{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T04:38:40Z","timestamp":1782448720776,"version":"3.54.5"},"reference-count":145,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100021783","name":"Courtois Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100021783","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["molpharm.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Pharmacology"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1124\/molpharm.124.000958","type":"journal-article","created":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T19:55:16Z","timestamp":1729713316000},"page":"100002","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Modeling the contribution of cardiac fibroblasts in dilated cardiomyopathy using induced pluripotent stem cells"],"prefix":"10.1016","volume":"107","author":[{"given":"Grace R.","family":"Mazarura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terence E.","family":"H\u00e9bert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1124\/molpharm.124.000958_bib1","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1093\/cvr\/cvt191","article-title":"Super-resolution fluorescence microscopy of the cardiac connexome reveals plakophilin-2 inside the connexin43 plaque","volume":"100","author":"Agullo-Pascual","year":"2013","journal-title":"Cardiovasc Res"},{"key":"10.1124\/molpharm.124.000958_bib2","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1152\/physrev.00032.2006","article-title":"Cardiac myocyte cell cycle control in development, disease, and regeneration","volume":"87","author":"Ahuja","year":"2007","journal-title":"Physiol Rev"},{"key":"10.1124\/molpharm.124.000958_bib3","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s10741-023-10358-7","article-title":"Electrocardiographic abnormalities in patients with cardiomyopathies","volume":"29","author":"Aimo","year":"2024","journal-title":"Heart Fail Rev"},{"key":"10.1124\/molpharm.124.000958_bib4","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1161\/CIRCRESAHA.115.303794","article-title":"Developmental heterogeneity of cardiac fibroblasts does not predict pathological proliferation and activation","volume":"115","author":"Ali","year":"2014","journal-title":"Circ Res"},{"key":"10.1124\/molpharm.124.000958_bib5","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1016\/j.cell.2019.11.025","article-title":"A\u00a0spatiotemporal organ-wide gene expression and cell atlas of the developing human heart","volume":"179","author":"Asp","year":"2019","journal-title":"Cell"},{"key":"10.1124\/molpharm.124.000958_bib6","first-page":"62","article-title":"Cardiac remodeling: Concepts, clinical impact, pathophysiological mechanisms and pharmacologic treatment","volume":"106","author":"Azevedo","year":"2016","journal-title":"Arq Bras Cardiol"},{"key":"10.1124\/molpharm.124.000958_bib7","doi-asserted-by":"crossref","first-page":"2136","DOI":"10.1172\/JCI70577","article-title":"Cardiac fibroblast\u2013derived microRNA passenger strand-enriched exosomes mediate cardiomyocyte hypertrophy","volume":"124","author":"Bang","year":"2014","journal-title":"J\u00a0Clin Invest"},{"key":"10.1124\/molpharm.124.000958_bib8","doi-asserted-by":"crossref","first-page":"0003","DOI":"10.1038\/s41551-016-0003","article-title":"Long-term self-renewing human epicardial cells generated from pluripotent stem cells under defined xeno-free conditions","volume":"1","author":"Bao","year":"2016","journal-title":"Nat Biomed Eng"},{"key":"10.1124\/molpharm.124.000958_bib9","doi-asserted-by":"crossref","first-page":"9795","DOI":"10.1038\/s41598-024-60102-w","article-title":"Mechanical stimulation of induced pluripotent stem derived cardiac fibroblasts","volume":"14","author":"Bekedam","year":"2024","journal-title":"Sci Rep"},{"key":"10.1124\/molpharm.124.000958_bib10","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1007\/s12265-012-9415-2","article-title":"Cardiac fibroblasts and cellular cross talk in heart failure","volume":"5","author":"Blaxall","year":"2012","journal-title":"J\u00a0Cardiovasc Transl Res"},{"key":"10.1124\/molpharm.124.000958_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2021.110239","article-title":"Biosensor-based profiling to track cellular signalling in patient-derived models of dilated cardiomyopathy","volume":"91","author":"Bourque","year":"2022","journal-title":"Cell Signal"},{"key":"10.1124\/molpharm.124.000958_bib12","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-023-39525-4","article-title":"Comparing the signaling and transcriptome profiling landscapes of human iPSC-derived and primary rat neonatal cardiomyocytes","volume":"13","author":"Bourque","year":"2023","journal-title":"Sci Rep"},{"key":"10.1124\/molpharm.124.000958_bib13","series-title":"Principles of Tissue Engineering (Fourth Edition)","first-page":"279","article-title":"Chapter 15 - Regulation of Cell Behavior by Extracellular Proteins","author":"Bradshaw","year":"2014"},{"key":"10.1124\/molpharm.124.000958_bib14","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-60685-4","article-title":"The local mechanosensitive response of primary cardiac fibroblasts is influenced by the microenvironment mechanics","volume":"14","author":"Braidotti","year":"2024","journal-title":"Sci Rep"},{"key":"10.1124\/molpharm.124.000958_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.108117","article-title":"iPSC modeling of RBM20-deficient DCM identifies upregulation of RBM20 as a therapeutic strategy","volume":"32","author":"Briganti","year":"2020","journal-title":"Cell Rep"},{"key":"10.1124\/molpharm.124.000958_bib16","doi-asserted-by":"crossref","first-page":"4381","DOI":"10.3390\/ijms20184381","article-title":"Human induced pluripotent stem-cell-derived cardiomyocytes as models for genetic cardiomyopathies","volume":"20","author":"Brodehl","year":"2019","journal-title":"Int J Mol