and beta-agonists","volume":"26","author":"Ammit","year":"2002","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1124\/molpharm.120.000146_bib4","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/j.1476-5381.2010.01199.x","article-title":"Glucocorticosteroids: current and future directions","volume":"163","author":"Barnes","year":"2011","journal-title":"Br J Pharmacol"},{"key":"10.1124\/molpharm.120.000146_bib5","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1124\/mol.114.093393","article-title":"Superiority of combined phosphodiesterase PDE3\/PDE4 inhibition over PDE4 inhibition alone on glucocorticoid- and long-acting \u03b22-adrenoceptor agonist-induced gene expression in human airway epithelial cells","volume":"87","author":"BinMahfouz","year":"2015","journal-title":"Mol Pharmacol"},{"key":"10.1124\/molpharm.120.000146_bib6","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1210\/me.2014-1362","article-title":"Glucocorticoid regulation of lung development: lessons learned from conditional GR knockout mice","volume":"29","author":"Bird","year":"2015","journal-title":"Mol Endocrinol"},{"key":"10.1124\/molpharm.120.000146_bib7","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.tem.2012.11.005","article-title":"The five Rs of glucocorticoid action during inflammation: ready, reinforce, repress, resolve, and restore","volume":"24","author":"Busillo","year":"2013","journal-title":"Trends Endocrinol Metab"},{"key":"10.1124\/molpharm.120.000146_bib8","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1186\/1471-2164-15-656","article-title":"Glucocorticoid receptor coordinates transcription factor-dominated regulatory network in macrophages","volume":"15","author":"Chinenov","year":"2014","journal-title":"BMC Genomics"},{"key":"10.1124\/molpharm.120.000146_bib9","doi-asserted-by":"crossref","first-page":"19428","DOI":"10.1073\/pnas.0709013104","article-title":"Distinguishing protein-coding and noncoding genes in the human genome","volume":"104","author":"Clamp","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/molpharm.120.000146_bib10","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.pharmthera.2011.12.004","article-title":"Maps and legends: the quest for dissociated ligands of the glucocorticoid receptor","volume":"134","author":"Clark","year":"2012","journal-title":"Pharmacol Ther"},{"key":"10.1124\/molpharm.120.000146_bib11","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1042\/BST20160166","article-title":"The control of inflammation via the phosphorylation and dephosphorylation of tristetraprolin: a tale of two phosphatases","volume":"44","author":"Clark","year":"2016","journal-title":"Biochem Soc Trans"},{"key":"10.1124\/molpharm.120.000146_bib12","doi-asserted-by":"crossref","first-page":"25765","DOI":"10.1074\/jbc.R700053200","article-title":"Role of dual specificity phosphatases in biological responses to glucocorticoids","volume":"283","author":"Clark","year":"2008","journal-title":"J Biol Chem"},{"key":"10.1124\/molpharm.120.000146_bib13","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/S2213-2600(13)70044-4","article-title":"Are inhaled longacting \u03b22 agonists detrimental to asthma?","volume":"1","author":"Cockcroft","year":"2013","journal-title":"Lancet Respir Med"},{"key":"10.1124\/molpharm.120.000146_bib14","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1164\/rccm.201905-0953ED","article-title":"Advancing understanding of mechanisms of severe asthma and drug effects using transcriptomics","volume":"200","author":"Djukanovi\u0107","year":"2019","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1124\/molpharm.120.000146_bib15","doi-asserted-by":"crossref","first-page":"15366","DOI":"10.1074\/jbc.M701325200","article-title":"Corticosteroids and beta2 agonists differentially regulate rhinovirus-induced interleukin-6 via distinct Cis-acting elements","volume":"282","author":"Edwards","year":"2007","journal-title":"J Biol Chem"},{"key":"10.1124\/molpharm.120.000146_bib16","doi-asserted-by":"crossref","first-page":"5866","DOI":"10.1093\/hmg\/ddu309","article-title":"Multiple evidence strands suggest that there may be as few as 19,000 human protein-coding genes","volume":"23","author":"Ezkurdia","year":"2014","journal-title":"Hum Mol