{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T17:47:36Z","timestamp":1792432056126,"version":"4.5.0"},"reference-count":602,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":1736,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["pharmrev.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Reviews"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1124\/pr.119.018440","type":"journal-article","created":{"date-parts":[[2020,3,20]],"date-time":"2020-03-20T18:55:10Z","timestamp":1584730510000},"page":"486-526","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":299,"title":["Targeting Janus Kinases and Signal Transducer and Activator of Transcription 3 To Treat Inflammation, Fibrosis, and Cancer: Rationale, Progress, and Caution"],"prefix":"10.1016","volume":"72","author":[{"given":"Uddalak","family":"Bharadwaj","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moses M.","family":"Kasembeli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prema","family":"Robinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Tweardy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1124\/pr.119.018440_bib1","doi-asserted-by":"crossref","first-page":"3464","DOI":"10.1038\/sj.onc.1204461","article-title":"The YXXQ motif in gp 130 is crucial for STAT3 phosphorylation at Ser727 through an H7-sensitive kinase pathway","volume":"20","author":"Abe","year":"2001","journal-title":"Oncogene"},{"key":"10.1124\/pr.119.018440_bib2","first-page":"5","article-title":"Bone marrow fibrosis in primary myelofibrosis: pathogenic mechanisms and the role of TGF-\u03b2","volume":"3","author":"Agarwal","year":"2016","journal-title":"Stem Cell Investig"},{"key":"10.1124\/pr.119.018440_bib3","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/j.1749-6632.2009.04911.x","article-title":"Signal transducer and activator of transcription-3, inflammation, and cancer: how intimate is the relationship?","volume":"1171","author":"Aggarwal","year":"2009","journal-title":"Ann N Y Acad Sci"},{"key":"10.1124\/pr.119.018440_bib4","doi-asserted-by":"crossref","first-page":"2920","DOI":"10.1158\/0008-5472.CAN-07-3036","article-title":"Triterpenoid CDDO-methyl ester inhibits the Janus-activated kinase-1 (JAK1)-->signal transducer and activator of transcription-3 (STAT3) pathway by direct inhibition of JAK1 and STAT3","volume":"68","author":"Ahmad","year":"2008","journal-title":"Cancer Res"},{"key":"10.1124\/pr.119.018440_bib5","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/0092-8674(94)90235-6","article-title":"Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway","volume":"77","author":"Akira","year":"1994","journal-title":"Cell"},{"key":"10.1124\/pr.119.018440_bib6","doi-asserted-by":"crossref","first-page":"546","DOI":"10.2174\/138945011794751528","article-title":"The use of structural biology in Janus kinase targeted drug discovery","volume":"12","author":"Alicea-Vel\u00e1zquez","year":"2011","journal-title":"Curr Drug Targets"},{"key":"10.1124\/pr.119.018440_bib7","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.cyto.2003.12.002","article-title":"Induced somatic inactivation of STAT3 in mice triggers the development of a fulminant form of enterocolitis","volume":"26","author":"Alonzi","year":"2004","journal-title":"Cytokine"},{"key":"10.1124\/pr.119.018440_bib8","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1016\/j.jaci.2009.02.024","article-title":"T(H)17-associated cytokines (IL-17A and IL-17F) in severe asthma","volume":"123","author":"Al-Ramli","year":"2009","journal-title":"J Allergy Clin Immunol"},{"key":"10.1124\/pr.119.018440_bib9","doi-asserted-by":"crossref","DOI":"10.1096\/fasebj.30.1_supplement.165.6","article-title":"STAT3 regulates endothelial permeability downstream of the pro-inflammatory cytokines IL6 and TNF-alpha","volume":"30","author":"Alsaffar","year":"2016","journal-title":"FASEB J"},{"key":"10.1124\/pr.119.018440_bib10","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1097\/MCC.0b013e32801162cb","article-title":"Hyperoxia in the intensive care unit: why more is not always better","volume":"13","author":"Altemeier","year":"2007","journal-title":"Curr Opin Crit Care"},{"key":"10.1124\/pr.119.018440_bib601","doi-asserted-by":"crossref","first-page":"2341","DOI":"10.1164\/ajrccm.162.6.ats9-00","article-title":"Proceedings of the ATS workshop on refractory asthma: current understanding, recommendations, and unanswered questions. American Thoracic Society","volume":"162","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1124\/pr.119.018440_bib11","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/S0140-6736(16)32538-7","article-title":"Filgotinib for Crohn\u2019s disease - expanding treatment options","volume":"389","author":"Ananthakrishnan","year":"2017","journal-title":"Lancet"},{"key":"10.1124\/pr.119.018440_bib12","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1038\/ng.764","article-title":"Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47","volume":"43","author":"Anderson","year":"2011","journal-title":"Nat Genet"},{"key":"10.1124\/pr.119.018440_bib13","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.bcmd.2014.11.006","article-title":"IL-6, IL-10, c-Jun and STAT3 expression in B-CLL","volume":"54","author":"Antosz","year":"2015","journal-title":"Blood Cells Mol Dis"},{"key":"10.1124\/pr.119.018440_bib14","doi-asserted-by":"crossref","first-page":"2907","DOI":"10.1242\/jcs.00501","article-title":"A STAT-regulated, stress-induced signalling pathway in Dictyostelium","volume":"116","author":"Araki","year":"2003","journal-title":"J Cell Sci"},{"key":"10.1124\/pr.119.018440_bib15","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1097\/01.CCM.0000201901.30292.C2","article-title":"Interleukin-6 treatment reverses apoptosis and blunts susceptibility to intraperitoneal bacterial challenge following hemorrhagic shock","volume":"34","author":"Arikan","year":"2006","journal-title":"Crit Care Med"},{"key":"10.1124\/pr.119.018440_bib16","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/75068","article-title":"Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in Crohn disease and experimental colitis in vivo","volume":"6","author":"Atreya","year":"2000","journal-title":"Nat Med"},{"key":"10.1124\/pr.119.018440_bib17","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1038\/s41418-018-0171-y","article-title":"STAT3 localizes to the ER, acting as a gatekeeper for ER-mitochondrion Ca2+ fluxes and apoptotic responses","volume":"26","author":"Avalle","year":"2019","journal-title":"Cell Death Differ"},{"key":"10.1124\/pr.119.018440_bib18","doi-asserted-by":"crossref","first-page":"2820","DOI":"10.3390\/ijms19092820","article-title":"Nucleus, mitochondrion, or reticulum? STAT3 \u00e0 La Carte","volume":"19","author":"Avalle","year":"2018","journal-title":"Int J Mol Sci"},{"key":"10.1124\/pr.119.018440_bib19","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1002\/mc.20356","article-title":"Protein kinase Cepsilon interacts with Stat3 and regulates its activation that is essential for the development of skin cancer","volume":"46","author":"Aziz","year":"2007","journal-title":"Mol Carcinog"},{"key":"10.1124\/pr.119.018440_bib20","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1158\/0008-5472.CAN-06-3350","article-title":"Protein kinase C epsilon, which sensitizes skin to sun\u2019s UV radiation-induced cutaneous damage and development of squamous cell carcinomas, associates with Stat3","volume":"67","author":"Aziz","year":"2007","journal-title":"Cancer Res"},{"key":"10.1124\/pr.119.018440_bib21","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.aai7838","article-title":"Jak-TGF\u03b2 cross-talk links transient adipose tissue inflammation to beige adipogenesis","volume":"11","author":"Babaei","year":"2018","journal-title":"Sci Signal"},{"key":"10.1124\/pr.119.018440_bib22","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.immuni.2011.12.015","article-title":"Suppression of cytokine signaling by SOCS3: characterization of the mode of inhibition and the basis of its specificity","volume":"36","author":"Babon","year":"2012","journal-title":"Immunity"},{"key":"10.1124\/pr.119.018440_bib23","doi-asserted-by":"crossref","first-page":"6724","DOI":"10.1038\/sj.onc.1210757","article-title":"Hematopoietic cytokine receptor signaling","volume":"26","author":"Baker","year":"2007","journal-title":"Oncogene"},{"key":"10.1124\/pr.119.018440_bib24","doi-asserted-by":"crossref","first-page":"20669","DOI":"10.18632\/oncotarget.7838","article-title":"Signal transducer and activator of transcription 3 (STAT3) inhibitor, S3I-201, acts as a potent and non-selective alkylating