Sci"},{"key":"10.1124\/molpharm.124.000958_bib17","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/BF03403533","article-title":"Circulating fibrocytes define a new leukocyte subpopulation that mediates tissue repair","volume":"1","author":"Bucala","year":"1994","journal-title":"Mol Med"},{"key":"10.1124\/molpharm.124.000958_bib18","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/nature06969","article-title":"A\u00a0myocardial lineage derives from Tbx18 epicardial cells","volume":"454","author":"Cai","year":"2008","journal-title":"Nature"},{"key":"10.1124\/molpharm.124.000958_bib19","doi-asserted-by":"crossref","first-page":"2396","DOI":"10.1016\/j.bbagen.2014.01.013","article-title":"Thrombospondin-2 and extracellular matrix assembly","volume":"1840","author":"Calabro","year":"2014","journal-title":"Biochim Biophys Acta"},{"key":"10.1124\/molpharm.124.000958_bib20","article-title":"Harnessing human genetics and stem cells for precision cardiovascular medicine","volume":"4","author":"Caudal","year":"2024","journal-title":"Cell Genom"},{"key":"10.1124\/molpharm.124.000958_bib21","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1038\/s41586-022-04817-8","article-title":"Single-nucleus profiling of human dilated and hypertrophic cardiomyopathy","volume":"608","author":"Chaffin","year":"2022","journal-title":"Nature"},{"key":"10.1124\/molpharm.124.000958_bib22","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1016\/j.jacc.2003.06.010","article-title":"Involvement of reactive oxygen species in angiotensin II-induced endothelin-1 gene expression in rat cardiac fibroblasts","volume":"42","author":"Cheng","year":"2003","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1124\/molpharm.124.000958_bib23","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.1016\/j.celrep.2019.01.079","article-title":"Single-cell transcriptome analysis maps the developmental track of the human heart","volume":"26","author":"Cui","year":"2019","journal-title":"Cell Rep"},{"key":"10.1124\/molpharm.124.000958_bib24","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/s41598-019-56597-3","article-title":"Troponin destabilization impairs sarcomere-cytoskeleton interactions in iPSC-derived cardiomyocytes from dilated cardiomyopathy patients","volume":"10","author":"Dai","year":"2020","journal-title":"Sci Rep"},{"key":"10.1124\/molpharm.124.000958_bib25","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.matbio.2020.03.010","article-title":"Cardiac fibroblast activation during myocardial infarction wound healing: Fibroblast polarization after MI","volume":"91\u201392","author":"Daseke","year":"2020","journal-title":"Matrix Biol"},{"key":"10.1124\/molpharm.124.000958_bib26","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s00395-019-0746-x","article-title":"Neutrophil proteome shifts over the myocardial infarction time continuum","volume":"114","author":"Daseke","year":"2019","journal-title":"Basic Res Cardiol"},{"key":"10.1124\/molpharm.124.000958_bib27","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1016\/0735-1097(95)00612-5","article-title":"Fractionated electrograms in dilated cardiomyopathy: origin and relation to abnormal conduction","volume":"27","author":"de Bakker","year":"1996","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1124\/molpharm.124.000958_bib28","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1038\/s41436-021-01233-7","article-title":"The genetic architecture of plakophilin 2 cardiomyopathy","volume":"23","author":"Dries","year":"2021","journal-title":"Genet Med"},{"key":"10.1124\/molpharm.124.000958_bib29","doi-asserted-by":"crossref","first-page":"4475","DOI":"10.3390\/ijms24054475","article-title":"Endothelin-1 induces cell proliferation and myofibroblast differentiation through the ETAR\/G\u03b1q\/ERK signaling pathway in human cardiac fibroblasts","volume":"24","author":"Duangrat","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1124\/molpharm.124.000958_bib30","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.tcm.2019.09.003","article-title":"Current understanding of fibrosis in genetic cardiomyopathies","volume":"30","author":"Eijgenraam","year":"2020","journal-title":"Trends in Cardiovasc Med"},{"key":"10.1124\/molpharm.124.000958_bib31","series-title":"myofibrillogenesis","first-page":"181","article-title":"Onset of a cardiac phenotype in the early embryo","author":"Eisenberg","year":"2002"},{"key":"10.1124\/molpharm.124.000958_bib32","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-22225-w","article-title":"Generation and maturation of human iPSC-derived 3D organotypic cardiac microtissues in long-term culture","volume":"12","author":"Ergir","year":"2022","journal-title":"Sci Rep"},{"key":"10.1124\/molpharm.124.000958_bib33","doi-asserted-by":"crossref","first-page":"8183","DOI":"10.1038\/s41467-023-43312-0","article-title":"Modeling cardiac fibroblast heterogeneity from human pluripotent stem cell-derived epicardial cells","volume":"14","author":"Fernandes","year":"2023","journal-title":"Nat Commun"},{"key":"10.1124\/molpharm.124.000958_bib34","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.cyto.2010.10.002","article-title":"Effects of interleukin-18 on cardiac fibroblast function and gene expression","volume":"53","author":"Fix","year":"2011","journal-title":"Cytokine"},{"key":"10.1124\/molpharm.124.000958_bib35","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202100523R","article-title":"Developmental lineage of human pluripotent stem cell-derived cardiac fibroblasts affects their functional phenotype","volume":"35","author":"Floy","year":"2021","journal-title":"FASEB J"},{"key":"10.1124\/molpharm.124.000958_bib36","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.144799","article-title":"Myofibroblast dedifferentiation proceeds via distinct transcriptomic and phenotypic transitions","volume":"6","author":"Fortier","year":"2021","journal-title":"JCI