{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T06:33:09Z","timestamp":1790404389349,"version":"4.1.0"},"reference-count":466,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":2467,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["pharmrev.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Reviews"],"published-print":{"date-parts":[[2018,4]]},"DOI":"10.1124\/pr.117.014399","type":"journal-article","created":{"date-parts":[[2018,3,2]],"date-time":"2018-03-02T22:01:17Z","timestamp":1520028077000},"page":"315-347","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":361,"title":["Etiology and Pharmacology of Neuropathic Pain"],"prefix":"10.1016","volume":"70","author":[{"given":"Sascha R.A.","family":"Alles","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter A.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1124\/pr.117.014399_bib1","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1124\/jpet.110.166363","article-title":"Analgesic effects of a substituted N-triazole oxindole (TROX-1), a state-dependent, voltage-gated calcium channel 2 blocker","volume":"334","author":"Abbadie","year":"2010","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/pr.117.014399_bib2","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1523\/JNEUROSCI.17-05-01633.1997","article-title":"Ectopic alpha2-adrenoceptors couple to N-type Ca2+ channels in axotomized rat sensory neurons","volume":"17","author":"Abdulla","year":"1997","journal-title":"J Neurosci"},{"key":"10.1124\/pr.117.014399_bib3","doi-asserted-by":"crossref","first-page":"9685","DOI":"10.1523\/JNEUROSCI.18-23-09685.1998","article-title":"Axotomy reduces the effect of analgesic opioids yet increases the effect of nociceptin on dorsal root ganglion neurons","volume":"18","author":"Abdulla","year":"1998","journal-title":"J Neurosci"},{"key":"10.1124\/pr.117.014399_bib4","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0306-4522(98)00443-6","article-title":"Nerve injury increases an excitatory action of neuropeptide Y and Y2-agonists on dorsal root ganglion neurons","volume":"89","author":"Abdulla","year":"1999","journal-title":"Neuroscience"},{"key":"10.1124\/pr.117.014399_bib5","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1152\/jn.2001.85.2.630","article-title":"Axotomy- and autotomy-induced changes in the excitability of rat dorsal root ganglion neurons","volume":"85","author":"Abdulla","year":"2001","journal-title":"J Neurophysiol"},{"key":"10.1124\/pr.117.014399_bib6","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1152\/jn.2001.85.2.644","article-title":"Axotomy- and autotomy-induced changes in Ca2+ and K+ channel currents of rat dorsal root ganglion neurons","volume":"85","author":"Abdulla","year":"2001","journal-title":"J Neurophysiol"},{"key":"10.1124\/pr.117.014399_bib7","doi-asserted-by":"crossref","first-page":"2518","DOI":"10.1152\/jn.00913.2001","article-title":"Changes in Na(+) channel currents of rat dorsal root ganglion neurons following axotomy and axotomy-induced autotomy","volume":"88","author":"Abdulla","year":"2002","journal-title":"J Neurophysiol"},{"key":"10.1124\/pr.117.014399_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2016.12.010","article-title":"The cellular and synaptic architecture of the mechanosensory dorsal horn","volume":"168","author":"Abraira","year":"2017","journal-title":"Cell"},{"key":"10.1124\/pr.117.014399_bib9","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.pain.2007.08.030","article-title":"Selective stimulation of GalR1 and GalR2 in rat substantia gelatinosa reveals a cellular basis for the anti- and pro-nociceptive actions of galanin","volume":"137","author":"Alier","year":"2008","journal-title":"Pain"},{"issue":"Pt A","key":"10.1124\/pr.117.014399_bib10","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.neuropharm.2016.11.011","article-title":"Acute anti-allodynic action of gabapentin in dorsal horn and primary somatosensory cortex: correlation of behavioural and physiological data","volume":"113","author":"Alles","year":"2017","journal-title":"Neuropharmacology"},{"key":"10.1124\/pr.117.014399_bib11","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1177\/1073858416628793","article-title":"The anti-allodynic gabapentinoids: myths, paradoxes, and acute effects","volume":"23","author":"Alles","year":"2016","journal-title":"Neuroscientist"},{"key":"10.1124\/pr.117.014399_bib12","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.tips.2004.07.004","article-title":"Targeting Ca2+ channels to treat pain: T-type versus N-type","volume":"25","author":"Altier","year":"2004","journal-title":"Trends Pharmacol Sci"},{"key":"10.1124\/pr.117.014399_bib13","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1080\/10799890801941947","article-title":"Signaling complexes of voltage-gated calcium channels and G protein-coupled receptors","volume":"28","author":"Altier","year":"2008","journal-title":"J Recept Signal Transduct Res"},{"key":"10.1124\/pr.117.014399_bib14","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/1744-8069-9-21","article-title":"Peripheral nerve injury is accompanied by chronic transcriptome-wide changes in the mouse prefrontal cortex","volume":"9","author":"Alvarado","year":"2013","journal-title":"Mol Pain"},{"key":"10.1124\/pr.117.014399_bib15","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1002\/j.1532-2149.2012.00269.x","article-title":"Angiotensin II type 2 receptor (AT2 R) localization and antagonist-mediated inhibition of capsaicin responses and neurite outgrowth in human and rat sensory neurons","volume":"17","author":"Anand","year":"2013","journal-title":"Eur J Pain"},{"key":"10.1124\/pr.117.014399_bib16","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1111\/j.1460-9568.2004.03235.x","article-title":"Expression of hyperpolarization-activated and cyclic nucleotide-gated cation channel subunit 2 in axon terminals of peptidergic nociceptive primary sensory neurons in the superficial spinal dorsal horn of rats","volume":"19","author":"Antal","year":"2004","journal-title":"Eur J Neurosci"},{"issue":"Suppl","key":"10.1124\/pr.117.014399_bib17","doi-asserted-by":"crossref","first-page":"S49","DOI":"10.1016\/j.pain.2010.11.010","article-title":"Pain and the brain: specificity and plasticity of the brain in clinical chronic pain","volume":"152","author":"Apkarian","year":"2011","journal-title":"Pain"},{"key":"10.1124\/pr.117.014399_bib18","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1124\/pr.111.005108","article-title":"Brain-derived neurotrophic factor and neuropsychiatric disorders","volume":"64","author":"Autry","year":"2012","journal-title":"Pharmacol Rev"},{"key":"10.1124\/pr.117.014399_bib19","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1016\/S1044-7431(03)00236-7","article-title":"Removal of GABAergic inhibition facilitates polysynaptic A fiber-mediated excitatory transmission to the superficial spinal dorsal horn","volume":"24","author":"Baba","year":"2003","journal-title":"Mol Cell Neurosci"},{"key":"10.1124\/pr.117.014399_bib20","doi-asserted-by":"crossref","first-page":"2227","DOI":"10.1152\/jn.2000.83.4.2227","article-title":"Voltage-gated calcium currents in axotomized adult rat cutaneous afferent neurons","volume":"83","author":"Baccei","year":"2000","journal-title":"J Neurophysiol"},{"key":"10.1124\/pr.117.014399_bib21","doi-asserted-by":"crossref","first-page":"3690","DOI":"10.1016\/j.bmcl.2014.06.038","article-title":"Recent progress in sodium channel modulators for pain","volume":"24","author":"Bagal","year":"2014","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1124\/pr.117.014399_bib22","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1080\/19336950.2015.1079674","article-title":"Voltage gated sodium channels as drug discovery targets","volume":"9","author":"Bagal","year":"2015","journal-title":"Channels (Austin)"},{"key":"10.1124\/pr.117.014399_bib23","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.neuroscience.2005.11.051","article-title":"Transient loss of terminals from non-peptidergic nociceptive fibers in the substantia gelatinosa of spinal cord following chronic constriction injury of the sciatic nerve","volume":"138","author":"Bailey","year":"2006","journal-title":"Neuroscience"},{"key":"10.1124\/pr.117.014399_bib24","series-title":"L-type calcium channels and neuropathic pain. Abstract viewer\/itinerary planner.","author":"Balasubramanyan","year":"2005"},{"key":"10.1124\/pr.117.014399_bib25","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1152\/jn.00087.2006","article-title":"Sciatic chronic constriction injury produces cell-type-specific changes in the electrophysiological properties of rat substantia gelatinosa neurons","volume":"96","author":"Balasubramanyan","year":"2006","journal-title":"J Neurophysiol"},{"key":"10.1124\/pr.117.014399_bib26","doi-asserted-by":"crossref","first-page":"7417","DOI":"10.1523\/JNEUROSCI.20-19-07417.2000","article-title":"Activity-dependent release of endogenous brain-derived neurotrophic factor from primary sensory neurons detected by ELISA in situ","volume":"20","author":"Balkowiec","year":"2000","journal-title":"J Neurosci"},{"key":"10.1124\/pr.117.014399_bib27","doi-asserted-by":"crossref","first-page":"4159","DOI":"10.1113\/JP274165","article-title":"The plasticity of descending controls in pain: translational probing","volume":"595","author":"Bannister","year":"2017","journal-title":"J Physiol"},{"key":"10.1124\/pr.117.014399_bib28","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1002\/ejp.979","article-title":"An investigation into the inhibitory function of serotonin in diffuse noxious inhibitory controls in the neuropathic rat","volume":"21","author":"Bannister","year":"2017","journal-title":"Eur J Pain"},{"key":"10.1124\/pr.117.014399_bib29","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1097\/j.pain.0000000000000240","article-title":"Diffuse noxious inhibitory controls and nerve injury: restoring an imbalance between descending monoamine inhibitions and facilitations","volume":"156","author":"Bannister","year":"2015","journal-title":"Pain"},{"key":"10.1124\/pr.117.014399_bib30","doi-asserted-by":"crossref","first-page":"2386","DOI":"10.1097\/j.pain.0000000000001040","article-title":"Multiple sites and actions of gabapentin-induced relief of ongoing experimental neuropathic pain","volume":"158","author":"Bannister","year":"2017","journal-title":"Pain"},{"key":"10.1124\/pr.117.014399_bib31","doi-asserted-by":"crossref","first-page":"2774","DOI":"10.1523\/JNEUROSCI.4637-03.2004","article-title":"Presynaptic NMDA receptors modulate glutamate release from primary sensory neurons in rat spinal cord dorsal horn","volume":"24","author":"Bardoni","year":"2004","journal-title":"J Neurosci"},{"key":"10.1124\/pr.117.014399_bib32","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/S1474-4422(16)00056-9","article-title":"Fighting neuropathic pain with botulinum toxin A","volume":"15","author":"Baron","year":"2016","journal-title":"Lancet Neurol"},{"key":"10.1124\/pr.117.014399_bib33","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.cell.2009.09.028","article-title":"Cellular and molecular mechanisms of pain","volume":"139","author":"Basbaum","year":"2009","journal-title":"Cell"},{"key":"10.1124\/pr.117.014399_bib34","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.coph.2016.10.002","article-title":"Transient receptor potential channels in neuropathic pain","volume":"32","author":"Basso","year":"2017","journal-title":"Curr Opin Pharmacol"},{"key":"10.1124\/pr.117.014399_bib35","doi-asserted-by":"crossref","first-page":"4076","DOI":"10.1523\/JNEUROSCI.0356-09.2009","article-title":"The increased trafficking of the calcium channel subunit alpha2delta-1 to presynaptic terminals in neuropathic pain is inhibited by the alpha2delta ligand pregabalin","volume":"29","author":"Bauer","year":"2009","journal-title":"J Neurosci"},{"key":"10.1124\/pr.117.014399_bib36","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.conb.2010.05.007","article-title":"A new look at calcium channel \u03b12\u03b4 subunits","volume":"20","author":"Bauer","year":"2010","journal-title":"Curr Opin Neurobiol"},{"key":"10.1124\/pr.117.014399_bib37","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1093\/brain\/awr288","article-title":"Priming of adult pain responses by neonatal pain experience: maintenance by central neuroimmune activity","volume":"135","author":"Beggs","year":"2012","journal-title":"Brain"},{"key":"10.1124\/pr.117.014399_bib38","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/1744-8069-6-74","article-title":"Peripheral nerve injury and TRPV1-expressing primary afferent C-fibers cause opening of the blood-brain barrier","volume":"6","author":"Beggs","year":"2010","journal-title":"Mol Pain"},{"issue":"Pt A","key":"10.1124\/pr.117.014399_bib39","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.neulet.2013.08.037","article-title":"The known knowns of microglia-neuronal signalling in neuropathic pain","volume":"557","author":"Beggs","year":"2013","journal-title":"Neurosci Lett"},{"key":"10.1124\/pr.117.014399_bib40","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1038\/nn.3155","article-title":"P2X4R+ microglia drive neuropathic pain","volume":"15","author":"Beggs","year":"2012","journal-title":"Nat Neurosci"},{"key":"10.1124\/pr.117.014399_bib41","series-title":"Activated microglia induce tactile allodynia in the rat through a disruption of anion homeostasis in dorsal horn lamina I neurons. 2004 abstract viewer\/itinerary planner.","author":"Beggs","year":"2004"},{"key":"10.1124\/pr.117.014399_bib42","doi-asserted-by":"crossref","first-page":"2294","DOI":"10.1021\/jm049762l","article-title":"Structure-activity relationships of pregabalin and analogues that target the alpha(2)-delta protein","volume":"48","author":"Belliotti","year":"2005","journal-title":"J Med Chem"},{"key":"10.1124\/pr.117.014399_bib43","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/1744-8069-10-77","article-title":"NMP-7 inhibits chronic inflammatory and neuropathic pain via block of Cav3.2\u00a0T-type calcium channels and activation of CB2 receptors","volume":"10","author":"Berger","year":"2014","journal-title":"Mol Pain"},{"key":"10.1124\/pr.117.014399_bib44","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/S1059131102001425","article-title":"The absorption of gabapentin following high dose escalation","volume":"12","author":"Berry","year":"2003","journal-title":"Seizure"},{"key":"10.1124\/pr.117.014399_bib45","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1111\/bcpt.12017","article-title":"Antihyperalgesic effect of the GABA(A) ligand clobazam in a neuropathic pain model in mice: a pharmacokinetic-pharmacodynamic study","volume":"112","author":"Besson","year":"2013","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"10.1124\/pr.117.014399_bib46","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1097\/01.j.pain.0000460331.33385.e8","article-title":"GABAergic modulation in central sensitization in humans: a randomized placebo-controlled pharmacokinetic-pharmacodynamic study comparing clobazam with clonazepam in healthy volunteers [published correction appears in Pain (2015) 156:1370]","volume":"156","author":"Besson","year":"2015","journal-title":"Pain"},{"key":"10.1124\/pr.117.014399_bib47","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1038\/emboj.2011.89","article-title":"Neuronal CCL21 up-regulates microglia P2X4 expression and initiates neuropathic pain development","volume":"30","author":"Biber","year":"2011","journal-title":"EMBO J"},{"key":"10.1124\/pr.117.014399_bib48","series-title":"Isolated Brain Circuits","first-page":"405","article-title":"Defined medium organotypic cultures of spinal cord put \u2018pain in a dish\u2019","author":"Biggs","year":"2012"},{"key":"10.1124\/pr.117.014399_bib49","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/1744-8069-6-44","article-title":"Is BDNF sufficient for information transfer between microglia and dorsal horn neurons during the onset of central sensitization?","volume":"6","author":"Biggs","year":"2010","journal-title":"Mol Pain"},{"key":"10.1124\/pr.117.014399_bib50","doi-asserted-by":"crossref","first-page":"2398","DOI":"10.1152\/jn.00168.2014","article-title":"Analysis of the long-term actions of gabapentin and pregabalin in dorsal root ganglia and substantia gelatinosa","volume":"112","author":"Biggs","year":"2014","journal-title":"J Neurophysiol"},{"key":"10.1124\/pr.117.014399_bib51","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.neulet.2014.07.033","article-title":"Suppression of network activity in dorsal horn by gabapentin permeation of TRPV1 channels: implications for drug access to cytoplasmic targets","volume":"584","author":"Biggs","year":"2015","journal-title":"Neurosci Lett"},{"key":"10.1124\/pr.117.014399_bib52","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1038\/nature06191","article-title":"Inhibition of nociceptors by TRPV1-mediated entry of impermeant sodium channel blockers","volume":"449","author":"Binshtok","year":"2007","journal-title":"Nature"},{"key":"10.1124\/pr.117.014399_bib53","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1097\/ALN.0b013e3181a915e7","article-title":"Coapplication of lidocaine and the permanently charged sodium channel blocker QX-314 produces a long-lasting nociceptive blockade in rodents","volume":"111","author":"Binshtok","year":"2009","journal-title":"Anesthesiology"},{"key":"10.1124\/pr.117.014399_bib54","doi-asserted-by":"crossref","first-page":"14062","DOI":"10.1523\/JNEUROSCI.3795-08.2008","article-title":"Nociceptors are interleukin-1beta sensors","volume":"28","author":"Binshtok","year":"2008","journal-title":"J Neurosci"},{"key":"10.1124\/pr.117.014399_bib55","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.ejphar.2008.08.002","article-title":"Adenosine A1 and A3 receptors protect astrocytes from hypoxic damage","volume":"596","author":"Bj\u00f6rklund","year":"2008","journal-title":"Eur J Pharmacol"},{"key":"10.1124\/pr.117.014399_bib56","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1021\/cn500206a","article-title":"Characterization of novel cannabinoid based T-type calcium channel blockers with analgesic effects","volume":"6","author":"Bladen","year":"2015","journal-title":"ACS Chem