{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T11:06:42Z","timestamp":1783508802304,"version":"3.55.0"},"reference-count":66,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":1249,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["molpharm.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Pharmacology"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1124\/molpharm.120.000184","type":"journal-article","created":{"date-parts":[[2021,5,24]],"date-time":"2021-05-24T22:05:14Z","timestamp":1621893914000},"page":"155-169","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["Cysteine Modification by Ebselen Reduces the Stability and Cellular Levels of 14-3-3 Proteins"],"prefix":"10.1016","volume":"100","author":[{"given":"Kai","family":"Wal\u00f8en","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunwar","family":"Jung-KC","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa D.","family":"Vecchia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunil","family":"Pandey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norbert","family":"Gasparik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"D\u00f8skeland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudarshan","family":"Patil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rune","family":"Kleppe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jozef","family":"Hritz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William H.J.","family":"Norton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurora","family":"Martinez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Haavik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1124\/molpharm.120.000184_bib1","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.semcancer.2006.03.005","article-title":"14-3-3 proteins: a historic overview","volume":"16","author":"Aitken","year":"2006","journal-title":"Semin Cancer Biol"},{"key":"10.1124\/molpharm.120.000184_bib2","doi-asserted-by":"crossref","first-page":"8402","DOI":"10.1021\/acs.jmedchem.5b01589","article-title":"Discovery of a specific inhibitor of pyomelanin synthesis in Legionella pneumophila","volume":"58","author":"Aubi","year":"2015","journal-title":"J Med Chem"},{"key":"10.1124\/molpharm.120.000184_bib3","doi-asserted-by":"crossref","first-page":"4865","DOI":"10.1007\/s11033-014-3417-x","article-title":"Ebselen, a promising antioxidant drug: mechanisms of action and targets of biological pathways","volume":"41","author":"Azad","year":"2014","journal-title":"Mol Biol Rep"},{"key":"10.1124\/molpharm.120.000184_bib4","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.3390\/molecules23061386","article-title":"14-3-3: a case study in PPI modulation","volume":"23","author":"Ballone","year":"2018","journal-title":"Molecules"},{"key":"10.1124\/molpharm.120.000184_bib5","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1002\/cmdc.201500484","article-title":"Small-molecule stabilization of the 14-3-3\/Gab2 protein-protein interaction (PPI) interface","volume":"11","author":"Bier","year":"2016","journal-title":"ChemMedChem"},{"key":"10.1124\/molpharm.120.000184_bib6","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1093\/protein\/5.3.191","article-title":"Quantitative analysis of protein far UV circular dichroism spectra by neural networks","volume":"5","author":"B\u00f6hm","year":"1992","journal-title":"Protein Eng"},{"key":"10.1124\/molpharm.120.000184_bib7","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.bbrc.2015.05.003","article-title":"Down-regulation of 14-3-3\u03b2 exerts anti-cancer effects through inducing ER stress in human glioma U87 cells: Involvement of CHOP-Wnt pathway","volume":"462","author":"Cao","year":"2015","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1124\/molpharm.120.000184_bib8","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1038\/s41467-018-04114-x","article-title":"The cysteine-reactive small molecule ebselen facilitates effective SOD1 maturation","volume":"9","author":"Capper","year":"2018","journal-title":"Nat Commun"},{"key":"10.1124\/molpharm.120.000184_bib9","doi-asserted-by":"crossref","first-page":"3040","DOI":"10.1038\/s41598-019-39907-7","article-title":"Endothelin neurotransmitter signalling controls zebrafish social behaviour","volume":"9","author":"Carre\u00f1o Guti\u00e9rrez","year":"2019","journal-title":"Sci Rep"},{"key":"10.1124\/molpharm.120.000184_bib10","doi-asserted-by":"crossref","first-page":"818","DOI":"10.3892\/ijo.2014.2740","article-title":"p53 suppresses 14-3-3\u03b3 by stimulating proteasome-mediated 14-3-3\u03b3 protein degradation","volume":"46","author":"Chen","year":"2015","journal-title":"Int J