{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T17:57:50Z","timestamp":1793383070915,"version":"4.5.0"},"reference-count":148,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["pharmrev.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Reviews"],"published-print":{"date-parts":[[2015,1]]},"DOI":"10.1124\/pr.114.009381","type":"journal-article","created":{"date-parts":[[2014,11,13]],"date-time":"2014-11-13T23:16:45Z","timestamp":1415920605000},"page":"103-117","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":227,"title":["The Rho Kinases: Critical Mediators of Multiple Profibrotic Processes and Rational Targets for New Therapies for Pulmonary Fibrosis"],"prefix":"10.1016","volume":"67","author":[{"given":"Rachel S.","family":"Knipe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew M.","family":"Tager","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James K.","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1124\/pr.114.009381_bib1","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1007\/s11926-007-0008-z","article-title":"New developments in fibroblast and myofibroblast biology: implications for fibrosis and scleroderma","volume":"9","author":"Abraham","year":"2007","journal-title":"Curr Rheumatol Rep"},{"key":"10.1124\/pr.114.009381_bib2","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1164\/rccm.201403-0509PP","article-title":"New therapeutic targets in idiopathic pulmonary fibrosis: aiming to rein in runaway wound healing responses","volume":"190","author":"Ahluwalia","year":"2014","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1124\/pr.114.009381_bib3","doi-asserted-by":"crossref","first-page":"2553","DOI":"10.1002\/art.23677","article-title":"Rho-associated kinases are crucial for myofibroblast differentiation and production of extracellular matrix in scleroderma fibroblasts","volume":"58","author":"Akhmetshina","year":"2008","journal-title":"Arthritis Rheum"},{"key":"10.1124\/pr.114.009381_bib4","doi-asserted-by":"crossref","first-page":"20246","DOI":"10.1074\/jbc.271.34.20246","article-title":"Phosphorylation and activation of myosin by Rho-associated kinase (Rho-kinase)","volume":"271","author":"Amano","year":"1996","journal-title":"J Biol Chem"},{"key":"10.1124\/pr.114.009381_bib5","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1242\/jcs.00229","article-title":"Making sense of latent TGFbeta activation","volume":"116","author":"Annes","year":"2003","journal-title":"J Cell Sci"},{"key":"10.1124\/pr.114.009381_bib6","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1039\/c2ib00149g","article-title":"The mechanical memory of lung myofibroblasts","volume":"4","author":"Balestrini","year":"2012","journal-title":"Integr Biol (Camb)"},{"key":"10.1124\/pr.114.009381_bib7","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.pupt.2013.07.008","article-title":"Long-term treatment with fasudil improves bleomycin-induced pulmonary fibrosis and pulmonary hypertension via inhibition of Smad2\/3 phosphorylation","volume":"26","author":"Bei","year":"2013","journal-title":"Pulm Pharmacol Ther"},{"key":"10.1124\/pr.114.009381_bib8","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1164\/rccm.201306-1141WS","article-title":"Future directions in idiopathic pulmonary fibrosis research. An NHLBI workshop report","volume":"189","author":"Blackwell","year":"2014","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1124\/pr.114.009381_bib9","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1164\/rccm.200405-612OC","article-title":"Progressive transforming growth factor beta1-induced lung fibrosis is blocked by an orally active ALK5 kinase inhibitor","volume":"171","author":"Bonniaud","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1124\/pr.114.009381_bib10","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1038\/ncb2756","article-title":"Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts","volume":"15","author":"Calvo","year":"2013","journal-title":"Nat Cell Biol"},{"key":"10.1124\/pr.114.009381_bib11","doi-asserted-by":"crossref","first-page":"C195","DOI":"10.1152\/ajpcell.2000.279.1.C195","article-title":"ROCK mediates thrombin\u2019s endothelial barrier dysfunction","volume":"279","author":"Carbajal","year":"2000","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1124\/pr.114.009381_bib12","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1083\/jcb.200203034","article-title":"The Rho-associated protein kinase p160ROCK is required for centrosome positioning","volume":"157","author":"Chevrier","year":"2002","journal-title":"J Cell Biol"},{"key":"10.1124\/pr.114.009381_bib13","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/35070009","article-title":"Membrane blebbing during apoptosis results from caspase-mediated activation of ROCK I","volume":"3","author":"Coleman","year":"2001","journal-title":"Nat Cell Biol"},{"key":"10.1124\/pr.114.009381_bib14","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1177\/1753465810379801","article-title":"The pathogenesis of idiopathic pulmonary fibrosis","volume":"4","author":"Coward","year":"2010","journal-title":"Ther Adv Respir Dis"},{"key":"10.1124\/pr.114.009381_bib15","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1042\/bj3510095","article-title":"Specificity and mechanism of action of some commonly used protein kinase inhibitors","volume":"351","author":"Davies","year":"2000","journal-title":"Biochem J"},{"key":"10.1124\/pr.114.009381_bib16","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/j.1067-1927.2005.130102.x","article-title":"Tissue repair, contraction, and the myofibroblast","volume":"13","author":"Desmouli\u00e8re","year":"2005","journal-title":"Wound Repair Regen"},{"key":"10.1124\/pr.114.009381_bib17","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1016\/j.cell.2007.07.019","article-title":"Elucidation of a universal size-control mechanism in Drosophila and