Neurosci"},{"key":"10.1124\/pr.117.014399_bib57","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1038\/nn.3758","article-title":"A spinal analog of memory reconsolidation enables reversal of hyperalgesia","volume":"17","author":"Bonin","year":"2014","journal-title":"Nat Neurosci"},{"key":"10.1124\/pr.117.014399_bib58","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.pain.2008.05.004","article-title":"Injury discharges regulate calcium channel alpha-2-delta-1 subunit upregulation in the dorsal horn that contributes to initiation of neuropathic pain","volume":"139","author":"Boroujerdi","year":"2008","journal-title":"Pain"},{"key":"10.1124\/pr.117.014399_bib59","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.pain.2010.12.014","article-title":"Calcium channel alpha-2-delta-1 protein upregulation in dorsal spinal cord mediates spinal cord injury-induced neuropathic pain states","volume":"152","author":"Boroujerdi","year":"2011","journal-title":"Pain"},{"key":"10.1124\/pr.117.014399_bib60","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.neuroscience.2016.03.029","article-title":"Translational neuropathic pain research: a clinical perspective","volume":"338","author":"Bouhassira","year":"2016","journal-title":"Neuroscience"},{"key":"10.1124\/pr.117.014399_bib61","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1152\/physrev.00023.2013","article-title":"Calcium-permeable ion channels in pain signaling","volume":"94","author":"Bourinet","year":"2014","journal-title":"Physiol Rev"},{"key":"10.1124\/pr.117.014399_bib62","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.neuroscience.2017.08.044","article-title":"A quantitative study of neurochemically defined populations of inhibitory interneurons in the superficial dorsal horn of the mouse spinal cord","volume":"363","author":"Boyle","year":"2017","journal-title":"Neuroscience"},{"key":"10.1124\/pr.117.014399_bib63","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.neuron.2014.01.018","article-title":"Transmitting pain and itch messages: a contemporary view of the spinal cord circuits that generate gate control","volume":"82","author":"Braz","year":"2014","journal-title":"Neuron"},{"key":"10.1124\/pr.117.014399_bib64","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1093\/bja\/89.5.711","article-title":"Efficacy of intravenous magnesium in neuropathic pain","volume":"89","author":"Brill","year":"2002","journal-title":"Br J Anaesth"},{"issue":"Suppl 1","key":"10.1124\/pr.117.014399_bib65","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.1097\/j.pain.0000000000000368","article-title":"Potassium channels in neuropathic pain: advances, challenges, and emerging ideas","volume":"157","author":"Busserolles","year":"2016","journal-title":"Pain"},{"key":"10.1124\/pr.117.014399_bib66","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.1073\/pnas.1614447114","article-title":"In vivo imaging reveals that pregabalin inhibits cortical spreading depression and propagation to subcortical brain structures","volume":"114","author":"Cain","year":"2017","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/pr.117.014399_bib67","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1097\/WNF.0b013e3181bf1dbe","article-title":"Pregabalin in the treatment of chronic migraine: an open-label study","volume":"33","author":"Calandre","year":"2010","journal-title":"Clin Neuropharmacol"},{"key":"10.1124\/pr.117.014399_bib68","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/S1474-4422(12)70134-5","article-title":"The role of the immune system in the generation of neuropathic pain","volume":"11","author":"Calvo","year":"2012","journal-title":"Lancet Neurol"},{"key":"10.1124\/pr.117.014399_bib69","doi-asserted-by":"crossref","first-page":"11230","DOI":"10.1073\/pnas.0504183102","article-title":"The metal-ion-dependent adhesion site in the Von Willebrand factor-A domain of alpha2delta subunits is key to trafficking voltage-gated Ca2+ channels","volume":"102","author":"Cant\u00ed","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/pr.117.014399_bib70","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1111\/j.1471-4159.2010.06863.x","article-title":"Reduction in voltage-gated K+ channel activity in primary sensory neurons in painful diabetic neuropathy: role of brain-derived neurotrophic factor","volume":"114","author":"Cao","year":"2010","journal-title":"J Neurochem"},{"key":"10.1124\/pr.117.014399_bib71","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1111\/j.1471-4159.2012.07736.x","article-title":"Nerve injury increases brain-derived neurotrophic factor levels to suppress BK channel activity in primary sensory neurons","volume":"121","author":"Cao","year":"2012","journal-title":"J Neurochem"},{"key":"10.1124\/pr.117.014399_bib72","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1007\/s12031-014-0391-7","article-title":"Effect of histone deacetylase inhibitor JNJ-26481585 in pain","volume":"55","author":"Capasso","year":"2015","journal-title":"J Mol Neurosci"},{"key":"10.1124\/pr.117.014399_bib73","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1097\/01.WNF.0000228174.08885.AB","article-title":"Gabapentin treatment of neurogenic overactive bladder [published correction appears in Clin Neuropharmacol (2009) 32:57; Clin Neuropharmacol (2006) 29:301]","volume":"29","author":"Carbone","year":"2006","journal-title":"Clin Neuropharmacol"},{"key":"10.1124\/pr.117.014399_bib74","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.pain.2009.09.030","article-title":"Peripheral and central sensitization in remote spinal cord regions contribute to central neuropathic pain after spinal cord injury","volume":"147","author":"Carlton","year":"2009","journal-title":"Pain"},{"key":"10.1124\/pr.117.014399_bib75","doi-asserted-by":"crossref","first-page":"8979","DOI":"10.1073\/pnas.1403731111","article-title":"Functional exofacially tagged N-type calcium channels elucidate the interaction with auxiliary \u03b12\u03b4-1 subunits","volume":"111","author":"Cassidy","year":"2014","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/pr.117.014399_bib76","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.neuroscience.2005.11.009","article-title":"Altered discharges of spinal wide dynamic range neurons and down-regulation of glutamate transporter expression in rats with paclitaxel-induced hyperalgesia","volume":"138","author":"Cata","year":"2006","journal-title":"Neuroscience"},{"key":"10.1124\/pr.117.014399_bib77","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1146\/annurev.neuro.24.1.487","article-title":"The vanilloid receptor: a molecular gateway to the pain pathway","volume":"24","author":"Caterina","year":"2001","journal-title":"Annu Rev Neurosci"},{"key":"10.1124\/pr.117.014399_bib78","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1002\/ejp.585","article-title":"Differential effects of voltage-gated calcium channel blockers on calcium channel alpha-2-delta-1 subunit protein-mediated nociception","volume":"19","author":"Chang","year":"2015","journal-title":"Eur J Pain"},{"key":"10.1124\/pr.117.014399_bib79","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1523\/JNEUROSCI.23-04-01169.2003","article-title":"Neuronal hyperpolarization-activated pacemaker channels drive neuropathic pain","volume":"23","author":"Chaplan","year":"2003","journal-title":"J Neurosci"},{"key":"10.1124\/pr.117.014399_bib80","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1124\/jpet.113.208363","article-title":"Nerve injury increases GluA2-lacking AMPA receptor prevalence in spinal cords: functional significance and signaling mechanisms","volume":"347","author":"Chen","year":"2013","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/pr.117.014399_bib81","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1111\/ejn.12516","article-title":"BDNF released during neuropathic pain potentiates NMDA receptors in primary afferent terminals","volume":"39","author":"Chen","year":"2014","journal-title":"Eur J Neurosci"},{"key":"10.1124\/pr.117.014399_bib82","doi-asserted-by":"crossref","first-page":"3203","DOI":"10.1152\/jn.00296.2009","article-title":"Effects of sciatic nerve axotomy on excitatory synaptic transmission in rat substantia gelatinosa","volume":"102","author":"Chen","year":"2009","journal-title":"J Neurophysiol"},{"key":"10.1124\/pr.117.014399_bib83","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.expneurol.2016.03.001","article-title":"Loss of Ca(2+)-permeable AMPA receptors in synapses of tonic firing substantia gelatinosa neurons in the chronic constriction injury model of neuropathic pain","volume":"279","author":"Chen","year":"2016","journal-title":"Exp Neurol"},{"key":"10.1124\/pr.117.014399_bib84","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1254\/jphs.CR0050020","article-title":"Mechanisms of the antinociceptive action of gabapentin","volume":"100","author":"Cheng","year":"2006","journal-title":"J Pharmacol Sci"},{"key":"10.1124\/pr.117.014399_bib85","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1054\/jpai.2002.122944","article-title":"Defining the role for gabapentin in the treatment of trigeminal neuralgia: a retrospective study","volume":"3","author":"Cheshire","year":"2002","journal-title":"J Pain"},{"key":"10.1124\/pr.117.014399_bib86","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1586\/14737175.7.11.1565","article-title":"Trigeminal neuralgia: for one nerve a multitude of treatments","volume":"7","author":"Cheshire","year":"2007","journal-title":"Expert Rev Neurother"},{"key":"10.1124\/pr.117.014399_bib87","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1038\/nature12479","article-title":"Bacteria activate sensory neurons that modulate pain and inflammation","volume":"501","author":"Chiu","year":"2013","journal-title":"Nature"},{"key":"10.1124\/pr.117.014399_bib88","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1038\/nn.3144","article-title":"Neurogenic inflammation and the peripheral nervous system in host defense and immunopathology","volume":"15","author":"Chiu","year":"2012","journal-title":"Nat Neurosci"},{"key":"10.1124\/pr.117.014399_bib89","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1213\/ANE.0b013e318249d36e","article-title":"The prevention of chronic postsurgical pain using gabapentin and pregabalin: a combined systematic review and meta-analysis","volume":"115","author":"Clarke","year":"2012","journal-title":"Anesth Analg"},{"key":"10.1124\/pr.117.014399_bib90","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1002\/cne.20693","article-title":"Differential distribution of voltage-gated calcium channel alpha-2 delta (alpha2delta) subunit mRNA-containing cells in the rat central nervous system and the dorsal root ganglia","volume":"491","author":"Cole","year":"2005","journal-title":"J Comp Neurol"},{"key":"10.1124\/pr.117.014399_bib91","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.neuroscience.2016.08.048","article-title":"Neuronal networks and nociceptive processing in the dorsal horn of the spinal cord","volume":"338","author":"Cordero-Erausquin","year":"2016","journal-title":"Neuroscience"},{"key":"10.1124\/pr.117.014399_bib92","doi-asserted-by":"crossref","first-page":"14415","DOI":"10.1523\/JNEUROSCI.4569-09.2009","article-title":"T-cell infiltration and signaling in the adult dorsal spinal cord is a major contributor to neuropathic pain-like hypersensitivity","volume":"29","author":"Costigan","year":"2009","journal-title":"J Neurosci"},{"key":"10.1124\/pr.117.014399_bib93","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev.neuro.051508.135531","article-title":"Neuropathic pain: a maladaptive response of the nervous system to damage","volume":"32","author":"Costigan","year":"2009","journal-title":"Annu Rev Neurosci"},{"key":"10.1124\/pr.117.014399_bib94","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1038\/nature04223","article-title":"BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain","volume":"438","author":"Coull","year":"2005","journal-title":"Nature"},{"key":"10.1124\/pr.117.014399_bib95","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1038\/nature01868","article-title":"Trans-synaptic shift in anion gradient in spinal lamina I neurons as a mechanism of neuropathic pain","volume":"424","author":"Coull","year":"2003","journal-title":"Nature"},{"key":"10.1124\/pr.117.014399_bib96","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.expneurol.2014.11.015","article-title":"Thrombospondin-4 and excitatory synaptogenesis promote spinal sensitization after painful mechanical joint injury","volume":"264","author":"Crosby","year":"2015","journal-title":"Exp Neurol"},{"key":"10.1124\/pr.117.014399_bib97","doi-asserted-by":"crossref","first-page":"5952","DOI":"10.1523\/JNEUROSCI.21-16-05952.2001","article-title":"Nav1.3 sodium channels: rapid repriming and slow closed-state inactivation display quantitative differences after expression in a mammalian cell line and in spinal sensory neurons","volume":"21","author":"Cummins","year":"2001","journal-title":"J Neurosci"},{"key":"10.1124\/pr.117.014399_bib98","series-title":"Proceedings of the 9th World Congress on Pain; Vienna, Austria","first-page":"119","article-title":"Altered excitability of large-diameter cutaneous afferents following nerve injury: consequences for chronic pain","author":"Cummins","year":"2000"},{"key":"10.1124\/pr.117.014399_bib99","doi-asserted-by":"crossref","first-page":"3503","DOI":"10.1523\/JNEUROSCI.17-10-03503.1997","article-title":"Downregulation of tetrodotoxin-resistant sodium currents and upregulation of a rapidly repriming tetrodotoxin-sensitive sodium current in small spinal sensory neurons after nerve injury","volume":"17","author":"Cummins","year":"1997","journal-title":"J Neurosci"},{"key":"10.1124\/pr.117.014399_bib100","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1124\/jpet.104.067934","article-title":"XP13512 [(+\/-)-1-([(alpha-isobutanoyloxyethoxy)carbonyl] aminomethyl)-1-cyclohexane acetic acid], a novel gabapentin prodrug. I. Design, synthesis, enzymatic conversion to gabapentin, and transport by intestinal solute transporters","volume":"311","author":"Cundy","year":"2004","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/pr.117.014399_bib101","doi-asserted-by":"crossref","first-page":"5891","DOI":"10.1523\/JNEUROSCI.3997-14.2015","article-title":"The upregulation of \u03b12\u03b4-1 subunit modulates activity-dependent Ca2+ signals in sensory neurons","volume":"35","author":"D\u2019Arco","year":"2015","journal-title":"J Neurosci"},{"key":"10.1124\/pr.117.014399_bib102","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0306-4522(99)00328-0","article-title":"Spontaneous activity of rat dorsal horn cells in spinal segments of sciatic projection following transection of sciatic nerve or of corresponding dorsal roots","volume":"94","author":"Dalal","year":"1999","journal-title":"Neuroscience"},{"key":"10.1124\/pr.117.014399_bib103","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1523\/JNEUROSCI.5120-08.2009","article-title":"Low-threshold primary afferent drive onto GABAergic interneurons in the superficial dorsal horn of the mouse","volume":"29","author":"Daniele","year":"2009","journal-title":"J Neurosci"},{"key":"10.1124\/pr.117.014399_bib104","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0140-15.2016","article-title":"Optogenetic silencing of Nav1.8-positive afferents alleviates inflammatory and neuropathic pain","volume":"3","author":"Daou","year":"2016","journal-title":"eNeuro"},{"key":"10.1124\/pr.117.014399_bib105","doi-asserted-by":"crossref","first-page":"716","DOI":"10.2174\/138945009788982513","article-title":"Gabapentin and pregabalin for the acute post-operative pain management: a systematic-narrative review of the recent clinical evidences","volume":"10","author":"Dauri","year":"2009","journal-title":"Curr Drug Targets"},{"key":"10.1124\/pr.117.014399_bib106","doi-asserted-by":"crossref","first-page":"8748","DOI":"10.1523\/JNEUROSCI.2764-06.2006","article-title":"The calcium channel alpha2delta-2 subunit partitions with CaV2.1 into lipid rafts in cerebellum: implications for localization and function","volume":"26","author":"Davies","year":"2006","journal-title":"J Neurosci"},{"key":"10.1124\/pr.117.014399_bib107","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1073\/pnas.0908735107","article-title":"The alpha2delta subunits of voltage-gated calcium channels form GPI-anchored proteins, a posttranslational modification essential for function","volume":"107","author":"Davies","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/pr.117.014399_bib108","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/S0896-6273(02)01001-2","article-title":"Cellular and systems reconsolidation in the hippocampus","volume":"36","author":"Debiec","year":"2002","journal-title":"Neuron"},{"key":"10.1124\/pr.117.014399_bib109","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0304-3959(00)00276-1","article-title":"Spared nerve injury: an animal model of persistent peripheral neuropathic pain","volume":"87","author":"Decosterd","year":"2000","journal-title":"Pain"},{"key":"10.1124\/pr.117.014399_bib110","series-title":"Immune and Glial Regulation of Pain","author":"DeLeo","year":"2007"},{"key":"10.1124\/pr.117.014399_bib111","doi-asserted-by":"crossref","first-page":"2263","DOI":"10.1016\/j.pain.2014.08.014","article-title":"The effect of oxcarbazepine in peripheral neuropathic pain depends on pain phenotype: a randomised, double-blind, placebo-controlled phenotype-stratified study","volume":"155","author":"Demant","year":"2014","journal-title":"Pain"},{"key":"10.1124\/pr.117.014399_bib112","article-title":"Pharmacological characterisation of the highly NaV1.7 selective spider venom peptide Pn3a","volume":"7","author":"Deuis","year":"2017","journal-title":"Sci Rep"},{"key":"10.1124\/pr.117.014399_bib113","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1152\/jn.00365.2006","article-title":"Centralization, central sensitization and neuropathic pain: focus on \u201csciatic chronic constriction injury produces cell-type-specific changes in the electrophysiological properties of rat substantia gelatinosa neurons.