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\u201cantagomirs.\u201d","volume":"438","author":"Kr\u00fctzfeldt","year":"2005","journal-title":"Nature"},{"key":"10.1124\/pharmrev.124.001297_bib122","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1161\/CIRCRESAHA.120.316819","article-title":"RYR2 channel inhibition is the principal mechanism of flecainide action in CPVT","volume":"128","author":"Kryshtal","year":"2021","journal-title":"Circ Res"},{"key":"10.1124\/pharmrev.124.001297_bib123","doi-asserted-by":"crossref","first-page":"222","DOI":"10.2174\/1573403X10666140514102528","article-title":"Electrocardiogram in Andersen-Tawil syndrome. 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