Insight"},{"key":"10.1124\/molpharm.124.000958_bib37","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1152\/physrev.00008.2011","article-title":"Matricellular proteins in cardiac adaptation and disease","volume":"92","author":"Frangogiannis","year":"2012","journal-title":"Physiol Rev"},{"key":"10.1124\/molpharm.124.000958_bib38","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.mam.2018.07.001","article-title":"Cardiac fibrosis: Cell biological mechanisms, molecular pathways and therapeutic opportunities","volume":"65","author":"Frangogiannis","year":"2019","journal-title":"Mol Aspects of Med"},{"key":"10.1124\/molpharm.124.000958_bib39","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1093\/cvr\/cvaa324","article-title":"Cardiac fibrosis","volume":"117","author":"Frangogiannis","year":"2021","journal-title":"Cardiovasc Res"},{"key":"10.1124\/molpharm.124.000958_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2023.105963","article-title":"Exosomes mediated fibrogenesis in dilated cardiomyopathy through a microRNA pathway","volume":"26","author":"Fu","year":"2023","journal-title":"iScience"},{"key":"10.1124\/molpharm.124.000958_bib41","doi-asserted-by":"crossref","first-page":"3633","DOI":"10.1007\/s00204-021-03172-3","article-title":"Recent progress of iPSC technology in cardiac diseases","volume":"95","author":"Funakoshi","year":"2021","journal-title":"Arch Toxicol"},{"key":"10.1124\/molpharm.124.000958_bib42","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1161\/CIRCRESAHA.114.302530","article-title":"Cardiogenic genes expressed in cardiac fibroblasts contribute to heart development and repair","volume":"114","author":"Furtado","year":"2014","journal-title":"Circ Res"},{"key":"10.1124\/molpharm.124.000958_bib43","first-page":"H801","article-title":"Species variability in angiotensin receptor expression by cultured cardiac fibroblasts and the infarcted heart","volume":"274","author":"Gallagher","year":"1998","journal-title":"Am J Physiol"},{"key":"10.1124\/molpharm.124.000958_bib44","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.yexcr.2016.10.022","article-title":"PDGF-A and PDGF-B induces cardiac fibrosis in transgenic mice","volume":"349","author":"Gallini","year":"2016","journal-title":"Exp Cell Res"},{"key":"10.1124\/molpharm.124.000958_bib45","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/s11302-022-09910-1","article-title":"Species dependence of A3 adenosine receptor pharmacology and function","volume":"19","author":"Gao","year":"2022","journal-title":"Purinergic Signal"},{"key":"10.1124\/molpharm.124.000958_bib46","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1016\/j.stem.2020.05.004","article-title":"Human-iPSC-derived cardiac stromal cells enhance maturation in 3D cardiac microtissues and reveal non-cardiomyocyte contributions to heart disease","volume":"26","author":"Giacomelli","year":"2020","journal-title":"Cell Stem Cell"},{"key":"10.1124\/molpharm.124.000958_bib47","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1161\/01.RES.82.10.1043","article-title":"Epicardium-derived cells contribute a novel population to the myocardial wall and the atrioventricular cushions","volume":"82","author":"Gittenberger-de Groot","year":"1998","journal-title":"Circ Res"},{"key":"10.1124\/molpharm.124.000958_bib48","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/S0008-6363(98)00121-7","article-title":"Angiotensin II stimulates cardiac myocyte hypertrophy via paracrine release of TGF-\u03b21 and endothelin-1 from fibroblasts","volume":"40","author":"Gray","year":"1998","journal-title":"Cardiovasc Res"},{"key":"10.1124\/molpharm.124.000958_bib49","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1038\/s41588-023-01337-7","article-title":"Dual genetic tracing reveals a unique fibroblast subpopulation modulating cardiac fibrosis","volume":"55","author":"Han","year":"2023","journal-title":"Nat Genet"},{"key":"10.1124\/molpharm.124.000958_bib50","doi-asserted-by":"crossref","first-page":"258","DOI":"10.3324\/haematol.13699","article-title":"Mesenchymal stem cells: the fibroblasts\u2019 new clothes?","volume":"94","author":"Haniffa","year":"2009","journal-title":"Haematologica"},{"key":"10.1124\/molpharm.124.000958_bib51","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.matbio.2015.05.006","article-title":"The extracellular matrix and transforming growth factor-\u03b21: Tale of a strained relationship","volume":"47","author":"Hinz","year":"2015","journal-title":"Matrix Biol"},{"key":"10.1124\/molpharm.124.000958_bib52","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1056\/NEJMoa1002659","article-title":"Myocardial fibrosis as an early manifestation of hypertrophic cardiomyopathy","volume":"363","author":"Ho","year":"2010","journal-title":"N\u00a0Engl J Med"},{"key":"10.1124\/molpharm.124.000958_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.scr.2021.102420","article-title":"Cardiac fibrosis models using human induced pluripotent stem cell-derived cardiac tissues allow anti-fibrotic drug screening in\u00a0vitro","volume":"54","author":"Iseoka","year":"2021","journal-title":"Stem Cell Res"},{"key":"10.1124\/molpharm.124.000958_bib54","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1136\/heartjnl-2013-305471","article-title":"Role of late gadolinium enhancement cardiovascular magnetic resonance in the risk stratification of hypertrophic cardiomyopathy","volume":"100","author":"Ismail","year":"2014","journal-title":"Heart"},{"key":"10.1124\/molpharm.124.000958_bib55","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1006\/jmcc.1999.1007","article-title":"Tumor necrosis factor-alpha at acute myocardial infarction in rats and effects on cardiac fibroblasts","volume":"31","author":"Jacobs","year":"1999","journal-title":"J\u00a0Mol Cell Cardiol"},{"key":"10.1124\/molpharm.124.000958_bib56","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCGEN.120.003273","article-title":"International