Genet"},{"key":"10.1124\/molpharm.120.000146_bib17","doi-asserted-by":"crossref","DOI":"10.1002\/prp2.149","article-title":"Analysis of drug combinations: current methodological landscape","volume":"3","author":"Foucquier","year":"2015","journal-title":"Pharmacol Res Perspect"},{"key":"10.1124\/molpharm.120.000146_bib18","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0170269","article-title":"Protective roles for RGS2 in a mouse model of house dust mite-induced airway inflammation","volume":"12","author":"George","year":"2017","journal-title":"PLoS One"},{"key":"10.1124\/molpharm.120.000146_bib19","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s13223-018-0266-5","article-title":"Rgs2 in a murine model of lipopolysaccharide-induced airways inflammation","volume":"14","author":"George","year":"2018","journal-title":"Allergy Asthma Clin Immunol"},{"key":"10.1124\/molpharm.120.000146_bib20","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0076-6879(04)90005-5","article-title":"RGS2-mediated regulation of Gqalpha","volume":"390","author":"Heximer","year":"2004","journal-title":"Methods Enzymol"},{"key":"10.1124\/molpharm.120.000146_bib21","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0099625","article-title":"RNA-Seq transcriptome profiling identifies CRISPLD2 as a glucocorticoid responsive gene that modulates cytokine function in airway smooth muscle cells","volume":"9","author":"Himes","year":"2014","journal-title":"PLoS One"},{"key":"10.1124\/molpharm.120.000146_bib22","doi-asserted-by":"crossref","first-page":"19713","DOI":"10.1073\/pnas.1110226108","article-title":"\u03b22-Adrenoceptor agonist-induced RGS2 expression is a genomic mechanism of bronchoprotection that is enhanced by glucocorticoids","volume":"108","author":"Holden","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/molpharm.120.000146_bib23","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1124\/jpet.113.204586","article-title":"Induction of regulator of G-protein signaling 2 expression by long-acting \u03b22-adrenoceptor agonists and glucocorticoids in human airway epithelial cells","volume":"348","author":"Holden","year":"2014","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/molpharm.120.000146_bib24","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1111\/j.1476-5381.2010.00708.x","article-title":"Enhancement of inflammatory mediator release by beta(2)-adrenoceptor agonists in airway epithelial cells is reversed by glucocorticoid action","volume":"160","author":"Holden","year":"2010","journal-title":"Br J Pharmacol"},{"key":"10.1124\/molpharm.120.000146_bib25","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2008.211","article-title":"Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources","volume":"4","author":"Huang","year":"2009","journal-title":"Nat Protoc"},{"key":"10.1124\/molpharm.120.000146_bib26","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1183\/09031936.00128809","article-title":"Cigarette smoke modulates rhinovirus-induced airway epithelial cell chemokine production","volume":"35","author":"Hudy","year":"2010","journal-title":"Eur Respir J"},{"key":"10.1124\/molpharm.120.000146_bib27","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/nrd2289","article-title":"Targeting dual-specificity phosphatases: manipulating MAP kinase signalling and immune responses","volume":"6","author":"Jeffrey","year":"2007","journal-title":"Nat Rev Drug Discov"},{"key":"10.1124\/molpharm.120.000146_bib28","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1165\/rcmb.2014-0319OC","article-title":"Regulator of G-protein signaling 2 repression exacerbates airway hyper-responsiveness and remodeling in asthma","volume":"53","author":"Jiang","year":"2015","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1124\/molpharm.120.000146_bib29","doi-asserted-by":"crossref","first-page":"2634","DOI":"10.1111\/bph.13087","article-title":"The long-acting \u03b22 -adrenoceptor agonist, indacaterol, enhances glucocorticoid receptor-mediated transcription in human airway epithelial cells in a gene- and agonist-dependent manner","volume":"172","author":"Joshi","year":"2015","journal-title":"Br J Pharmacol"},{"key":"10.1124\/molpharm.120.000146_bib30","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1165\/rcmb.2018-0385OC","article-title":"Airway smooth muscle-specific transcriptomic signatures