{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:15:00Z","timestamp":1790957700884,"version":"4.1.0"},"reference-count":63,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":397,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["molpharm.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Pharmacology"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1124\/molpharm.123.000720","type":"journal-article","created":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T16:45:15Z","timestamp":1694105115000},"page":"275-286","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["Screening for Novel Type 2 Ryanodine Receptor Inhibitors by Endoplasmic Reticulum Ca2+ Monitoring"],"prefix":"10.1016","volume":"104","author":[{"given":"Mai","family":"Takenaka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masami","family":"Kodama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3845-2980","authenticated-orcid":false,"given":"Takashi","family":"Murayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mari","family":"Ishigami-Yuasa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuichi","family":"Mori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryosuke","family":"Ishida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junji","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazunori","family":"Kanemaru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masami","family":"Sugihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masamitsu","family":"Iino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aya","family":"Miura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hajime","family":"Nishio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachio","family":"Morimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Kagechika","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Sakurai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5005-9698","authenticated-orcid":false,"given":"Nagomi","family":"Kurebayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1124\/molpharm.123.000720_bib1","doi-asserted-by":"crossref","first-page":"e151","DOI":"10.1016\/j.ddmec.2010.09.009","article-title":"Fixing ryanodine receptor Ca leak - a novel therapeutic strategy for contractile failure in heart and skeletal muscle","volume":"7","author":"Andersson","year":"2010","journal-title":"Drug Discov Today Dis Mech"},{"key":"10.1124\/molpharm.123.000720_bib2","doi-asserted-by":"crossref","first-page":"2558","DOI":"10.1111\/bph.15718","article-title":"Moving in the right direction: elucidating the mechanisms of interaction between flecainide and the cardiac ryanodine receptor","volume":"179","author":"Bannister","year":"2022","journal-title":"Br J Pharmacol"},{"key":"10.1124\/molpharm.123.000720_bib3","doi-asserted-by":"crossref","first-page":"4810","DOI":"10.1073\/pnas.1816685116","article-title":"Unnatural verticilide enantiomer inhibits type 2 ryanodine receptor-mediated calcium leak and is antiarrhythmic","volume":"116","author":"Batiste","year":"2019","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/molpharm.123.000720_bib4","doi-asserted-by":"crossref","first-page":"734210","DOI":"10.3389\/fphys.2021.734210","article-title":"RyR2 and Calcium Release in Heart Failure","volume":"12","author":"Benitah","year":"2021","journal-title":"Front Physiol"},{"key":"10.1124\/molpharm.123.000720_bib5","doi-asserted-by":"crossref","unstructured":"Bers DM(2001) Excitation\u2010Contraction Coupling and Cardiac Contractile Force. 2nd ed. Kluwer Academic Publishers ed. Springer, Netherlands.","DOI":"10.1007\/978-94-010-0658-3"},{"key":"10.1124\/molpharm.123.000720_bib6","doi-asserted-by":"crossref","DOI":"10.2174\/092986710791163939","article-title":"Riluzole, neuroprotection and amyotrophic lateral sclerosis","volume":"17","author":"Cheah","year":"2010","journal-title":"Curr Med Chem"},{"key":"10.1124\/molpharm.123.000720_bib7","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1038\/s41569-020-0394-8","article-title":"Intracellular calcium leak in heart failure and atrial fibrillation: a unifying mechanism and therapeutic target","volume":"17","author":"Dridi","year":"2020","journal-title":"Nat Rev Cardiol"},{"key":"10.1124\/molpharm.123.000720_bib8","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1161\/CIRCRESAHA.106.146670","article-title":"Knock-in mouse model of dilated cardiomyopathy caused by troponin mutation","volume":"101","author":"Du","year":"2007","journal-title":"Circ Res"},{"key":"10.1124\/molpharm.123.000720_bib9","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.hrthm.2016.10.015","article-title":"A type 2 ryanodine receptor variant associated with reduced Ca2+ release and short-coupled torsades de pointes ventricular