mammals","volume":"130","author":"Dong","year":"2007","journal-title":"Cell"},{"key":"10.1124\/pr.114.009381_bib18","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1146\/annurev-pathol-020712-163930","article-title":"Host responses in tissue repair and fibrosis","volume":"8","author":"Duffield","year":"2013","journal-title":"Annu Rev Pathol"},{"key":"10.1124\/pr.114.009381_bib19","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nature10137","article-title":"Role of YAP\/TAZ in mechanotransduction","volume":"474","author":"Dupont","year":"2011","journal-title":"Nature"},{"key":"10.1124\/pr.114.009381_bib20","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1056\/NEJM198612253152606","article-title":"Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing","volume":"315","author":"Dvorak","year":"1986","journal-title":"N Engl J Med"},{"key":"10.1124\/pr.114.009381_bib21","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1172\/JCI118396","article-title":"Bleomycin-induced pulmonary fibrosis in transgenic mice that either lack or overexpress the murine plasminogen activator inhibitor-1 gene","volume":"97","author":"Eitzman","year":"1996","journal-title":"J Clin Invest"},{"key":"10.1124\/pr.114.009381_bib22","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/S0014-5793(97)00657-1","article-title":"Molecular cloning of a novel phosphorylation-dependent inhibitory protein of protein phosphatase-1 (CPI17) in smooth muscle: its specific localization in smooth muscle","volume":"410","author":"Eto","year":"1997","journal-title":"FEBS Lett"},{"key":"10.1124\/pr.114.009381_bib23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1165\/rcmb.2010-0365TR","article-title":"Pulmonary hypertension and idiopathic pulmonary fibrosis: a tale of angiogenesis, apoptosis, and growth factors","volume":"45","author":"Farkas","year":"2011","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1124\/pr.114.009381_bib24","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1089\/ars.2007.1907","article-title":"Apoptosis in pulmonary fibrosis: too much or not enough?","volume":"10","author":"Fattman","year":"2008","journal-title":"Antioxid Redox Signal"},{"key":"10.1124\/pr.114.009381_bib25","doi-asserted-by":"crossref","first-page":"37385","DOI":"10.1074\/jbc.274.52.37385","article-title":"Inhibitory phosphorylation site for Rho-associated kinase on smooth muscle myosin phosphatase","volume":"274","author":"Feng","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1124\/pr.114.009381_bib26","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1083\/jcb.124.4.619","article-title":"Disruption of epithelial cell-matrix interactions induces apoptosis","volume":"124","author":"Frisch","year":"1994","journal-title":"J Cell Biol"},{"key":"10.1124\/pr.114.009381_bib27","doi-asserted-by":"crossref","first-page":"3105","DOI":"10.1681\/ASN.2005121366","article-title":"Signaling mechanism of renal fibrosis in unilateral ureteral obstructive kidney disease in ROCK1 knockout mice","volume":"17","author":"Fu","year":"2006","journal-title":"J Am Soc Nephrol"},{"key":"10.1124\/pr.114.009381_bib28","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1165\/rcmb.2010-0155OC","article-title":"The lysophosphatidic acid receptor LPA1 promotes epithelial cell apoptosis after lung injury","volume":"46","author":"Funke","year":"2012","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1124\/pr.114.009381_bib29","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1007\/s12015-009-9107-8","article-title":"Effect of ROCK inhibitor Y-27632 on normal and variant human embryonic stem cells (hESCs) in vitro: its benefits in hESC expansion","volume":"6","author":"Gauthaman","year":"2010","journal-title":"Stem Cell Rev"},{"key":"10.1124\/pr.114.009381_bib30","doi-asserted-by":"crossref","first-page":"G1147","DOI":"10.1152\/ajpgi.00032.2007","article-title":"Increased stiffness of the rat liver precedes matrix deposition: implications for fibrosis","volume":"293","author":"Georges","year":"2007","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1124\/pr.114.009381_bib31","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1136\/thx.48.10.959","article-title":"Effect of antibody to transforming growth factor beta on bleomycin induced accumulation of lung collagen in mice","volume":"48","author":"Giri","year":"1993","journal-title":"Thorax"},{"key":"10.1124\/pr.114.009381_bib32","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1056\/NEJMra003200","article-title":"Idiopathic pulmonary fibrosis","volume":"345","author":"Gross","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1124\/pr.114.009381_bib33","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1164\/rccm.2201082","article-title":"Prevention of bleomycin-induced lung fibrosis by aerosolization of heparin or urokinase in rabbits","volume":"168","author":"G\u00fcnther","year":"2003","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1124\/pr.114.009381_bib34","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1006\/bbrc.2000.3225","article-title":"Phosphorylation of CPI-17, an inhibitor of myosin phosphatase, by protein kinase N","volume":"274","author":"Hamaguchi","year":"2000","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1124\/pr.114.009381_bib35","doi-asserted-by":"crossref","first-page":"5496","DOI":"10.1074\/jbc.M709037200","article-title":"Tumor suppressor LATS1 is a negative regulator of oncogene YAP","volume":"283","author":"Hao","year":"2008","journal-title":"J Biol Chem"},{"key":"10.1124\/pr.114.009381_bib36","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1164\/rccm.200706-805OC","article-title":"Partial inhibition of integrin alpha(v)beta6 prevents pulmonary fibrosis without exacerbating inflammation","volume":"177","author":"Horan","year":"2008","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1124\/pr.114.009381_bib37","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1165\/rcmb.2013-0046TE","article-title":"Rho-associated protein kinase inhibition enhances airway epithelial Basal-cell proliferation and lentivirus