evidence based reappraisal of genes associated with arrhythmogenic right ventricular cardiomyopathy using the clinical genome resource framework","volume":"14","author":"James","year":"2021","journal-title":"Circ Genom Precis Med"},{"key":"10.1124\/molpharm.124.000958_bib57","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1161\/CIRCRESAHA.117.305365","article-title":"Human induced pluripotent stem cell-derived cardiomyocytes: insights into molecular, cellular, and functional phenotypes","volume":"117","author":"Karakikes","year":"2015","journal-title":"Circ Res"},{"key":"10.1124\/molpharm.124.000958_bib58","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2023.103064","article-title":"G\u03b2\u03b3 subunits colocalize with RNA polymerase II and regulate transcription in cardiac fibroblasts","volume":"299","author":"Khan","year":"2023","journal-title":"J\u00a0Biol Chem"},{"key":"10.1124\/molpharm.124.000958_bib59","doi-asserted-by":"crossref","first-page":"38","DOI":"10.4330\/wjc.v11.i1.38","article-title":"Contemporary characteristics and outcomes of adults with familial dilated cardiomyopathy listed for heart transplantation","volume":"11","author":"Khayata","year":"2019","journal-title":"World J Cardiol"},{"key":"10.1124\/molpharm.124.000958_bib60","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1126\/science.1137325","article-title":"Polony multiplex analysis of gene expression (PMAGE) in mouse hypertrophic cardiomyopathy","volume":"316","author":"Kim","year":"2007","journal-title":"Science"},{"key":"10.1124\/molpharm.124.000958_bib61","doi-asserted-by":"crossref","first-page":"2451","DOI":"10.1161\/CIRCULATIONAHA.118.037357","article-title":"Human-induced pluripotent stem cell model of trastuzumab-induced cardiac dysfunction in patients with breast cancer","volume":"139","author":"Kitani","year":"2019","journal-title":"Circulation"},{"key":"10.1124\/molpharm.124.000958_bib62","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/s44161-022-00028-6","article-title":"Single-cell transcriptomics reveals cell-type-specific diversification in human heart failure","volume":"1","author":"Koenig","year":"2022","journal-title":"Nat Cardiovasc Res"},{"key":"10.1124\/molpharm.124.000958_bib63","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-49285-9","article-title":"An improved method of maintaining primary murine cardiac fibroblasts in two-dimensional cell culture","volume":"9","author":"Landry","year":"2019","journal-title":"Sci Rep"},{"key":"10.1124\/molpharm.124.000958_bib64","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/978-1-0716-1382-5_13","article-title":"Soft substrate culture to mechanically control cardiac myofibroblast activation","volume":"2299","author":"Landry","year":"2021","journal-title":"Methods Mol Biol"},{"key":"10.1124\/molpharm.124.000958_bib65","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1161\/CIRCRESAHA.116.309386","article-title":"Pediatric cardiomyopathies","volume":"121","author":"Lee","year":"2017","journal-title":"Circ Res"},{"key":"10.1124\/molpharm.124.000958_bib66","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1136\/hrt.2010.205542","article-title":"Use of cardiovascular magnetic resonance for risk stratification in chronic heart failure: prognostic value of late gadolinium enhancement in patients with non-ischaemic dilated cardiomyopathy","volume":"97","author":"Lehrke","year":"2011","journal-title":"Heart"},{"key":"10.1124\/molpharm.124.000958_bib67","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1186\/s13287-022-02905-0","article-title":"Modeling hypertrophic cardiomyopathy with human cardiomyocytes derived from induced pluripotent stem cells","volume":"13","author":"Li","year":"2022","journal-title":"Stem Cell Res Ther"},{"key":"10.1124\/molpharm.124.000958_bib68","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/nprot.2012.150","article-title":"Directed cardiomyocyte differentiation from human pluripotent stem cells by modulating Wnt\/\u03b2-catenin signaling under fully defined conditions","volume":"8","author":"Lian","year":"2013","journal-title":"Nat Protoc"},{"key":"10.1124\/molpharm.124.000958_bib69","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1038\/s41586-020-2797-4","article-title":"Cells of the adult human heart","volume":"588","author":"Litvi\u0148ukov\u00e1","year":"2020","journal-title":"Nature"},{"key":"10.1124\/molpharm.124.000958_bib70","doi-asserted-by":"crossref","first-page":"129","DOI":"10.4137\/CMC.S5900","article-title":"Characteristics and prognostic importance of myocardial fibrosis in patients with dilated cardiomyopathy assessed by contrast-enhanced cardiac magnetic resonance imaging","volume":"4","author":"Looi","year":"2010","journal-title":"Clin Med Insights Cardiol"},{"key":"10.1124\/molpharm.124.000958_bib71","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/s44161-022-00200-y","article-title":"Surfaceome mapping of primary human heart cells with CellSurfer uncovers cardiomyocyte surface protein LSMEM2 and proteome dynamics in failing hearts","volume":"2","author":"Luecke","year":"2023","journal-title":"Nat Cardiovasc Res"},{"key":"10.1124\/molpharm.124.000958_bib72","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.tips.2017.03.001","article-title":"Cardiac fibroblast activation post-myocardial infarction: Current knowledge gaps","volume":"38","author":"Ma","year":"2017","journal-title":"Trends Pharmacol Sci"},{"key":"10.1124\/molpharm.124.000958_bib73","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1016\/j.jcmg.2020.11.006","article-title":"Progression of myocardial fibrosis in nonischemic DCM and association with mortality and heart failure outcomes","volume":"14","author":"Mandawat","year":"2021","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1124\/molpharm.124.000958_bib74","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1038\/nature08494","article-title":"Finding