agent","volume":"7","author":"Ball","year":"2016","journal-title":"Oncotarget"},{"key":"10.1124\/pr.119.018440_bib25","doi-asserted-by":"crossref","first-page":"2570","DOI":"10.1002\/ijc.29923","article-title":"Constitutive activation of STAT3 in breast cancer cells: a review","volume":"138","author":"Banerjee","year":"2016","journal-title":"Int J Cancer"},{"key":"10.1124\/pr.119.018440_bib26","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1111\/j.1365-2613.2010.00734.x","article-title":"STAT3 modulates the DNA damage response pathway","volume":"91","author":"Barry","year":"2010","journal-title":"Int J Exp Pathol"},{"key":"10.1124\/pr.119.018440_bib27","doi-asserted-by":"crossref","first-page":"96710","DOI":"10.18632\/oncotarget.18073","article-title":"Inhibitors of the PI3K\/mTOR pathway prevent STAT5 phosphorylation in JAK2V617F mutated cells through PP2A\/CIP2A axis","volume":"8","author":"Bartalucci","year":"2017","journal-title":"Oncotarget"},{"key":"10.1124\/pr.119.018440_bib28","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1517\/14728222.10.3.459","article-title":"STAT3: a potential therapeutic target in dendritic cells for the induction of transplant tolerance","volume":"10","author":"Barton","year":"2006","journal-title":"Expert Opin Ther Targets"},{"key":"10.1124\/pr.119.018440_bib29","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1007\/s00109-003-0494-z","article-title":"The role of leptin-->STAT3 signaling in neuroendocrine function: an integrative perspective","volume":"82","author":"Bates","year":"2004","journal-title":"J Mol Med (Berl)"},{"key":"10.1124\/pr.119.018440_bib30","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1038\/nature01388","article-title":"STAT3 signalling is required for leptin regulation of energy balance but not reproduction","volume":"421","author":"Bates","year":"2003","journal-title":"Nature"},{"key":"10.1124\/pr.119.018440_bib31","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/S0140-6736(05)71142-9","article-title":"Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders","volume":"365","author":"Baxter","year":"2005","journal-title":"Lancet"},{"key":"10.1124\/pr.119.018440_bib32","doi-asserted-by":"crossref","first-page":"13638","DOI":"10.1038\/s41598-018-31835-2","article-title":"Targeting a phospho-STAT3-miRNAs pathway improves vesicular hepatic steatosis in an in vitro and in vivo model","volume":"8","author":"Belloni","year":"2018","journal-title":"Sci Rep"},{"key":"10.1124\/pr.119.018440_bib33","doi-asserted-by":"crossref","first-page":"637","DOI":"10.3324\/haematol.2016.143958","article-title":"Dual role of IL-21 in megakaryopoiesis and platelet homeostasis","volume":"102","author":"Benbarche","year":"2017","journal-title":"Haematologica"},{"key":"10.1124\/pr.119.018440_bib34","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s00280-014-2480-2","article-title":"Phase 1, open-label, dose-escalation, and pharmacokinetic study of STAT3 inhibitor OPB-31121 in subjects with advanced solid tumors","volume":"74","author":"Bendell","year":"2014","journal-title":"Cancer Chemother Pharmacol"},{"key":"10.1124\/pr.119.018440_bib35","doi-asserted-by":"crossref","first-page":"4422","DOI":"10.1200\/JCO.2008.21.3264","article-title":"Targeting signal transducer and activator of transcription signaling pathway in leukemias","volume":"27","author":"Benekli","year":"2009","journal-title":"J Clin Oncol"},{"key":"10.1124\/pr.119.018440_bib36","doi-asserted-by":"crossref","first-page":"26307","DOI":"10.18632\/oncotarget.8368","article-title":"Small-molecule inhibition of STAT3 in radioresistant head and neck squamous cell carcinoma","volume":"7","author":"Bharadwaj","year":"2016","journal-title":"Oncotarget"},{"key":"10.1124\/pr.119.018440_bib37","series-title":"STAT Inhibitors in Cancer","first-page":"95","article-title":"STAT3 inhibitors in cancer: a comprehensive update","author":"Bharadwaj","year":"2016"},{"key":"10.1124\/pr.119.018440_bib38","doi-asserted-by":"crossref","first-page":"5479","DOI":"10.1158\/0008-5472.CAN-06-3963","article-title":"Elevated interleukin-6 and G-CSF in human pancreatic cancer cell conditioned medium suppress dendritic cell differentiation and activation","volume":"67","author":"Bharadwaj","year":"2007","journal-title":"Cancer Res"},{"key":"10.1124\/pr.119.018440_bib39","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.jdermsci.2010.03.013","article-title":"Evaluation of toxicity and Stat3 activation induced by hydrogen peroxide exposure to the skin in healthy individuals","volume":"58","author":"Bito","year":"2010","journal-title":"J Dermatol Sci"},{"key":"10.1124\/pr.119.018440_bib40","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1111\/j.1600-0625.2010.01084.x","article-title":"Ultraviolet light induces Stat3 activation in human keratinocytes and fibroblasts through reactive oxygen species and DNA damage","volume":"19","author":"Bito","year":"2010","journal-title":"Exp Dermatol"},{"key":"10.1124\/pr.119.018440_bib41","doi-asserted-by":"crossref","first-page":"30059","DOI":"10.1074\/jbc.274.42.30059","article-title":"The role of SOCS-3 in leptin signaling and leptin resistance","volume":"274","author":"Bj\u00f8rbaek","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1124\/pr.119.018440_bib42","doi-asserted-by":"crossref","first-page":"3061","DOI":"10.1182\/blood-2016-02-702373","article-title":"Protein stabilization improves STAT3 function in autosomal dominant hyper-IgE syndrome","volume":"128","author":"Bocchini","year":"2016","journal-title":"Blood"},{"key":"10.1124\/pr.119.018440_bib43","doi-asserted-by":"crossref","first-page":"30222","DOI":"10.1074\/jbc.274.42.30222","article-title":"The mitogen-activated protein (MAP) kinase p38 and its upstream activator MAP kinase kinase 6 are involved in the activation of signal transducer and activator of transcription by hyperosmolarity","volume":"274","author":"Bode","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1124\/pr.119.018440_bib44","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1007\/s00395-010-0124-1","article-title":"Inhibition of permeability transition pore opening by mitochondrial STAT3 and its role in myocardial ischemia\/reperfusion","volume":"105","author":"Boengler","year":"2010","journal-title":"Basic Res Cardiol"},{"key":"10.1124\/pr.119.018440_bib45","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1182\/blood-2014-04-570762","article-title":"Endothelial cells translate pathogen signals into G-CSF-driven emergency granulopoiesis","volume":"124","author":"Boettcher","year":"2014","journal-title":"Blood"},{"key":"10.1124\/pr.119.018440_bib46","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.yjmcc.2011.01.002","article-title":"A murine model of inducible, cardiac-specific deletion of STAT3: its use to determine the role of STAT3 in the upregulation of cardioprotective proteins by ischemic preconditioning","volume":"50","author":"Bolli","year":"2011","journal-title":"J Mol Cell Cardiol"},{"key":"10.1124\/pr.119.018440_bib47","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1080\/13543784.2017.1323871","article-title":"Investigational Janus kinase inhibitors in development for myelofibrosis","volume":"26","author":"Bose","year":"2017","journal-title":"Expert Opin Investig Drugs"},{"key":"10.1124\/pr.119.018440_bib48","doi-asserted-by":"crossref","first-page":"6915","DOI":"10.1073\/pnas.92.15.6915","article-title":"STAT3 activation by cytokines utilizing gp130 and related transducers involves a secondary modification requiring an H7-sensitive kinase","volume":"92","author":"Boulton","year":"1995","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/pr.119.018440_bib49","doi-asserted-by":"crossref","first-page":"2474","DOI":"10.1038\/sj.onc.1203527","article-title":"STATs in oncogenesis","volume":"19","author":"Bowman","year":"2000","journal-title":"Oncogene"},{"key":"10.1124\/pr.119.018440_bib50","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1016\/j.molonc.2015.02.012","article-title":"Hitting the right spot: mechanism of action of OPB-31121, a novel and potent inhibitor of the signal transducer and activator of transcription 3 (STAT3)","volume":"9","author":"Brambilla","year":"2015","journal-title":"Mol Oncol"},{"key":"10.1124\/pr.119.018440_bib51","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1210\/me.2014-1300","article-title":"Serine-727 phosphorylation activates hypothalamic STAT-3 independently from tyrosine-705 phosphorylation","volume":"29","author":"Breit","year":"2015","journal-title":"Mol Endocrinol"},{"key":"10.1124\/pr.119.018440_bib52","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1161\/CIRCRESAHA.109.197491","article-title":"Interleukin-6 