transduction","volume":"49","author":"Horani","year":"2013","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1124\/pr.114.009381_bib38","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1016\/S0002-9440(10)62354-1","article-title":"Absence of proteinase-activated receptor-1 signaling affords protection from bleomycin-induced lung inflammation and fibrosis","volume":"166","author":"Howell","year":"2005","journal-title":"Am J Pathol"},{"key":"10.1124\/pr.114.009381_bib39","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1165\/rcmb.2013-0070OC","article-title":"Lysophosphatidic acid receptor-2 deficiency confers protection against bleomycin-induced lung injury and fibrosis in mice","volume":"49","author":"Huang","year":"2013","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1124\/pr.114.009381_bib40","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1165\/rcmb.2012-0050OC","article-title":"Matrix stiffness-induced myofibroblast differentiation is mediated by intrinsic mechanotransduction","volume":"47","author":"Huang","year":"2012","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1124\/pr.114.009381_bib41","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1513\/pats.200702-036MS","article-title":"Does current knowledge explain the pathogenesis of idiopathic pulmonary fibrosis? A perspective","volume":"4","author":"Hunninghake","year":"2007","journal-title":"Proc Am Thorac Soc"},{"key":"10.1124\/pr.114.009381_bib42","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1046\/j.1471-4159.2002.00801.x","article-title":"Inhibition of rho-kinase-induced myristoylated alanine-rich C kinase substrate (MARCKS) phosphorylation in human neuronal cells by H-1152, a novel and specific Rho-kinase inhibitor","volume":"81","author":"Ikenoya","year":"2002","journal-title":"J Neurochem"},{"key":"10.1124\/pr.114.009381_bib43","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1164\/ajrccm.156.2.9608094","article-title":"Tissue factor expression and fibrin deposition in the lungs of patients with idiopathic pulmonary fibrosis and systemic sclerosis","volume":"156","author":"Imokawa","year":"1997","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1124\/pr.114.009381_bib44","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1097\/FJC.0b013e318064f150","article-title":"Fasudil attenuates myocardial fibrosis in association with inhibition of monocyte\/macrophage infiltration in the heart of DOCA\/salt hypertensive rats","volume":"50","author":"Ishimaru","year":"2007","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1124\/pr.114.009381_bib45","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1002\/j.1460-2075.1996.tb00539.x","article-title":"The small GTP-binding protein Rho binds to and activates a 160 kDa Ser\/Thr protein kinase homologous to myotonic dystrophy kinase","volume":"15","author":"Ishizaki","year":"1996","journal-title":"EMBO J"},{"key":"10.1124\/pr.114.009381_bib46","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/S0026-895X(24)26508-1","article-title":"Pharmacological properties of Y-27632, a specific inhibitor of rho-associated kinases","volume":"57","author":"Ishizaki","year":"2000","journal-title":"Mol Pharmacol"},{"key":"10.1124\/pr.114.009381_bib47","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1038\/ni1112","article-title":"Toll-like receptor control of the adaptive immune responses","volume":"5","author":"Iwasaki","year":"2004","journal-title":"Nat Immunol"},{"key":"10.1124\/pr.114.009381_bib48","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1172\/JCI27183","article-title":"Ligation of protease-activated receptor 1 enhances alpha(v)beta6 integrin-dependent TGF-beta activation and promotes acute lung injury","volume":"116","author":"Jenkins","year":"2006","journal-title":"J Clin Invest"},{"key":"10.1124\/pr.114.009381_bib49","doi-asserted-by":"crossref","first-page":"8293","DOI":"10.3390\/ijms13078293","article-title":"Fasudil, a rho-kinase inhibitor, attenuates bleomycin-induced pulmonary fibrosis in mice","volume":"13","author":"Jiang","year":"2012","journal-title":"Int J Mol Sci"},{"key":"10.1124\/pr.114.009381_bib50","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1189\/jlb.0607374","article-title":"Early events in the recognition of danger signals after tissue injury","volume":"83","author":"Kaczorowski","year":"2008","journal-title":"J Leukoc Biol"},{"key":"10.1124\/pr.114.009381_bib51","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1083\/jcb.147.5.1023","article-title":"Phosphorylation of myosin-binding subunit (MBS) of myosin phosphatase by Rho-kinase in vivo","volume":"147","author":"Kawano","year":"1999","journal-title":"J Cell Biol"},{"key":"10.1124\/pr.114.009381_bib52","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1136\/thorax.58.9.772","article-title":"TGF-beta1 causes airway fibrosis and increased collagen I and III mRNA in mice","volume":"58","author":"Kenyon","year":"2003","journal-title":"Thorax"},{"key":"10.1124\/pr.114.009381_bib53","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1677\/JOE-06-0045","article-title":"A Rho-kinase inhibitor, fasudil, prevents development of diabetes and nephropathy in insulin-resistant diabetic rats","volume":"192","author":"Kikuchi","year":"2007","journal-title":"J Endocrinol"},{"key":"10.1124\/pr.114.009381_bib54","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.1111\/j.1440-1746.2006.04735.x","article-title":"Rho\/Rho kinase is a key enzyme system involved in the angiotensin II signaling pathway of liver fibrosis and steatosis","volume":"22","author":"Kitamura","year":"2007","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1124\/pr.114.009381_bib55","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1111\/j.1469-7793.1999.00139.x","article-title":"Reconstitution of protein kinase C-induced contractile Ca2+ sensitization in triton X-100-demembranated rabbit arterial smooth muscle","volume":"520","author":"Kitazawa","year":"1999","journal-title":"J