the missing heritability of complex diseases","volume":"461","author":"Manolio","year":"2009","journal-title":"Nature"},{"key":"10.1124\/molpharm.124.000958_bib75","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1161\/CIRCULATIONAHA.106.174287","volume":"113","author":"Maron","year":"2006","journal-title":"Circulation"},{"key":"10.1124\/molpharm.124.000958_bib76","doi-asserted-by":"crossref","first-page":"C813","DOI":"10.1152\/ajpcell.00120.2022","article-title":"The complicated lives of GPCRs in cardiac fibroblasts","volume":"323","author":"Mazarura","year":"2022","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1124\/molpharm.124.000958_bib77","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2022.1015473","article-title":"Transcriptome and proteome profiling of activated cardiac fibroblasts supports target prioritization in cardiac fibrosis","volume":"9","author":"Moita","year":"2022","journal-title":"Front Cardiovasc Med"},{"key":"10.1124\/molpharm.124.000958_bib78","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1007\/s00395-019-0715-4","article-title":"Fibroblast polarization over the myocardial infarction time continuum shifts roles from inflammation to angiogenesis","volume":"114","author":"Mouton","year":"2019","journal-title":"Basic Res Cardiol"},{"key":"10.1124\/molpharm.124.000958_bib79","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.stem.2012.02.013","article-title":"Recurrent variations in DNA methylation in human pluripotent stem cells and their differentiated derivatives","volume":"10","author":"Nazor","year":"2012","journal-title":"Cell Stem Cell"},{"key":"10.1124\/molpharm.124.000958_bib80","doi-asserted-by":"crossref","first-page":"8345","DOI":"10.1002\/jcp.29678","article-title":"Matrix stiffness controls cardiac fibroblast activation through regulating YAP via AT1 R","volume":"235","author":"Niu","year":"2020","journal-title":"J\u00a0Cell Physiol"},{"key":"10.1124\/molpharm.124.000958_bib81","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1124\/pr.116.013003","article-title":"Patient and disease-specific induced pluripotent stem cells for discovery of personalized cardiovascular drugs and therapeutics","volume":"72","author":"Paik","year":"2020","journal-title":"Pharmacol Rev"},{"key":"10.1124\/molpharm.124.000958_bib82","doi-asserted-by":"crossref","first-page":"2555","DOI":"10.1172\/JCI117956","article-title":"Interleukin-1 beta induces cardiac myocyte growth but inhibits cardiac fibroblast proliferation in culture","volume":"95","author":"Palmer","year":"1995","journal-title":"J\u00a0Clin Invest"},{"key":"10.1124\/molpharm.124.000958_bib83","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.yjmcc.2016.03.005","article-title":"Myocyte-fibroblast communication in cardiac fibrosis and arrhythmias: Mechanisms and model systems","volume":"94","author":"Pellman","year":"2016","journal-title":"J\u00a0Mol Cell Cardiol"},{"key":"10.1124\/molpharm.124.000958_bib84","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1161\/CIRCRESAHA.120.317685","article-title":"Multiscale analysis of extracellular matrix remodeling in the failing heart","volume":"128","author":"Perestrelo","year":"2021","journal-title":"Circ Res"},{"key":"10.1124\/molpharm.124.000958_bib85","first-page":"1172","article-title":"The dynamic facets of the cardiac stroma: from classical markers to omics and translational perspectives","volume":"14","author":"Picchio","year":"2022","journal-title":"Am J Transl Res"},{"key":"10.1124\/molpharm.124.000958_bib86","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/s10741-016-9536-9","article-title":"The fibrosis-cell death axis in heart failure","volume":"21","author":"Piek","year":"2016","journal-title":"Heart Fail Rev"},{"key":"10.1124\/molpharm.124.000958_bib87","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.stem.2016.10.005","article-title":"Cardiac fibroblasts adopt osteogenic fates and can be targeted to attenuate pathological heart calcification","volume":"20","author":"Pillai","year":"2017","journal-title":"Cell Stem Cell"},{"key":"10.1124\/molpharm.124.000958_bib88","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.actbio.2022.08.060","article-title":"Matrix produced by diseased cardiac fibroblasts affects early myotube formation and function","volume":"152","author":"Pi\u00f1eiro-Llanes","year":"2022","journal-title":"Acta Biomater"},{"key":"10.1124\/molpharm.124.000958_bib89","article-title":"2D and 3D-organized cardiac cells shows differences in cellular morphology, adhesion junctions, presence of myofibrils and protein expression","volume":"7","author":"Pontes Soares","year":"2012","journal-title":"PLoS One"},{"key":"10.1124\/molpharm.124.000958_bib90","doi-asserted-by":"crossref","DOI":"10.1016\/j.mbplus.2020.100055","article-title":"Mechano-chemo signaling interactions modulate matrix production by cardiac fibroblasts","volume":"10","author":"Rogers","year":"2021","journal-title":"Matrix Biol Plus"},{"key":"10.1124\/molpharm.124.000958_bib91","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1161\/01.CIR.97.9.934","article-title":"Images in cardiovascular medicine. Connective tissue skeleton of the human heart: a demonstration by cell-maceration scanning electron microscope method","volume":"97","author":"Rossi","year":"1998","journal-title":"Circulation"},{"key":"10.1124\/molpharm.124.000958_bib92","doi-asserted-by":"crossref","first-page":"30","DOI":"10.20517\/jca.2022.14","article-title":"Deletion of the Lmna gene in fibroblasts causes senescence-associated dilated cardiomyopathy by activating the double-stranded DNA damage response and induction of senescence-associated secretory phenotype","volume":"2","author":"Rouhi","year":"2022","journal-title":"J\u00a0Cardiovasc