arrhythmia","volume":"14","author":"Fujii","year":"2017","journal-title":"Heart Rhythm"},{"key":"10.1124\/molpharm.123.000720_bib10","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.healun.2021.12.008","article-title":"Glycation of ryanodine receptor in circulating lymphocytes predicts the response to cardiac resynchronization therapy","volume":"41","author":"Gambardella","year":"2022","journal-title":"J Heart Lung Transplant"},{"key":"10.1124\/molpharm.123.000720_bib11","doi-asserted-by":"crossref","first-page":"e011387","DOI":"10.1161\/CIRCEP.122.011387","article-title":"Novel Calmodulin Variant p.E46K Associated With Severe Catecholaminergic Polymorphic Ventricular Tachycardia Produces Robust Arrhythmogenicity in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes","volume":"16","author":"Gao","year":"2023","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"10.1124\/molpharm.123.000720_bib12","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1093\/europace\/euab250","article-title":"Loss-of-function mutations in cardiac ryanodine receptor channel cause various types of arrhythmias including long QT syndrome","volume":"24","author":"Hirose","year":"2022","journal-title":"Europace"},{"key":"10.1124\/molpharm.123.000720_bib13","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.bbrc.2008.08.084","article-title":"Ryanodine receptor phosphorylation at Serine 2030, 2808 and 2814 in rat cardiomyocytes","volume":"376","author":"Huke","year":"2008","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1124\/molpharm.123.000720_bib14","doi-asserted-by":"crossref","first-page":"eabb2964","DOI":"10.1126\/sciadv.abb2964","article-title":"Structural mechanism of two gain-of-function cardiac and skeletal RyR mutations at an equivalent site by cryo-EM","volume":"6","author":"Iyer","year":"2020","journal-title":"Sci Adv"},{"key":"10.1124\/molpharm.123.000720_bib15","doi-asserted-by":"crossref","first-page":"18309","DOI":"10.1073\/pnas.0706573104","article-title":"Loss of luminal Ca2+ activation in the cardiac ryanodine receptor is associated with ventricular fibrillation and sudden death","volume":"104","author":"Jiang","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/molpharm.123.000720_bib16","doi-asserted-by":"crossref","first-page":"12179","DOI":"10.1073\/pnas.0600268103","article-title":"Mice with the R176Q cardiac ryanodine receptor mutation exhibit catecholamine-induced ventricular tachycardia and cardiomyopathy","volume":"103","author":"Kannankeril","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/molpharm.123.000720_bib17","doi-asserted-by":"crossref","first-page":"e91","DOI":"10.1093\/ehjcvp\/pvab069","article-title":"Advances in the understanding of excitation-contraction coupling: the pulsing quest for drugs against heart failure and arrhythmias","volume":"7","author":"Kansakar","year":"2021","journal-title":"Eur Heart J Cardiovasc Pharmacother"},{"key":"10.1124\/molpharm.123.000720_bib18","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s00204-022-03385-0","article-title":"Role of Ca2+ in healthy and pathologic cardiac function: from normal excitation-contraction coupling to mutations that cause inherited arrhythmia","volume":"97","author":"Keefe","year":"2023","journal-title":"Arch Toxicol"},{"key":"10.1124\/molpharm.123.000720_bib19","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.hrthm.2017.12.017","article-title":"EL20, a potent antiarrhythmic compound, selectively inhibits calmodulin-deficient ryanodine receptor type 2","volume":"15","author":"Klipp","year":"2018","journal-title":"Heart Rhythm"},{"key":"10.1124\/molpharm.123.000720_bib20","doi-asserted-by":"crossref","first-page":"2579","DOI":"10.1253\/circj.CJ-10-0680","article-title":"Dantrolene, a therapeutic agent for malignant hyperthermia, inhibits catecholaminergic polymorphic ventricular tachycardia in a RyR2(R2474S\/+) knock-in mouse model","volume":"74","author":"Kobayashi","year":"2010","journal-title":"Circ J"},{"key":"10.1124\/molpharm.123.000720_bib21","doi-asserted-by":"crossref","first-page":"10795","DOI":"10.3390\/ijms221910795","article-title":"The Ryanodine Receptor as a Sensor for Intracellular Environments in Muscles","volume":"22","author":"Kobayashi","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1124\/molpharm.123.000720_bib22","doi-asserted-by":"crossref","first-page":"2821","DOI":"10.1038\/s41467-022-30429-x","article-title":"Molecular basis for gating of cardiac ryanodine receptor explains the mechanisms for gain- and loss-of function mutations","volume":"13","author":"Kobayashi","year":"2022","journal-title":"Nat Commun"},{"key":"10.1124\/molpharm.123.000720_bib23","doi-asserted-by":"crossref","first-page":"e202112869","DOI":"10.1085\/jgp.202112869","article-title":"Cytosolic Ca2+-dependent