Physiol"},{"key":"10.1124\/pr.114.009381_bib56","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1038\/ki.2010.428","article-title":"Rho kinase inhibition protects kidneys from diabetic nephropathy without reducing blood pressure","volume":"79","author":"Komers","year":"2011","journal-title":"Kidney Int"},{"key":"10.1124\/pr.114.009381_bib57","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0014-5793(00)01654-9","article-title":"Phosphorylation of CPI-17, an inhibitory phosphoprotein of smooth muscle myosin phosphatase, by Rho-kinase","volume":"475","author":"Koyama","year":"2000","journal-title":"FEBS Lett"},{"key":"10.1124\/pr.114.009381_bib58","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1002\/jnr.21502","article-title":"Inhibition of the Rho\/ROCK pathway reduces apoptosis during transplantation of embryonic stem cell-derived neural precursors","volume":"86","author":"Koyanagi","year":"2008","journal-title":"J Neurosci Res"},{"key":"10.1124\/pr.114.009381_bib59","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1164\/ajrccm.154.2.8756825","article-title":"P21Waf1\/Cip1\/Sdi1 and p53 expression in association with DNA strand breaks in idiopathic pulmonary fibrosis","volume":"154","author":"Kuwano","year":"1996","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1124\/pr.114.009381_bib60","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/j.bbadis.2012.12.001","article-title":"Macrophages and fibrosis: How resident and infiltrating mononuclear phagocytes orchestrate all phases of tissue injury and repair","volume":"1832","author":"Lech","year":"2013","journal-title":"Biochim Biophys Acta"},{"key":"10.1124\/pr.114.009381_bib61","doi-asserted-by":"crossref","first-page":"29051","DOI":"10.1074\/jbc.270.49.29051","article-title":"A novel serine\/threonine kinase binding the Ras-related RhoA GTPase which translocates the kinase to peripheral membranes","volume":"270","author":"Leung","year":"1995","journal-title":"J Biol Chem"},{"key":"10.1124\/pr.114.009381_bib62","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1089\/scd.2007.0247","article-title":"The ROCK inhibitor Y-27632 enhances the survival rate of human embryonic stem cells following cryopreservation","volume":"17","author":"Li","year":"2008","journal-title":"Stem Cells Dev"},{"key":"10.1124\/pr.114.009381_bib63","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1002\/hep.21792","article-title":"Transforming growth factor-beta and substrate stiffness regulate portal fibroblast activation in culture","volume":"46","author":"Li","year":"2007","journal-title":"Hepatology"},{"key":"10.1124\/pr.114.009381_bib64","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1097\/FJC.0b013e318070d1bd","article-title":"Rho kinase (ROCK) inhibitors","volume":"50","author":"Liao","year":"2007","journal-title":"J Cardiovasc Pharmacol"},{"issue":"Suppl 1","key":"10.1124\/pr.114.009381_bib65","doi-asserted-by":"crossref","first-page":"S24","DOI":"10.1186\/1755-1536-5-S1-S24","article-title":"CTGF is a central mediator of tissue remodeling and fibrosis and its inhibition can reverse the process of fibrosis","volume":"5","author":"Lipson","year":"2012","journal-title":"Fibrogenesis Tissue Repair"},{"key":"10.1124\/pr.114.009381_bib66","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1083\/jcb.201004082","article-title":"Feedback amplification of fibrosis through matrix stiffening and COX-2 suppression","volume":"190","author":"Liu","year":"2010","journal-title":"J Cell Biol"},{"key":"10.1124\/pr.114.009381_bib67","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s00228-011-1100-x","article-title":"Systematic assessment and meta-analysis of the efficacy and safety of fasudil in the treatment of cerebral vasospasm in patients with subarachnoid hemorrhage","volume":"68","author":"Liu","year":"2012","journal-title":"Eur J Clin Pharmacol"},{"key":"10.1124\/pr.114.009381_bib68","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1126\/science.285.5429.895","article-title":"Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase","volume":"285","author":"Maekawa","year":"1999","journal-title":"Science"},{"key":"10.1124\/pr.114.009381_bib69","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1083\/jcb.140.3.647","article-title":"Rho-kinase phosphorylates COOH-terminal threonines of ezrin\/radixin\/moesin (ERM) proteins and regulates their head-to-tail association","volume":"140","author":"Matsui","year":"1998","journal-title":"J Cell Biol"},{"key":"10.1124\/pr.114.009381_bib70","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1183\/09031936.00060708","article-title":"MMP expression and abnormal lung permeability are important determinants of outcome in IPF","volume":"33","author":"McKeown","year":"2009","journal-title":"Eur Respir J"},{"key":"10.1124\/pr.114.009381_bib71","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1136\/thorax.56.12.916","article-title":"Pulmonary (99m)Tc-DTPA aerosol clearance and survival in usual interstitial pneumonia (UIP)","volume":"56","author":"Mogulkoc","year":"2001","journal-title":"Thorax"},{"key":"10.1124\/pr.114.009381_bib72","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1002\/path.1531","article-title":"Comparison of the morphological and biochemical changes in normal human lung fibroblasts and fibroblasts derived from lungs of patients with idiopathic pulmonary fibrosis during FasL-induced apoptosis","volume":"202","author":"Moodley","year":"2004","journal-title":"J Pathol"},{"key":"10.1124\/pr.114.009381_bib73","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1165\/rcmb.2013-0094TR","article-title":"Animal models of fibrotic lung disease","volume":"49","author":"Moore","year":"2013","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"1, Suppl","key":"10.1124\/pr.114.009381_bib74","doi-asserted-by":"crossref","first-page":"S20","DOI":"10.1016\/j.jacc.2009.04.018","article-title":"Cellular and molecular basis of pulmonary arterial hypertension","volume":"54","author":"Morrell","year":"2009","journal-title":"J