Aging"},{"key":"10.1124\/molpharm.124.000958_bib93","doi-asserted-by":"crossref","first-page":"44108","DOI":"10.1021\/acsami.1c13630","article-title":"Development of cell-derived matrices for three-dimensional in\u00a0vitro cancer cell models","volume":"13","author":"Rub\u00ed-Sans","year":"2021","journal-title":"ACS Appl Mater Interfaces"},{"key":"10.1124\/molpharm.124.000958_bib94","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/9363809","article-title":"Human cardiac fibroblast number and activation state modulate electromechanical function of hiPSC-cardiomyocytes in engineered myocardium","volume":"2020","author":"Rupert","year":"2020","journal-title":"Stem Cells Int"},{"key":"10.1124\/molpharm.124.000958_bib95","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1126\/science.abm0594","article-title":"CAR T cells produced in\u00a0vivo to treat cardiac injury","volume":"375","author":"Rurik","year":"2022","journal-title":"Science"},{"key":"10.1124\/molpharm.124.000958_bib96","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.ymeth.2021.04.004","article-title":"Isolation and culture of adult murine cardiac atrial and ventricular fibroblasts and myofibroblasts","volume":"203","author":"Sahadevan","year":"2022","journal-title":"Methods"},{"key":"10.1124\/molpharm.124.000958_bib97","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aax9276","article-title":"Clinical trial in a dish using iPSCs shows lovastatin improves endothelial dysfunction and cellular cross-talk in LMNA cardiomyopathy","volume":"12","author":"Sayed","year":"2020","journal-title":"Sci Transl Med"},{"key":"10.1124\/molpharm.124.000958_bib98","doi-asserted-by":"crossref","first-page":"e79","DOI":"10.1016\/j.carpath.2010.04.004","article-title":"Idiopathic massive myocardial calcification: a case report and review of the literature","volume":"20","author":"Shackley","year":"2011","journal-title":"Cardiovasc Pathol"},{"key":"10.1124\/molpharm.124.000958_bib99","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aaf2584","article-title":"High-throughput screening of tyrosine kinase inhibitor cardiotoxicity with human induced pluripotent stem cells","volume":"9","author":"Sharma","year":"2017","journal-title":"Sci Transl Med"},{"key":"10.1124\/molpharm.124.000958_bib100","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1161\/CIRCRESAHA.120.318049","article-title":"Generation of vascular smooth muscle cells from induced pluripotent stem cells: methods, applications, and considerations","volume":"128","author":"Shen","year":"2021","journal-title":"Circ Res"},{"key":"10.1124\/molpharm.124.000958_bib101","doi-asserted-by":"crossref","first-page":"8610","DOI":"10.3390\/ijms21228610","article-title":"Cardiac ECM: Its epigenetic regulation and role in heart development and repair","volume":"21","author":"Song","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1124\/molpharm.124.000958_bib102","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1161\/CIRCRESAHA.109.209809","article-title":"Cardiac fibroblast: the renaissance cell","volume":"105","author":"Souders","year":"2009","journal-title":"Circ Res"},{"key":"10.1124\/molpharm.124.000958_bib103","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s13062-023-00398-2","article-title":"IPSC derived cardiac fibroblasts of DMD patients show compromised actin microfilaments, metabolic shift and pro-fibrotic phenotype","volume":"18","author":"Soussi","year":"2023","journal-title":"Biol Direct"},{"key":"10.1124\/molpharm.124.000958_bib104","doi-asserted-by":"crossref","first-page":"e337","DOI":"10.1542\/peds.2005-2667","article-title":"Cardiac and clinical phenotype in Barth syndrome","volume":"118","author":"Spencer","year":"2006","journal-title":"Pediatrics"},{"key":"10.1124\/molpharm.124.000958_bib105","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/j.yjmcc.2005.07.008","article-title":"Altered fibroblast function following myocardial infarction","volume":"39","author":"Squires","year":"2005","journal-title":"J\u00a0Mol Cell Cardiol"},{"key":"10.1124\/molpharm.124.000958_bib106","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1007\/s13239-024-00711-8","article-title":"Influence of remodeled ECM and co-culture with iPSC-derived cardiac fibroblasts on the mechanical function of micropatterned iPSC-derived cardiomyocytes","volume":"15","author":"Stempien","year":"2024","journal-title":"Cardiovasc Eng Technol"},{"key":"10.1124\/molpharm.124.000958_bib107","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.gene.2015.05.065","article-title":"HEK293 in cell biology and cancer research: phenotype, karyotype, tumorigenicity, and stress-induced genome-phenotype evolution","volume":"569","author":"Stepanenko","year":"2015","journal-title":"Gene"},{"key":"10.1124\/molpharm.124.000958_bib108","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1002\/pd.2599","article-title":"Barth syndrome: an X-linked cause of fetal cardiomyopathy and stillbirth","volume":"30","author":"Steward","year":"2010","journal-title":"Prenat Diagn"},{"key":"10.1124\/molpharm.124.000958_bib109","doi-asserted-by":"crossref","first-page":"990","DOI":"10.3390\/cells10050990","article-title":"Channelling the force to reprogram the matrix: Mechanosensitive ion channels in cardiac fibroblasts","volume":"10","author":"Stewart","year":"2021","journal-title":"Cells"},{"key":"10.1124\/molpharm.124.000958_bib110","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3003552","article-title":"Patient-specific induced pluripotent stem cells as a model for familial dilated cardiomyopathy","volume":"4","author":"Sun","year":"2012","journal-title":"Sci Transl Med"},{"key":"10.1124\/molpharm.124.000958_bib111","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.cell.2006.07.024","article-title":"Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors","volume":"126","author":"Takahashi","year":"2006","journal-title":"Cell"},{"key":"10.1124\/molpharm.124.000958_bib112","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1002\/ehf2.12616","article-title":"Reactive