Oncol"},{"key":"10.1124\/molpharm.120.000184_bib11","doi-asserted-by":"crossref","first-page":"318","DOI":"10.3389\/fnmol.2017.00318","article-title":"14-3-3 proteins in brain development: neurogenesis, neuronal migration and neuromorphogenesis","volume":"10","author":"Cornell","year":"2017","journal-title":"Front Mol Neurosci"},{"key":"#cr-split#-10.1124\/molpharm.120.000184_bib63.1","doi-asserted-by":"crossref","unstructured":"Dalla Vecchia E, Di Donato V, Young AMJ, Del Bene F, Norton WHJ (2019) Reelin Signaling Controls the Preference for Social Novelty in Zebrafish. Front Behav Neurosci. Sep 19","DOI":"10.3389\/fnbeh.2019.00214"},{"key":"#cr-split#-10.1124\/molpharm.120.000184_bib63.2","doi-asserted-by":"crossref","unstructured":"13:214. doi: 10.3389\/fnbeh.2019.00214. eCollection 2019. PMID: 31607872.","DOI":"10.3389\/fnbeh.2019.00214"},{"key":"10.1124\/molpharm.120.000184_bib12","doi-asserted-by":"crossref","first-page":"e145","DOI":"10.1016\/j.biopsych.2011.02.036","article-title":"The roles of dopamine and noradrenaline in the pathophysiology and treatment of attention-deficit\/hyperactivity disorder","volume":"69","author":"Del Campo","year":"2011","journal-title":"Biol Psychiatry"},{"key":"10.1124\/molpharm.120.000184_bib13","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.phrs.2018.11.021","article-title":"Can 14-3-3 proteins serve as therapeutic targets for the treatment of metabolic diseases?","volume":"139","author":"Diallo","year":"2019","journal-title":"Pharmacol Res"},{"key":"10.1124\/molpharm.120.000184_bib14","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.bbr.2009.06.022","article-title":"Understanding behavioral and physiological phenotypes of stress and anxiety in zebrafish","volume":"205","author":"Egan","year":"2009","journal-title":"Behav Brain Res"},{"key":"10.1124\/molpharm.120.000184_bib15","doi-asserted-by":"crossref","first-page":"2748","DOI":"10.1038\/ncomms3748","article-title":"Mechanism of inhibition of Mycobacterium tuberculosis antigen 85 by ebselen","volume":"4","author":"Favrot","year":"2013","journal-title":"Nat Commun"},{"key":"10.1124\/molpharm.120.000184_bib16","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1007\/s00726-015-2157-0","article-title":"Regulation of tyrosine hydroxylase is preserved across different homo- and heterodimeric 14-3-3 proteins","volume":"48","author":"Ghorbani","year":"2016","journal-title":"Amino Acids"},{"key":"10.1124\/molpharm.120.000184_bib17","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0135976","article-title":"Biophysical characterization of essential phosphorylation at the flexible C-terminal region of C-Raf with 14-3-3\u03b6 protein","volume":"10","author":"Ghosh","year":"2015","journal-title":"PLoS One"},{"issue":"1","key":"10.1124\/molpharm.120.000184_bib64","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/jnc.14872","article-title":"Serine 19 phosphorylation and 14-3-3 binding regulate phosphorylation and dephosphorylation of tyrosine hydroxylase on serine 31 and serine 40","volume":"152","author":"Ghorbani","year":"2020","journal-title":"J. Neurochem"},{"key":"10.1124\/molpharm.120.000184_bib18","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1021\/acsinfecdis.7b00003","article-title":"Exploring covalent allosteric inhibition of antigen 85c from mycobacterium tuberculosis by ebselen derivatives","volume":"3","author":"Goins","year":"2017","journal-title":"ACS Infect Dis"},{"key":"10.1124\/molpharm.120.000184_bib19","doi-asserted-by":"crossref","first-page":"7420","DOI":"10.1073\/pnas.0600729103","article-title":"Identification of S-nitrosylation motifs by site-specific mapping of the S-nitrosocysteine proteome in human vascular smooth muscle cells","volume":"103","author":"Greco","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/molpharm.120.000184_bib20","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1039\/C5MB00744E","article-title":"Photodynamic treatment with hexyl-aminolevulinate mediates reversible thiol oxidation in core oxidative stress signaling proteins","volume":"12","author":"Helander","year":"2016","journal-title":"Mol Biosyst"},{"key":"10.1124\/molpharm.120.000184_bib21","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1038\/nrc1230","article-title":"The 14-3-3 cancer connection","volume":"3","author":"Hermeking","year":"2003","journal-title":"Nat Rev Cancer"},{"key":"10.1124\/molpharm.120.000184_bib22","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0014-5793(87)81194-8","article-title":"Brain 14-3-3 protein is an activator protein that activates tryptophan 5-monooxygenase and tyrosine 3-monooxygenase in the presence of Ca2+,calmodulin-dependent protein kinase II","volume":"219","author":"Ichimura","year":"1987","journal-title":"FEBS