Am Coll Cardiol"},{"key":"10.1124\/pr.114.009381_bib75","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S0092-8674(00)80545-0","article-title":"The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis","volume":"96","author":"Munger","year":"1999","journal-title":"Cell"},{"key":"10.1124\/pr.114.009381_bib76","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1038\/nri3073","article-title":"Protective and pathogenic functions of macrophage subsets","volume":"11","author":"Murray","year":"2011","journal-title":"Nat Rev Immunol"},{"key":"10.1124\/pr.114.009381_bib77","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1046\/j.1523-1755.2002.00328.x","article-title":"Y-27632 prevents tubulointerstitial fibrosis in mouse kidneys with unilateral ureteral obstruction","volume":"61","author":"Nagatoya","year":"2002","journal-title":"Kidney Int"},{"key":"10.1124\/pr.114.009381_bib78","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0014-5793(96)00811-3","article-title":"ROCK-I and ROCK-II, two isoforms of Rho-associated coiled-coil forming protein serine\/threonine kinase in mice","volume":"392","author":"Nakagawa","year":"1996","journal-title":"FEBS Lett"},{"key":"10.1124\/pr.114.009381_bib79","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1136\/thoraxjnl-2013-203740","article-title":"Presence of a prothrombotic state in people with idiopathic pulmonary fibrosis: a population-based case-control study","volume":"69","author":"Navaratnam","year":"2014","journal-title":"Thorax"},{"key":"10.1124\/pr.114.009381_bib80","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1042\/bj20021040","article-title":"Agonist-induced changes in the phosphorylation of the myosin- binding subunit of myosin light chain phosphatase and CPI17, two regulatory factors of myosin light chain phosphatase, in smooth muscle","volume":"369","author":"Niiro","year":"2003","journal-title":"Biochem J"},{"key":"10.1124\/pr.114.009381_bib81","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.atherosclerosis.2008.12.023","article-title":"Statins inhibit Rho kinase activity in patients with atherosclerosis","volume":"205","author":"Nohria","year":"2009","journal-title":"Atherosclerosis"},{"key":"10.1124\/pr.114.009381_bib82","doi-asserted-by":"crossref","first-page":"C661","DOI":"10.1152\/ajpcell.00459.2005","article-title":"Physiological role of ROCKs in the cardiovascular system","volume":"290","author":"Noma","year":"2006","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1124\/pr.114.009381_bib83","doi-asserted-by":"crossref","first-page":"3577","DOI":"10.1074\/jbc.275.5.3577","article-title":"Rho-associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loop","volume":"275","author":"Ohashi","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1124\/pr.114.009381_bib84","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1172\/JCI118201","article-title":"Changes in procoagulant and fibrinolytic gene expression during bleomycin-induced lung injury in the mouse","volume":"96","author":"Olman","year":"1995","journal-title":"J Clin Invest"},{"key":"10.1124\/pr.114.009381_bib85","first-page":"L519","article-title":"Polymerization of fibrinogen in murine bleomycin-induced lung injury","volume":"271","author":"Olman","year":"1996","journal-title":"Am J Physiol"},{"key":"10.1124\/pr.114.009381_bib86","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/nrm2890","article-title":"Linking actin dynamics and gene transcription to drive cellular motile functions","volume":"11","author":"Olson","year":"2010","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1124\/pr.114.009381_bib87","doi-asserted-by":"crossref","first-page":"958","DOI":"10.3109\/0886022X.2013.808565","article-title":"Inhibition of Rho-kinase alleviates peritoneal fibrosis and angiogenesis in a rat model of peritoneal dialysis","volume":"35","author":"Peng","year":"2013","journal-title":"Ren Fail"},{"key":"10.1124\/pr.114.009381_bib88","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1378\/chest.127.1.266","article-title":"Expression of apoptotic and antiapoptotic markers in epithelial cells in idiopathic pulmonary fibrosis","volume":"127","author":"Plataki","year":"2005","journal-title":"Chest"},{"key":"10.1124\/pr.114.009381_bib89","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.ejphar.2012.08.010","article-title":"Targeted inhibition of renal Rho kinase reduces macrophage infiltration and lymphangiogenesis in acute renal allograft rejection","volume":"694","author":"Poosti","year":"2012","journal-title":"Eur J Pharmacol"},{"key":"10.1124\/pr.114.009381_bib90","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1164\/rccm.200706-806OC","article-title":"Inhibition of integrin alpha(v)beta6, an activator of latent transforming growth factor-beta, prevents radiation-induced lung fibrosis","volume":"177","author":"Puthawala","year":"2008","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1124\/pr.114.009381_bib91","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.1056\/NEJMoa1113354","article-title":"Prednisone, azathioprine, and N-acetylcysteine for pulmonary fibrosis","volume":"366","author":"Raghu","year":"2012","journal-title":"N Engl J Med"},{"key":"10.1124\/pr.114.009381_bib92","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1164\/rccm.2009-040GL","article-title":"An official ATS\/ERS\/JRS\/ALAT statement: idiopathic pulmonary fibrosis: evidence-based guidelines for diagnosis and management","volume":"183","author":"Raghu","year":"2011","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1124\/pr.114.009381_bib93","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1038\/nrm1128","article-title":"Rocks: multifunctional kinases in cell behaviour","volume":"4","author":"Riento","year":"2003","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1124\/pr.114.009381_bib94","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.1161\/01.STR.0000181077.84981.11","article-title":"Inhibition