fibrosis precedes doxorubicin-induced heart failure through sterile inflammation","volume":"7","author":"Tanaka","year":"2020","journal-title":"ESC Heart Fail"},{"key":"10.1124\/molpharm.124.000958_bib113","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.yjmcc.2020.03.016","article-title":"Human induced pluripotent stem cell-derived cardiomyocytes reveal abnormal TGF\u03b2 signaling in type 2 diabetes mellitus","volume":"142","author":"Tang","year":"2020","journal-title":"J\u00a0Mol Cell Cardiol"},{"key":"10.1124\/molpharm.124.000958_bib114","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1002\/ar.20952","article-title":"The application of stereological methods for estimating structural parameters in the human heart","volume":"292","author":"Tang","year":"2009","journal-title":"Anat Rec (Hoboken)"},{"key":"10.1124\/molpharm.124.000958_bib115","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.ijbiomac.2016.04.010","article-title":"MicroRNA-29a suppresses cardiac fibroblasts proliferation via targeting VEGF-A\/MAPK signal pathway","volume":"88","author":"Tao","year":"2016","journal-title":"Int J Biol Macromol"},{"key":"10.1124\/molpharm.124.000958_bib116","first-page":"33","article-title":"Prognosis of heart transplant patients in Mashhad University of Medical Sciences","volume":"17","author":"Teshnisi","year":"2020","journal-title":"Kardiochir Torakochirurgia Pol"},{"key":"10.1124\/molpharm.124.000958_bib117","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.addr.2015.11.001","article-title":"Extracellular matrix structure","volume":"97","author":"Theocharis","year":"2016","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1124\/molpharm.124.000958_bib118","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1093\/cvr\/cvab115","article-title":"Human-induced pluripotent stem cells in cardiovascular research: current approaches in cardiac differentiation, maturation strategies, and scalable production","volume":"118","author":"Thomas","year":"2022","journal-title":"Cardiovasc Res"},{"key":"10.1124\/molpharm.124.000958_bib119","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejcb.2023.151288","article-title":"Mechanical stress regulates the mechanotransduction and metabolism of cardiac fibroblasts in fibrotic cardiac diseases","volume":"102","author":"Tian","year":"2023","journal-title":"Eur J Cell Biol"},{"key":"10.1124\/molpharm.124.000958_bib120","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1006\/excr.2002.5635","article-title":"Mesenchymal cells potentiate vascular endothelial growth factor-induced angiogenesis in\u00a0vitro","volume":"280","author":"Tille","year":"2002","journal-title":"Exp Cell Res"},{"key":"10.1124\/molpharm.124.000958_bib121","first-page":"423","article-title":"Beyond cardiomyocytes: Cellular diversity in the heart\u2019s response to exercise","volume":"12","author":"Trager","year":"2023","journal-title":"J\u00a0Sport Health Sci"},{"key":"10.1124\/molpharm.124.000958_bib122","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1161\/CIRCRESAHA.115.306565","article-title":"Cardiac fibrosis: the fibroblast awakens","volume":"118","author":"Travers","year":"2016","journal-title":"Circ Res"},{"key":"10.1124\/molpharm.124.000958_bib123","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1161\/CIRCULATIONAHA.119.045401","article-title":"Transcriptional and cellular diversity of the human heart","volume":"142","author":"Tucker","year":"2020","journal-title":"Circulation"},{"key":"10.1124\/molpharm.124.000958_bib124","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1002\/path.2281","article-title":"Bone marrow-derived myofibroblasts contribute functionally to scar formation after myocardial infarction","volume":"214","author":"van Amerongen","year":"2008","journal-title":"J\u00a0Pathol"},{"key":"10.1124\/molpharm.124.000958_bib125","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1161\/CIRCRESAHA.110.227421","article-title":"Enhanced fibroblast\u2013myocyte interactions in response to cardiac injury","volume":"107","author":"Vasquez","year":"2010","journal-title":"Circ Res"},{"key":"10.1124\/molpharm.124.000958_bib126","article-title":"Role of targeted therapy in dilated cardiomyopathy: The challenging road toward a personalized approach","volume":"8","author":"Verdonschot","year":"2019","journal-title":"J\u00a0Am Heart Assoc"},{"key":"10.1124\/molpharm.124.000958_bib127","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1093\/eurheartj\/ehaa841","article-title":"Phenotypic clustering of dilated cardiomyopathy patients highlights important pathophysiological differences","volume":"42","author":"Verdonschot","year":"2021","journal-title":"Eur Heart J"},{"key":"10.1124\/molpharm.124.000958_bib128","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1152\/physrev.00024.2022","article-title":"Genome-wide association studies of cardiovascular disease","volume":"103","author":"Walsh","year":"2023","journal-title":"Physiol Rev"},{"key":"10.1124\/molpharm.124.000958_bib129","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.actbio.2014.09.038","article-title":"Evolving insights in cell-matrix interactions: elucidating how non-soluble properties of the extracellular niche direct stem cell fate","volume":"11","author":"Walters","year":"2015","journal-title":"Acta Biomater"},{"key":"10.1124\/molpharm.124.000958_bib130","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1038\/labinvest.2016.65","article-title":"Hypoxia-stimulated cardiac fibroblast production of IL-6 promotes myocardial fibrosis via the TGF-\u03b21 signaling pathway","volume":"96","author":"Wang","year":"2016","journal-title":"Lab Invest"},{"issue":"Suppl 1","key":"10.1124\/molpharm.124.000958_bib131","doi-asserted-by":"crossref","first-page":"i69","DOI":"10.1136\/bjsports-2012-091482","article-title":"Imaging