\u201d","volume":"96","author":"Devor","year":"2006","journal-title":"J Neurophysiol"},{"key":"10.1124\/pr.117.014399_bib114","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s00221-009-1724-6","article-title":"Ectopic discharge in Abeta afferents as a source of neuropathic pain","volume":"196","author":"Devor","year":"2009","journal-title":"Exp Brain Res"},{"key":"10.1124\/pr.117.014399_bib115","doi-asserted-by":"crossref","first-page":"2207","DOI":"10.1016\/j.pain.2014.08.018","article-title":"PNS origin of phantom limb sensation and pain: reply to letter to the editor regarding Foell et al., peripheral origin of phantom limb pain: is it all resolved?","volume":"155","author":"Devor","year":"2014","journal-title":"Pain"},{"key":"10.1124\/pr.117.014399_bib116","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/276075a0","article-title":"Reorganisation of spinal cord sensory map after peripheral nerve injury","volume":"276","author":"Devor","year":"1978","journal-title":"Nature"},{"key":"10.1124\/pr.117.014399_bib117","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/0304-3959(92)90067-L","article-title":"Systemic lidocaine silences ectopic neuroma and DRG discharge without blocking nerve conduction","volume":"48","author":"Devor","year":"1992","journal-title":"Pain"},{"key":"10.1124\/pr.117.014399_bib118","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/nrn3404","article-title":"The Na(V)1.7 sodium channel: from molecule to man","volume":"14","author":"Dib-Hajj","year":"2013","journal-title":"Nat Rev Neurosci"},{"key":"10.1124\/pr.117.014399_bib119","doi-asserted-by":"crossref","first-page":"6488","DOI":"10.1523\/JNEUROSCI.3816-16.2017","article-title":"Inflammatory pain reduces C fiber activity-dependent slowing in a sex-dependent manner, amplifying nociceptive input to the spinal cord","volume":"37","author":"Dickie","year":"2017","journal-title":"J Neurosci"},{"key":"10.1124\/pr.117.014399_bib120","doi-asserted-by":"crossref","DOI":"10.1038\/tp.2016.168","article-title":"Glial contributions to visceral pain: implications for disease etiology and the female predominance of persistent pain","volume":"6","author":"Dodds","year":"2016","journal-title":"Transl Psychiatry"},{"key":"10.1124\/pr.117.014399_bib121","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1113\/jphysiol.1967.sp008367","article-title":"Co-operative action a calcium ions in transmitter release at the neuromuscular junction","volume":"193","author":"Dodge","year":"1967","journal-title":"J Physiol"},{"key":"10.1124\/pr.117.014399_bib122","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0304-3959(03)00177-5","article-title":"Reversal of experimental neuropathic pain by T-type calcium channel blockers","volume":"105","author":"Dogrul","year":"2003","journal-title":"Pain"},{"key":"10.1124\/pr.117.014399_bib123","series-title":"Calcium Channel Alpha2delta Subunits in Epilepsy and as Targets for Antiepileptic Drugs","author":"Dolphin","year":"2012"},{"key":"10.1124\/pr.117.014399_bib124","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1038\/nrn3311","article-title":"Calcium channel auxiliary \u03b12\u03b4 and \u03b2 subunits: trafficking and one step beyond","volume":"13","author":"Dolphin","year":"2012","journal-title":"Nat Rev Neurosci"},{"key":"10.1124\/pr.117.014399_bib125","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1016\/j.bbamem.2012.11.019","article-title":"The \u03b12\u03b4 subunits of voltage-gated calcium channels","volume":"1828","author":"Dolphin","year":"2013","journal-title":"Biochim Biophys Acta"},{"key":"10.1124\/pr.117.014399_bib126","doi-asserted-by":"crossref","first-page":"5369","DOI":"10.1113\/JP272262","article-title":"Voltage-gated calcium channels and their auxiliary subunits: physiology and pathophysiology and pharmacology","volume":"594","author":"Dolphin","year":"2016","journal-title":"J Physiol"},{"key":"10.1124\/pr.117.014399_bib127","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1172\/JCI86812","article-title":"Local GABAergic signaling within sensory ganglia controls peripheral nociceptive transmission","volume":"127","author":"Du","year":"2017","journal-title":"J Clin Invest"},{"key":"10.1124\/pr.117.014399_bib128","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.pain.2007.08.033","article-title":"Pharmacologic management of neuropathic pain: evidence-based recommendations","volume":"132","author":"Dworkin","year":"2007","journal-title":"Pain"},{"key":"10.1124\/pr.117.014399_bib129","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1038\/ncomms2673","article-title":"A role for Piezo2 in EPAC1-dependent mechanical allodynia","volume":"4","author":"Eijkelkamp","year":"2013","journal-title":"Nat Commun"},{"key":"10.1124\/pr.117.014399_bib130","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1126\/science.1206243","article-title":"HCN2 ion channels play a central role in inflammatory and neuropathic pain","volume":"333","author":"Emery","year":"2011","journal-title":"Science"},{"key":"10.1124\/pr.117.014399_bib131","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.tips.2012.04.004","article-title":"HCN2 ion channels: an emerging role as the pacemakers of pain","volume":"33","author":"Emery","year":"2012","journal-title":"Trends Pharmacol Sci"},{"key":"10.1124\/pr.117.014399_bib132","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.cell.2009.09.025","article-title":"Gabapentin receptor alpha2delta-1 is a neuronal thrombospondin receptor responsible for excitatory CNS synaptogenesis","volume":"139","author":"Eroglu","year":"2009","journal-title":"Cell"},{"key":"10.1124\/pr.117.014399_bib133","doi-asserted-by":"crossref","first-page":"7425","DOI":"10.1523\/JNEUROSCI.22-17-07425.2002","article-title":"The presence and role of the tetrodotoxin-resistant sodium channel Na(v)1.9 (NaN) in nociceptive primary afferent neurons","volume":"22","author":"Fang","year":"2002","journal-title":"J Neurosci"},{"key":"10.1124\/pr.117.014399_bib134","doi-asserted-by":"crossref","first-page":"7281","DOI":"10.1523\/JNEUROSCI.1072-06.2006","article-title":"Intense isolectin-B4 binding in rat dorsal root ganglion neurons distinguishes C-fiber nociceptors with broad action potentials and high Nav1.9 expression","volume":"26","author":"Fang","year":"2006","journal-title":"J Neurosci"},{"key":"10.1124\/pr.117.014399_bib135","doi-asserted-by":"crossref","first-page":"17383","DOI":"10.1523\/JNEUROSCI.3076-11.2011","article-title":"Heterosynaptic long-term potentiation at GABAergic synapses of spinal lamina I neurons","volume":"31","author":"Fenselau","year":"2011","journal-title":"J Neurosci"},{"key":"10.1124\/pr.117.014399_bib136","doi-asserted-by":"crossref","first-page":"17537","DOI":"10.1073\/pnas.0409066103","article-title":"Identification of the alpha2-delta-1 subunit of voltage-dependent calcium channels as a molecular target for pain mediating the analgesic actions of pregabalin","volume":"103","author":"Field","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/pr.117.014399_bib137","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/S1474-4422(14)70251-0","article-title":"Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis","volume":"14","author":"Finnerup","year":"2015","journal-title":"Lancet Neurol"},{"key":"10.1124\/pr.117.014399_bib138","doi-asserted-by":"crossref","first-page":"6057","DOI":"10.1523\/JNEUROSCI.4495-14.2015","article-title":"Engagement of the GABA to KCC2 signaling pathway contributes to the analgesic effects of A3AR agonists in neuropathic pain","volume":"35","author":"Ford","year":"2015","journal-title":"J Neurosci"},{"key":"10.1124\/pr.117.014399_bib139","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1523\/JNEUROSCI.3145-09.2010","article-title":"Knockdown of L calcium channel subtypes: differential effects in neuropathic pain","volume":"30","author":"Fossat","year":"2010","journal-title":"J Neurosci"},{"key":"10.1124\/pr.117.014399_bib140","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0304-3959(02)00067-2","article-title":"VR1, but not P2X(3), increases in the spared L4 DRG in rats with L5 spinal nerve ligation","volume":"99","author":"Fukuoka","year":"2002","journal-title":"Pain"},{"key":"10.1124\/pr.117.014399_bib141","doi-asserted-by":"crossref","first-page":"2485","DOI":"10.1007\/s00424-015-1725-1","article-title":"Analgesic effect of a broad-spectrum dihydropyridine inhibitor of voltage-gated calcium channels","volume":"467","author":"Gadotti","year":"2015","journal-title":"Pflugers Arch"},{"key":"10.1124\/pr.117.014399_bib142","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1038\/nm.3356","article-title":"Chloride extrusion enhancers as novel therapeutics for neurological diseases","volume":"19","author":"Gagnon","year":"2013","journal-title":"Nat Med"},{"key":"10.1124\/pr.117.014399_bib143","doi-asserted-by":"crossref","first-page":"5768","DOI":"10.1074\/jbc.271.10.5768","article-title":"The novel anticonvulsant drug, gabapentin (Neurontin), binds to the alpha2delta subunit of a calcium channel","volume":"271","author":"Gee","year":"1996","journal-title":"J Biol Chem"},{"key":"10.1124\/pr.117.014399_bib144","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.mayocp.2015.01.018","article-title":"Neuropathic pain: principles of diagnosis and treatment","volume":"90","author":"Gilron","year":"2015","journal-title":"Mayo Clin Proc"},{"key":"10.1124\/pr.117.014399_bib145","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1503\/cmaj.060146","article-title":"Neuropathic pain: a practical guide for the clinician","volume":"175","author":"Gilron","year":"2006","journal-title":"CMAJ"},{"key":"10.1124\/pr.117.014399_bib146","doi-asserted-by":"crossref","first-page":"31","DOI":"10.2344\/0003-3006-62.1.31","article-title":"Alpha-2 adrenergic receptor agonists: a review of current clinical applications","volume":"62","author":"Giovannitti","year":"2015","journal-title":"Anesth Prog"},{"key":"10.1124\/pr.117.014399_bib147","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1038\/nm.2235","article-title":"Nociceptor sensitization in pain pathogenesis","volume":"16","author":"Gold","year":"2010","journal-title":"Nat Med"},{"issue":"Pt B","key":"10.1124\/pr.117.014399_bib148","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.expneurol.2016.05.001","article-title":"A silver lining of neuroinflammation: beneficial effects on myelination","volume":"283","author":"Goldstein","year":"2016","journal-title":"Exp Neurol"},{"key":"10.1124\/pr.117.014399_bib149","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s00232-001-0072-7","article-title":"Tissue-specific expression and gabapentin-binding properties of calcium channel alpha2delta subunit subtypes","volume":"184","author":"Gong","year":"2001","journal-title":"J Membr Biol"},{"key":"10.1124\/pr.117.014399_bib150","doi-asserted-by":"crossref","first-page":"3109","DOI":"10.1523\/JNEUROSCI.3553-16.2017","article-title":"Role of the excitability brake potassium current IKD in cold allodynia induced by chronic peripheral nerve injury","volume":"37","author":"Gonz\u00e1lez","year":"2017","journal-title":"J Neurosci"},{"key":"10.1124\/pr.117.014399_bib151","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1038\/bjp.2008.27","article-title":"Gabapentin evoked changes in functional activity in nociceptive regions in the brain of the anaesthetized rat: an fMRI study","volume":"153","author":"Governo","year":"2008","journal-title":"Br J Pharmacol"},{"key":"10.1124\/pr.117.014399_bib152","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/0006-8993(78)90548-6","article-title":"Ongoing activity in severed nerves: source and variation with time","volume":"159","author":"Govrin-Lippmann","year":"1978","journal-title":"Brain Res"},{"key":"10.1124\/pr.117.014399_bib153","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/nri3621","article-title":"Pathological pain and the neuroimmune interface","volume":"14","author":"Grace","year":"2014","journal-title":"Nat Rev Immunol"},{"key":"10.1124\/pr.117.014399_bib154","doi-asserted-by":"crossref","first-page":"6540","DOI":"10.1523\/JNEUROSCI.5087-12.2013","article-title":"Induction of thermal hyperalgesia and synaptic long-term potentiation in the spinal cord lamina I by TNF-\u03b1 and IL-1\u03b2 is mediated by glial cells","volume":"33","author":"Gruber-Schoffnegger","year":"2013","journal-title":"J Neurosci"},{"key":"10.1124\/pr.117.014399_bib155","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1113\/jphysiol.2001.012890","article-title":"Correlations between neuronal morphology and electrophysiological features in the rodent superficial dorsal horn","volume":"540","author":"Grudt","year":"2002","journal-title":"J Physiol"},{"key":"10.1124\/pr.117.014399_bib156","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1038\/nn.4189","article-title":"Injured sensory neuron-derived CSF1 induces microglial proliferation and DAP12-dependent pain","volume":"19","author":"Guan","year":"2016","journal-title":"Nat Neurosci"},{"key":"10.1124\/pr.117.014399_bib157","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/1744-8069-4-63","article-title":"Long-term actions of interleukin-1beta on delay and tonic firing neurons in rat superficial dorsal horn and their relevance to central sensitization","volume":"4","author":"Gustafson-Vickers","year":"2008","journal-title":"Mol Pain"},{"key":"10.1124\/pr.117.014399_bib158","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1046\/j.1471-4159.2003.01919.x","article-title":"Evidence for functional adenosine A3 receptors in microglia cells","volume":"86","author":"Hammarberg","year":"2003","journal-title":"J Neurochem"},{"key":"10.1124\/pr.117.014399_bib159","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1016\/j.pain.2012.03.022","article-title":"Ethnicity interacts with the OPRM1 gene in experimental pain sensitivity","volume":"153","author":"Hastie","year":"2012","journal-title":"Pain"},{"key":"10.1124\/pr.117.014399_bib160","article-title":"Efficacy, tolerability and safety of cannabis-based medicines for chronic pain management - an overview of systematic reviews","author":"H\u00e4user","year":"2017","journal-title":"Eur J Pain"},{"key":"10.1124\/pr.117.014399_bib161","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/1744-8069-10-15","article-title":"Activation of peripheral KCNQ channels attenuates inflammatory pain","volume":"10","author":"Hayashi","year":"2014","journal-title":"Mol Pain"},{"key":"10.1124\/pr.117.014399_bib162","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1016\/S0026-895X(25)10187-9","article-title":"Block of the rat brain IIA sodium channel alpha subunit by the neuroprotective drug riluzole","volume":"45","author":"Hebert","year":"1994","journal-title":"Mol Pharmacol"},{"key":"10.1124\/pr.117.014399_bib163","doi-asserted-by":"crossref","first-page":"124","DOI":"10.4161\/chan.19805","article-title":"Chronic pregabalin inhibits synaptic transmission between rat dorsal root ganglion and dorsal horn neurons in culture","volume":"6","author":"Hendrich","year":"2012","journal-title":"Channels (Austin)"},{"key":"10.1124\/pr.117.014399_bib164","doi-asserted-by":"crossref","first-page":"3628","DOI":"10.1073\/pnas.0708930105","article-title":"Pharmacological disruption of calcium channel trafficking by the alpha2delta ligand gabapentin","volume":"105","author":"Hendrich","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"issue":"Suppl","key":"10.1124\/pr.117.014399_bib165","doi-asserted-by":"crossref","first-page":"S73","DOI":"10.1097\/00002508-200006001-00013","article-title":"The use of NMDA-receptor antagonists in the treatment of chronic pain","volume":"16","author":"Hewitt","year":"2000","journal-title":"Clin J Pain"},{"key":"10.1124\/pr.117.014399_bib166","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.pneurobio.2015.09.002","article-title":"Genetic disruption of voltage-gated calcium channels in psychiatric and neurological disorders","volume":"134","author":"Heyes","year":"2015","journal-title":"Prog Neurobiol"},{"key":"10.1124\/pr.117.014399_bib167","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/j.pain.2010.12.035","article-title":"A novel slow-inactivation-specific ion channel modulator attenuates neuropathic pain","volume":"152","author":"Hildebrand","year":"2011","journal-title":"Pain"},{"key":"10.1124\/pr.117.014399_bib168","doi-asserted-by":"crossref","first-page":"2753","DOI":"10.1016\/j.celrep.2016.11.024","article-title":"Potentiation of synaptic GluN2B NMDAR currents by fyn kinase is gated through BDNF-mediated disinhibition in spinal pain processing","volume":"17","author":"Hildebrand","year":"2016","journal-title":"Cell Reports"},{"key":"10.1124\/pr.117.014399_bib169","doi-asserted-by":"crossref","first-page":"15044","DOI":"10.1074\/jbc.M111.333740","article-title":"Differential expression of sodium channel \u03b2 subunits in dorsal root ganglion sensory neurons","volume":"287","author":"Ho","year":"2012","journal-title":"J Biol Chem"},{"key":"10.1124\/pr.117.014399_bib170","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0304-3959(99)00313-9","article-title":"Painful neuropathy decreases membrane calcium current in mammalian primary afferent neurons","volume":"86","author":"Hogan","year":"2000","journal-title":"Pain"},{"key":"10.1124\/pr.117.014399_bib171","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.brainres.2008.02.066","article-title":"Hyperpolarization-activated current (I(h)) contributes to excitability of primary sensory neurons in rats","volume":"1207","author":"Hogan","year":"2008","journal-title":"Brain Res"},{"key":"10.1124\/pr.117.014399_bib172","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.brainres.2014.09.040","article-title":"Divergent effects of painful nerve injury on mitochondrial Ca(2+) buffering in axotomized and adjacent sensory neurons","volume":"1589","author":"Hogan","year":"2014","journal-title":"Brain Res"},{"key":"10.1124\/pr.117.014399_bib173","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1038\/nature11033","article-title":"\u03b12\u03b4 expression sets presynaptic calcium channel abundance and release probability","volume":"486","author":"Hoppa","year":"2012","journal-title":"Nature"},{"key":"10.1124\/pr.117.014399_bib174","doi-asserted-by":"crossref","first-page":"12855","DOI":"10.1523\/JNEUROSCI.1699-09.2009","article-title":"Retrograde viral vector-mediated inhibition of pontospinal noradrenergic neurons causes