Ca2+ release activity primarily determines the ER Ca2+ level in cells expressing the CPVT-linked mutant RYR2","volume":"154","author":"Kurebayashi","year":"2022","journal-title":"J Gen Physiol"},{"key":"10.1124\/molpharm.123.000720_bib24","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1007\/s00401-017-1733-7","article-title":"Post-translational remodeling of ryanodine receptor induces calcium leak leading to Alzheimer\u2019s disease-like pathologies and cognitive deficits","volume":"134","author":"Lacampagne","year":"2017","journal-title":"Acta Neuropathol"},{"key":"10.1124\/molpharm.123.000720_bib25","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1093\/cvr\/26.3.193","article-title":"Functional implications of spontaneous sarcoplasmic reticulum Ca2+ release in the heart","volume":"26","author":"Lakatta","year":"1992","journal-title":"Cardiovasc Res"},{"key":"10.1124\/molpharm.123.000720_bib26","doi-asserted-by":"crossref","first-page":"a003996","DOI":"10.1101\/cshperspect.a003996","article-title":"Ryanodine receptors: structure, expression, molecular details, and function in calcium release","volume":"2","author":"Lanner","year":"2010","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"10.1124\/molpharm.123.000720_bib27","first-page":"2230","article-title":"Leaky Ca2+ release channel\/ryanodine receptor 2 causes seizures and sudden cardiac death in mice","volume":"118","author":"Lehnart","year":"2008","journal-title":"J Clin Invest"},{"key":"10.1124\/molpharm.123.000720_bib28","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.hrthm.2018.08.025","article-title":"Linking the heart and the brain: Neurodevelopmental disorders in patients with catecholaminergic polymorphic ventricular tachycardia","volume":"16","author":"Lieve","year":"2019","journal-title":"Heart Rhythm"},{"key":"10.1124\/molpharm.123.000720_bib29","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1016\/j.jacc.2009.08.022","volume":"54","author":"Medeiros-Domingo","year":"2009","journal-title":"J Am Coll Cardiol"},{"key":"10.1124\/molpharm.123.000720_bib30","doi-asserted-by":"crossref","first-page":"e71","DOI":"10.1002\/cpph.71","article-title":"Assays for Modulators of Ryanodine Receptor (RyR)\/Ca2+ Release Channel Activity for Drug Discovery for Skeletal Muscle and Heart Diseases","volume":"87","author":"Murayama","year":"2019","journal-title":"Curr Protocols Pharmacol"},{"key":"10.1124\/molpharm.123.000720_bib31","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1124\/mol.117.111468","article-title":"Efficient High-Throughput Screening by Endoplasmic Reticulum Ca2+ Measurement to Identify Inhibitors of Ryanodine Receptor Ca2+-Release Channels","volume":"94","author":"Murayama","year":"2018","journal-title":"Mol Pharmacol"},{"key":"10.1124\/molpharm.123.000720_bib32","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1002\/humu.23072","article-title":"Genotype-Phenotype Correlations of Malignant Hyperthermia and Central Core Disease Mutations in the Central Region of the RYR1 Channel","volume":"37","author":"Murayama","year":"2016","journal-title":"Hum Mutat"},{"key":"10.1124\/molpharm.123.000720_bib33","doi-asserted-by":"crossref","first-page":"e0130606","DOI":"10.1371\/journal.pone.0130606","article-title":"Divergent Activity Profiles of Type 1 Ryanodine Receptor Channels Carrying Malignant Hyperthermia and Central Core Disease Mutations in the Amino-Terminal Region","volume":"10","author":"Murayama","year":"2015","journal-title":"PLoS One"},{"key":"10.1124\/molpharm.123.000720_bib34","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1253\/circj.70.1402","article-title":"Postmortem molecular screening for cardiac ryanodine receptor type 2 mutations in sudden unexplained death: R420W mutated case with characteristics of status thymico-lymphatics","volume":"70","author":"Nishio","year":"2006","journal-title":"Circ J"},{"key":"10.1124\/molpharm.123.000720_bib35","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1253\/circj.CJ-19-0720","article-title":"Co-phenotype of Left Ventricular Non-Compaction Cardiomyopathy and Atypical Catecholaminergic Polymorphic Ventricular Tachycardia in Association with R169Q, a Ryanodine Receptor Type 2 Missense Mutation","volume":"84","author":"Nozaki","year":"2020","journal-title":"Circ J"},{"key":"10.1124\/molpharm.123.000720_bib36","doi-asserted-by":"crossref","first-page":"e101838","DOI":"10.1371\/journal.pone.0101838","article-title":"Effects of candesartan on electrical remodeling in the hearts of inherited dilated cardiomyopathy model mice","volume":"9","author":"Odagiri","year":"2014","journal-title":"PLoS One"},{"key":"10.1124\/molpharm.123.000720_bib37","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.bbrc.2014.08.132","article-title":"A