modulates the expression of the bone morphogenic protein receptor type II through a novel STAT3-microRNA cluster 17\/92 pathway","volume":"104","author":"Brock","year":"2009","journal-title":"Circ Res"},{"key":"10.1124\/pr.119.018440_bib53","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S0092-8674(00)81959-5","article-title":"Stat3 as an oncogene","volume":"98","author":"Bromberg","year":"1999","journal-title":"Cell"},{"key":"10.1124\/pr.119.018440_bib54","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1002\/jlb.57.5.719","article-title":"Thrombopoietin, the c-mpl ligand, is a major regulator of platelet production","volume":"57","author":"Broudy","year":"1995","journal-title":"J Leukoc Biol"},{"key":"10.1124\/pr.119.018440_bib55","first-page":"784","article-title":"Inhibition of interleukin-12 and\/or -23 for the treatment of inflammatory bowel disease","volume":"12","author":"Bruce","year":"2016","journal-title":"Gastroenterol Hepatol (N Y)"},{"key":"10.1124\/pr.119.018440_bib56","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1038\/onc.2015.150","article-title":"Targeting JAK kinase in solid tumors: emerging opportunities and challenges","volume":"35","author":"Buchert","year":"2016","journal-title":"Oncogene"},{"key":"10.1124\/pr.119.018440_bib57","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1021\/cb500407d","article-title":"S-Glutathionylation at Cys328 and Cys542 impairs STAT3 phosphorylation","volume":"9","author":"Butturini","year":"2014","journal-title":"ACS Chem Biol"},{"key":"10.1124\/pr.119.018440_bib58","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1177\/2040620718786437","article-title":"Leveraging JAK-STAT regulation in myelofibrosis to improve outcomes with allogeneic hematopoietic stem-cell transplant","volume":"9","author":"Byrne","year":"2018","journal-title":"Ther Adv Hematol"},{"key":"10.1124\/pr.119.018440_bib59","doi-asserted-by":"crossref","first-page":"17580","DOI":"10.1074\/jbc.274.25.17580","article-title":"Oxidative stress triggers STAT3 tyrosine phosphorylation and nuclear translocation in human lymphocytes","volume":"274","author":"Carballo","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1124\/pr.119.018440_bib60","doi-asserted-by":"crossref","first-page":"26","DOI":"10.3109\/14767058.2012.722713","article-title":"Clues to apoptosis pathway involvement in hemolysis, elevated liver enzyme, and low platelet (HELLP) syndrome and intrauterine growth restriction (IUGR)","volume":"26","author":"Cecati","year":"2013","journal-title":"J Matern Fetal Neonatal Med"},{"key":"10.1124\/pr.119.018440_bib61","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1007\/s00277-017-2938-5","article-title":"Ruxolitinib rechallenge in combination with hydroxyurea is effective in reverting cachexia and reducing blood transfusion demand and splenomegaly symptoms in a patient with primary myelofibrosis","volume":"96","author":"Cerchione","year":"2017","journal-title":"Ann Hematol"},{"key":"10.1124\/pr.119.018440_bib62","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1210\/en.2007-1148","article-title":"Adipose-specific disruption of signal transducer and activator of transcription 3 increases body weight and adiposity","volume":"149","author":"Cernkovich","year":"2008","journal-title":"Endocrinology"},{"key":"10.1124\/pr.119.018440_bib63","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1038\/s41467-017-01236-6","article-title":"Activation of STAT3 integrates common profibrotic pathways to promote fibroblast activation and tissue fibrosis","volume":"8","author":"Chakraborty","year":"2017","journal-title":"Nat Commun"},{"key":"10.1124\/pr.119.018440_bib64","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.immuni.2011.12.019","article-title":"Stat3 and Gfi-1 transcription factors control Th17 cell immunosuppressive activity via the regulation of ectonucleotidase expression","volume":"36","author":"Chalmin","year":"2012","journal-title":"Immunity"},{"key":"10.1124\/pr.119.018440_bib65","doi-asserted-by":"crossref","first-page":"38020","DOI":"10.1074\/jbc.M112.348599","article-title":"Interleukin-10 inhibits lipopolysaccharide-induced tumor necrosis factor-\u03b1 translation through a SHIP1-dependent pathway","volume":"287","author":"Chan","year":"2012","journal-title":"J Biol Chem"},{"key":"10.1124\/pr.119.018440_bib66","doi-asserted-by":"crossref","first-page":"2382","DOI":"10.1158\/0008-5472.CAN-03-3197","article-title":"Epidermal growth factor receptor-mediated activation of Stat3 during multistage skin carcinogenesis","volume":"64","author":"Chan","year":"2004","journal-title":"Cancer Res"},{"key":"10.1124\/pr.119.018440_bib67","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1172\/JCI200421032","article-title":"Disruption of Stat3 reveals a critical role in both the initiation and the promotion stages of epithelial carcinogenesis","volume":"114","author":"Chan","year":"2004","journal-title":"J Clin Invest"},{"key":"10.1124\/pr.119.018440_bib68","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0095716","article-title":"miR-17-5p downregulation contributes to paclitaxel resistance of lung cancer cells through altering beclin1 expression","volume":"9","author":"Chatterjee","year":"2014","journal-title":"PLoS One"},{"key":"10.1124\/pr.119.018440_bib69","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1172\/JCI57175","article-title":"Control of inflammation by integration of environmental cues by regulatory T cells","volume":"123","author":"Chaudhry","year":"2013","journal-title":"J Clin Invest"},{"key":"10.1124\/pr.119.018440_bib70","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1126\/science.1172702","article-title":"CD4+ regulatory T cells control TH17 responses in a Stat3-dependent manner","volume":"326","author":"Chaudhry","year":"2009","journal-title":"Science"},{"key":"10.1124\/pr.119.018440_bib71","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.immuni.2011.03.018","article-title":"Interleukin-10 signaling in regulatory T cells is required for suppression of Th17 cell-mediated inflammation","volume":"34","author":"Chaudhry","year":"2011","journal-title":"Immunity"},{"key":"10.1124\/pr.119.018440_bib72","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1128\/iai.56.1.247-251.1988","article-title":"Production of colony-stimulating factors (CSFs) during infection: separate determinations of macrophage-, granulocyte-, granulocyte-macrophage-, and multi-CSFs","volume":"56","author":"Cheers","year":"1988","journal-title":"Infect Immun"},{"key":"10.1124\/pr.119.018440_bib73","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.immuni.2012.03.017","article-title":"Janus kinase deregulation in leukemia and lymphoma","volume":"36","author":"Chen","year":"2012","journal-title":"Immunity"},{"key":"10.1124\/pr.119.018440_bib74","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1038\/bjc.2013.808","article-title":"Jumonji domain-containing protein 2B silencing induces DNA damage response via STAT3 pathway in colorectal cancer","volume":"110","author":"Chen","year":"2014","journal-title":"Br J Cancer"},{"key":"10.1124\/pr.119.018440_bib75","doi-asserted-by":"crossref","first-page":"3455","DOI":"10.2147\/DDDT.S86438","article-title":"Siltuximab (CNTO 328): a promising option for human malignancies","volume":"9","author":"Chen","year":"2015","journal-title":"Drug Des Devel Ther"},{"key":"10.1124\/pr.119.018440_bib76","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.smim.2007.10.015","article-title":"Signal transduction pathways and transcriptional regulation in the control of Th17 differentiation","volume":"19","author":"Chen","year":"2007","journal-title":"Semin Immunol"},{"key":"10.1124\/pr.119.018440_bib77","doi-asserted-by":"crossref","first-page":"2850","DOI":"10.4049\/jimmunol.1302778","article-title":"A novel role for histone deacetylase 6 in the regulation of the tolerogenic STAT3\/IL-10 pathway in APCs","volume":"193","author":"Cheng","year":"2014","journal-title":"J Immunol"},{"key":"10.1124\/pr.119.018440_bib78","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S1074-7613(03)00232-2","article-title":"A critical role for Stat3 signaling in immune tolerance","volume":"19","author":"Cheng","year":"2003","journal-title":"Immunity"},{"key":"10.1124\/pr.119.018440_bib79","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.1084\/jem.20080132","article-title":"Inhibition of dendritic cell differentiation and accumulation of myeloid-derived suppressor cells in cancer is regulated by S100A9 protein","volume":"205","author":"Cheng","year":"2008","journal-title":"J Exp Med"},{"key":"10.1124\/pr.119.018440_bib80","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1089\/jir.2010.0100","article-title":"The