of Rho kinase (ROCK) leads to increased cerebral blood flow and stroke protection","volume":"36","author":"Rikitake","year":"2005","journal-title":"Stroke"},{"key":"10.1124\/pr.114.009381_bib95","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1161\/01.RES.0000196564.18314.23","article-title":"Rho GTPases, statins, and nitric oxide","volume":"97","author":"Rikitake","year":"2005","journal-title":"Circ Res"},{"key":"10.1124\/pr.114.009381_bib96","doi-asserted-by":"crossref","first-page":"2959","DOI":"10.1161\/CIRCULATIONAHA.105.584623","article-title":"Decreased perivascular fibrosis but not cardiac hypertrophy in ROCK1+\/- haploinsufficient mice","volume":"112","author":"Rikitake","year":"2005","journal-title":"Circulation"},{"key":"10.1124\/pr.114.009381_bib97","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1096\/fj.12-219378","article-title":"LPA1-induced cytoskeleton reorganization drives fibrosis through CTGF-dependent fibroblast proliferation","volume":"27","author":"Sakai","year":"2013","journal-title":"FASEB J"},{"key":"10.1124\/pr.114.009381_bib98","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/j.bbadis.2013.03.001","article-title":"Fibrosis of two: Epithelial cell-fibroblast interactions in pulmonary fibrosis","volume":"1832","author":"Sakai","year":"2013","journal-title":"Biochim Biophys Acta"},{"key":"10.1124\/pr.114.009381_bib99","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1165\/rcmb.2008-0288OC","article-title":"Critical role of serum response factor in pulmonary myofibroblast differentiation induced by TGF-beta","volume":"41","author":"Sandbo","year":"2009","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1124\/pr.114.009381_bib100","doi-asserted-by":"crossref","first-page":"L656","DOI":"10.1152\/ajplung.00166.2011","article-title":"Delayed stress fiber formation mediates pulmonary myofibroblast differentiation in response to TGF-\u03b2","volume":"301","author":"Sandbo","year":"2011","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1124\/pr.114.009381_bib101","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1042\/CS20110086","article-title":"TGF-\u03b2\/TGF-\u03b2 receptor system and its role in physiological and pathological conditions","volume":"121","author":"Santiba\u00f1ez","year":"2011","journal-title":"Clin Sci (Lond)"},{"key":"10.1124\/pr.114.009381_bib102","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0014-2999(02)02619-5","article-title":"Fasudil attenuates interstitial fibrosis in rat kidneys with unilateral ureteral obstruction","volume":"455","author":"Satoh","year":"2002","journal-title":"Eur J Pharmacol"},{"key":"10.1124\/pr.114.009381_bib103","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1378\/chest.06-2568","article-title":"Molecular targets in pulmonary fibrosis: the myofibroblast in focus","volume":"132","author":"Scotton","year":"2007","journal-title":"Chest"},{"key":"10.1124\/pr.114.009381_bib104","first-page":"2550","article-title":"Increased local expression of coagulation factor X contributes to the fibrotic response in human and murine lung injury","volume":"119","author":"Scotton","year":"2009","journal-title":"J Clin Invest"},{"key":"10.1124\/pr.114.009381_bib105","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/35070019","article-title":"Caspase-3-mediated cleavage of ROCK I induces MLC phosphorylation and apoptotic membrane blebbing","volume":"3","author":"Sebbagh","year":"2001","journal-title":"Nat Cell Biol"},{"key":"10.1124\/pr.114.009381_bib106","doi-asserted-by":"crossref","first-page":"136","DOI":"10.7326\/0003-4819-134-2-200101160-00015","article-title":"Idiopathic pulmonary fibrosis: prevailing and evolving hypotheses about its pathogenesis and implications for therapy","volume":"134","author":"Selman","year":"2001","journal-title":"Ann Intern Med"},{"key":"10.1124\/pr.114.009381_bib107","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1513\/pats.200601-003TK","article-title":"Role of epithelial cells in idiopathic pulmonary fibrosis: from innocent targets to serial killers","volume":"3","author":"Selman","year":"2006","journal-title":"Proc Am Thorac Soc"},{"key":"10.1124\/pr.114.009381_bib108","first-page":"43","article-title":"Endothelial contractile cytoskeleton and microvascular permeability","volume":"2009","author":"Shen","year":"2009","journal-title":"Cell Health Cytoskelet"},{"key":"10.1124\/pr.114.009381_bib109","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1513\/pats.200601-008AW","article-title":"Transforming growth factor beta: a central modulator of pulmonary and airway inflammation and fibrosis","volume":"3","author":"Sheppard","year":"2006","journal-title":"Proc Am Thorac Soc"},{"key":"10.1124\/pr.114.009381_bib110","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.yjmcc.2007.11.018","article-title":"Disruption of ROCK1 gene attenuates cardiac dilation and improves contractile function in pathological cardiac hypertrophy","volume":"44","author":"Shi","year":"2008","journal-title":"J Mol Cell Cardiol"},{"key":"10.1124\/pr.114.009381_bib111","doi-asserted-by":"crossref","first-page":"571","DOI":"10.3171\/jns.1992.76.4.0571","article-title":"Effect of AT877 on cerebral vasospasm after aneurysmal subarachnoid hemorrhage. Results of a prospective placebo-controlled double-blind trial","volume":"76","author":"Shibuya","year":"1992","journal-title":"J Neurosurg"},{"key":"10.1124\/pr.114.009381_bib112","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1164\/ajrccm.163.1.2001089","article-title":"Contribution of small GTPase Rho and its target protein rock in a murine model of lung fibrosis","volume":"163","author":"Shimizu","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1124\/pr.114.009381_bib113","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1083\/jcb.200411179","article-title":"ROCK-I regulates closure of the eyelids and ventral body wall by inducing assembly of actomyosin bundles","volume":"168","author":"Shimizu","year":"2005","journal-title":"J