Lett"},{"key":"10.1124\/molpharm.120.000184_bib23","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1002\/ajmg.b.32339","article-title":"Epistatic and gene wide effects in YWHA and aromatic amino hydroxylase genes across ADHD and other common neuropsychiatric disorders: Association with YWHAE","volume":"168","author":"Jacobsen","year":"2015","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"10.1124\/molpharm.120.000184_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuro.2004.07.012","article-title":"Thimerosal neurotoxicity is associated with glutathione depletion: protection with glutathione precursors","volume":"26","author":"James","year":"2005","journal-title":"Neurotoxicology"},{"key":"10.1124\/molpharm.120.000184_bib25","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.bbapap.2017.11.012","article-title":"Free energy calculations on the stability of the 14-3-3\u03b6 protein","volume":"1866","author":"Jandova","year":"2018","journal-title":"Biochim Biophys Acta Proteins Proteomics"},{"key":"10.1124\/molpharm.120.000184_bib26","doi-asserted-by":"crossref","first-page":"84","DOI":"10.7150\/ijms.28595","article-title":"Proteomic study of a Parkinson\u2019s disease model of undifferentiated SH-SY5Y cells induced by a proteasome inhibitor","volume":"16","author":"Jiang","year":"2019","journal-title":"Int J Med Sci"},{"key":"10.1124\/molpharm.120.000184_bib27","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/s41586-020-2223-y","article-title":"Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors","volume":"582","author":"Jin","year":"2020","journal-title":"Nature"},{"key":"10.1124\/molpharm.120.000184_bib28","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.ijpddr.2013.08.002","article-title":"Exploring the mode of action of ebselen in Trypanosoma brucei hexokinase inhibition","volume":"3","author":"Joice","year":"2013","journal-title":"Int J Parasitol Drugs Drug Resist"},{"key":"10.1124\/molpharm.120.000184_bib29","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1161\/ATVBAHA.114.303746","article-title":"Redox regulation of 14-3-3\u03b6 controls monocyte migration","volume":"34","author":"Kim","year":"2014","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1124\/molpharm.120.000184_bib30","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1074\/mcp.M113.035709","article-title":"Phosphorylation dependence and stoichiometry of the complex formed by tyrosine hydroxylase and 14-3-3\u03b3","volume":"13","author":"Kleppe","year":"2014","journal-title":"Mol Cell Proteomics"},{"key":"10.1124\/molpharm.120.000184_bib31","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/0005-2760(96)00088-4","article-title":"Inhibition of copper- and peroxyl radical-induced LDL lipid oxidation by ebselen: antioxidant actions in addition to hydroperoxide-reducing activity","volume":"1303","author":"Lass","year":"1996","journal-title":"Biochim Biophys Acta"},{"issue":"23","key":"10.1124\/molpharm.120.000184_bib65","doi-asserted-by":"crossref","first-page":"6141","DOI":"10.1158\/1078-0432.CCR-14-1182","article-title":"AMACR amplification in myxofibrosarcomas: a mechanism of overexpression that promotes cell proliferation with therapeutic relevance","volume":"20","author":"Li","year":"2014","journal-title":"Clin Cancer Res."},{"key":"10.1124\/molpharm.120.000184_bib32","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1111\/j.1742-4658.2005.04614.x","article-title":"14-3-3 proteins regulate glycogen synthase 3beta phosphorylation and inhibit cardiomyocyte hypertrophy","volume":"272","author":"Liao","year":"2005","journal-title":"FEBS J"},{"key":"10.1124\/molpharm.120.000184_bib33","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1021\/cb400485k","article-title":"High-throughput screening using the differential radial capillary action of ligand assay identifies ebselen as an inhibitor of diguanylate cyclases","volume":"9","author":"Lieberman","year":"2014","journal-title":"ACS Chem Biol"},{"key":"10.1124\/molpharm.120.000184_bib34","doi-asserted-by":"crossref","first-page":"4247","DOI":"10.1007\/s13277-013-1555-8","article-title":"A cancer-related protein 14-3-3\u03b6 is a potential tumor-associated antigen in immunodiagnosis of hepatocellular carcinoma","volume":"35","author":"Liu","year":"2014","journal-title":"Tumour Biol"},{"key":"10.1124\/molpharm.120.000184_bib35","doi-asserted-by":"crossref","first-page":"2655","DOI":"10.1007\/s00213-016-4319-5","article-title":"Effects of the potential lithium-mimetic, ebselen, on impulsivity and emotional processing","volume":"233","author":"Masaki","year":"2016","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1124\/molpharm.120.000184_bib36","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abd0345","article-title":"Molecular