hyperalgesia in rats","volume":"29","author":"Howorth","year":"2009","journal-title":"J Neurosci"},{"key":"10.1124\/pr.117.014399_bib175","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1038\/nn.3468","article-title":"TMEM16C facilitates Na(+)-activated K+ currents in rat sensory neurons and regulates pain processing","volume":"16","author":"Huang","year":"2013","journal-title":"Nat Neurosci"},{"key":"10.1124\/pr.117.014399_bib176","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1046\/j.0953-816x.2001.01591.x","article-title":"VR1 protein expression increases in undamaged DRG neurons after partial nerve injury","volume":"13","author":"Hudson","year":"2001","journal-title":"Eur J Neurosci"},{"key":"10.1124\/pr.117.014399_bib177","doi-asserted-by":"crossref","first-page":"9491","DOI":"10.1523\/JNEUROSCI.23-29-09491.2003","article-title":"Lack of evidence for sprouting of Abeta afferents into the superficial laminas of the spinal cord dorsal horn after nerve section","volume":"23","author":"Hughes","year":"2003","journal-title":"J Neurosci"},{"key":"10.1124\/pr.117.014399_bib178","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1016\/j.pain.2013.05.010","article-title":"Endogenous analgesic action of the pontospinal noradrenergic system spatially restricts and temporally delays the progression of neuropathic pain following tibial nerve injury","volume":"154","author":"Hughes","year":"2013","journal-title":"Pain"},{"key":"10.1124\/pr.117.014399_bib179","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0014-2999(97)00070-8","article-title":"The effect of novel anti-epileptic drugs in rat experimental models of acute and chronic pain","volume":"324","author":"Hunter","year":"1997","journal-title":"Eur J Pharmacol"},{"key":"10.1124\/pr.117.014399_bib180","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1126\/science.278.5336.239","article-title":"Good pain, bad pain","volume":"278","author":"Iadarola","year":"1997","journal-title":"Science"},{"key":"10.1124\/pr.117.014399_bib181","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.tips.2008.10.004","article-title":"Regulation of neuronal T-type calcium channels","volume":"30","author":"Iftinca","year":"2009","journal-title":"Trends Pharmacol Sci"},{"key":"10.1124\/pr.117.014399_bib182","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1126\/science.1080659","article-title":"Synaptic plasticity in spinal lamina I projection neurons that mediate hyperalgesia","volume":"299","author":"Ikeda","year":"2003","journal-title":"Science"},{"key":"10.1124\/pr.117.014399_bib183","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1126\/science.1127233","article-title":"Synaptic amplifier of inflammatory pain in the spinal dorsal horn","volume":"312","author":"Ikeda","year":"2006","journal-title":"Science"},{"key":"10.1124\/pr.117.014399_bib184","doi-asserted-by":"crossref","DOI":"10.1038\/srep37104","article-title":"Glycinergic dysfunction in a subpopulation of dorsal horn interneurons in a rat model of neuropathic pain","volume":"6","author":"Imlach","year":"2016","journal-title":"Sci Rep"},{"key":"10.1124\/pr.117.014399_bib185","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.pain.2007.09.016","article-title":"Intrathecal neuropeptide Y reduces behavioral and molecular markers of inflammatory or neuropathic pain","volume":"137","author":"Intondi","year":"2008","journal-title":"Pain"},{"key":"10.1124\/pr.117.014399_bib186","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/1744-8069-9-56","article-title":"Neurochemical characterisation of lamina II inhibitory interneurons that express GFP in the PrP-GFP mouse","volume":"9","author":"Iwagaki","year":"2013","journal-title":"Mol Pain"},{"key":"10.1124\/pr.117.014399_bib187","doi-asserted-by":"crossref","first-page":"3151","DOI":"10.1152\/jn.01031.2007","article-title":"Upregulation of the T-type calcium current in small rat sensory neurons after chronic constrictive injury of the sciatic nerve","volume":"99","author":"Jagodic","year":"2008","journal-title":"J Neurophysiol"},{"key":"10.1124\/pr.117.014399_bib188","doi-asserted-by":"crossref","first-page":"3305","DOI":"10.1523\/JNEUROSCI.4866-06.2007","article-title":"Cell-specific alterations of T-type calcium current in painful diabetic neuropathy enhance excitability of sensory neurons","volume":"27","author":"Jagodic","year":"2007","journal-title":"J Neurosci"},{"key":"10.1124\/pr.117.014399_bib189","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1111\/bph.13446","article-title":"Identification of A3 adenosine receptor agonists as novel non-narcotic analgesics","volume":"173","author":"Janes","year":"2016","journal-title":"Br J Pharmacol"},{"key":"10.1124\/pr.117.014399_bib190","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.bbi.2014.08.010","article-title":"Spinal neuroimmune activation is independent of T-cell infiltration and attenuated by A3 adenosine receptor agonists in a model of oxaliplatin-induced peripheral neuropathy","volume":"44","author":"Janes","year":"2015","journal-title":"Brain Behav Immun"},{"key":"10.1124\/pr.117.014399_bib191","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.bcp.2014.03.015","article-title":"A peripherally acting, selective T-type calcium channel blocker, ABT-639, effectively reduces nociceptive and neuropathic pain in rats","volume":"89","author":"Jarvis","year":"2014","journal-title":"Biochem Pharmacol"},{"key":"10.1124\/pr.117.014399_bib192","doi-asserted-by":"crossref","first-page":"2204","DOI":"10.1016\/j.pain.2011.06.017","article-title":"A new definition of neuropathic pain","volume":"152","author":"Jensen","year":"2011","journal-title":"Pain"},{"key":"10.1124\/pr.117.014399_bib193","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1126\/science.aaf8924","article-title":"Pain regulation by non-neuronal cells and inflammation","volume":"354","author":"Ji","year":"2016","journal-title":"Science"},{"key":"10.1124\/pr.117.014399_bib194","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/j.tins.2003.09.017","article-title":"Central sensitization and LTP: do pain and memory share similar mechanisms?","volume":"26","author":"Ji","year":"2003","journal-title":"Trends Neurosci"},{"key":"10.1124\/pr.117.014399_bib195","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/nbdi.2000.0360","article-title":"Neuronal plasticity and signal transduction in nociceptive neurons: implications for the initiation and maintenance of pathological pain","volume":"8","author":"Ji","year":"2001","journal-title":"Neurobiol Dis"},{"key":"10.1124\/pr.117.014399_bib196","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1097\/00007691-200306000-00016","article-title":"Therapeutic drug monitoring of the newer antiepileptic drugs","volume":"25","author":"Johannessen","year":"2003","journal-title":"Ther Drug Monit"},{"key":"10.1124\/pr.117.014399_bib197","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.21143","article-title":"Proteolytic maturation of \u03b12\u03b4 represents a checkpoint for activation and neuronal trafficking of latent calcium channels","volume":"5","author":"Kadurin","year":"2016","journal-title":"ELife"},{"key":"10.1124\/pr.117.014399_bib198","doi-asserted-by":"crossref","first-page":"5189","DOI":"10.1523\/JNEUROSCI.3338-07.2008","article-title":"Cytokine mechanisms of central sensitization: distinct and overlapping role of interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha in regulating synaptic and neuronal activity in the superficial spinal cord","volume":"28","author":"Kawasaki","year":"2008","journal-title":"J Neurosci"},{"key":"10.1124\/pr.117.014399_bib199","doi-asserted-by":"crossref","first-page":"7871","DOI":"10.1523\/JNEUROSCI.21-20-07871.2001","article-title":"Region-specific developmental specialization of GABA-glycine cosynapses in laminas I-II of the rat spinal dorsal horn","volume":"21","author":"Keller","year":"2001","journal-title":"J Neurosci"},{"key":"10.1124\/pr.117.014399_bib200","doi-asserted-by":"crossref","first-page":"439","DOI":"10.2147\/JPR.S128520","article-title":"EMA401: an old antagonist of the AT2R for a new indication in neuropathic pain","volume":"10","author":"Keppel Hesselink","year":"2017","journal-title":"J Pain Res"},{"key":"10.1124\/pr.117.014399_bib201","doi-asserted-by":"crossref","first-page":"5138","DOI":"10.1523\/JNEUROSCI.19-12-05138.1999","article-title":"Brain-derived neurotrophic factor modulates nociceptive sensory inputs and NMDA-evoked responses in the rat spinal cord","volume":"19","author":"Kerr","year":"1999","journal-title":"J Neurosci"},{"key":"10.1124\/pr.117.014399_bib202","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/S0169-328X(02)00388-1","article-title":"Downregulation of voltage-gated potassium channel alpha gene expression in dorsal root ganglia following chronic constriction injury of the rat sciatic nerve","volume":"105","author":"Kim","year":"2002","journal-title":"Brain Res Mol Brain Res"},{"key":"10.1124\/pr.117.014399_bib203","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1007\/BF02450318","article-title":"Comparison of three rodent neuropathic pain models","volume":"113","author":"Kim","year":"1997","journal-title":"Exp Brain Res"},{"key":"10.1124\/pr.117.014399_bib204","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1097\/j.pain.0000000000000608","article-title":"Gabapentin loses efficacy over time after nerve injury in rats: role of glutamate transporter-1 in the locus coeruleus","volume":"157","author":"Kimura","year":"2016","journal-title":"Pain"},{"key":"10.1124\/pr.117.014399_bib205","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1038\/nn.2407","article-title":"Unmasking the tonic-aversive state in neuropathic pain","volume":"12","author":"King","year":"2009","journal-title":"Nat Neurosci"},{"key":"10.1124\/pr.117.014399_bib206","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.bbi.2016.03.003","article-title":"Spinal activity of interleukin 6 mediates myelin basic protein-induced allodynia","volume":"56","author":"Ko","year":"2016","journal-title":"Brain Behav Immun"},{"key":"10.1124\/pr.117.014399_bib207","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.pain.2005.05.035","article-title":"Peripheral axonal injury results in reduced mu opioid receptor pre- and post-synaptic action in the spinal cord","volume":"117","author":"Kohno","year":"2005","journal-title":"Pain"},{"key":"10.1124\/pr.117.014399_bib208","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.neuroscience.2016.06.057","article-title":"Antidepressants and gabapentinoids in neuropathic pain: mechanistic insights","volume":"338","author":"Kremer","year":"2016","journal-title":"Neuroscience"},{"key":"10.1124\/pr.117.014399_bib209","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/j.neuint.2013.02.022","article-title":"Systemic pregabalin attenuates facial hypersensitivity and noxious stimulus-evoked release of glutamate in medullary dorsal horn in a rodent model of trigeminal neuropathic pain","volume":"62","author":"Kumar","year":"2013","journal-title":"Neurochem Int"},{"key":"10.1124\/pr.117.014399_bib210","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1038\/nm.2231","article-title":"Central mechanisms of pathological pain","volume":"16","author":"Kuner","year":"2010","journal-title":"Nat Med"},{"key":"10.1124\/pr.117.014399_bib211","doi-asserted-by":"crossref","first-page":"4391","DOI":"10.1523\/JNEUROSCI.1619-16.2017","article-title":"K+ channel modulatory subunits KChIP and DPP participate in Kv4-mediated mechanical pain control","volume":"37","author":"Kuo","year":"2017","journal-title":"J Neurosci"},{"key":"10.1124\/pr.117.014399_bib212","doi-asserted-by":"crossref","DOI":"10.1038\/srep24531","article-title":"Thrombospondin-4 reduces binding affinity of [(3)H]-gabapentin to calcium-channel \u03b12\u03b4-1-subunit but does not interact with \u03b12\u03b4-1 on the cell-surface when co-expressed","volume":"6","author":"Lana","year":"2016","journal-title":"Sci Rep"},{"key":"10.1124\/pr.117.014399_bib213","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1038\/nmeth.1455","article-title":"Coding of facial expressions of pain in the laboratory mouse","volume":"7","author":"Langford","year":"2010","journal-title":"Nat Methods"},{"key":"10.1124\/pr.117.014399_bib214","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/S0028-3908(01)00140-X","article-title":"Gabapentin is not a GABAB receptor agonist","volume":"41","author":"Lanneau","year":"2001","journal-title":"Neuropharmacology"},{"key":"10.1124\/pr.117.014399_bib215","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/j.jpain.2009.06.012","article-title":"Central sensitization: a generator of pain hypersensitivity by central neural plasticity","volume":"10","author":"Latremoliere","year":"2009","journal-title":"J Pain"},{"key":"10.1124\/pr.117.014399_bib216","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1093\/brain\/awt334","article-title":"Enhancing K-Cl co-transport restores normal spinothalamic sensory coding in a neuropathic pain model","volume":"137","author":"Lavertu","year":"2014","journal-title":"Brain"},{"key":"10.1124\/pr.117.014399_bib217","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1016\/j.cell.2014.03.064","article-title":"A monoclonal antibody that targets a NaV1.7 channel voltage sensor for pain and itch relief","volume":"157","author":"Lee","year":"2014","journal-title":"Cell"},{"key":"10.1124\/pr.117.014399_bib218","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0073370","article-title":"Impaired excitatory drive to spinal GABAergic neurons of neuropathic mice","volume":"8","author":"Leitner","year":"2013","journal-title":"PLoS One"},{"key":"10.1124\/pr.117.014399_bib219","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/1742-2094-7-27","article-title":"TNF-alpha and neuropathic pain--a review","volume":"7","author":"Leung","year":"2010","journal-title":"J Neuroinflammation"},{"key":"10.1124\/pr.117.014399_bib220","doi-asserted-by":"crossref","first-page":"7025","DOI":"10.1074\/jbc.M114.548990","article-title":"Calcium channel \u03b12\u03b41 proteins mediate trigeminal neuropathic pain states associated with aberrant excitatory synaptogenesis","volume":"289","author":"Li","year":"2014","journal-title":"J Biol Chem"},{"key":"10.1124\/pr.117.014399_bib221","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.ejphar.2011.05.054","article-title":"Pregabalin is a potent and selective ligand for \u03b1(2)\u03b4-1 and \u03b1(2)\u03b4-2 calcium channel subunits","volume":"667","author":"Li","year":"2011","journal-title":"Eur J Pharmacol"},{"key":"10.1124\/pr.117.014399_bib222","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1097\/j.pain.0000000000000959","article-title":"IKK\/NF-\u03baB-dependent satellite glia activation induces spinal cord microglia activation and neuropathic pain after nerve injury","volume":"158","author":"Lim","year":"2017","journal-title":"Pain"},{"key":"10.1124\/pr.117.014399_bib223","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/1744-8069-10-63","article-title":"Gabapentin reverses central hypersensitivity and suppresses medial prefrontal cortical glucose metabolism in rats with neuropathic pain","volume":"10","author":"Lin","year":"2014","journal-title":"Mol Pain"},{"key":"10.1124\/pr.117.014399_bib224","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1093\/brain\/awu330","article-title":"Endogenous adenosine A3 receptor activation selectively alleviates persistent pain states","volume":"138","author":"Little","year":"2015","journal-title":"Brain"},{"key":"10.1124\/pr.117.014399_bib225","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.3390\/toxins6082363","article-title":"Synthesis and analgesic effects of \u03bc-TRTX-Hhn1b on models of inflammatory and neuropathic pain","volume":"6","author":"Liu","year":"2014","journal-title":"Toxins (Basel)"},{"key":"10.1124\/pr.117.014399_bib226","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/S0022-3565(24)38813-5","article-title":"Coadministration of intrathecal strychnine and bicuculline effects synergistic allodynia in the rat: an isobolographic analysis","volume":"296","author":"Loomis","year":"2001","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/pr.117.014399_bib227","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/1744-8069-10-57","article-title":"Spatial and temporal pattern of changes in the number of GAD65-immunoreactive inhibitory terminals in the rat superficial dorsal horn following peripheral nerve injury","volume":"10","author":"Lorenzo","year":"2014","journal-title":"Mol Pain"},{"key":"10.1124\/pr.117.014399_bib228","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/j.eplepsyres.2014.03.002","article-title":"Anticonvulsant activity of pregabalin in the maximal electroshock-induced seizure assay in \u03b12\u03b41 (R217A) and \u03b12\u03b42 (R279A) mouse mutants","volume":"108","author":"Lotarski","year":"2014","journal-title":"Epilepsy Res"},{"key":"10.1124\/pr.117.014399_bib229","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1124\/jpet.111.180976","article-title":"Anxiolytic-like activity of pregabalin in the Vogel conflict test in \u03b12\u03b4-1 (R217A) and \u03b12\u03b4-2 (R279A) mouse mutants","volume":"338","author":"Lotarski","year":"2011","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/pr.117.014399_bib230","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1113\/jphysiol.2007.141267","article-title":"Neuron type-specific effects of brain-derived neurotrophic factor in rat superficial dorsal horn and their relevance to \u2018central sensitization.