of glucocorticoid exposure","volume":"61","author":"Kan","year":"2019","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1124\/molpharm.120.000146_bib31","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1124\/mol.107.040121","article-title":"Long-acting beta2-adrenoceptor agonists synergistically enhance glucocorticoid-dependent transcription in human airway epithelial and smooth muscle cells","volume":"73","author":"Kaur","year":"2008","journal-title":"Mol Pharmacol"},{"key":"10.1124\/molpharm.120.000146_bib32","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1111\/j.1476-5381.2011.01620.x","article-title":"Corticosteroid-induced gene expression in allergen-challenged asthmatic subjects taking inhaled budesonide","volume":"165","author":"Kelly","year":"2012","journal-title":"Br J Pharmacol"},{"key":"10.1124\/molpharm.120.000146_bib33","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1124\/pr.110.003038","article-title":"Regulators of G-protein signaling and their G\u03b1 substrates: promises and challenges in their use as drug discovery targets","volume":"63","author":"Kimple","year":"2011","journal-title":"Pharmacol Rev"},{"key":"10.1124\/molpharm.120.000146_bib34","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1124\/jpet.109.151423","article-title":"Regulation of tristetraprolin expression by interleukin-1 beta and dexamethasone in human pulmonary epithelial cells: roles for nuclear factor-kappa B and p38 mitogen-activated protein kinase","volume":"330","author":"King","year":"2009","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/molpharm.120.000146_bib35","doi-asserted-by":"crossref","first-page":"48","DOI":"10.4049\/jimmunol.1601691","article-title":"Airway epithelial cells are crucial targets of glucocorticoids in a mouse model of allergic asthma","volume":"199","author":"Kla\u00dfen","year":"2017","journal-title":"J Immunol"},{"key":"10.1124\/molpharm.120.000146_bib36","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1046\/j.1440-1843.2003.00493.x","article-title":"The airway epithelium: structural and functional properties in health and disease","volume":"8","author":"Knight","year":"2003","journal-title":"Respirology"},{"key":"10.1124\/molpharm.120.000146_bib37","doi-asserted-by":"crossref","DOI":"10.1002\/prp2.243","article-title":"An inhaled dose of budesonide induces genes involved in transcription and signaling in the human airways: enhancement of anti- and proinflammatory effector genes","volume":"4","author":"Leigh","year":"2016","journal-title":"Pharmacol Res Perspect"},{"key":"10.1124\/molpharm.120.000146_bib38","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0059635","article-title":"Long-acting \u03b22-agonists increase fluticasone propionate-induced mitogen-activated protein kinase phosphatase 1 (MKP-1) in airway smooth muscle cells","volume":"8","author":"Manetsch","year":"2013","journal-title":"PLoS One"},{"key":"10.1124\/molpharm.120.000146_bib39","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1111\/j.1476-5381.2012.01923.x","article-title":"Corticosteroids and \u03b22-agonists upregulate mitogen-activated protein kinase phosphatase 1: in vitro mechanisms","volume":"166","author":"Manetsch","year":"2012","journal-title":"Br J Pharmacol"},{"key":"10.1124\/molpharm.120.000146_bib40","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/35085068","article-title":"Transcriptional regulation by the phosphorylation-dependent factor CREB","volume":"2","author":"Mayr","year":"2001","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1124\/molpharm.120.000146_bib41","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.pharmthera.2016.06.009","article-title":"Biologics and the lung: TSLP and other epithelial cell-derived cytokines in asthma","volume":"169","author":"Mitchell","year":"2017","journal-title":"Pharmacol Ther"},{"key":"10.1124\/molpharm.120.000146_bib42","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s12920-018-0467-2","article-title":"Glucocorticoid-driven transcriptomes in human airway epithelial cells: commonalities, differences and functional insight from cell lines and primary cells","volume":"12","author":"Mostafa","year":"2019","journal-title":"BMC Med Genomics"},{"key":"10.1124\/molpharm.120.000146_bib43","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1378\/chest.129.1.15","article-title":"The