knock-in mouse model of N-terminal R420W mutation of cardiac ryanodine receptor exhibits arrhythmogenesis with abnormal calcium dynamics in cardiomyocytes","volume":"452","author":"Okudaira","year":"2014","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1124\/molpharm.123.000720_bib38","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1085\/jgp.201812155","article-title":"Phosphorylation of the ryanodine receptor 2 at serine 2030 is required for a complete \u03b2-adrenergic response","volume":"151","author":"Potenza","year":"2019","journal-title":"J Gen Physiol"},{"key":"10.1124\/molpharm.123.000720_bib39","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1161\/CIRCRESAHA.110.226845","article-title":"Inherited dysfunction of sarcoplasmic reticulum Ca2+ handling and arrhythmogenesis","volume":"108","author":"Priori","year":"2011","journal-title":"Circ Res"},{"key":"10.1124\/molpharm.123.000720_bib40","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1093\/cvr\/cvu262","article-title":"Neuronal Na+ channel blockade suppresses arrhythmogenic diastolic Ca2+ release","volume":"106","author":"Radwa\u0144ski","year":"2015","journal-title":"Cardiovasc Res"},{"key":"10.1124\/molpharm.123.000720_bib41","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1152\/physrev.1991.71.3.849","article-title":"Voltage sensor of excitation-contraction coupling in skeletal muscle","volume":"71","author":"R\u00edos","year":"1991","journal-title":"Physiol Rev"},{"key":"10.1124\/molpharm.123.000720_bib42","doi-asserted-by":"crossref","first-page":"e202213089","DOI":"10.1085\/jgp.202213089","article-title":"How does flecainide impact RyR2 channel function?","volume":"154","author":"Salvage","year":"2022","journal-title":"J Gen Physiol"},{"key":"10.1124\/molpharm.123.000720_bib43","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/978-981-10-7757-9_11","article-title":"Ryanodine Receptor Structure and Function in Health and Disease","volume":"87","author":"Santulli","year":"2018","journal-title":"Subcell Biochem"},{"key":"10.1124\/molpharm.123.000720_bib44","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.jpba.2017.08.045","article-title":"UPLC-MS\/MS assay of riluzole in human plasma and cerebrospinal fluid (CSF): Application in samples from spinal cord injured patients","volume":"146","author":"Sarkar","year":"2017","journal-title":"J Pharm Biomed Anal"},{"key":"10.1124\/molpharm.123.000720_bib45","doi-asserted-by":"crossref","first-page":"327","DOI":"10.2170\/physiolsci.RP010107","article-title":"A simple technique for isolating healthy heart cells from mouse models","volume":"57","author":"Shioya","year":"2007","journal-title":"J Physiol Sci"},{"key":"10.1124\/molpharm.123.000720_bib46","doi-asserted-by":"crossref","first-page":"eaba7287","DOI":"10.1126\/scitranslmed.aba7287","article-title":"Cardiac ryanodine receptor calcium release deficiency syndrome","volume":"13","author":"Sun","year":"2021","journal-title":"Sci Transl Med"},{"key":"10.1124\/molpharm.123.000720_bib47","doi-asserted-by":"crossref","first-page":"4153","DOI":"10.1038\/ncomms5153","article-title":"Imaging intraorganellar Ca2+ at subcellular resolution using CEPIA","volume":"5","author":"Suzuki","year":"2014","journal-title":"Nat Commun"},{"key":"10.1124\/molpharm.123.000720_bib48","doi-asserted-by":"crossref","first-page":"e35353","DOI":"10.1371\/journal.pone.0035353","article-title":"Multistep ion channel remodeling and lethal arrhythmia precede heart failure in a mouse model of inherited dilated cardiomyopathy","volume":"7","author":"Suzuki","year":"2012","journal-title":"PLoS One"},{"key":"10.1124\/molpharm.123.000720_bib49","doi-asserted-by":"crossref","first-page":"4435","DOI":"10.3390\/ijms23084435","article-title":"Therapeutic Approaches of Ryanodine Receptor-Associated Heart Diseases","volume":"23","author":"Szentandr\u00e1ssy","year":"2022","journal-title":"Int J Mol Sci"},{"key":"10.1124\/molpharm.123.000720_bib50","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.4065\/79.11.1380","article-title":"Targeted mutational analysis of the RyR2-encoded cardiac ryanodine receptor in sudden unexplained death: a molecular autopsy of 49 medical examiner\/coroner\u2019s cases","volume":"79","author":"Tester","year":"2004","journal-title":"Mayo Clin Proc"},{"key":"10.1124\/molpharm.123.000720_bib51","doi-asserted-by":"crossref","first-page":"2637","DOI":"10.1002\/ehf2.13431","article-title":"Ryanodine receptor and immune-related molecules in diabetic cardiomyopathy","volume":"8","author":"Tian","year":"2021","journal-title":"ESC Heart Fail"},{"key":"10.1124\/molpharm.123.000720_bib52","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1093\/hmg\/10.3.189","article-title":"Identification of mutations in the