\u2019","volume":"584","author":"Lu","year":"2007","journal-title":"J Physiol"},{"key":"10.1124\/pr.117.014399_bib231","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1113\/jphysiol.2008.166306","article-title":"BDNF drives the changes in excitatory synaptic transmission in the rat superficial dorsal horn that follow sciatic nerve injury","volume":"587","author":"Lu","year":"2009","journal-title":"J Physiol"},{"key":"10.1124\/pr.117.014399_bib232","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.pain.2006.01.009","article-title":"Substantia Gelatinosa neurons in defined-medium organotypic slice culture are similar to those in acute slices from young adult rats","volume":"121","author":"Lu","year":"2006","journal-title":"Pain"},{"key":"10.1124\/pr.117.014399_bib233","doi-asserted-by":"crossref","first-page":"4050","DOI":"10.1172\/JCI70026","article-title":"A feed-forward spinal cord glycinergic neural circuit gates mechanical allodynia","volume":"123","author":"Lu","year":"2013","journal-title":"J Clin Invest"},{"key":"10.1124\/pr.117.014399_bib234","doi-asserted-by":"crossref","first-page":"8752","DOI":"10.1523\/JNEUROSCI.23-25-08752.2003","article-title":"A specific inhibitory pathway between substantia gelatinosa neurons receiving direct C-fiber input","volume":"23","author":"Lu","year":"2003","journal-title":"J Neurosci"},{"key":"10.1124\/pr.117.014399_bib235","doi-asserted-by":"crossref","first-page":"3900","DOI":"10.1523\/JNEUROSCI.0102-05.2005","article-title":"Modular organization of excitatory circuits between neurons of the spinal superficial dorsal horn (laminae I and II)","volume":"25","author":"Lu","year":"2005","journal-title":"J Neurosci"},{"key":"10.1124\/pr.117.014399_bib236","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.tins.2014.04.002","article-title":"Synaptic plasticity in pathological pain","volume":"37","author":"Luo","year":"2014","journal-title":"Trends Neurosci"},{"key":"10.1124\/pr.117.014399_bib237","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1016\/j.neuroscience.2006.10.048","article-title":"Role of peripheral hyperpolarization-activated cyclic nucleotide-modulated channel pacemaker channels in acute and chronic pain models in the rat","volume":"144","author":"Luo","year":"2007","journal-title":"Neuroscience"},{"key":"10.1124\/pr.117.014399_bib238","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1124\/jpet.102.041574","article-title":"Injury type-specific calcium channel alpha 2 delta-1 subunit up-regulation in rat neuropathic pain models correlates with antiallodynic effects of gabapentin","volume":"303","author":"Luo","year":"2002","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/pr.117.014399_bib239","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1523\/JNEUROSCI.21-06-01868.2001","article-title":"Upregulation of dorsal root ganglion (alpha)2(delta) calcium channel subunit and its correlation with allodynia in spinal nerve-injured rats","volume":"21","author":"Luo","year":"2001","journal-title":"J Neurosci"},{"key":"10.1124\/pr.117.014399_bib240","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.phrs.2017.02.019","article-title":"Allodynia lowering induced by cannabinoids and endocannabinoids (ALICE)","volume":"119","author":"Luongo","year":"2017","journal-title":"Pharmacol Res"},{"key":"10.1124\/pr.117.014399_bib241","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s00424-015-1733-1","article-title":"Effect of the T-type channel blocker KYS-05090S in mouse models of acute and neuropathic pain","volume":"468","author":"M\u2019Dahoma","year":"2016","journal-title":"Pflugers Arch"},{"key":"10.1124\/pr.117.014399_bib242","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1046\/j.1460-9568.2002.01940.x","article-title":"Morphological and pharmacological evidence for the role of peripheral prostaglandins in the pathogenesis of neuropathic pain","volume":"15","author":"Ma","year":"2002","journal-title":"Eur J Neurosci"},{"key":"10.1124\/pr.117.014399_bib243","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/1744-8069-4-65","article-title":"Gene transfer of GLT-1, a glial glutamate transporter, into the spinal cord by recombinant adenovirus attenuates inflammatory and neuropathic pain in rats","volume":"4","author":"Maeda","year":"2008","journal-title":"Mol Pain"},{"key":"10.1124\/pr.117.014399_bib244","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s12990-015-0029-y","article-title":"Novel expression pattern of neuropeptide Y immunoreactivity in the peripheral nervous system in a rat model of neuropathic pain","volume":"11","author":"Magnussen","year":"2015","journal-title":"Mol Pain"},{"key":"10.1124\/pr.117.014399_bib245","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1213\/ANE.0000000000001787","article-title":"Intravenous ketamine infusions for neuropathic pain management: a promising therapy in need of optimization","volume":"124","author":"Maher","year":"2017","journal-title":"Anesth Analg"},{"key":"10.1124\/pr.117.014399_bib246","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/S0165-6147(03)00025-7","article-title":"A common thread for pain and memory synapses? Brain-derived neurotrophic factor and trkB receptors","volume":"24","author":"Malcangio","year":"2003","journal-title":"Trends Pharmacol Sci"},{"key":"10.1124\/pr.117.014399_bib247","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1016\/S0026-895X(24)12585-0","article-title":"Calcium channel alpha(2)delta subunits-structure and gabapentin binding","volume":"59","author":"Marais","year":"2001","journal-title":"Mol Pharmacol"},{"key":"10.1124\/pr.117.014399_bib248","doi-asserted-by":"crossref","DOI":"10.1098\/rstb.2015.0430","article-title":"Effect of knockout of \u03b12\u03b4-1 on action potentials in mouse sensory neurons","volume":"371","author":"Margas","year":"2016","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"10.1124\/pr.117.014399_bib249","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms12529","article-title":"Dorsal horn neurons release extracellular ATP in a VNUT-dependent manner that underlies neuropathic pain","volume":"7","author":"Masuda","year":"2016","journal-title":"Nat Commun"},{"key":"10.1124\/pr.117.014399_bib250","doi-asserted-by":"crossref","first-page":"69","DOI":"10.2147\/nedt.2007.3.1.69","article-title":"Ziconotide: a review of its pharmacology and use in the treatment of pain","volume":"3","author":"McGivern","year":"2007","journal-title":"Neuropsychiatr Dis Treat"},{"key":"10.1124\/pr.117.014399_bib251","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/S0306-4522(97)00680-5","article-title":"Axonal sprouts containing calcitonin gene-related peptide and substance P form pericellular baskets around large diameter neurons after sciatic nerve transection in the rat","volume":"84","author":"McLachlan","year":"1998","journal-title":"Neuroscience"},{"key":"10.1124\/pr.117.014399_bib252","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1038\/363543a0","article-title":"Peripheral nerve injury triggers noradrenergic sprouting within dorsal root ganglia","volume":"363","author":"McLachlan","year":"1993","journal-title":"Nature"},{"key":"10.1124\/pr.117.014399_bib253","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.neuroscience.2016.05.007","article-title":"Insights into the mechanisms and the emergence of sex-differences in pain","volume":"338","author":"Melchior","year":"2016","journal-title":"Neuroscience"},{"key":"10.1124\/pr.117.014399_bib254","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.ejphar.2008.02.066","article-title":"Analgesic activity of ZC88, a novel N-type voltage-dependent calcium channel blocker, and its modulation of morphine analgesia, tolerance and dependence","volume":"586","author":"Meng","year":"2008","journal-title":"Eur J Pharmacol"},{"key":"10.1124\/pr.117.014399_bib255","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.jneuroim.2017.02.005","article-title":"Voluntary wheel running differentially affects disease outcomes in male and female mice with experimental autoimmune encephalomyelitis","volume":"305","author":"Mifflin","year":"2017","journal-title":"J Neuroimmunol"},{"key":"10.1124\/pr.117.014399_bib256","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s12630-012-9881-7","article-title":"Sex-related differences in acute and chronic pain: a bench to bedside perspective","volume":"60","author":"Mifflin","year":"2013","journal-title":"Can J Anaesth"},{"key":"10.1124\/pr.117.014399_bib257","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1002\/jnr.23844","article-title":"Pain in autoimmune disorders","volume":"95","author":"Mifflin","year":"2017","journal-title":"J Neurosci Res"},{"key":"10.1124\/pr.117.014399_bib258","doi-asserted-by":"crossref","first-page":"2190","DOI":"10.1111\/ejn.13667","article-title":"Phenotypic change in trigeminal ganglion neurons associated with satellite cell activation via extracellular signal-regulated kinase phosphorylation is involved in lingual neuropathic pain","volume":"46","author":"Mikuzuki","year":"2017","journal-title":"Eur J Neurosci"},{"key":"10.1124\/pr.117.014399_bib259","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S0301-0082(02)00009-6","article-title":"Descending control of pain","volume":"66","author":"Millan","year":"2002","journal-title":"Prog Neurobiol"},{"key":"10.1124\/pr.117.014399_bib260","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/nrn2533","article-title":"Pathological and protective roles of glia in chronic pain","volume":"10","author":"Milligan","year":"2009","journal-title":"Nat Rev Neurosci"},{"key":"10.1124\/pr.117.014399_bib261","doi-asserted-by":"crossref","first-page":"2294","DOI":"10.1111\/j.1460-9568.2004.03709.x","article-title":"Evidence that exogenous and endogenous fractalkine can induce spinal nociceptive facilitation in rats","volume":"20","author":"Milligan","year":"2004","journal-title":"Eur J Neurosci"},{"key":"10.1124\/pr.117.014399_bib262","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1038\/ncomms1795","article-title":"Distinct Nav1.7-dependent pain sensations require different sets of sensory and sympathetic neurons","volume":"3","author":"Minett","year":"2012","journal-title":"Nat Commun"},{"key":"10.1124\/pr.117.014399_bib263","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.neuroscience.2016.05.017","article-title":"Modulation of pain, nociception, and analgesia by the brain reward center","volume":"338","author":"Mitsi","year":"2016","journal-title":"Neuroscience"},{"key":"10.1124\/pr.117.014399_bib264","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/nrn2606","article-title":"Animal models of pain: progress and challenges","volume":"10","author":"Mogil","year":"2009","journal-title":"Nat Rev Neurosci"},{"key":"10.1124\/pr.117.014399_bib265","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.tig.2012.02.004","article-title":"Pain genetics: past, present and future","volume":"28","author":"Mogil","year":"2012","journal-title":"Trends Genet"},{"key":"10.1124\/pr.117.014399_bib266","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1038\/nrn3360","article-title":"Sex differences in pain and pain inhibition: multiple explanations of a controversial phenomenon","volume":"13","author":"Mogil","year":"2012","journal-title":"Nat Rev Neurosci"},{"key":"10.1124\/pr.117.014399_bib267","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1038\/laban.1223","article-title":"Laboratory environmental factors and pain behavior: the relevance of unknown unknowns to reproducibility and translation","volume":"46","author":"Mogil","year":"2017","journal-title":"Lab Anim (NY)"},{"key":"10.1124\/pr.117.014399_bib268","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.pain.2004.09.028","article-title":"What should we be measuring in behavioral studies of chronic pain in animals?","volume":"112","author":"Mogil","year":"2004","journal-title":"Pain"},{"key":"10.1124\/pr.117.014399_bib269","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/S0896-6273(00)80966-6","article-title":"IB4-binding DRG neurons switch from NGF to GDNF dependence in early postnatal life","volume":"19","author":"Molliver","year":"1997","journal-title":"Neuron"},{"key":"10.1124\/pr.117.014399_bib270","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1002\/hipo.22144","article-title":"Blockade of BDNF signaling turns chemically-induced long-term potentiation into long-term depression","volume":"23","author":"Montalbano","year":"2013","journal-title":"Hippocampus"},{"key":"10.1124\/pr.117.014399_bib271","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1016\/S0028-3908(02)00226-5","article-title":"Gabapentin--actions on adult superficial dorsal horn neurons","volume":"43","author":"Moore","year":"2002","journal-title":"Neuropharmacology"},{"key":"10.1124\/pr.117.014399_bib272","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD011603","article-title":"Amitriptyline for neuropathic pain in adults","volume":"7","author":"Moore","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1124\/pr.117.014399_bib273","article-title":"Gabapentin for chronic neuropathic pain and fibromyalgia in adults","volume":"3","author":"Moore","year":"2011","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1124\/pr.117.014399_bib274","article-title":"Gabapentin for chronic neuropathic pain and fibromyalgia in adults","volume":"4","author":"Moore","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1124\/pr.117.014399_bib275","doi-asserted-by":"crossref","first-page":"3266","DOI":"10.1152\/jn.00096.2004","article-title":"Opioid-like actions of neuropeptide Y in rat substantia gelatinosa: Y1 suppression of inhibition and Y2 suppression of excitation","volume":"92","author":"Moran","year":"2004","journal-title":"J Neurophysiol"},{"key":"10.1124\/pr.117.014399_bib276","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1155\/2014\/754693","article-title":"Pharmacological management of chronic neuropathic pain: revised consensus statement from the Canadian Pain Society","volume":"19","author":"Moulin","year":"2014","journal-title":"Pain Res Manag"},{"key":"10.1124\/pr.117.014399_bib277","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.neuropharm.2007.07.002","article-title":"Pharmacological comparison of anticonvulsant drugs in animal models of persistent pain and anxiety","volume":"53","author":"Munro","year":"2007","journal-title":"Neuropharmacology"},{"key":"10.1124\/pr.117.014399_bib278","doi-asserted-by":"crossref","first-page":"12533","DOI":"10.1523\/JNEUROSCI.2840-11.2011","article-title":"Functional recovery after peripheral nerve injury is dependent on the pro-inflammatory cytokines IL-1\u03b2 and TNF: implications for neuropathic pain","volume":"31","author":"Nadeau","year":"2011","journal-title":"J Neurosci"},{"key":"10.1124\/pr.117.014399_bib279","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1038\/35044580","article-title":"The labile nature of consolidation theory","volume":"1","author":"Nader","year":"2000","journal-title":"Nat Rev Neurosci"},{"key":"10.1124\/pr.117.014399_bib280","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.neuroscience.2012.05.016","article-title":"Systemic pregabalin attenuates sensorimotor responses and medullary glutamate release in inflammatory tooth pain model","volume":"218","author":"Narita","year":"2012","journal-title":"Neuroscience"},{"key":"10.1124\/pr.117.014399_bib281","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1744-8069-5-6","article-title":"Enhanced pre-synaptic glutamate release in deep-dorsal horn contributes to calcium channel alpha-2-delta-1 protein-mediated spinal sensitization and behavioral hypersensitivity","volume":"5","author":"Nguyen","year":"2009","journal-title":"Mol Pain"},{"key":"10.1124\/pr.117.014399_bib282","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.1152\/jn.91138.2008","article-title":"Glutamate transporters prevent excessive activation of NMDA receptors and extrasynaptic glutamate spillover in the spinal dorsal horn","volume":"101","author":"Nie","year":"2009","journal-title":"J Neurophysiol"},{"key":"10.1124\/pr.117.014399_bib283","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1111\/bcp.12094","article-title":"Ketamine for chronic pain: risks and benefits","volume":"77","author":"Niesters","year":"2014","journal-title":"Br J Clin Pharmacol"},{"key":"10.1124\/pr.117.014399_bib284","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1152\/physrev.00021.2006","article-title":"Transient receptor potential cation channels in disease","volume":"87","author":"Nilius","year":"2007","journal-title":"Physiol Rev"},{"key":"10.1124\/pr.117.014399_bib285","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1002\/j.1532-2149.2014.00460.x","article-title":"The heart-rate-reducing agent, ivabradine, reduces mechanical allodynia in a rodent model of neuropathic pain","volume":"18","author":"Noh","year":"2014","journal-title":"Eur J Pain"},{"key":"10.1124\/pr.117.014399_bib286","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1146\/annurev-physiol-021014-071846","article-title":"Sodium channel \u03b2 subunits: emerging targets in channelopathies","volume":"77","author":"O\u2019Malley","year":"2015","journal-title":"Annu Rev Physiol"},{"key":"10.1124\/pr.117.014399_bib287","doi-asserted-by":"crossref","first-page":"246","DOI":"10.3109\/10409238.2016.1173010","article-title":"Drugging the undruggable: gabapentin, pregabalin and the calcium channel \u03b12\u03b4 subunit","volume":"51","author":"Offord","year":"2015","journal-title":"Crit Rev Biochem Mol Biol"},{"key":"10.1124\/pr.117.014399_bib288","doi-asserted-by":"crossref","first-page":"3127","DOI":"10.3390\/toxins7083127","article-title":"Botulinum toxin for neuropathic pain: a review of the literature","volume":"7","author":"Oh","year":"2015","journal-title":"Toxins (Basel)"},{"key":"10.1124\/pr.117.014399_bib289","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0153375","article-title":"Macrophage-colony stimulating factor derived from injured primary afferent induces proliferation of spinal microglia and neuropathic pain in rats","volume":"11","author":"Okubo","year":"2016","journal-title":"PLoS One"},{"key":"10.1124\/pr.117.014399_bib290","doi-asserted-by":"crossref","first-page":"3779","DOI":"10.1172\/JCI43766","article-title":"Central modulation of pain","volume":"120","author":"Ossipov","year":"2010","journal-title":"J Clin Invest"},{"key":"10.1124\/pr.117.014399_bib291","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.1097\/j.pain.0000000000000612","article-title":"Thrombospondin-4 divergently regulates voltage-gated Ca2+ channel subtypes in sensory neurons after nerve injury","volume":"157","author":"Pan","year":"2016","journal-title":"Pain"},{"key":"10.1124\/pr.117.014399_bib292","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1002\/jnr.23498","article-title":"Painful nerve injury upregulates thrombospondin-4 expression in dorsal root ganglia","volume":"93","author":"Pan","year":"2015","journal-title":"J Neurosci