Salmeterol Multicenter Asthma Research Trial: a comparison of usual pharmacotherapy for asthma or usual pharmacotherapy plus salmeterol","volume":"129","author":"Nelson","year":"2006","journal-title":"Chest"},{"key":"10.1124\/molpharm.120.000146_bib44","doi-asserted-by":"crossref","first-page":"3405","DOI":"10.1111\/bph.13628","article-title":"Understanding how long-acting \u03b22 -adrenoceptor agonists enhance the clinical efficacy of inhaled corticosteroids in asthma - an update","volume":"173","author":"Newton","year":"2016","journal-title":"Br J Pharmacol"},{"key":"10.1124\/molpharm.120.000146_bib45","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1124\/mol.107.038794","article-title":"Separating transrepression and transactivation: a distressing divorce for the glucocorticoid receptor?","volume":"72","author":"Newton","year":"2007","journal-title":"Mol Pharmacol"},{"key":"10.1124\/molpharm.120.000146_bib46","doi-asserted-by":"crossref","first-page":"7163","DOI":"10.1074\/jbc.R117.777318","article-title":"Glucocorticoid and cytokine crosstalk: feedback, feedforward, and co-regulatory interactions determine repression or resistance","volume":"292","author":"Newton","year":"2017","journal-title":"J Biol Chem"},{"key":"10.1124\/molpharm.120.000146_bib47","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/j.jaci.2013.09.007","article-title":"The biology of the glucocorticoid receptor: new signaling mechanisms in health and disease","volume":"132","author":"Oakley","year":"2013","journal-title":"J Allergy Clin Immunol"},{"key":"10.1124\/molpharm.120.000146_bib48","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.immuni.2017.07.012","article-title":"Anti-inflammatory chromatinscape suggests alternative mechanisms of glucocorticoid receptor action","volume":"47","author":"Oh","year":"2017","journal-title":"Immunity"},{"key":"10.1124\/molpharm.120.000146_bib49","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.01046-2019","article-title":"GINA 2019: a fundamental change in asthma management: treatment of asthma with short-acting bronchodilators alone is no longer recommended for adults and adolescents","volume":"53","author":"Reddel","year":"2019","journal-title":"Eur Respir J"},{"key":"10.1124\/molpharm.120.000146_bib50","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1101\/gr.097022.109","article-title":"Genomic determination of the glucocorticoid response reveals unexpected mechanisms of gene regulation","volume":"19","author":"Reddy","year":"2009","journal-title":"Genome Res"},{"key":"10.1124\/molpharm.120.000146_bib51","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1124\/mol.118.112755","article-title":"Long-acting \u03b22-adrenoceptor agonists enhance glucocorticoid receptor (GR)-Mediated transcription by gene-specific mechanisms rather than generic effects via GR","volume":"94","author":"Rider","year":"2018","journal-title":"Mol Pharmacol"},{"key":"10.1124\/molpharm.120.000146_bib52","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1124\/jpet.111.181016","article-title":"Inflammatory stimuli inhibit glucocorticoid-dependent transactivation in human pulmonary epithelial cells: rescue by long-acting beta2-adrenoceptor agonists","volume":"338","author":"Rider","year":"2011","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/molpharm.120.000146_bib53","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0116773","article-title":"Cytokine-induced loss of glucocorticoid function: effect of kinase inhibitors, long-acting \u03b2(2)-adrenoceptor [corrected] agonist and glucocorticoid receptor ligands [published correction appears in PLoS One (2015) 10:e0128728]","volume":"10","author":"Rider","year":"2015","journal-title":"PLoS One"},{"key":"10.1124\/molpharm.120.000146_bib54","doi-asserted-by":"crossref","first-page":"265","DOI":"10.4049\/jimmunol.1402826","article-title":"Dominant suppression of inflammation via targeted mutation of the mRNA destabilizing protein tristetraprolin","volume":"195","author":"Ross","year":"2015","journal-title":"J Immunol"},{"key":"10.1124\/molpharm.120.000146_bib55","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.pharmthera.2014.08.004","article-title":"Feed-forward transcriptional programming by nuclear receptors: regulatory principles