characterization of ebselen binding activity to SARS-CoV-2 main protease","volume":"6","author":"Men\u00e9ndez","year":"2020","journal-title":"Sci Adv"},{"key":"10.1124\/molpharm.120.000184_bib37","doi-asserted-by":"crossref","first-page":"2393","DOI":"10.1021\/cb500512z","article-title":"Ebselen inhibits hepatitis C virus NS3 helicase binding to nucleic acid and prevents viral replication","volume":"9","author":"Mukherjee","year":"2014","journal-title":"ACS Chem Biol"},{"key":"10.1124\/molpharm.120.000184_bib38","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.pnpbp.2014.04.011","article-title":"Sustained behavioral effects of lithium exposure during early development in zebrafish: involvement of the Wnt-\u03b2-catenin signaling pathway","volume":"55","author":"Nery","year":"2014","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1124\/molpharm.120.000184_bib39","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1038\/nprot.2007.321","article-title":"The use of differential scanning fluorimetry to detect ligand interactions that promote protein stability","volume":"2","author":"Niesen","year":"2007","journal-title":"Nat Protoc"},{"key":"10.1124\/molpharm.120.000184_bib40","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.semcdb.2011.09.001","article-title":"Structural basis of 14-3-3 protein functions","volume":"22","author":"Obsil","year":"2011","journal-title":"Semin Cell Dev Biol"},{"key":"10.1124\/molpharm.120.000184_bib41","doi-asserted-by":"crossref","first-page":"2096","DOI":"10.1038\/s41598-017-02152-x","article-title":"Disruption of melatonin synthesis is associated with impaired 14-3-3 and miR-451 levels in patients with autism spectrum disorders","volume":"7","author":"Pagan","year":"2017","journal-title":"Sci Rep"},{"key":"10.1124\/molpharm.120.000184_bib42","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1093\/toxsci\/kfi175","article-title":"Effects of thimerosal on NGF signal transduction and cell death in neuroblastoma cells","volume":"86","author":"Parran","year":"2005","journal-title":"Toxicol Sci"},{"key":"10.1124\/molpharm.120.000184_bib43","doi-asserted-by":"crossref","first-page":"5587","DOI":"10.1038\/s41388-018-0348-3","article-title":"The dynamic and stress-adaptive signaling hub of 14-3-3: emerging mechanisms of regulation and context-dependent protein-protein interactions","volume":"37","author":"Pennington","year":"2018","journal-title":"Oncogene"},{"key":"10.1124\/molpharm.120.000184_bib44","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1042\/bj20031797","article-title":"14-3-3-affinity purification of over 200 human phosphoproteins reveals new links to regulation of cellular metabolism, proliferation and trafficking","volume":"379","author":"Pozuelo Rubio","year":"2004","journal-title":"Biochem J"},{"key":"10.1124\/molpharm.120.000184_bib45","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1021\/acs.jmedchem.7b01249","article-title":"Target identification and mode of action of four chemically divergent drugs against ebolavirus infection","volume":"61","author":"Ren","year":"2018","journal-title":"J Med Chem"},{"key":"10.1124\/molpharm.120.000184_bib46","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.freeradbiomed.2020.06.032","article-title":"Potential therapeutic use of ebselen for COVID-19 and other respiratory viral infections","volume":"156","author":"Sies","year":"2020","journal-title":"Free Radic Biol Med"},{"key":"10.1124\/molpharm.120.000184_bib47","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1038\/ncomms2320","article-title":"A safe lithium mimetic for bipolar disorder","volume":"4","author":"Singh","year":"2013","journal-title":"Nat Commun"},{"key":"10.1124\/molpharm.120.000184_bib48","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1038\/npp.2015.343","article-title":"Effect of the putative lithium mimetic ebselen on brain myo-inositol, sleep, and emotional processing in humans","volume":"41","author":"Singh","year":"2016","journal-title":"Neuropsychopharmacology"},{"key":"10.1124\/molpharm.120.000184_bib49","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.jmb.2013.09.012","article-title":"The N-terminal sequence of tyrosine hydroxylase is a conformationally versatile motif that binds 14-3-3 proteins and membranes","volume":"426","author":"Skjevik","year":"2014","journal-title":"J Mol Biol"},{"key":"10.1124\/molpharm.120.000184_bib50","doi-asserted-by":"crossref","first-page":"3755","DOI":"10.1021\/acs.jmedchem.7b00574","article-title":"Modulators of 14-3-3 protein-protein interactions","volume":"61","author":"Stevers","year":"2018","journal-title":"J Med Chem"},{"issue":"Suppl 