Res"},{"key":"10.1124\/pr.117.014399_bib293","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1111\/j.1460-9568.2006.05013.x","volume":"24","author":"Papp","year":"2006","journal-title":"Eur J Neurosci"},{"key":"10.1124\/pr.117.014399_bib294","doi-asserted-by":"crossref","DOI":"10.3390\/toxins9090260","article-title":"Botulinum toxin for the treatment of neuropathic pain","volume":"9","author":"Park","year":"2017","journal-title":"Toxins (Basel)"},{"key":"10.1124\/pr.117.014399_bib295","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1002\/cne.23844","article-title":"Synaptic ultrastructure changes in trigeminocervical complex posttrigeminal nerve injury","volume":"524","author":"Park","year":"2016","journal-title":"J Comp Neurol"},{"key":"10.1124\/pr.117.014399_bib296","doi-asserted-by":"crossref","first-page":"13335","DOI":"10.1074\/jbc.M116.723478","article-title":"Central mechanisms mediating thrombospondin-4-induced pain states","volume":"291","author":"Park","year":"2016","journal-title":"J Biol Chem"},{"key":"10.1124\/pr.117.014399_bib297","doi-asserted-by":"crossref","first-page":"7227","DOI":"10.1523\/JNEUROSCI.23-18-07227.2003","article-title":"KCNQ\/M currents in sensory neurons: significance for pain therapy","volume":"23","author":"Passmore","year":"2003","journal-title":"J Neurosci"},{"key":"10.1124\/pr.117.014399_bib298","doi-asserted-by":"crossref","first-page":"16412","DOI":"10.1523\/JNEUROSCI.1026-13.2013","article-title":"\u03b12\u03b4-1 gene deletion affects somatosensory neuron function and delays mechanical hypersensitivity in response to peripheral nerve damage","volume":"33","author":"Patel","year":"2013","journal-title":"J Neurosci"},{"key":"10.1124\/pr.117.014399_bib299","doi-asserted-by":"crossref","DOI":"10.1002\/prp2.205","article-title":"Mechanisms of the gabapentinoids and \u03b1 2 \u03b4-1 calcium channel subunit in neuropathic pain","volume":"4","author":"Patel","year":"2016","journal-title":"Pharmacol Res Perspect"},{"key":"10.1124\/pr.117.014399_bib300","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1152\/jn.00237.2016","article-title":"Neuronal hyperexcitability in the ventral posterior thalamus of neuropathic rats: modality selective effects of pregabalin","volume":"116","author":"Patel","year":"2016","journal-title":"J Neurophysiol"},{"key":"10.1124\/pr.117.014399_bib301","article-title":"Calcium channel modulation as a target in chronic pain control","author":"Patel","year":"2017","journal-title":"Br J Pharmacol"},{"key":"10.1124\/pr.117.014399_bib302","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.neuroscience.2015.03.057","article-title":"Electrophysiological characterization of activation state-dependent Ca(v)2 channel antagonist TROX-1 in spinal nerve injured rats","volume":"297","author":"Patel","year":"2015","journal-title":"Neuroscience"},{"key":"10.1124\/pr.117.014399_bib303","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/npp.2013.221","article-title":"Antihyperalgesia by \u03b12-GABAA receptors occurs via a genuine spinal action and does not involve supraspinal sites","volume":"39","author":"Paul","year":"2014","journal-title":"Neuropsychopharmacology"},{"key":"10.1124\/pr.117.014399_bib304","doi-asserted-by":"crossref","first-page":"3895","DOI":"10.1002\/cne.23129","article-title":"Selective distribution of GABA(A) receptor subtypes in mouse spinal dorsal horn neurons and primary afferents","volume":"520","author":"Paul","year":"2012","journal-title":"J Comp Neurol"},{"key":"10.1124\/pr.117.014399_bib305","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1038\/nm.3986","article-title":"Targeting Toll-like receptors to treat chronic pain","volume":"21","author":"Peirs","year":"2015","journal-title":"Nat Med"},{"key":"10.1124\/pr.117.014399_bib306","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1126\/science.aaf8933","article-title":"Neural circuits for pain: recent advances and current views","volume":"354","author":"Peirs","year":"2016","journal-title":"Science"},{"key":"10.1124\/pr.117.014399_bib307","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.neuron.2015.07.029","article-title":"Dorsal horn circuits for persistent mechanical pain","volume":"87","author":"Peirs","year":"2015","journal-title":"Neuron"},{"key":"10.1124\/pr.117.014399_bib308","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1684\/mrh.2011.0282","article-title":"Oral magnesium treatment in patients with neuropathic pain: a randomized clinical trial","volume":"24","author":"Pickering","year":"2011","journal-title":"Magnes Res"},{"key":"10.1124\/pr.117.014399_bib309","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.expneurol.2008.08.003","article-title":"Governing role of primary afferent drive in increased excitation of spinal nociceptive neurons in a model of sciatic neuropathy","volume":"214","author":"Pitcher","year":"2008","journal-title":"Exp Neurol"},{"key":"10.1124\/pr.117.014399_bib310","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1007\/s10194-011-0338-0","article-title":"Efficacy and tolerability of pregabalin as preventive treatment for migraine: a 3-month follow-up study","volume":"12","author":"Pizzolato","year":"2011","journal-title":"J Headache Pain"},{"key":"10.1124\/pr.117.014399_bib311","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S0166-2236(02)02157-4","article-title":"Chronic pain and medullary descending facilitation","volume":"25","author":"Porreca","year":"2002","journal-title":"Trends Neurosci"},{"key":"10.1124\/pr.117.014399_bib312","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/nn.3629","article-title":"Normal and abnormal coding of somatosensory stimuli causing pain","volume":"17","author":"Prescott","year":"2014","journal-title":"Nat Neurosci"},{"key":"10.1124\/pr.117.014399_bib313","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/1744-8069-2-32","article-title":"Reduction of anion reversal potential subverts the inhibitory control of firing rate in spinal lamina I neurons: towards a biophysical basis for neuropathic pain","volume":"2","author":"Prescott","year":"2006","journal-title":"Mol Pain"},{"key":"10.1124\/pr.117.014399_bib314","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/0304-3940(91)90569-F","article-title":"Intrathecal administration of clonidine suppresses autotomy, a behavioral sign of chronic pain in rats after sciatic nerve section","volume":"133","author":"Puke","year":"1991","journal-title":"Neurosci Lett"},{"key":"10.1124\/pr.117.014399_bib315","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1113\/jphysiol.2013.264937","article-title":"Morphological, biophysical and synaptic properties of glutamatergic neurons of the mouse spinal dorsal horn","volume":"592","author":"Punnakkal","year":"2014","journal-title":"J Physiol"},{"key":"10.1124\/pr.117.014399_bib316","doi-asserted-by":"crossref","first-page":"6607","DOI":"10.1113\/JP272725","article-title":"Cav1.2 and Cav1.3 L-type calcium channels independently control short- and long-term sensitization to pain","volume":"594","author":"Radwani","year":"2016","journal-title":"J Physiol"},{"key":"10.1124\/pr.117.014399_bib317","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.neuropharm.2016.07.004","article-title":"The clobazam metabolite N-desmethyl clobazam is an \u03b12 preferring benzodiazepine with an improved therapeutic window for antihyperalgesia","volume":"109","author":"Ralvenius","year":"2016","journal-title":"Neuropharmacology"},{"key":"10.1124\/pr.117.014399_bib318","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/nature13980","article-title":"Piezo2 is the major transducer of mechanical forces for touch sensation in mice","volume":"516","author":"Ranade","year":"2014","journal-title":"Nature"},{"key":"10.1124\/pr.117.014399_bib319","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.jpainsymman.2012.07.011","article-title":"Once-daily gastroretentive gabapentin for postherpetic neuralgia: integrated efficacy, time to onset of pain relief and safety analyses of data from two phase 3, multicenter, randomized, double-blind, placebo-controlled studies","volume":"46","author":"Rauck","year":"2013","journal-title":"J Pain Symptom Manage"},{"key":"10.1124\/pr.117.014399_bib320","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1098\/rstb.2006.1894","article-title":"Neurotrophin-regulated signalling pathways","volume":"361","author":"Reichardt","year":"2006","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"10.1124\/pr.117.014399_bib321","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1038\/nn.4199","article-title":"The indirect pathway of the nucleus accumbens shell amplifies neuropathic pain","volume":"19","author":"Ren","year":"2016","journal-title":"Nat Neurosci"},{"key":"10.1124\/pr.117.014399_bib322","doi-asserted-by":"crossref","first-page":"7363","DOI":"10.1073\/pnas.93.14.7363","article-title":"Isoform-specific interaction of the alpha1A subunits of brain Ca2+ channels with the presynaptic proteins syntaxin and SNAP-25","volume":"93","author":"Rettig","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/pr.117.014399_bib323","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1002\/cne.900960303","article-title":"The cytoarchitectonic organization of the spinal cord in the cat","volume":"96","author":"Rexed","year":"1952","journal-title":"J Comp Neurol"},{"key":"10.1124\/pr.117.014399_bib324","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1002\/cpt.29","article-title":"Angiotensin II type 2-receptor: new clinically validated target in the treatment of neuropathic pain","volume":"97","author":"Rice","year":"2015","journal-title":"Clin Pharmacol Ther"},{"key":"10.1124\/pr.117.014399_bib325","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1016\/S0140-6736(13)62337-5","article-title":"EMA401, an orally administered highly selective angiotensin II type 2 receptor antagonist, as a novel treatment for postherpetic neuralgia: a randomised, double-blind, placebo-controlled phase 2 clinical trial","volume":"383","author":"Rice","year":"2014","journal-title":"Lancet"},{"key":"10.1124\/pr.117.014399_bib326","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1523\/JNEUROSCI.1594-14.2015","article-title":"Dysregulation of Kv3.4 channels in dorsal root ganglia following spinal cord injury","volume":"35","author":"Ritter","year":"2015","journal-title":"J Neurosci"},{"key":"10.1124\/pr.117.014399_bib327","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/S0197-0186(03)00023-8","article-title":"Beta-amyloid and brain-derived neurotrophic factor, BDNF, up-regulate the expression of glutamate transporter GLT-1\/EAAT2 via different signaling pathways utilizing transcription factor NF-kappaB","volume":"43","author":"Rodriguez-Kern","year":"2003","journal-title":"Neurochem Int"},{"key":"10.1124\/pr.117.014399_bib328","doi-asserted-by":"crossref","first-page":"4205","DOI":"10.1113\/jphysiol.2010.197004","article-title":"Magnesium attenuates chronic hypersensitivity and spinal cord NMDA receptor phosphorylation in a rat model of diabetic neuropathic pain","volume":"588","author":"Rond\u00f3n","year":"2010","journal-title":"J Physiol"},{"key":"10.1124\/pr.117.014399_bib329","doi-asserted-by":"crossref","first-page":"16124","DOI":"10.1074\/jbc.M707104200","article-title":"Inhibition of recombinant human T-type calcium channels by Delta9-tetrahydrocannabinol and cannabidiol","volume":"283","author":"Ross","year":"2008","journal-title":"J Biol Chem"},{"key":"10.1124\/pr.117.014399_bib330","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/1744-8069-7-20","article-title":"Long-term potentiation in spinal nociceptive pathways as a novel target for pain therapy","volume":"7","author":"Ruscheweyh","year":"2011","journal-title":"Mol Pain"},{"key":"10.1124\/pr.117.014399_bib331","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.1093\/emboj\/20.10.2349","article-title":"Suppression of inflammatory and neuropathic pain symptoms in mice lacking the N-type Ca2+ channel","volume":"20","author":"Saegusa","year":"2001","journal-title":"EMBO J"},{"key":"10.1124\/pr.117.014399_bib332","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1038\/nrd1107","article-title":"Neurotrophic factors as novel therapeutics for neuropathic pain","volume":"2","author":"Sah","year":"2003","journal-title":"Nat Rev Drug Discov"},{"key":"10.1124\/pr.117.014399_bib333","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1742-4658.2011.08390.x","article-title":"Dysregulated Src upregulation of NMDA receptor activity: a common link in chronic pain and schizophrenia","volume":"279","author":"Salter","year":"2012","journal-title":"FEBS J"},{"key":"10.1124\/pr.117.014399_bib334","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1093\/brain\/awu028","article-title":"Deepening understanding of the neural substrates of chronic pain","volume":"137","author":"Salter","year":"2014","journal-title":"Brain"},{"key":"10.1124\/pr.117.014399_bib335","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1744-8069-3-9","article-title":"Understanding LTP in pain pathways","volume":"3","author":"Sandk\u00fchler","year":"2007","journal-title":"Mol Pain"},{"key":"10.1124\/pr.117.014399_bib336","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1152\/physrev.00025.2008","article-title":"Models and mechanisms of hyperalgesia and allodynia","volume":"89","author":"Sandk\u00fchler","year":"2009","journal-title":"Physiol Rev"},{"key":"10.1124\/pr.117.014399_bib337","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.coph.2011.10.018","article-title":"Hyperalgesia by synaptic long-term potentiation (LTP): an update","volume":"12","author":"Sandk\u00fchler","year":"2012","journal-title":"Curr Opin Pharmacol"},{"key":"10.1124\/pr.117.014399_bib338","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.tins.2013.03.004","article-title":"How to erase memory traces of pain and fear","volume":"36","author":"Sandk\u00fchler","year":"2013","journal-title":"Trends Neurosci"},{"key":"10.1124\/pr.117.014399_bib339","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1113\/jphysiol.2006.126912","article-title":"Excitatory interneurons dominate sensory processing in the spinal substantia gelatinosa of rat","volume":"581","author":"Santos","year":"2007","journal-title":"J Physiol"},{"key":"10.1124\/pr.117.014399_bib340","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1124\/pr.117.014035","article-title":"The hyperpolarization-activated cyclic nucleotide-gated channels: from biophysics to pharmacology of a unique family of ion channels","volume":"69","author":"Sartiani","year":"2017","journal-title":"Pharmacol Rev"},{"key":"10.1124\/pr.117.014399_bib341","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuroscience.2015.10.031","article-title":"Adenosine receptor targets for pain","volume":"338","author":"Sawynok","year":"2016","journal-title":"Neuroscience"},{"key":"10.1124\/pr.117.014399_bib342","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1124\/mi.10.3.7","article-title":"Mechanism of cancer pain","volume":"10","author":"Schmidt","year":"2010","journal-title":"Mol Interv"},{"key":"10.1124\/pr.117.014399_bib343","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1038\/nn1992","article-title":"The neuropathic pain triad: neurons, immune cells and glia","volume":"10","author":"Scholz","year":"2007","journal-title":"Nat Neurosci"},{"key":"10.1124\/pr.117.014399_bib344","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.pain.2013.12.006","article-title":"Prostacyclin mediates neuropathic pain through interleukin 1\u03b2-expressing resident macrophages","volume":"155","author":"Schuh","year":"2014","journal-title":"Pain"},{"key":"10.1124\/pr.117.014399_bib345","doi-asserted-by":"crossref","first-page":"3788","DOI":"10.1172\/JCI43498","article-title":"Pain imaging in health and disease--how far have we come?","volume":"120","author":"Schweinhardt","year":"2010","journal-title":"J Clin Invest"},{"key":"10.1124\/pr.117.014399_bib346","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/BF00370703","article-title":"Characterization of two components of the N-like, high-threshold-activated calcium channel current in differentiated SH-SY5Y cells","volume":"417","author":"Seward","year":"1990","journal-title":"Pflugers Arch"},{"key":"10.1124\/pr.117.014399_bib347","article-title":"The genetics of pain: implications for therapeutics","author":"Sexton","year":"2017","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"10.1124\/pr.117.014399_bib348","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1002\/ejp.971","article-title":"Topical gabapentin gel alleviates allodynia and hyperalgesia in the chronic sciatic nerve constriction injury neuropathic pain model","volume":"21","author":"Shahid","year":"2017","journal-title":"Eur J Pain"},{"key":"10.1124\/pr.117.014399_bib349","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1097\/MJT.0b013e3181d5e4f3","article-title":"Time to onset of neuropathic pain reduction: a retrospective analysis of data from nine controlled trials of pregabalin for painful diabetic peripheral neuropathy and postherpetic neuralgia","volume":"17","author":"Sharma","year":"2010","journal-title":"Am J Ther"},{"key":"10.1124\/pr.117.014399_bib350","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1038\/379451a0","article-title":"Calcium-dependent interaction of N-type calcium channels with the synaptic core complex","volume":"379","author":"Sheng","year":"1996","journal-title":"Nature"},{"key":"10.1124\/pr.117.014399_bib351","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0304-3959(94)90146-5","article-title":"Morphine insensitive allodynia is produced by intrathecal strychnine in the lightly anesthetized rat","volume":"56","author":"Sherman","year":"1994","journal-title":"Pain"},{"key":"10.1124\/pr.117.014399_bib352","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1111\/pme.12063","article-title":"Small molecule angiotensin II type 2 receptor (AT2R) antagonists as novel analgesics for neuropathic pain: comparative pharmacokinetics, radioligand binding, and efficacy in rats","volume":"14","author":"Smith","year":"2013","journal-title":"Pain Med"},{"key":"10.1124\/pr.117.014399_bib353","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.neuroscience.2014.05.044","article-title":"BDNF: no gain without