functions of signal transducers and activators of transcriptions 1 and 3 as cytokine-inducible proteins","volume":"31","author":"Cheon","year":"2011","journal-title":"J Interferon Cytokine Res"},{"key":"10.1124\/pr.119.018440_bib81","doi-asserted-by":"crossref","first-page":"3005","DOI":"10.1182\/blood-2006-05-024430","article-title":"STAT3 positively regulates an early step in B-cell development","volume":"108","author":"Chou","year":"2006","journal-title":"Blood"},{"key":"10.1124\/pr.119.018440_bib82","doi-asserted-by":"crossref","first-page":"301ra129","DOI":"10.1126\/scitranslmed.aab3142","article-title":"TH2 and TH17 inflammatory pathways are reciprocally regulated in asthma","volume":"7","author":"Choy","year":"2015","journal-title":"Sci Transl Med"},{"key":"10.1124\/pr.119.018440_bib83","doi-asserted-by":"crossref","first-page":"6508","DOI":"10.1128\/MCB.17.11.6508","article-title":"STAT3 serine phosphorylation by ERK-dependent and -independent pathways negatively modulates its tyrosine phosphorylation","volume":"17","author":"Chung","year":"1997","journal-title":"Mol Cell Biol"},{"key":"10.1124\/pr.119.018440_bib84","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1182\/blood-2006-01-010199","article-title":"Unique effects of Stat3 on the early phase of hematopoietic stem cell regeneration","volume":"108","author":"Chung","year":"2006","journal-title":"Blood"},{"key":"10.1124\/pr.119.018440_bib85","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1053\/j.gastro.2006.11.041","article-title":"Adalimumab for maintenance of clinical response and remission in patients with Crohn\u2019s disease: the CHARM trial","volume":"132","author":"Colombel","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1124\/pr.119.018440_bib86","doi-asserted-by":"crossref","first-page":"6027","DOI":"10.1074\/jbc.RA118.007290","article-title":"Innate lymphoid cell type 3-derived interleukin-22 boosts lipocalin-2 production in intestinal epithelial cells via synergy between STAT3 and NF-\u03baB","volume":"294","author":"Coorens","year":"2019","journal-title":"J Biol Chem"},{"key":"10.1124\/pr.119.018440_bib87","doi-asserted-by":"crossref","first-page":"26765","DOI":"10.1074\/jbc.M109.092304","article-title":"The cdk5 kinase regulates the STAT3 transcription factor to prevent DNA damage upon topoisomerase I inhibition","volume":"285","author":"Courapied","year":"2010","journal-title":"J Biol Chem"},{"key":"10.1124\/pr.119.018440_bib88","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1038\/nrm3198","article-title":"Forming functional fat: a growing understanding of adipocyte differentiation","volume":"12","author":"Cristancho","year":"2011","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1124\/pr.119.018440_bib89","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/j.immuni.2011.09.017","article-title":"An interleukin-21-interleukin-10-STAT3 pathway is critical for functional maturation of memory CD8+ T cells","volume":"35","author":"Cui","year":"2011","journal-title":"Immunity"},{"key":"10.1124\/pr.119.018440_bib90","doi-asserted-by":"crossref","first-page":"11499","DOI":"10.1073\/pnas.1219852110","article-title":"Negative regulation of Toll-like receptor 4 signaling by IL-10-dependent microRNA-146b","volume":"110","author":"Curtale","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/pr.119.018440_bib91","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1084\/jem.20030107","article-title":"The early progenitors of mouse dendritic cells and plasmacytoid predendritic cells are within the bone marrow hemopoietic precursors expressing Flt3","volume":"198","author":"D\u2019Amico","year":"2003","journal-title":"J Exp Med"},{"key":"10.1124\/pr.119.018440_bib92","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1038\/nrc906","article-title":"Transcription factors as targets for cancer therapy","volume":"2","author":"Darnell","year":"2002","journal-title":"Nat Rev Cancer"},{"key":"10.1124\/pr.119.018440_bib93","doi-asserted-by":"crossref","first-page":"17707","DOI":"10.1074\/jbc.M600088200","article-title":"Stat3 cleavage by caspases: impact on full-length Stat3 expression, fragment formation, and transcriptional activity","volume":"281","author":"Darnowski","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1124\/pr.119.018440_bib94","doi-asserted-by":"crossref","first-page":"3985","DOI":"10.1073\/pnas.1503152112","article-title":"STAT3-driven transcription depends upon the dimethylation of K49 by EZH2","volume":"112","author":"Dasgupta","year":"2015","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/pr.119.018440_bib95","doi-asserted-by":"crossref","first-page":"30763","DOI":"10.1074\/jbc.M114.603894","article-title":"Critical role for lysine 685 in gene expression mediated by transcription factor unphosphorylated STAT3","volume":"289","author":"Dasgupta","year":"2014","journal-title":"J Biol Chem"},{"key":"10.1124\/pr.119.018440_bib96","doi-asserted-by":"crossref","first-page":"3397","DOI":"10.1038\/sj.onc.1208469","article-title":"Stat3 regulates genes common to both wound healing and cancer","volume":"24","author":"Dauer","year":"2005","journal-title":"Oncogene"},{"key":"10.1124\/pr.119.018440_bib97","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1182\/blood-2015-03-635235","article-title":"The effect of long-term ruxolitinib treatment on JAK2p.V617F allele burden in patients with myelofibrosis","volume":"126","author":"Deininger","year":"2015","journal-title":"Blood"},{"key":"10.1124\/pr.119.018440_bib98","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1101\/gad.1606508","article-title":"Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway","volume":"22","author":"de la Iglesia","year":"2008","journal-title":"Genes Dev"},{"key":"10.1124\/pr.119.018440_bib99","doi-asserted-by":"crossref","first-page":"E187","DOI":"10.1152\/ajpendo.00056.2011","article-title":"Diet-induced obesity leads to the development of leptin resistance in vagal afferent neurons","volume":"301","author":"de Lartigue","year":"2011","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1124\/pr.119.018440_bib100","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1093\/ecco-jcc\/jjx003","article-title":"The future of Janus kinase inhibitors in inflammatory bowel disease [published correction appears in J Crohns Colitis (2017) 11:1028]","volume":"11","author":"De Vries","year":"2017","journal-title":"J Crohn\u2019s Colitis"},{"key":"10.1124\/pr.119.018440_bib101","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1530\/JME-15-0171","article-title":"Erythropoietin regulates POMC expression via STAT3 and potentiates leptin response","volume":"56","author":"Dey","year":"2016","journal-title":"J Mol Endocrinol"},{"key":"10.1124\/pr.119.018440_bib102","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.4049\/jimmunol.1201678","article-title":"IL-21 and CD40L synergistically promote plasma cell differentiation through upregulation of Blimp-1 in human B cells","volume":"190","author":"Ding","year":"2013","journal-title":"J Immunol"},{"key":"10.1124\/pr.119.018440_bib103","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1038\/ijo.2016.44","article-title":"Epigenomic elements analyses for promoters identify ESRRG as a new susceptibility gene for obesity-related traits","volume":"40","author":"Dong","year":"2016","journal-title":"Int J Obes"},{"key":"10.1124\/pr.119.018440_bib104","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1093\/neuonc\/nos139","article-title":"Signal transducer and activator of transcription 3 promotes angiogenesis and drives malignant progression in glioma","volume":"14","author":"Doucette","year":"2012","journal-title":"Neuro-oncol"},{"key":"10.1124\/pr.119.018440_bib105","doi-asserted-by":"crossref","first-page":"2350","DOI":"10.1073\/pnas.94.6.2350","article-title":"Dissecting the thrombopoietin receptor: functional elements of the Mpl cytoplasmic domain","volume":"94","author":"Drachman","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/pr.119.018440_bib106","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1182\/blood.V89.2.483","article-title":"Thrombopoietin signal transduction in purified murine megakaryocytes","volume":"89","author":"Drachman","year":"1997","journal-title":"Blood"},{"key":"10.1124\/pr.119.018440_bib107","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s00418-018-1656-y","article-title":"Bilateral activation of STAT3 by phosphorylation at the tyrosine-705 (Y705) and serine-727 (S727) positions and its nuclear translocation in primary sensory neurons following unilateral sciatic nerve