focal and interstitial fibrosis with cardiovascular magnetic resonance in athletes with left ventricular hypertrophy: implications for sporting participation","volume":"46","author":"Waterhouse","year":"2012","journal-title":"Br J Sports Med"},{"key":"10.1124\/molpharm.124.000958_bib132","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1186\/s12881-020-01088-w","article-title":"Gene expression profiling of fibroblasts in a family with LMNA-related cardiomyopathy reveals molecular pathways implicated in disease pathogenesis","volume":"21","author":"Widyastuti","year":"2020","journal-title":"BMC Med Genet"},{"key":"10.1124\/molpharm.124.000958_bib133","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.actbio.2013.08.037","article-title":"Young developmental age cardiac extracellular matrix promotes the expansion of neonatal cardiomyocytes in\u00a0vitro","volume":"10","author":"Williams","year":"2014","journal-title":"Acta Biomater"},{"key":"10.1124\/molpharm.124.000958_bib134","doi-asserted-by":"crossref","first-page":"3685","DOI":"10.1093\/eurheartj\/ehz326","article-title":"Modelling diastolic dysfunction in induced pluripotent stem cell-derived cardiomyocytes from hypertrophic cardiomyopathy patients","volume":"40","author":"Wu","year":"2019","journal-title":"Eur Heart J"},{"key":"10.1124\/molpharm.124.000958_bib135","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1111\/cts.12393","article-title":"Pharmacological modulation of calcium homeostasis in familial dilated cardiomyopathy: An in\u00a0vitro analysis from an RBM20 patient-derived iPSC model","volume":"9","author":"Wyles","year":"2016","journal-title":"Clin Transl Sci"},{"key":"10.1124\/molpharm.124.000958_bib136","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2021.778982","article-title":"Phenotypic variability in iPSC-induced cardiomyocytes and cardiac fibroblasts carrying diverse LMNA mutations","volume":"12","author":"Yang","year":"2021","journal-title":"Front Physiol"},{"key":"10.1124\/molpharm.124.000958_bib137","doi-asserted-by":"crossref","DOI":"10.1038\/srep33067","article-title":"Paracrine effects of adipose-derived stem cells on matrix stiffness-induced cardiac myofibroblast differentiation via angiotensin II type 1 receptor and Smad7","volume":"6","author":"Yong","year":"2016","journal-title":"Sci Rep"},{"issue":"Suppl 1","key":"10.1124\/molpharm.124.000958_bib138","doi-asserted-by":"crossref","first-page":"S20","DOI":"10.1097\/IJG.0000000000000108","article-title":"Biology of the extracellular matrix: an overview","volume":"23","author":"Yue","year":"2014","journal-title":"J\u00a0Glaucoma"},{"key":"10.1124\/molpharm.124.000958_bib139","series-title":"induced Pluripotent Stem (iPS) Cells: Methods and Protocols","first-page":"109","article-title":"Generation of quiescent cardiac fibroblasts derived from human induced pluripotent stem cells","author":"Zhang","year":"2022"},{"key":"10.1124\/molpharm.124.000958_bib140","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1161\/CIRCRESAHA.119.315491","article-title":"Generation of quiescent cardiac fibroblasts from human induced pluripotent stem cells for in\u00a0vitro modeling of cardiac fibrosis","volume":"125","author":"Zhang","year":"2019","journal-title":"Circ Res"},{"key":"10.1124\/molpharm.124.000958_bib141","article-title":"Functional cardiac fibroblasts derived from human pluripotent stem cells via second heart field progenitors","volume":"10","author":"Zhang","year":"2019","journal-title":"Nat Commun"},{"key":"10.1124\/molpharm.124.000958_bib142","article-title":"Necrotic myocardial cells release damage-associated molecular patterns that provoke fibroblast activation in\u00a0vitro and trigger myocardial inflammation and fibrosis in\u00a0vivo","volume":"4","author":"Zhang","year":"2015","journal-title":"J\u00a0Am Heart Assoc"},{"key":"10.1124\/molpharm.124.000958_bib143","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1161\/CIRCRESAHA.116.308139","article-title":"Recounting cardiac cellular composition","volume":"118","author":"Zhou","year":"2016","journal-title":"Circ Res"},{"key":"10.1124\/molpharm.124.000958_bib144","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1038\/s41419-022-05403-6","article-title":"MYBPC3 deficiency in cardiac fibroblasts drives their activation and contributes to fibrosis","volume":"13","author":"Zou","year":"2022","journal-title":"Cell Death Dis"},{"key":"10.1124\/molpharm.124.000958_bib145","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1016\/j.jacc.2006.07.060","article-title":"The role of platelet-derived growth factor signaling in healing myocardial infarcts","volume":"48","author":"Zymek","year":"2006","journal-title":"J\u00a0Am Coll Cardiol"}],"container-title":["Molecular Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026895X24120081?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026895X24120081?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/molpharm.124.000958","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T04:31:45Z","timestamp":1740544305000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0026895X24120081"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":145,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["S0026895X24120081"],"URL":"https:\/\/doi.org\/10.1124\/molpharm.124.000958","relation":{},"ISSN":["0026-895X"],"issn-type":[{"value":"0026-895X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Modeling the contribution of cardiac fibroblasts in dilated cardiomyopathy using induced pluripotent stem cells","name":"articletitle","label":"Article Title"},{"value":"Molecular Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/molpharm.124.000958","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 American Society for Pharmacology and Experimental Therapeutics. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"100002"}}