and therapeutic implications","volume":"145","author":"Sasse","year":"2014","journal-title":"Pharmacol Ther"},{"key":"10.1124\/molpharm.120.000146_bib56","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a011148","article-title":"The cyclic AMP pathway","volume":"4","author":"Sassone-Corsi","year":"2012","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"10.1124\/molpharm.120.000146_bib57","doi-asserted-by":"crossref","first-page":"13667","DOI":"10.1074\/jbc.M113.540799","article-title":"Roles for the mitogen-activated protein kinase (MAPK) phosphatase, DUSP1, in feedback control of inflammatory gene expression and repression by dexamethasone","volume":"289","author":"Shah","year":"2014","journal-title":"J Biol Chem"},{"key":"10.1124\/molpharm.120.000146_bib58","doi-asserted-by":"crossref","first-page":"9126","DOI":"10.1128\/MCB.00679-06","article-title":"Glucocorticoids regulate tristetraprolin synthesis and posttranscriptionally regulate tumor necrosis factor alpha inflammatory signaling","volume":"26","author":"Smoak","year":"2006","journal-title":"Mol Cell Biol"},{"key":"10.1124\/molpharm.120.000146_bib59","doi-asserted-by":"crossref","DOI":"10.2202\/1544-6115.1027","article-title":"Linear models and empirical bayes methods for assessing differential expression in microarray experiments","volume":"3","author":"Smyth","year":"2004","journal-title":"Stat Appl Genet Mol Biol"},{"key":"10.1124\/molpharm.120.000146_bib60","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1016\/j.rmed.2006.11.014","article-title":"Effect of formoterol and salmeterol on IL-6 and IL-8 release in airway epithelial cells","volume":"101","author":"Strandberg","year":"2007","journal-title":"Respir Med"},{"key":"10.1124\/molpharm.120.000146_bib61","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1164\/rccm.201811-2221OC","article-title":"BAL cell gene expression in severe asthma reveals mechanisms of severe disease and influences of medications","volume":"200","author":"Weathington","year":"2019","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1124\/molpharm.120.000146_bib62","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1016\/j.jaci.2012.05.004","article-title":"Regulator of G protein signaling 2 is a key modulator of airway hyperresponsiveness","volume":"130","author":"Xie","year":"2012","journal-title":"J Allergy Clin Immunol"},{"key":"10.1124\/molpharm.120.000146_bib63","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1124\/jpet.118.249292","article-title":"Analysis of the indacaterol-regulated transcriptome in human airway epithelial cells implicates gene expression changes in the adverse and therapeutic effects of \u03b22-adrenoceptor agonists","volume":"366","author":"Yan","year":"2018","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/molpharm.120.000146_bib64","doi-asserted-by":"crossref","first-page":"4459","DOI":"10.1073\/pnas.0501076102","article-title":"Genome-wide analysis of cAMP-response element binding protein occupancy, phosphorylation, and target gene activation in human tissues","volume":"102","author":"Zhang","year":"2005","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["Molecular Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026895X24011179?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026895X24011179?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/molpharm.120.000146","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T10:36:50Z","timestamp":1739961410000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0026895X24011179"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":64,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["S0026895X24011179"],"URL":"https:\/\/doi.org\/10.1124\/molpharm.120.000146","relation":{},"ISSN":["0026-895X"],"issn-type":[{"value":"0026-895X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Transcriptome-Level Interactions between Budesonide and Formoterol Provide Insight into the Mechanism of Action of Inhaled Corticosteroid\/Long-Acting \u03b22-Adrenoceptor Agonist Combination Therapy in Asthma","name":"articletitle","label":"Article Title"},{"value":"Molecular Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/molpharm.120.000146","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 by The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}