injury","volume":"150","author":"Dubov\u00fd","year":"2018","journal-title":"Histochem Cell Biol"},{"key":"10.1124\/pr.119.018440_bib108","doi-asserted-by":"crossref","first-page":"41667","DOI":"10.1074\/jbc.M112.390781","article-title":"STAT3 protein up-regulates G\u03b1-interacting vesicle-associated protein (GIV)\/Girdin expression, and GIV enhances STAT3 activation in a positive feedback loop during wound healing and tumor invasion\/metastasis","volume":"287","author":"Dunkel","year":"2012","journal-title":"J Biol Chem"},{"key":"10.1124\/pr.119.018440_bib109","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.immuni.2010.05.003","article-title":"Diverse targets of the transcription factor STAT3 contribute to T cell pathogenicity and homeostasis","volume":"32","author":"Durant","year":"2010","journal-title":"Immunity"},{"key":"10.1124\/pr.119.018440_bib110","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.tips.2019.03.001","article-title":"Targeting SOCS proteins to control JAK-STAT signalling in disease","volume":"40","author":"Durham","year":"2019","journal-title":"Trends Pharmacol Sci"},{"key":"10.1124\/pr.119.018440_bib111","doi-asserted-by":"crossref","first-page":"7215","DOI":"10.4049\/jimmunol.179.11.7215","article-title":"Cutting edge: a transcriptional repressor and corepressor induced by the STAT3-regulated anti-inflammatory signaling pathway [published correction appears in J Immunol (2008) 180:3612]","volume":"179","author":"El Kasmi","year":"2007","journal-title":"J Immunol"},{"key":"10.1124\/pr.119.018440_bib112","doi-asserted-by":"crossref","first-page":"H471","DOI":"10.1152\/ajpheart.00730.2014","article-title":"Cardiac-specific ablation of the STAT3 gene in the subacute phase of myocardial infarction exacerbated cardiac remodeling","volume":"309","author":"Enomoto","year":"2015","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1124\/pr.119.018440_bib113","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.jaci.2013.12.1075","article-title":"Mitochondrial STAT3 plays a major role in IgE-antigen-mediated mast cell exocytosis","volume":"134","author":"Erlich","year":"2014","journal-title":"J Allergy Clin Immunol"},{"key":"10.1124\/pr.119.018440_bib114","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.immuni.2008.02.013","article-title":"The signal transducer STAT5 inhibits plasmacytoid dendritic cell development by suppressing transcription factor IRF8","volume":"28","author":"Esashi","year":"2008","journal-title":"Immunity"},{"key":"10.1124\/pr.119.018440_bib602","unstructured":"EU Clinical Trials Register (2017) Phase I\/II Open-Label Study to Evaluate the Safety, Tolerability and Recommended Phase II Dose (RP2D) of GLG-801 in patients with Advanced Solid Tumors (Phase I); and safety, tolerability and anticancer activity of GLG-801 in patients with Metastatic TNBC (Phase II)., 2017-005057-36 A"},{"key":"10.1124\/pr.119.018440_bib115","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1084\/jem.188.2.267","article-title":"Physical and functional association of the Src family kinases Fyn and Lyn with the collagen receptor glycoprotein VI-Fc receptor gamma chain complex on human platelets","volume":"188","author":"Ezumi","year":"1998","journal-title":"J Exp Med"},{"key":"10.1124\/pr.119.018440_bib116","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1513\/pats.200808-087RM","article-title":"Eosinophilic and neutrophilic inflammation in asthma: insights from clinical studies","volume":"6","author":"Fahy","year":"2009","journal-title":"Proc Am Thorac Soc"},{"key":"10.1124\/pr.119.018440_bib117","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.athoracsur.2006.03.060","article-title":"Interleukin-6 regulation of direct lung ischemia reperfusion injury","volume":"82","author":"Farivar","year":"2006","journal-title":"Ann Thorac Surg"},{"key":"10.1124\/pr.119.018440_bib118","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1172\/JCI0215693","article-title":"Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine\/metabolic dysfunction of human congenital leptin deficiency","volume":"110","author":"Farooqi","year":"2002","journal-title":"J Clin Invest"},{"key":"10.1124\/pr.119.018440_bib119","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1055\/s-0038-1673614","article-title":"IL-9 promotes the development of deep venous thrombosis by facilitating platelet function","volume":"118","author":"Feng","year":"2018","journal-title":"Thromb Haemost"},{"key":"10.1124\/pr.119.018440_bib120","doi-asserted-by":"crossref","first-page":"71","DOI":"10.3389\/fendo.2017.00071","article-title":"The Janus kinase (JAK) FERM and SH2 domains: bringing specificity to JAK-receptor interactions","volume":"8","author":"Ferrao","year":"2017","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1124\/pr.119.018440_bib121","first-page":"1329","article-title":"tyk2, prototype of a novel class of non-receptor tyrosine kinase genes","volume":"5","author":"Firmbach-Kraft","year":"1990","journal-title":"Oncogene"},{"key":"10.1124\/pr.119.018440_bib122","doi-asserted-by":"crossref","first-page":"1978","DOI":"10.1038\/s41375-019-0379-y","article-title":"Cytokine production in myelofibrosis exhibits differential responsiveness to JAK-STAT, MAP kinase, and NF\u03baB signaling","volume":"33","author":"Fisher","year":"2019","journal-title":"Leukemia"},{"key":"10.1124\/pr.119.018440_bib123","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1182\/blood-2005-07-2871","article-title":"Critical role for Stat3 in T-dependent terminal differentiation of IgG B cells","volume":"107","author":"Fornek","year":"2006","journal-title":"Blood"},{"key":"10.1124\/pr.119.018440_bib124","doi-asserted-by":"crossref","first-page":"3140","DOI":"10.1172\/JCI119869","article-title":"B lymphocytes from patients with chronic lymphocytic leukemia contain signal transducer and activator of transcription (STAT) 1 and STAT3 constitutively phosphorylated on serine residues","volume":"100","author":"Frank","year":"1997","journal-title":"J Clin Invest"},{"key":"10.1124\/pr.119.018440_bib125","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1002\/oby.21383","article-title":"Obesity decreases B cell responses in young and elderly individuals","volume":"24","author":"Frasca","year":"2016","journal-title":"Obesity (Silver Spring)"},{"key":"10.1124\/pr.119.018440_bib126","doi-asserted-by":"crossref","first-page":"6728","DOI":"10.1073\/pnas.0307606100","article-title":"Cyclin-dependent kinase 5 phosphorylates signal transducer and activator of transcription 3 and regulates its transcriptional activity","volume":"101","author":"Fu","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/pr.119.018440_bib127","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/S1074-7613(00)80501-4","article-title":"Two signals are necessary for cell proliferation induced by a cytokine receptor gp130: involvement of STAT3 in anti-apoptosis","volume":"5","author":"Fukada","year":"1996","journal-title":"Immunity"},{"key":"10.1124\/pr.119.018440_bib128","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.2337\/db09-1365","article-title":"T-cell protein tyrosine phosphatase attenuates STAT3 and insulin signaling in the liver to regulate gluconeogenesis","volume":"59","author":"Fukushima","year":"2010","journal-title":"Diabetes"},{"key":"10.1124\/pr.119.018440_bib129","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.4049\/jimmunol.1201126","article-title":"Cutting edge: IL-10-mediated tristetraprolin induction is part of a feedback loop that controls macrophage STAT3 activation and cytokine production","volume":"189","author":"Gaba","year":"2012","journal-title":"J Immunol"},{"key":"10.1124\/pr.119.018440_bib130","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1038\/nri2586","article-title":"Structure and signalling in the IL-17 receptor family","volume":"9","author":"Gaffen","year":"2009","journal-title":"Nat Rev Immunol"},{"key":"10.1124\/pr.119.018440_bib131","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.coi.2011.07.006","article-title":"Recent advances in the IL-17 cytokine family","volume":"23","author":"Gaffen","year":"2011","journal-title":"Curr Opin Immunol"},{"key":"10.1124\/pr.119.018440_bib132","doi-asserted-by":"crossref","first-page":"6161","DOI":"10.7314\/APJCP.2014.15.15.6161","article-title":"Radiation induces phosphorylation of STAT3 in a dose- and time-dependent manner","volume":"15","author":"Gao","year":"2014","journal-title":"Asian Pac J Cancer Prev"},{"key":"10.1124\/pr.119.018440_bib133","doi-asserted-by":"crossref","first-page":"4661","DOI":"10.1073\/pnas.0303992101","article-title":"Disruption of neural signal transducer and activator of transcription 3 causes