cardiac ryanodine receptor gene in families affected with arrhythmogenic right ventricular cardiomyopathy type 2 (ARVD2)","volume":"10","author":"Tiso","year":"2001","journal-title":"Hum Mol Genet"},{"key":"10.1124\/molpharm.123.000720_bib53","doi-asserted-by":"crossref","first-page":"26332","DOI":"10.1074\/jbc.272.42.26332","article-title":"Caffeine and halothane sensitivity of intracellular Ca2+ release is altered by 15 calcium release channel (ryanodine receptor) mutations associated with malignant hyperthermia and\/or central core disease","volume":"272","author":"Tong","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1124\/molpharm.123.000720_bib54","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1242\/jeb.81.1.205","article-title":"Cellular and subcellular mechanisms of cardiac pacemaker oscillations","volume":"81","author":"Tsien","year":"1979","journal-title":"J Exp Biol"},{"key":"10.1124\/molpharm.123.000720_bib55","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1085\/jgp.201611624","article-title":"Extensive Ca2+ leak through K4750Q cardiac ryanodine receptors caused by cytosolic and luminal Ca2+ hypersensitivity","volume":"149","author":"Uehara","year":"2017","journal-title":"J Gen Physiol"},{"key":"10.1124\/molpharm.123.000720_bib56","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1038\/nm.1942","article-title":"Flecainide prevents catecholaminergic polymorphic ventricular tachycardia in mice and humans","volume":"15","author":"Watanabe","year":"2009","journal-title":"Nat Med"},{"key":"10.1124\/molpharm.123.000720_bib57","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0143-4160(98)90078-1","article-title":"Effects of ryanodine receptor agonist 4-chloro-m-cresol on myoplasmic free Ca2+ concentration and force of contraction in mouse skeletal muscle","volume":"24","author":"Westerblad","year":"1998","journal-title":"Cell Calcium"},{"key":"10.1124\/molpharm.123.000720_bib58","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1152\/physrev.00033.2020","article-title":"Calcium-release channels: structure and function of IP3 receptors and ryanodine receptors","volume":"102","author":"Woll","year":"2022","journal-title":"Physiol Rev"},{"key":"10.1124\/molpharm.123.000720_bib59","doi-asserted-by":"crossref","first-page":"6115","DOI":"10.1111\/jcmm.16521","article-title":"Efficacy of RyR2 inhibitor EL20 in induced pluripotent stem cell-derived cardiomyocytes from a patient with catecholaminergic polymorphic ventricular tachycardia","volume":"25","author":"Word","year":"2021","journal-title":"J Cell Mol Med"},{"key":"10.1124\/molpharm.123.000720_bib60","doi-asserted-by":"crossref","first-page":"7425","DOI":"10.1038\/srep07425","article-title":"Functional role of Calstabin2 in age-related cardiac alterations","volume":"4","author":"Yuan","year":"2014","journal-title":"Sci Rep"},{"key":"10.1124\/molpharm.123.000720_bib61","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1126\/science.1208592","article-title":"An expanded palette of genetically encoded Ca2+ indicators","volume":"333","author":"Zhao","year":"2011","journal-title":"Science"},{"key":"10.1124\/molpharm.123.000720_bib62","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1038\/nm.2406","article-title":"Carvedilol and its new analogs suppress arrhythmogenic store overload-induced Ca2+ release","volume":"17","author":"Zhou","year":"2011","journal-title":"Nat Med"},{"key":"10.1124\/molpharm.123.000720_bib63","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1016\/S0026-895X(25)13345-2","article-title":"Chlorocresol: an activator of ryanodine receptor-mediated Ca2+ release","volume":"44","author":"Zorzato","year":"1993","journal-title":"Mol Pharmacol"}],"container-title":["Molecular Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026895X24000683?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026895X24000683?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/molpharm.123.000720","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T17:20:20Z","timestamp":1740763220000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0026895X24000683"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":63,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["S0026895X24000683"],"URL":"https:\/\/doi.org\/10.1124\/molpharm.123.000720","relation":{},"ISSN":["0026-895X"],"issn-type":[{"value":"0026-895X","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Screening for Novel Type 2 Ryanodine Receptor Inhibitors by Endoplasmic Reticulum Ca2+ Monitoring","name":"articletitle","label":"Article Title"},{"value":"Molecular Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/molpharm.123.000720","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Author(s)","name":"copyright","label":"Copyright"}]}}