Cell Biol"},{"key":"10.1124\/pr.114.009381_bib114","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1097\/00005344-200211000-00013","article-title":"Anti-anginal effect of fasudil, a Rho-kinase inhibitor, in patients with stable effort angina: a multicenter study","volume":"40","author":"Shimokawa","year":"2002","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1124\/pr.114.009381_bib115","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.molmed.2011.07.009","article-title":"Metchnikoff\u2019s policemen: macrophages in development, homeostasis and regeneration","volume":"17","author":"Stefater","year":"2011","journal-title":"Trends Mol Med"},{"key":"10.1124\/pr.114.009381_bib116","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1074\/jbc.M007074200","article-title":"Specific activation of LIM kinase 2 via phosphorylation of threonine 505 by ROCK, a Rho-dependent protein kinase","volume":"276","author":"Sumi","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1124\/pr.114.009381_bib117","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1080\/10739680600556944","article-title":"Rho and ROCK signaling in VEGF-induced microvascular endothelial hyperpermeability","volume":"13","author":"Sun","year":"2006","journal-title":"Microcirculation"},{"key":"10.1124\/pr.114.009381_bib118","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.surneu.2006.10.037","article-title":"A postmarketing surveillance study of fasudil treatment after aneurysmal subarachnoid hemorrhage","volume":"68","author":"Suzuki","year":"2007","journal-title":"Surg Neurol"},{"key":"10.1124\/pr.114.009381_bib119","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/S0168-8278(00)00059-3","article-title":"A selective ROCK inhibitor, Y27632, prevents dimethylnitrosamine-induced hepatic fibrosis in rats","volume":"34","author":"Tada","year":"2001","journal-title":"J Hepatol"},{"key":"10.1124\/pr.114.009381_bib120","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/nm1685","article-title":"The lysophosphatidic acid receptor LPA1 links pulmonary fibrosis to lung injury by mediating fibroblast recruitment and vascular leak","volume":"14","author":"Tager","year":"2008","journal-title":"Nat Med"},{"key":"10.1124\/pr.114.009381_bib121","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1161\/01.CIR.0000020682.73694.AB","article-title":"Rho-kinase mediates hypoxia-induced downregulation of endothelial nitric oxide synthase","volume":"106","author":"Takemoto","year":"2002","journal-title":"Circulation"},{"key":"10.1124\/pr.114.009381_bib122","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1165\/rcmb.2004-0009OC","article-title":"Attenuation of endotoxin-induced acute lung injury by the Rho-associated kinase inhibitor, Y-27632","volume":"32","author":"Tasaka","year":"2005","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1124\/pr.114.009381_bib123","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1513\/pats.200601-001TK","article-title":"Evolving concepts of apoptosis in idiopathic pulmonary fibrosis","volume":"3","author":"Thannickal","year":"2006","journal-title":"Proc Am Thorac Soc"},{"key":"10.1124\/pr.114.009381_bib124","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.exer.2013.05.014","article-title":"Substratum stiffness and latrunculin B modulate the gene expression of the mechanotransducers YAP and TAZ in human trabecular meshwork cells","volume":"113","author":"Thomasy","year":"2013","journal-title":"Exp Eye Res"},{"key":"10.1124\/pr.114.009381_bib125","doi-asserted-by":"crossref","first-page":"5043","DOI":"10.1128\/MCB.23.14.5043-5055.2003","article-title":"Targeted disruption of the mouse rho-associated kinase 2 gene results in intrauterine growth retardation and fetal death","volume":"23","author":"Thumkeo","year":"2003","journal-title":"Mol Cell Biol"},{"key":"10.1124\/pr.114.009381_bib126","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1097\/BOR.0b013e32835b13cd","article-title":"Biomechanical regulation of mesenchymal cell function","volume":"25","author":"Tschumperlin","year":"2013","journal-title":"Curr Opin Rheumatol"},{"key":"10.1124\/pr.114.009381_bib127","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1161\/01.RES.87.4.335","article-title":"Activation of RhoA by thrombin in endothelial hyperpermeability: role of Rho kinase and protein tyrosine kinases","volume":"87","author":"van Nieuw Amerongen","year":"2000","journal-title":"Circ Res"},{"key":"10.1124\/pr.114.009381_bib128","first-page":"E127","article-title":"Role of RhoA and Rho kinase in lysophosphatidic acid-induced endothelial barrier dysfunction","volume":"20","author":"van Nieuw Amerongen","year":"2000","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1124\/pr.114.009381_bib129","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0014-5793(02)03175-7","article-title":"Phosphorylation of the regulatory subunit of smooth muscle protein phosphatase 1M at Thr850 induces its dissociation from myosin","volume":"527","author":"Velasco","year":"2002","journal-title":"FEBS Lett"},{"key":"10.1124\/pr.114.009381_bib130","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1016\/j.jacc.2005.07.047","article-title":"Efficacy and safety of fasudil in patients with stable angina: a double-blind, placebo-controlled, phase 2 trial","volume":"46","author":"Vicari","year":"2005","journal-title":"J Am Coll Cardiol"},{"key":"10.1124\/pr.114.009381_bib131","doi-asserted-by":"crossref","first-page":"3561","DOI":"10.1096\/fj.08-108829","article-title":"Deficiency of ROCK1 in bone marrow-derived cells protects against atherosclerosis in LDLR-\/- mice","volume":"22","author":"Wang","year":"2008","journal-title":"FASEB J"},{"key":"10.1124\/pr.114.009381_bib132","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/nature02382","article-title":"Myocardin and ternary complex factors compete for SRF to control smooth muscle gene