obesity, diabetes, infertility, and thermal dysregulation","volume":"101","author":"Gao","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/pr.119.018440_bib134","doi-asserted-by":"crossref","first-page":"3646","DOI":"10.1128\/MCB.00541-15","article-title":"A synthetic lethal interaction between glutathione synthesis and mitochondrial reactive oxygen species provides a tumor-specific vulnerability dependent on STAT3","volume":"35","author":"Garama","year":"2015","journal-title":"Mol Cell Biol"},{"key":"10.1124\/pr.119.018440_bib135","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.cyto.2016.05.019","article-title":"Mitochondrial STAT3: powering up a potent factor","volume":"87","author":"Garama","year":"2016","journal-title":"Cytokine"},{"key":"10.1124\/pr.119.018440_bib136","doi-asserted-by":"crossref","first-page":"5578","DOI":"10.1200\/JCO.2016.34.15_suppl.5578","article-title":"A phase Ib\/II study of cancer stemness inhibitor napabucasin (BB608) combined with weekly paclitaxel in platinum-resistant ovarian cancer","volume":"34","author":"Garcia","year":"2016","journal-title":"J Clin Oncol"},{"key":"10.1124\/pr.119.018440_bib137","doi-asserted-by":"crossref","first-page":"22962","DOI":"10.1074\/jbc.273.36.22962","article-title":"Activation of the Janus kinase\/signal transducer and activator of transcription pathway by osmotic shock","volume":"273","author":"Gatsios","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1124\/pr.119.018440_bib138","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1111\/all.12937","article-title":"STAT3 inhibition prevents lung inflammation, remodeling, and accumulation of Th2 and Th17 cells in a murine asthma model","volume":"71","author":"Gavino","year":"2016","journal-title":"Allergy"},{"key":"10.1124\/pr.119.018440_bib139","doi-asserted-by":"crossref","first-page":"E4924","DOI":"10.1073\/pnas.1615730114","article-title":"Mitochondrial dysfunction induced by a SH2 domain-targeting STAT3 inhibitor leads to metabolic synthetic lethality in cancer cells","volume":"114","author":"Genini","year":"2017","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/pr.119.018440_bib140","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1111\/j.1600-065X.2008.00754.x","article-title":"Janus kinases in immune cell signaling","volume":"228","author":"Ghoreschi","year":"2009","journal-title":"Immunol Rev"},{"key":"10.1124\/pr.119.018440_bib141","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1242\/dmm.012062","article-title":"Diverse functions of matrix metalloproteinases during fibrosis","volume":"7","author":"Giannandrea","year":"2014","journal-title":"Dis Model Mech"},{"key":"10.1124\/pr.119.018440_bib142","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.cell.2010.09.043","article-title":"DNA damage-mediated induction of a chemoresistant niche","volume":"143","author":"Gilbert","year":"2010","journal-title":"Cell"},{"key":"10.1124\/pr.119.018440_bib143","doi-asserted-by":"crossref","first-page":"699","DOI":"10.3892\/ol.2016.4614","article-title":"JNK1\/2 expression and modulation of STAT3 signaling in oral cancer","volume":"12","author":"Gkouveris","year":"2016","journal-title":"Oncol Lett"},{"key":"10.1124\/pr.119.018440_bib144","doi-asserted-by":"crossref","first-page":"4472","DOI":"10.4049\/jimmunol.162.8.4472","article-title":"The functional synergy between IL-12 and IL-2 involves p38 mitogen-activated protein kinase and is associated with the augmentation of STAT serine phosphorylation","volume":"162","author":"Gollob","year":"1999","journal-title":"J Immunol"},{"key":"10.1124\/pr.119.018440_bib145","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1126\/science.1171721","article-title":"Mitochondrial STAT3 supports Ras-dependent oncogenic transformation","volume":"324","author":"Gough","year":"2009","journal-title":"Science"},{"key":"10.1124\/pr.119.018440_bib146","doi-asserted-by":"crossref","first-page":"456","DOI":"10.2337\/db13-0885","article-title":"Myeloid-cell protein tyrosine phosphatase-1B deficiency in mice protects against high-fat diet and lipopolysaccharide-induced inflammation, hyperinsulinemia, and endotoxemia through an IL-10 STAT3-dependent mechanism","volume":"63","author":"Grant","year":"2014","journal-title":"Diabetes"},{"key":"10.1124\/pr.119.018440_bib147","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1158\/1078-0432.CCR-04-1752","article-title":"Persistent activation of stat3 signaling induces survivin gene expression and confers resistance to apoptosis in human breast cancer cells","volume":"12","author":"Gritsko","year":"2006","journal-title":"Clin Cancer Res"},{"key":"10.1124\/pr.119.018440_bib148","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1016\/j.cell.2018.09.053","article-title":"Obesity drives STAT-1-dependent NASH and STAT-3-dependent HCC","volume":"175","author":"Grohmann","year":"2018","journal-title":"Cell"},{"key":"10.1124\/pr.119.018440_bib149","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1097\/MOH.0000000000000170","article-title":"Novel mechanisms of platelet clearance and thrombopoietin regulation","volume":"22","author":"Grozovsky","year":"2015","journal-title":"Curr Opin Hematol"},{"key":"10.1124\/pr.119.018440_bib150","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.3390\/ijms19082265","article-title":"STAT3 in skeletal muscle function and disorders","volume":"19","author":"Guadagnin","year":"2018","journal-title":"Int J Mol Sci"},{"key":"10.1124\/pr.119.018440_bib151","doi-asserted-by":"crossref","first-page":"39640","DOI":"10.18632\/oncotarget.17387","article-title":"Pantoprazole blocks the JAK2\/STAT3 pathway to alleviate skeletal muscle wasting in cancer cachexia by inhibiting inflammatory response","volume":"8","author":"Guo","year":"2017","journal-title":"Oncotarget"},{"key":"10.1124\/pr.119.018440_bib152","doi-asserted-by":"crossref","first-page":"3002","DOI":"10.1111\/febs.13709","article-title":"The JAK\/STAT pathway in obesity and diabetes","volume":"283","author":"Gurzov","year":"2016","journal-title":"FEBS J"},{"key":"10.1124\/pr.119.018440_bib153","doi-asserted-by":"crossref","first-page":"2","DOI":"10.3389\/fphar.2014.00002","article-title":"Heterogeneity in fibroblast proliferation and survival in idiopathic pulmonary fibrosis","volume":"5","author":"Habiel","year":"2014","journal-title":"Front Pharmacol"},{"key":"10.1124\/pr.119.018440_bib154","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1016\/S0140-6736(02)08512-4","article-title":"Maintenance infliximab for Crohn\u2019s disease: the ACCENT I randomised trial","volume":"359","author":"Hanauer","year":"2002","journal-title":"Lancet"},{"key":"10.1124\/pr.119.018440_bib155","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1053\/j.gastro.2005.11.030","article-title":"Human anti-tumor necrosis factor monoclonal antibody (adalimumab) in Crohn\u2019s disease: the CLASSIC-I trial","volume":"130","author":"Hanauer","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1124\/pr.119.018440_bib156","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.mce.2013.03.014","article-title":"STAT signaling in mammary gland differentiation, cell survival and tumorigenesis","volume":"382","author":"Haricharan","year":"2014","journal-title":"Mol Cell Endocrinol"},{"key":"10.1124\/pr.119.018440_bib157","first-page":"1347","article-title":"JAK2, a third member of the JAK family of protein tyrosine kinases","volume":"7","author":"Harpur","year":"1992","journal-title":"Oncogene"},{"key":"10.1124\/pr.119.018440_bib158","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1056\/NEJMoa1110556","article-title":"JAK inhibition with ruxolitinib versus best available therapy for myelofibrosis","volume":"366","author":"Harrison","year":"2012","journal-title":"N Engl J Med"},{"key":"10.1124\/pr.119.018440_bib159","doi-asserted-by":"crossref","first-page":"e166","DOI":"10.1038\/bcj.2013.63","article-title":"A novel STAT inhibitor, OPB-31121, has a significant antitumor effect on leukemia with STAT-addictive oncokinases","volume":"3","author":"Hayakawa","year":"2013","journal-title":"Blood Cancer J"},{"key":"10.1124\/pr.119.018440_bib160","doi-asserted-by":"crossref","first-page":"2852","DOI":"10.1182\/blood-2009-10-230060","article-title":"STAT3 is constitutively phosphorylated on serine 727 residues, binds DNA, and activates transcription in CLL cells","volume":"115","author":"Hazan-Halevy","year":"2010","journal-title":"Blood"},{"key":"10.1124\/pr.119.018440_bib161","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1038\/nrc1190","article-title":"Tobacco carcinogens, their biomarkers and tobacco-induced cancer","volume":"3","author":"Hecht","year":"2003","journal-title":"Nat