1","key":"10.1124\/molpharm.120.000184_bib51","first-page":"S137","article-title":"Glycogen synthase kinase 3 (GSK3) in the heart: a point of integration in hypertrophic signalling and a therapeutic target? A critical analysis","volume":"153","author":"Sugden","year":"2008","journal-title":"Br J Pharmacol"},{"key":"10.1124\/molpharm.120.000184_bib52","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.3390\/jcm9061851","article-title":"Involvement of the 14-3-3 gene family in autism spectrum disorder and schizophrenia: genetics, transcriptomics and functional analyses","volume":"9","author":"Torrico","year":"2020","journal-title":"J Clin Med"},{"key":"10.1124\/molpharm.120.000184_bib53","doi-asserted-by":"crossref","first-page":"13959","DOI":"10.1038\/s41598-017-14497-4","article-title":"Conformational stabilization as a strategy to prevent nucleophosmin mislocalization in leukemia","volume":"7","author":"Urbaneja","year":"2017","journal-title":"Sci Rep"},{"key":"10.1124\/molpharm.120.000184_bib54","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1039\/C9MD00215D","article-title":"Set-up and screening of a fragment library targeting the 14-3-3 protein interface","volume":"10","author":"Valenti","year":"2019","journal-title":"MedChemComm"},{"key":"10.1124\/molpharm.120.000184_bib55","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1080\/15216540500252666","article-title":"14-3-3 proteins: regulators of numerous eukaryotic proteins","volume":"57","author":"van Heusden","year":"2005","journal-title":"IUBMB Life"},{"key":"10.1124\/molpharm.120.000184_bib56","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/nbt.3109","article-title":"PeptideShaker enables reanalysis of MS-derived proteomics data sets","volume":"33","author":"Vaudel","year":"2015","journal-title":"Nat Biotechnol"},{"key":"10.1124\/molpharm.120.000184_bib57","doi-asserted-by":"crossref","first-page":"5659","DOI":"10.1038\/ncomms6659","article-title":"The role of protein clearance mechanisms in organismal ageing and age-related diseases","volume":"5","author":"Vilchez","year":"2014","journal-title":"Nat Commun"},{"key":"10.1124\/molpharm.120.000184_bib58","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1080\/14728222.2017.1272581","article-title":"Tyrosine and tryptophan hydroxylases as therapeutic targets in human disease","volume":"21","author":"Wal\u00f8en","year":"2017","journal-title":"Expert Opin Ther Targets"},{"key":"10.1124\/molpharm.120.000184_bib59","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.2147\/DDDT.S124977","article-title":"Developing selective histone deacetylases (HDACs) inhibitors through ebselen and analogs","volume":"11","author":"Wang","year":"2017","journal-title":"Drug Des Devel Ther"},{"key":"10.1124\/molpharm.120.000184_bib60","doi-asserted-by":"crossref","first-page":"14522","DOI":"10.18632\/oncotarget.3995","article-title":"Destabilisation of dimeric 14-3-3 proteins as a novel approach to anti-cancer therapeutics","volume":"6","author":"Woodcock","year":"2015","journal-title":"Oncotarget"},{"key":"10.1124\/molpharm.120.000184_bib61","doi-asserted-by":"crossref","first-page":"2635","DOI":"10.1128\/MCB.00076-14","article-title":"14-3-3\u03c4 promotes breast cancer invasion and metastasis by inhibiting RhoGDI\u03b1","volume":"34","author":"Xiao","year":"2014","journal-title":"Mol Cell Biol"},{"key":"10.1124\/molpharm.120.000184_bib62","doi-asserted-by":"crossref","first-page":"17237","DOI":"10.1073\/pnas.0605779103","article-title":"Structural basis for protein-protein interactions in the 14-3-3 protein family","volume":"103","author":"Yang","year":"2006","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["Molecular Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026895X24011283?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026895X24011283?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/molpharm.120.000184","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T17:27:16Z","timestamp":1740763636000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0026895X24011283"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8]]},"references-count":66,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["S0026895X24011283"],"URL":"https:\/\/doi.org\/10.1124\/molpharm.120.000184","relation":{},"ISSN":["0026-895X"],"issn-type":[{"value":"0026-895X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cysteine Modification by Ebselen Reduces the Stability and Cellular Levels of 14-3-3 Proteins","name":"articletitle","label":"Article Title"},{"value":"Molecular Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/molpharm.120.000184","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 by The Author(s)","name":"copyright","label":"Copyright"}]}}