pain?","volume":"283","author":"Smith","year":"2014","journal-title":"Neuroscience"},{"key":"10.1124\/pr.117.014399_bib354","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.peptides.2006.09.029","article-title":"Spinal mechanisms of NPY analgesia","volume":"28","author":"Smith","year":"2007","journal-title":"Peptides"},{"key":"10.1124\/pr.117.014399_bib355","article-title":"Recent advances in the development of T-type calcium channel blockers for pain intervention","author":"Snutch","year":"2017","journal-title":"Br J Pharmacol"},{"key":"10.1124\/pr.117.014399_bib356","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1038\/nn.4053","article-title":"Different immune cells mediate mechanical pain hypersensitivity in male and female mice","volume":"18","author":"Sorge","year":"2015","journal-title":"Nat Neurosci"},{"key":"10.1124\/pr.117.014399_bib357","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1002\/jnr.23841","article-title":"Sex differences in pain","volume":"95","author":"Sorge","year":"2017","journal-title":"J Neurosci Res"},{"key":"10.1124\/pr.117.014399_bib358","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1016\/j.jpain.2008.05.014","article-title":"Pregabalin for postherpetic neuralgia: placebo-controlled trial of fixed and flexible dosing regimens on allodynia and time to onset of pain relief","volume":"9","author":"Stacey","year":"2008","journal-title":"J Pain"},{"key":"10.1124\/pr.117.014399_bib359","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.neuroscience.2016.03.016","article-title":"Calbindin-D-28K like immunoreactivity in superficial dorsal horn neurons and effects of sciatic chronic constriction injury","volume":"324","author":"Stebbing","year":"2016","journal-title":"Neuroscience"},{"key":"10.1124\/pr.117.014399_bib360","doi-asserted-by":"crossref","DOI":"10.1177\/1744806917724698","article-title":"Identification of interleukin-1 beta as a key mediator in the upregulation of Cav3.2-USP5 interactions in the pain pathway","volume":"13","author":"Stemkowski","year":"2017","journal-title":"Mol Pain"},{"key":"10.1124\/pr.117.014399_bib362","doi-asserted-by":"crossref","first-page":"3739","DOI":"10.1113\/JP270905","article-title":"Increased excitability of medium-sized dorsal root ganglion neurons by prolonged interleukin-1\u03b2 exposure is K(+) channel dependent and reversible","volume":"593","author":"Stemkowski","year":"2015","journal-title":"J Physiol"},{"key":"10.1124\/pr.117.014399_bib363","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1152\/jn.00587.2011","article-title":"Long-term IL-1\u03b2 exposure causes subpopulation-dependent alterations in rat dorsal root ganglion neuron excitability","volume":"107","author":"Stemkowski","year":"2012","journal-title":"J Neurophysiol"},{"key":"10.1124\/pr.117.014399_bib364","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1017\/S0317167100013937","article-title":"Sensory neurons, ion channels, inflammation and the onset of neuropathic pain","volume":"39","author":"Stemkowski","year":"2012","journal-title":"Can J Neurol Sci"},{"key":"10.1124\/pr.117.014399_bib365","series-title":"Neuropathic Pain, Causes, Management and Understanding","first-page":"33","article-title":"An overview of animal models of neuropathic pain","author":"Stemkowski","year":"2013"},{"key":"10.1124\/pr.117.014399_bib366","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pain.2012.10.016","article-title":"The emerging field of pain epigenetics","volume":"154","author":"Stone","year":"2013","journal-title":"Pain"},{"key":"10.1124\/pr.117.014399_bib367","doi-asserted-by":"crossref","first-page":"6497","DOI":"10.1523\/JNEUROSCI.19-15-06497.1999","article-title":"Isolectin B(4)-positive and -negative nociceptors are functionally distinct","volume":"19","author":"Stucky","year":"1999","journal-title":"J Neurosci"},{"key":"10.1124\/pr.117.014399_bib368","doi-asserted-by":"crossref","first-page":"2899","DOI":"10.1523\/JNEUROSCI.23-07-02899.2003","article-title":"Altered expression and uptake activity of spinal glutamate transporters after nerve injury contribute to the pathogenesis of neuropathic pain in rats","volume":"23","author":"Sung","year":"2003","journal-title":"J Neurosci"},{"key":"10.1124\/pr.117.014399_bib369","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1046\/j.1528-1157.2003.36802.x","article-title":"Gabapentin increases the hyperpolarization-activated cation current Ih in rat CA1 pyramidal cells","volume":"44","author":"Surges","year":"2003","journal-title":"Epilepsia"},{"key":"10.1124\/pr.117.014399_bib370","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.neuropharm.2014.01.040","article-title":"Gabapentin increases extracellular glutamatergic level in the locus coeruleus via astroglial glutamate transporter-dependent mechanisms","volume":"81","author":"Suto","year":"2014","journal-title":"Neuropharmacology"},{"key":"10.1124\/pr.117.014399_bib371","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1038\/sj.bjp.0704439","article-title":"Gabapentin inhibits high-threshold calcium channel currents in cultured rat dorsal root ganglion neurones","volume":"135","author":"Sutton","year":"2002","journal-title":"Br J Pharmacol"},{"key":"10.1124\/pr.117.014399_bib372","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.pain.2005.06.015","article-title":"Spinal-supraspinal serotonergic circuits regulating neuropathic pain and its treatment with gabapentin","volume":"117","author":"Suzuki","year":"2005","journal-title":"Pain"},{"key":"10.1124\/pr.117.014399_bib373","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1124\/mol.111.075226","article-title":"Characterization of the substituted N-triazole oxindole TROX-1, a small-molecule, state-dependent inhibitor of Ca(V)2 calcium channels","volume":"81","author":"Swensen","year":"2012","journal-title":"Mol Pharmacol"},{"key":"10.1124\/pr.117.014399_bib374","doi-asserted-by":"crossref","first-page":"554","DOI":"10.3389\/fphar.2017.00554","article-title":"Gabapentin modulates HCN4 channel voltage-dependence","volume":"8","author":"Tae","year":"2017","journal-title":"Front Pharmacol"},{"key":"10.1124\/pr.117.014399_bib375","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0055259","article-title":"Peripheral nerve injury is associated with chronic, reversible changes in global DNA methylation in the mouse prefrontal cortex","volume":"8","author":"Tajerian","year":"2013","journal-title":"PLoS One"},{"key":"10.1124\/pr.117.014399_bib376","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1097\/ALN.0000000000000403","article-title":"Brain neuroplastic changes accompany anxiety and memory deficits in a model of complex regional pain syndrome","volume":"121","author":"Tajerian","year":"2014","journal-title":"Anesthesiology"},{"key":"10.1124\/pr.117.014399_bib377","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1038\/nn.4645","article-title":"A pathway from midcingulate cortex to posterior insula gates nociceptive hypersensitivity","volume":"20","author":"Tan","year":"2017","journal-title":"Nat Neurosci"},{"key":"10.1124\/pr.117.014399_bib378","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1152\/jn.00830.2005","article-title":"Effects of a chronic compression of the dorsal root ganglion on voltage-gated Na+ and K+ currents in cutaneous afferent neurons","volume":"95","author":"Tan","year":"2006","journal-title":"J Neurophysiol"},{"key":"10.1124\/pr.117.014399_bib379","doi-asserted-by":"crossref","first-page":"8442","DOI":"10.1523\/JNEUROSCI.4036-14.2015","article-title":"Microglia disrupt mesolimbic reward circuitry in chronic pain","volume":"35","author":"Taylor","year":"2015","journal-title":"J Neurosci"},{"key":"10.1124\/pr.117.014399_bib380","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1002\/jnr.23883","article-title":"Topography of microglial activation in sensory- and affect-related brain regions in chronic pain","volume":"95","author":"Taylor","year":"2017","journal-title":"J Neurosci Res"},{"key":"10.1124\/pr.117.014399_bib381","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.pain.2008.11.019","article-title":"Mechanisms of analgesia by gabapentin and pregabalin--calcium channel alpha2-delta [Cavalpha2-delta] ligands","volume":"142","author":"Taylor","year":"2009","journal-title":"Pain"},{"key":"10.1124\/pr.117.014399_bib382","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.eplepsyres.2006.09.008","article-title":"Pharmacology and mechanism of action of pregabalin: the calcium channel alpha2-delta (alpha2-delta) subunit as a target for antiepileptic drug discovery","volume":"73","author":"Taylor","year":"2007","journal-title":"Epilepsy Res"},{"key":"10.1124\/pr.117.014399_bib383","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1038\/nrn2947","article-title":"Neuronal circuitry for pain processing in the dorsal horn","volume":"11","author":"Todd","year":"2010","journal-title":"Nat Rev Neurosci"},{"key":"10.1124\/pr.117.014399_bib384","doi-asserted-by":"crossref","DOI":"10.1177\/1744806917693003","article-title":"Identifying functional populations among the interneurons in laminae I-III of the spinal dorsal horn","volume":"13","author":"Todd","year":"2017","journal-title":"Mol Pain"},{"key":"10.1124\/pr.117.014399_bib385","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1007\/s00424-012-1211-y","article-title":"Neuropathic pain: role for presynaptic T-type channels in nociceptive signaling","volume":"465","author":"Todorovic","year":"2013","journal-title":"Pflugers Arch"},{"key":"10.1124\/pr.117.014399_bib386","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1113\/jphysiol.2006.110072","article-title":"Both Ca2+-permeable and -impermeable AMPA receptors contribute to primary synaptic drive onto rat dorsal horn neurons","volume":"575","author":"Tong","year":"2006","journal-title":"J Physiol"},{"key":"10.1124\/pr.117.014399_bib387","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1016\/j.pain.2012.12.022","article-title":"Neuropathic pain in the community: more under-treated than refractory?","volume":"154","author":"Torrance","year":"2013","journal-title":"Pain"},{"key":"10.1124\/pr.117.014399_bib388","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.jpain.2005.11.008","article-title":"The epidemiology of chronic pain of predominantly neuropathic origin: results from a general population survey","volume":"7","author":"Torrance","year":"2006","journal-title":"J Pain"},{"key":"10.1124\/pr.117.014399_bib389","doi-asserted-by":"crossref","first-page":"5158","DOI":"10.1523\/JNEUROSCI.6241-10.2011","article-title":"Inflammatory pain unmasks heterosynaptic facilitation in lamina I neurokinin 1 receptor-expressing neurons in rat spinal cord","volume":"31","author":"Torsney","year":"2011","journal-title":"J Neurosci"},{"key":"10.1124\/pr.117.014399_bib390","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1523\/JNEUROSCI.4584-05.2006","article-title":"Disinhibition opens the gate to pathological pain signaling in superficial neurokinin 1 receptor-expressing neurons in rat spinal cord","volume":"26","author":"Torsney","year":"2006","journal-title":"J Neurosci"},{"key":"10.1124\/pr.117.014399_bib391","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/s11302-011-9288-x","article-title":"CCL2 promotes P2X4 receptor trafficking to the cell surface of microglia","volume":"8","author":"Toyomitsu","year":"2012","journal-title":"Purinergic Signal"},{"key":"10.1124\/pr.117.014399_bib392","doi-asserted-by":"crossref","first-page":"4949","DOI":"10.1523\/JNEUROSCI.0323-08.2008","article-title":"P2Y12 receptors in spinal microglia are required for neuropathic pain after peripheral nerve injury","volume":"28","author":"Tozaki-Saitoh","year":"2008","journal-title":"J Neurosci"},{"key":"10.1124\/pr.117.014399_bib393","doi-asserted-by":"crossref","first-page":"12856","DOI":"10.1523\/JNEUROSCI.2700-10.2010","article-title":"The alpha2delta ligand gabapentin inhibits the Rab11-dependent recycling of the calcium channel subunit alpha2delta-2","volume":"30","author":"Tran-Van-Minh","year":"2010","journal-title":"J Neurosci"},{"key":"10.1124\/pr.117.014399_bib394","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1017\/S1740925X12000087","article-title":"Brain-derived neurotrophic factor from microglia: a molecular substrate for neuropathic pain","volume":"7","author":"Trang","year":"2011","journal-title":"Neuron Glia Biol"},{"key":"10.1124\/pr.117.014399_bib395","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.expneurol.2011.11.012","article-title":"ATP receptors gate microglia signaling in neuropathic pain","volume":"234","author":"Trang","year":"2012","journal-title":"Exp Neurol"},{"key":"10.1124\/pr.117.014399_bib396","doi-asserted-by":"crossref","first-page":"3518","DOI":"10.1523\/JNEUROSCI.5714-08.2009","article-title":"P2X4-receptor-mediated synthesis and release of brain-derived neurotrophic factor in microglia is dependent on calcium and p38-mitogen-activated protein kinase activation","volume":"29","author":"Trang","year":"2009","journal-title":"J Neurosci"},{"key":"10.1124\/pr.117.014399_bib397","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1212\/01.wnl.0000282763.29778.59","article-title":"Neuropathic pain: redefinition and a grading system for clinical and research purposes","volume":"70","author":"Treede","year":"2008","journal-title":"Neurology"},{"key":"10.1124\/pr.117.014399_bib398","doi-asserted-by":"crossref","first-page":"7163","DOI":"10.1073\/pnas.95.12.7163","article-title":"Modulation of an early step in the secretory machinery in hippocampal nerve terminals","volume":"95","author":"Trudeau","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/pr.117.014399_bib399","doi-asserted-by":"crossref","first-page":"2717","DOI":"10.1042\/BCJ20160287","article-title":"HCN2 ion channels: basic science opens up possibilities for therapeutic intervention in neuropathic pain","volume":"473","author":"Tsantoulas","year":"2016","journal-title":"Biochem J"},{"key":"10.1124\/pr.117.014399_bib400","doi-asserted-by":"crossref","first-page":"17502","DOI":"10.1523\/JNEUROSCI.3561-12.2012","article-title":"Sensory neuron downregulation of the Kv9.1 potassium channel subunit mediates neuropathic pain following nerve injury","volume":"32","author":"Tsantoulas","year":"2012","journal-title":"J Neurosci"},{"key":"10.1124\/pr.117.014399_bib401","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.eplepsyres.2005.11.001","article-title":"Activity profile of pregabalin in rodent models of epilepsy and ataxia","volume":"68","author":"Vartanian","year":"2006","journal-title":"Epilepsy Res"},{"key":"10.1124\/pr.117.014399_bib402","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1016\/j.pain.2014.04.018","article-title":"Peripheral nervous system origin of phantom limb pain","volume":"155","author":"Vaso","year":"2014","journal-title":"Pain"},{"key":"10.1124\/pr.117.014399_bib403","doi-asserted-by":"crossref","DOI":"10.1038\/srep36407","article-title":"Fxyd2 regulates A\u03b4- and C-fiber mechanosensitivity and is required for the maintenance of neuropathic pain","volume":"6","author":"Vent\u00e9o","year":"2016","journal-title":"Sci Rep"},{"key":"10.1124\/pr.117.014399_bib404","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1038\/nm.3852","article-title":"The serine protease inhibitor serpinA3N attenuates neuropathic pain by inhibiting T cell-derived leukocyte elastase","volume":"21","author":"Vicuna","year":"2015","journal-title":"Nat Med"},{"key":"10.1124\/pr.117.014399_bib405","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.neuron.2012.02.008","article-title":"Deconstructing the neuropathic pain phenotype to reveal neural mechanisms","volume":"73","author":"von Hehn","year":"2012","journal-title":"Neuron"},{"key":"10.1124\/pr.117.014399_bib406","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/0304-3959(83)90164-1","article-title":"Sensory afferent impulses originate from dorsal root ganglia as well as from the periphery in normal and nerve injured rats","volume":"17","author":"Wall","year":"1983","journal-title":"Pain"},{"key":"10.1124\/pr.117.014399_bib407","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/0304-3959(79)90002-2","article-title":"Autotomy following peripheral nerve lesions: experimental anaesthesia dolorosa","volume":"7","author":"Wall","year":"1979","journal-title":"Pain"},{"key":"10.1124\/pr.117.014399_bib408","doi-asserted-by":"crossref","first-page":"22310","DOI":"10.1074\/jbc.M109.017152","article-title":"Three-dimensional structure of CaV3.1: comparison with the cardiac L-type voltage-gated calcium channel monomer architecture","volume":"284","author":"Walsh","year":"2009","journal-title":"J Biol Chem"},{"key":"10.1124\/pr.117.014399_bib409","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1111\/j.1526-4610.1968.hed0802062.x","article-title":"Tegretol--a new treatment for tic douloureux","volume":"8","author":"Walsh","year":"1968","journal-title":"Headache"},{"key":"10.1124\/pr.117.014399_bib410","doi-asserted-by":"crossref","first-page":"5508","DOI":"10.1523\/JNEUROSCI.4288-08.2009","article-title":"TrkB signaling is required for both the induction and maintenance of tissue and nerve injury-induced persistent pain","volume":"29","author":"Wang","year":"2009","journal-title":"J Neurosci"},{"key":"10.1124\/pr.117.014399_bib411","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1152\/physrev.00011.2002","article-title":"Beyond neurons: evidence that immune and glial cells contribute to pathological pain states","volume":"82","author":"Watkins","year":"2002","journal-title":"Physiol Rev"},{"key":"10.1124\/pr.117.014399_bib412","first-page":"517","article-title":"Voltage-gated sodium channels and the molecular pathogenesis of pain: a review","volume":"37","author":"Waxman","year":"2000","journal-title":"J Rehabil Res Dev"},{"key":"10.1124\/pr.117.014399_bib413","doi-asserted-by":"crossref","first-page":"7635","DOI":"10.1073\/pnas.96.14.7635","article-title":"Sodium channels and pain","volume":"96","author":"Waxman","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/pr.117.014399_bib414","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S0006-8993(00)02774-8","article-title":"Sodium channels and their genes: dynamic expression in the normal nervous system, dysregulation in disease states (1)","volume":"886","author":"Waxman","year":"2000","journal-title":"Brain Res"},{"key":"10.1124\/pr.117.014399_bib415","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/nn.3602","article-title":"Regulating excitability of peripheral afferents: emerging ion channel targets","volume":"17","author":"Waxman","year":"2014","journal-title":"Nat Neurosci"},{"key":"10.1124\/pr.117.014399_bib416","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1016\/j.neuroscience.2005.11.061","article-title":"Inhibition of glutamate uptake in the spinal cord induces hyperalgesia and increased responses of spinal dorsal horn neurons to peripheral afferent stimulation","volume":"138","author":"Weng","year":"2006","journal-title":"Neuroscience"},{"key":"10.1124\/pr.117.014399_bib417","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.neuroscience.2015.05.020","article-title":"Circuitry and plasticity of the dorsal horn--toward a better understanding of neuropathic pain","volume":"300","author":"West","year":"2015","journal-title":"Neuroscience"},{"key":"10.1124\/pr.117.014399_bib418","doi-asserted-by":"crossref","first-page":"6319","DOI":"10.1523\/JNEUROSCI.18-16-06319.1998","article-title":"Localization of Ca2+ channel subtypes on rat spinal motor neurons, interneurons, and nerve terminals","volume":"18","author":"Westenbroek","year":"1998","journal-title":"J Neurosci"},{"key":"10.1124\/pr.117.014399_bib419","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1038\/nature05394","article-title":"A stomatin-domain protein essential for touch sensation in the mouse","volume":"445","author":"Wetzel","year":"2007","journal-title":"Nature"},{"key":"10.1124\/pr.117.014399_bib420","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/nn.4454","article-title":"Small-molecule inhibition of STOML3 oligomerization reverses pathological mechanical hypersensitivity","volume":"20","author":"Wetzel","year":"2017","journal-title":"Nat Neurosci"},{"key":"10.1124\/pr.117.014399_bib421","doi-asserted-by":"crossref","first-page":"20151","DOI":"10.1073\/pnas.0709250104","article-title":"Chemokines and the pathophysiology of neuropathic pain","volume":"104","author":"White","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/pr.117.014399_bib422","doi-asserted-by":"crossref","first-page":"3369","DOI":"10.1091\/mbc.e02-05-0259","article-title":"Distribution and evolution of von Willebrand\/integrin A domains: widely dispersed domains with roles in cell adhesion and elsewhere","volume":"13","author":"Whittaker","year":"2002","journal-title":"Mol Biol Cell"},{"key":"10.1124\/pr.117.014399_bib423","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.neures.2016.02.006","article-title":"Amitriptyline and carbamazepine utilize voltage-gated ion channel suppression to impair excitability of sensory dorsal horn neurons in thin tissue slice: an in vitro study","volume":"109","author":"Wolff","year":"2016","journal-title":"Neurosci Res"},{"key":"10.1124\/pr.117.014399_bib424","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1038\/306686a0","article-title":"Evidence for a central component of post-injury pain hypersensitivity","volume":"306","author":"Woolf","year":"1983","journal-title":"Nature"},{"key":"10.1124\/pr.117.014399_bib425","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1016\/S0140-6736(99)01307-0","article-title":"Neuropathic pain: aetiology, symptoms, mechanisms, and management","volume":"353","author":"Woolf","year":"1999","journal-title":"Lancet"},{"key":"10.1124\/pr.117.014399_bib426","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/0304-3959(91)90100-C","article-title":"The induction and maintenance of central sensitization is dependent on N-methyl-D-aspartic acid receptor activation; implications for the treatment of post-injury pain hypersensitivity states","volume":"44","author":"Woolf","year":"1991","journal-title":"Pain"},{"key":"10.1124\/pr.117.014399_bib427","doi-asserted-by":"crossref","first-page":"8360","DOI":"10.1073\/pnas.122231899","article-title":"Identification of gene expression profile of dorsal root ganglion in the rat peripheral axotomy model of neuropathic pain","volume":"99","author":"Xiao","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/pr.117.014399_bib428","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/j.neuroscience.2006.09.044","article-title":"Chemotherapy-evoked painful peripheral neuropathy: analgesic effects of gabapentin and effects on expression of the alpha-2-delta type-1 calcium channel subunit","volume":"144","author":"Xiao","year":"2007","journal-title":"Neuroscience"},{"key":"10.1124\/pr.117.014399_bib429","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1152\/jn.00463.2013","article-title":"A mixed Ca2+ channel blocker, A-1264087, utilizes peripheral and spinal mechanisms to inhibit spinal nociceptive transmission in a rat model of neuropathic pain","volume":"111","author":"Xu","year":"2014","journal-title":"J Neurophysiol"},{"key":"10.1124\/pr.117.014399_bib430","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1038\/nm.3978","article-title":"Inhibition of mechanical allodynia in neuropathic pain by TLR5-mediated A-fiber blockade","volume":"21","author":"Xu","year":"2015","journal-title":"Nat Med"},{"key":"10.1124\/pr.117.014399_bib431","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/0304-3959(89)90160-7","article-title":"Behavioral and autonomic correlates of the tactile evoked allodynia produced by spinal glycine inhibition: effects of modulatory receptor systems and excitatory amino acid antagonists","volume":"37","author":"Yaksh","year":"1989","journal-title":"Pain"},{"key":"10.1124\/pr.117.014399_bib432","doi-asserted-by":"crossref","first-page":"232","DOI":"10.2174\/1570159X14666160307145542","article-title":"Current and future issues in the development of spinal agents for the management of pain","volume":"15","author":"Yaksh","year":"2017","journal-title":"Curr Neuropharmacol"},{"key":"10.1124\/pr.117.014399_bib433","doi-asserted-by":"crossref","first-page":"30544","DOI":"10.1074\/jbc.M113.495465","article-title":"Endogenous interleukin-1\u03b2 in neuropathic rats enhances glutamate release from the primary afferents in the spinal dorsal horn through coupling with presynaptic N-methyl-D-aspartic acid receptors","volume":"288","author":"Yan","year":"2013","journal-title":"J Biol Chem"},{"key":"10.1124\/pr.117.014399_bib434","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.pain.2013.10.024","article-title":"Analgesic treatment with pregabalin does not prevent persistent pain after peripheral nerve injury in the rat","volume":"155","author":"Yang","year":"2014","journal-title":"Pain"},{"key":"10.1124\/pr.117.014399_bib435","doi-asserted-by":"crossref","first-page":"10765","DOI":"10.1523\/JNEUROSCI.5316-13.2014","article-title":"Persistent pain after spinal cord injury is maintained by primary afferent activity","volume":"34","author":"Yang","year":"2014","journal-title":"J Neurosci"},{"key":"10.1124\/pr.117.014399_bib436","doi-asserted-by":"crossref","first-page":"17534","DOI":"10.1073\/pnas.1306285110","article-title":"Discovery of a selective NaV1.7 inhibitor from centipede venom with analgesic efficacy exceeding morphine in rodent pain models","volume":"110","author":"Yang","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/pr.117.014399_bib437","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s12264-015-0008-3","article-title":"Gabapentinoid insensitivity after repeated administration is associated with down-regulation of the \u03b1(2)\u03b4-1 subunit in rats with central post-stroke pain hypersensitivity","volume":"32","author":"Yang","year":"2016","journal-title":"Neurosci Bull"},{"key":"10.1124\/pr.117.014399_bib438","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.pain.2010.08.008","article-title":"Populations of inhibitory and excitatory interneurons in lamina II of the adult rat spinal dorsal horn revealed by a combined electrophysiological and anatomical approach","volume":"151","author":"Yasaka","year":"2010","journal-title":"Pain"},{"key":"10.1124\/pr.117.014399_bib439","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1460-9568.2004.03434.x","article-title":"Auxiliary subunit regulation of high-voltage activated calcium channels expressed in mammalian cells","volume":"20","author":"Yasuda","year":"2004","journal-title":"Eur J Neurosci"},{"key":"10.1124\/pr.117.014399_bib440","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1038\/nrd.2017.87","article-title":"Breaking barriers to novel analgesic drug development","volume":"16","author":"Yekkirala","year":"2017","journal-title":"Nat Rev Drug Discov"},{"key":"10.1124\/pr.117.014399_bib441","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1002\/cne.20899","article-title":"Sympathetic sprouting and changes in nociceptive sensory innervation in the glabrous skin of the rat hind paw following partial peripheral nerve injury","volume":"495","author":"Yen","year":"2006","journal-title":"J Comp Neurol"},{"key":"10.1124\/pr.117.014399_bib442","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.ceca.2016.04.009","article-title":"Paclitaxel-induced increase in NCX activity in subpopulations of nociceptive afferents: a protective mechanism against chemotherapy-induced peripheral neuropathy?","volume":"60","author":"Yilmaz","year":"2016","journal-title":"Cell Calcium"},{"key":"10.1124\/pr.117.014399_bib443","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.ceca.2017.01.005","article-title":"Paclitaxel-induced increase in mitochondrial volume mediates dysregulation of intracellular Ca2+ in putative nociceptive glabrous skin neurons from the rat","volume":"62","author":"Yilmaz","year":"2017","journal-title":"Cell Calcium"},{"key":"10.1124\/pr.117.014399_bib444","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1016\/j.pain.2014.05.021","article-title":"Inflammatory and neuropathic pain are rapidly suppressed by peripheral block of hyperpolarisation-activated cyclic nucleotide-gated ion channels","volume":"155","author":"Young","year":"2014","journal-title":"Pain"},{"key":"10.1124\/pr.117.014399_bib445","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1152\/jn.1992.67.3.561","article-title":"Heterogeneous calcium currents and transmitter release in cultured mouse spinal cord and dorsal root ganglion neurons","volume":"67","author":"Yu","year":"1992","journal-title":"J Neurophysiol"},{"key":"10.1124\/pr.117.014399_bib446","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1002\/cne.20675","article-title":"Morphology and neurokinin 1 receptor expression of spinothalamic lamina I neurons in the rat spinal cord [published correction appears in J Comp Neurol (2005) 493:475]","volume":"491","author":"Yu","year":"2005","journal-title":"J Comp Neurol"},{"key":"10.1124\/pr.117.014399_bib447","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S1474-4422(17)30005-4","article-title":"Safety and efficacy of a Nav1.7 selective sodium channel blocker in patients with trigeminal neuralgia: a double-blind, placebo-controlled, randomised withdrawal phase 2a trial","volume":"16","author":"Zakrzewska","year":"2017","journal-title":"Lancet Neurol"},{"key":"10.1124\/pr.117.014399_bib448","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/nrd.2015.5","article-title":"Targeting voltage-gated calcium channels in neurological and psychiatric diseases","volume":"15","author":"Zamponi","year":"2016","journal-title":"Nat Rev Drug Discov"},{"key":"10.1124\/pr.117.014399_bib449","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1124\/pr.114.009654","article-title":"The physiology, pathology, and pharmacology of voltage-gated calcium channels and their future therapeutic potential","volume":"67","author":"Zamponi","year":"2015","journal-title":"Pharmacol Rev"},{"key":"10.1124\/pr.117.014399_bib450","article-title":"Glycine receptors and glycine transporters: targets for novel analgesics?","author":"Zeilhofer","year":"2017","journal-title":"Cell Mol Life Sci"},{"key":"10.1124\/pr.117.014399_bib451","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1146\/annurev-pharmtox-010611-134636","article-title":"Chronic pain states: pharmacological strategies to restore diminished inhibitory spinal pain control","volume":"52","author":"Zeilhofer","year":"2012","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"10.1124\/pr.117.014399_bib452","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/bs.apha.2014.11.007","article-title":"Restoring the spinal pain gate: GABA(A) receptors as targets for novel analgesics","volume":"73","author":"Zeilhofer","year":"2015","journal-title":"Adv Pharmacol"},{"key":"10.1124\/pr.117.014399_bib453","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1152\/physrev.00043.2010","article-title":"Fast synaptic inhibition in spinal sensory processing and pain control","volume":"92","author":"Zeilhofer","year":"2012","journal-title":"Physiol Rev"},{"key":"10.1124\/pr.117.014399_bib454","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1111\/j.1476-5381.2012.02232.x","article-title":"Modulation of K(v)7 potassium channels by a novel opener pyrazolo[1,5-a]pyrimidin-7(4H)-one compound QO-58","volume":"168","author":"Zhang","year":"2013","journal-title":"Br J Pharmacol"},{"key":"10.1124\/pr.117.014399_bib455","doi-asserted-by":"crossref","first-page":"4511","DOI":"10.1113\/jphysiol.2011.215301","article-title":"Acute inhibition of signalling phenotype of spinal GABAergic neurons by tumour necrosis factor-alpha","volume":"589","author":"Zhang","year":"2011","journal-title":"J Physiol"},{"key":"10.1124\/pr.117.014399_bib456","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1021\/acsmedchemlett.5b00023","article-title":"Optimization of ADME properties for sulfonamides leading to the discovery of a T-type calcium channel blocker, ABT-639","volume":"6","author":"Zhang","year":"2015","journal-title":"ACS Med Chem Lett"},{"key":"10.1124\/pr.117.014399_bib457","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.brainres.2015.01.054","article-title":"ZC88, a novel N-type calcium channel blocker from 4-amino-piperidine derivatives state-dependent inhibits Cav2.2 calcium channels","volume":"1605","author":"Zhang","year":"2015","journal-title":"Brain Res"},{"key":"10.1124\/pr.117.014399_bib458","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0306-4522(97)00240-6","article-title":"Down-regulation of mu-opioid receptors in rat and monkey dorsal root ganglion neurons and spinal cord after peripheral axotomy","volume":"82","author":"Zhang","year":"1998","journal-title":"Neuroscience"},{"key":"10.1124\/pr.117.014399_bib459","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/j.celrep.2015.07.001","article-title":"Role of prelimbic GABAergic circuits in sensory and emotional aspects of neuropathic pain","volume":"12","author":"Zhang","year":"2015","journal-title":"Cell Reports"},{"key":"10.1124\/pr.117.014399_bib460","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1152\/jn.00107.2011","article-title":"Regulation of Nav1.6 and Nav1.8 peripheral nerve Na+ channels by auxiliary \u03b2-subunits","volume":"106","author":"Zhao","year":"2011","journal-title":"J Neurophysiol"},{"key":"10.1124\/pr.117.014399_bib461","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1002\/j.1532-2149.2013.00416.x","article-title":"Electrophysiological characterization of spinal neuron sensitization by elevated calcium channel alpha-2-delta-1 subunit protein","volume":"18","author":"Zhou","year":"2014","journal-title":"Eur J Pain"},{"key":"10.1124\/pr.117.014399_bib462","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1002\/ejp.656","article-title":"Nerve injury-induced calcium channel alpha-2-delta-1 protein dysregulation leads to increased pre-synaptic excitatory input into deep dorsal horn neurons and neuropathic allodynia","volume":"19","author":"Zhou","year":"2015","journal-title":"Eur J Pain"},{"key":"10.1124\/pr.117.014399_bib463","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpain.2013.12.002","article-title":"Mechanistic insights into the analgesic efficacy of A-1264087, a novel neuronal Ca(2+) channel blocker that reduces nociception in rat preclinical pain models","volume":"15","author":"Zhu","year":"2014","journal-title":"J Pain"},{"key":"10.1124\/pr.117.014399_bib464","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.tins.2008.01.003","article-title":"Cortical excitation and chronic pain","volume":"31","author":"Zhuo","year":"2008","journal-title":"Trends Neurosci"},{"key":"10.1124\/pr.117.014399_bib465","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.neuroscience.2016.08.014","article-title":"Contribution of synaptic plasticity in the insular cortex to chronic pain","volume":"338","author":"Zhuo","year":"2016","journal-title":"Neuroscience"},{"key":"10.1124\/pr.117.014399_bib466","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.tins.2016.01.006","article-title":"Neural mechanisms underlying anxiety-chronic pain interactions","volume":"39","author":"Zhuo","year":"2016","journal-title":"Trends Neurosci"},{"key":"10.1124\/pr.117.014399_bib467","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.neuroscience.2016.04.041","article-title":"Genetic predictors of human chronic pain conditions","volume":"338","author":"Zorina-Lichtenwalter","year":"2016","journal-title":"Neuroscience"}],"container-title":["Pharmacological Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S003169972401250X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S003169972401250X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/pr.117.014399","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T17:57:37Z","timestamp":1740765457000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S003169972401250X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4]]},"references-count":466,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["S003169972401250X"],"URL":"https:\/\/doi.org\/10.1124\/pr.117.014399","relation":{},"ISSN":["0031-6997"],"issn-type":[{"value":"0031-6997","type":"print"}],"subject":[],"published":{"date-parts":[[2018,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Etiology and Pharmacology of Neuropathic Pain","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/pr.117.014399","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 by The Author(s)","name":"copyright","label":"Copyright"}]}}