Rev Cancer"},{"key":"10.1124\/pr.119.018440_bib162","doi-asserted-by":"crossref","first-page":"3349","DOI":"10.1038\/onc.2009.202","article-title":"Stat3 promotes the development of erythroleukemia by inducing Pu.1 expression and inhibiting erythroid differentiation","volume":"28","author":"Hegde","year":"2009","journal-title":"Oncogene"},{"key":"10.1124\/pr.119.018440_bib163","doi-asserted-by":"crossref","first-page":"4719","DOI":"10.1016\/j.bmcl.2013.05.066","article-title":"Investigation of the protein alkylation sites of the STAT3:STAT3 inhibitor Stattic by mass spectrometry","volume":"23","author":"Heidelberger","year":"2013","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1124\/pr.119.018440_bib164","doi-asserted-by":"crossref","first-page":"3956","DOI":"10.1210\/en.2013-2095","article-title":"Ghrelin induces leptin resistance by activation of suppressor of cytokine signaling 3 expression in male rats: implications in satiety regulation","volume":"155","author":"Heldsinger","year":"2014","journal-title":"Endocrinology"},{"key":"10.1124\/pr.119.018440_bib165","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/j.trecan.2017.10.004","article-title":"Targeting oncogenic transcription factors: therapeutic implications of endogenous STAT inhibitors","volume":"3","author":"Heppler","year":"2017","journal-title":"Trends Cancer"},{"key":"10.1124\/pr.119.018440_bib166","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/j.crohns.2012.09.016","article-title":"Efficacy, safety and tolerability of vidofludimus in patients with inflammatory bowel disease: the ENTRANCE study","volume":"7","author":"Herrlinger","year":"2013","journal-title":"J Crohn\u2019s Colitis"},{"key":"10.1124\/pr.119.018440_bib167","first-page":"9","article-title":"STAT3 nuclear egress requires exportin 7 via engaging lysine acetylation","volume":"1","author":"Herrmann Hua Yu","year":"2014","journal-title":"MOJ Cell Sci Rep"},{"key":"10.1124\/pr.119.018440_bib168","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1084\/jem.187.6.917","article-title":"Essential role of induced nitric oxide in the initiation of the inflammatory response after hemorrhagic shock","volume":"187","author":"Hierholzer","year":"1998","journal-title":"J Exp Med"},{"key":"10.1124\/pr.119.018440_bib169","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1007\/s004020050269","article-title":"Activation of STAT proteins in the lung of rats following resuscitation from hemorrhagic shock","volume":"117","author":"Hierholzer","year":"1998","journal-title":"Arch Orthop Trauma Surg"},{"key":"10.1124\/pr.119.018440_bib170","first-page":"L611","article-title":"Interleukin-6 production in hemorrhagic shock is accompanied by neutrophil recruitment and lung injury","volume":"275","author":"Hierholzer","year":"1998","journal-title":"Am J Physiol"},{"key":"10.1124\/pr.119.018440_bib171","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1097\/00024382-200202000-00003","article-title":"A nitric oxide scavenger protects against pulmonary inflammation following hemorrhagic shock","volume":"17","author":"Hierholzer","year":"2002","journal-title":"Shock"},{"key":"10.1124\/pr.119.018440_bib172","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1161\/01.RES.0000134921.50377.61","article-title":"Signal transducer and activator of transcription 3 is required for myocardial capillary growth, control of interstitial matrix deposition, and heart protection from ischemic injury","volume":"95","author":"Hilfiker-Kleiner","year":"2004","journal-title":"Circ Res"},{"key":"10.1124\/pr.119.018440_bib173","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1161\/CIRCULATIONAHA.109.933127","article-title":"Continuous glycoprotein-130-mediated signal transducer and activator of transcription-3 activation promotes inflammation, left ventricular rupture, and adverse outcome in subacute myocardial infarction","volume":"122","author":"Hilfiker-Kleiner","year":"2010","journal-title":"Circulation"},{"key":"10.1124\/pr.119.018440_bib174","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/S0140-6736(74)91942-4","article-title":"Defect in neutrophil granulocyte chemotaxis in Job\u2019s syndrome of recurrent \u201ccold\u201d staphylococcal abscesses","volume":"2","author":"Hill","year":"1974","journal-title":"Lancet"},{"key":"10.1124\/pr.119.018440_bib175","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0140-6736(74)92493-3","article-title":"Raised serum-IgE levels and defective neutrophil chemotaxis in three children with eczema and recurrent bacterial infections","volume":"1","author":"Hill","year":"1974","journal-title":"Lancet"},{"key":"10.1124\/pr.119.018440_bib176","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cytogfr.2016.05.001","article-title":"STAT3 signaling in immunity","volume":"31","author":"Hillmer","year":"2016","journal-title":"Cytokine Growth Factor Rev"},{"key":"10.1124\/pr.119.018440_bib177","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1038\/ni1354","article-title":"C\/EBPbeta is required for \u2018emergency\u2019 granulopoiesis","volume":"7","author":"Hirai","year":"2006","journal-title":"Nat Immunol"},{"key":"10.1124\/pr.119.018440_bib178","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1111\/j.1349-7006.2010.01552.x","article-title":"Bcl-XL and STAT3 mediate malignant actions of gamma-irradiation in lung cancer cells","volume":"101","author":"Ho","year":"2010","journal-title":"Cancer Sci"},{"issue":"Suppl 2","key":"10.1124\/pr.119.018440_bib179","doi-asserted-by":"crossref","first-page":"S68","DOI":"10.1016\/S0049-3848(16)30370-X","article-title":"Platelet clearance by the hepatic Ashwell-Morrell receptor: mechanisms and biological significance","volume":"141","author":"Hoffmeister","year":"2016","journal-title":"Thromb Res"},{"key":"10.1124\/pr.119.018440_bib180","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1172\/JCI19491","article-title":"Stat-3 is required for pulmonary homeostasis during hyperoxia","volume":"113","author":"Hokuto","year":"2004","journal-title":"J Clin Invest"},{"key":"10.1124\/pr.119.018440_bib181","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1056\/NEJMoa073687","article-title":"STAT3 mutations in the hyper-IgE syndrome","volume":"357","author":"Holland","year":"2007","journal-title":"N Engl J Med"},{"key":"10.1124\/pr.119.018440_bib182","doi-asserted-by":"crossref","first-page":"314ra185","DOI":"10.1126\/scitranslmed.aac5272","article-title":"AZD9150, a next-generation antisense oligonucleotide inhibitor of STAT3 with early evidence of clinical activity in lymphoma and lung cancer","volume":"7","author":"Hong","year":"2015","journal-title":"Sci Transl Med"},{"key":"10.1124\/pr.119.018440_bib183","doi-asserted-by":"crossref","first-page":"3396","DOI":"10.1158\/1078-0432.CCR-11-2703","article-title":"A phase I first-in-human trial of bardoxolone methyl in patients with advanced solid tumors and lymphomas","volume":"18","author":"Hong","year":"2012","journal-title":"Clin Cancer Res"},{"key":"10.1124\/pr.119.018440_bib184","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1053\/j.gastro.2008.01.016","article-title":"Cell type-dependent pro- and anti-inflammatory role of signal transducer and activator of transcription 3 in alcoholic liver injury","volume":"134","author":"Horiguchi","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1124\/pr.119.018440_bib185","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/S1534-5807(02)00376-3","article-title":"The Jak\/STAT pathway in model organisms: emerging roles in cell movement","volume":"3","author":"Hou","year":"2002","journal-title":"Dev Cell"},{"key":"10.1124\/pr.119.018440_bib186","doi-asserted-by":"crossref","first-page":"30725","DOI":"10.1074\/jbc.M805941200","article-title":"The STAT3 NH2-terminal domain stabilizes enhanceosome assembly by interacting with the p300 bromodomain","volume":"283","author":"Hou","year":"2008","journal-title":"J Biol Chem"},{"key":"10.1124\/pr.119.018440_bib187","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1038\/nm1072","article-title":"Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3","volume":"10","author":"Howard","year":"2004","journal-title":"Nat Med"},{"key":"10.1124\/pr.119.018440_bib188","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.jaci.2015.11.024","article-title":"Diminution of signal transducer and activator of transcription 3 signaling inhibits vascular permeability and anaphylaxis","volume":"138","author":"Hox","year":"2016","journal-title":"J Allergy Clin Immunol"},{"key":"10.1124\/pr.119.018440_bib189","doi-asserted-by":"crossref","first-page":"693","DOI":"10.2337\/diabetes.53.3.693","article-title":"Inflammatory