expression","volume":"428","author":"Wang","year":"2004","journal-title":"Nature"},{"key":"10.1124\/pr.114.009381_bib133","doi-asserted-by":"crossref","first-page":"2770","DOI":"10.1093\/ndt\/gfr012","article-title":"Rho-kinase inhibition ameliorates peritoneal fibrosis and angiogenesis in a rat model of peritoneal sclerosis","volume":"26","author":"Washida","year":"2011","journal-title":"Nephrol Dial Transplant"},{"key":"10.1124\/pr.114.009381_bib134","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1038\/nbt1310","article-title":"A ROCK inhibitor permits survival of dissociated human embryonic stem cells","volume":"25","author":"Watanabe","year":"2007","journal-title":"Nat Biotechnol"},{"key":"10.1124\/pr.114.009381_bib135","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1111\/febs.12661","article-title":"Hyperoxia increases the elastic modulus of alveolar epithelial cells through Rho kinase","volume":"281","author":"Wilhelm","year":"2014","journal-title":"FEBS J"},{"key":"10.1124\/pr.114.009381_bib136","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1083\/jcb.200704042","article-title":"Myofibroblast contraction activates latent TGF-beta1 from the extracellular matrix","volume":"179","author":"Wipff","year":"2007","journal-title":"J Cell Biol"},{"key":"10.1124\/pr.114.009381_bib137","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S1537-1891(03)00008-9","article-title":"Rho GTPases and the regulation of endothelial permeability","volume":"39","author":"Wojciak-Stothard","year":"2002","journal-title":"Vascul Pharmacol"},{"key":"10.1124\/pr.114.009381_bib138","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1111\/j.1469-7793.2001.t01-1-00553.x","article-title":"Expression of CPI-17 and myosin phosphatase correlates with Ca(2+) sensitivity of protein kinase C-induced contraction in rabbit smooth muscle","volume":"535","author":"Woodsome","year":"2001","journal-title":"J Physiol"},{"key":"10.1124\/pr.114.009381_bib139","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.atherosclerosis.2009.04.025","article-title":"Effects of fasudil on early atherosclerotic plaque formation and established lesion progression in apolipoprotein E-knockout mice","volume":"207","author":"Wu","year":"2009","journal-title":"Atherosclerosis"},{"key":"10.1124\/pr.114.009381_bib140","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1038\/nm.2807","article-title":"Mechanisms of fibrosis: therapeutic translation for fibrotic disease","volume":"18","author":"Wynn","year":"2012","journal-title":"Nat Med"},{"key":"10.1124\/pr.114.009381_bib141","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.2353\/ajpath.2009.080160","article-title":"Lysophosphatidic acid induces alphavbeta6 integrin-mediated TGF-beta activation via the LPA2 receptor and the small G protein G alpha(q)","volume":"174","author":"Xu","year":"2009","journal-title":"Am J Pathol"},{"key":"10.1124\/pr.114.009381_bib142","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/j.cell.2012.06.037","article-title":"Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling","volume":"150","author":"Yu","year":"2012","journal-title":"Cell"},{"key":"10.1124\/pr.114.009381_bib143","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1096\/fj.05-5129com","article-title":"Targeted deletion of ROCK1 protects the heart against pressure overload by inhibiting reactive fibrosis","volume":"20","author":"Zhang","year":"2006","journal-title":"FASEB J"},{"key":"10.1124\/pr.114.009381_bib144","doi-asserted-by":"crossref","first-page":"2747","DOI":"10.1101\/gad.1602907","article-title":"Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control","volume":"21","author":"Zhao","year":"2007","journal-title":"Genes Dev"},{"key":"10.1124\/pr.114.009381_bib145","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.1101\/gad.1664408","article-title":"TEAD mediates YAP-dependent gene induction and growth control","volume":"22","author":"Zhao","year":"2008","journal-title":"Genes Dev"},{"key":"10.1124\/pr.114.009381_bib146","doi-asserted-by":"crossref","first-page":"679","DOI":"10.2176\/nmc.51.679","article-title":"Efficacy and safety of fasudil in patients with subarachnoid hemorrhage: final results of a randomized trial of fasudil versus nimodipine","volume":"51","author":"Zhao","year":"2011","journal-title":"Neurol Med Chir (Tokyo)"},{"key":"10.1124\/pr.114.009381_bib147","doi-asserted-by":"crossref","first-page":"225","DOI":"10.3760\/cma.j.issn.0366-6999.20131917","article-title":"Fasudil hydrochloride hydrate, a Rho-kinase inhibitor, ameliorates hepatic fibrosis in rats with type 2 diabetes","volume":"127","author":"Zhou","year":"2014","journal-title":"Chin Med J (Engl)"},{"key":"10.1124\/pr.114.009381_bib148","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1172\/JCI66700","article-title":"Inhibition of mechanosensitive signaling in myofibroblasts ameliorates experimental pulmonary fibrosis","volume":"123","author":"Zhou","year":"2013","journal-title":"J Clin Invest"}],"container-title":["Pharmacological Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031699724011268?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031699724011268?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/pr.114.009381","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T07:26:45Z","timestamp":1740036405000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0031699724011268"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1]]},"references-count":148,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["S0031699724011268"],"URL":"https:\/\/doi.org\/10.1124\/pr.114.009381","relation":{},"ISSN":["0031-6997"],"issn-type":[{"value":"0031-6997","type":"print"}],"subject":[],"published":{"date-parts":[[2015,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Rho Kinases: Critical Mediators of Multiple Profibrotic Processes and Rational Targets for New Therapies for Pulmonary Fibrosis","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/pr.114.009381","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2014 by The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}