markers and risk of developing type 2 diabetes in women","volume":"53","author":"Hu","year":"2004","journal-title":"Diabetes"},{"key":"10.1124\/pr.119.018440_bib190","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.plipres.2018.04.002","article-title":"STAT3: the art of multi-tasking of metabolic and immune functions in obesity","volume":"70","author":"Hu","year":"2018","journal-title":"Prog Lipid Res"},{"key":"10.1124\/pr.119.018440_bib191","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1111\/jphp.13014","article-title":"PPAR\u03b1-independent action against metabolic syndrome development by fibrates is mediated by inhibition of STAT3 signalling","volume":"70","author":"Hua","year":"2018","journal-title":"J Pharm Pharmacol"},{"key":"10.1124\/pr.119.018440_bib192","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.canlet.2011.10.011","article-title":"Inhibition of activated Stat3 reverses drug resistance to chemotherapeutic agents in gastric cancer cells","volume":"315","author":"Huang","year":"2012","journal-title":"Cancer Lett"},{"key":"10.1124\/pr.119.018440_bib193","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1007\/s40265-017-0759-4","article-title":"Napabucasin: an update on the first-in-class cancer stemness inhibitor","volume":"77","author":"Hubbard","year":"2017","journal-title":"Drugs"},{"key":"10.1124\/pr.119.018440_bib194","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1093\/bfgp\/elt028","article-title":"The IL-10\/STAT3-mediated anti-inflammatory response: recent developments and future challenges","volume":"12","author":"Hutchins","year":"2013","journal-title":"Brief Funct Genomics"},{"key":"10.1124\/pr.119.018440_bib195","doi-asserted-by":"crossref","first-page":"e110","DOI":"10.1182\/blood-2011-09-381483","article-title":"Genome-wide analysis of STAT3 binding in vivo predicts effectors of the anti-inflammatory response in macrophages","volume":"119","author":"Hutchins","year":"2012","journal-title":"Blood"},{"key":"10.1124\/pr.119.018440_bib196","doi-asserted-by":"crossref","first-page":"12058","DOI":"10.1073\/pnas.1206458109","article-title":"The Sin3a repressor complex is a master regulator of STAT transcriptional activity","volume":"109","author":"Icardi","year":"2012","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/pr.119.018440_bib197","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0161-5890(00)00018-3","article-title":"The Jak-STAT pathway","volume":"37","author":"Imada","year":"2000","journal-title":"Mol Immunol"},{"key":"10.1124\/pr.119.018440_bib198","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1507\/endocrj.EJ15-0540","article-title":"Central insulin-mediated regulation of hepatic glucose production [Review]","volume":"63","author":"Inoue","year":"2016","journal-title":"Endocr J"},{"key":"10.1124\/pr.119.018440_bib199","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/nm980","article-title":"Role of STAT-3 in regulation of hepatic gluconeogenic genes and carbohydrate metabolism in vivo","volume":"10","author":"Inoue","year":"2004","journal-title":"Nat Med"},{"key":"10.1124\/pr.119.018440_bib200","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1053\/j.gastro.2004.01.012","article-title":"A pilot randomized trial of a human anti-interleukin-6 receptor monoclonal antibody in active Crohn\u2019s disease","volume":"126","author":"Ito","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1124\/pr.119.018440_bib201","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/j.cell.2006.07.035","article-title":"The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells","volume":"126","author":"Ivanov","year":"2006","journal-title":"Cell"},{"key":"10.1124\/pr.119.018440_bib202","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1161\/CIRCRESAHA.110.225326","article-title":"Disruption of protein arginine N-methyltransferase 2 regulates leptin signaling and produces leanness in vivo through loss of STAT3 methylation","volume":"107","author":"Iwasaki","year":"2010","journal-title":"Circ Res"},{"key":"10.1124\/pr.119.018440_bib203","doi-asserted-by":"crossref","first-page":"12929","DOI":"10.1073\/pnas.2134694100","article-title":"Cardiomyocyte-restricted knockout of STAT3 results in higher sensitivity to inflammation, cardiac fibrosis, and heart failure with advanced age","volume":"100","author":"Jacoby","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/pr.119.018440_bib204","doi-asserted-by":"crossref","first-page":"24392","DOI":"10.1074\/jbc.274.34.24392","article-title":"Protein kinase C delta associates with and phosphorylates Stat3 in an interleukin-6-dependent manner","volume":"274","author":"Jain","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1124\/pr.119.018440_bib205","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1097\/SPC.0000000000000014","article-title":"Anti-inflammatory therapy: exploring exercise, serum-derived bovine immunoglobulin\/protein isolates, and ruxolitinib for the cancer-associated weight loss syndrome","volume":"7","author":"Jatoi","year":"2013","journal-title":"Curr Opin Support Palliat Care"},{"key":"10.1124\/pr.119.018440_bib206","doi-asserted-by":"crossref","first-page":"3789","DOI":"10.1128\/MCB.21.11.3789-3806.2001","article-title":"c-Myc is a critical target for c\/EBPalpha in granulopoiesis","volume":"21","author":"Johansen","year":"2001","journal-title":"Mol Cell Biol"},{"key":"10.1124\/pr.119.018440_bib207","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1038\/nrclinonc.2018.8","article-title":"Targeting the IL-6\/JAK\/STAT3 signalling axis in cancer","volume":"15","author":"Johnson","year":"2018","journal-title":"Nat Rev Clin Oncol"},{"key":"10.1124\/pr.119.018440_bib208","doi-asserted-by":"crossref","first-page":"2546","DOI":"10.1200\/jco.2014.32.15_suppl.2546","article-title":"A phase I extension study of BBI608, a first-in-class cancer stem cell (CSC) inhibitor, in patients with advanced solid tumors","volume":"32","author":"Jonker","year":"2014","journal-title":"J Clin Oncol"},{"key":"10.1124\/pr.119.018440_bib209","doi-asserted-by":"crossref","first-page":"56","DOI":"10.2337\/db12-0443","article-title":"Deletion of skeletal muscle SOCS3 prevents insulin resistance in obesity","volume":"62","author":"Jorgensen","year":"2013","journal-title":"Diabetes"},{"key":"10.1124\/pr.119.018440_bib210","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/nature11582","article-title":"Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease","volume":"491","author":"Jostins","year":"2012","journal-title":"Nature"},{"key":"10.1124\/pr.119.018440_bib211","doi-asserted-by":"crossref","first-page":"5537","DOI":"10.1158\/1078-0432.CCR-16-2253","article-title":"Multifunctional effects of a small-molecule STAT3 inhibitor on NASH and hepatocellular carcinoma in mice","volume":"23","author":"Jung","year":"2017","journal-title":"Clin Cancer Res"},{"key":"10.1124\/pr.119.018440_bib212","doi-asserted-by":"crossref","first-page":"10782","DOI":"10.1038\/ncomms10782","article-title":"Hypothalamic leptin action is mediated by histone deacetylase 5","volume":"7","author":"Kabra","year":"2016","journal-title":"Nat Commun"},{"key":"10.1124\/pr.119.018440_bib213","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1038\/nri3307","article-title":"Transcriptional control of effector and memory CD8+ T cell differentiation","volume":"12","author":"Kaech","year":"2012","journal-title":"Nat Rev Immunol"},{"key":"10.1124\/pr.119.018440_bib214","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.mam.2011.10.011","article-title":"Immunity as a link between obesity and insulin resistance","volume":"33","author":"Kalupahana","year":"2012","journal-title":"Mol Aspects Med"},{"key":"10.1124\/pr.119.018440_bib215","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/8351374","article-title":"SHP2-mediated signal networks in stem cell homeostasis and dysfunction","volume":"2018","author":"Kan","year":"2018","journal-title":"Stem Cells Int"},{"key":"10.1124\/pr.119.018440_bib216","article-title":"Dimethylfumarate suppresses adipogenic differentiation in 3T3-L1 preadipocytes through inhibition of STAT3 activity","volume":"8","author":"Kang","year":"2013","journal-title":"PLoS One"},{"key":"10.1124\/pr.119.018440_bib217","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1146\/annurev-immunol-020711-075058","article-title":"Transcriptional and epigenetic control of T helper cell specification: molecular mechanisms underlying commitment and plasticity","volume":"30","author":"Kanno","year":"2012","journal-title":"Annu Rev Immunol"},{"key":"10.1124\/pr.119.018440_bib218","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.3390\/ijms19082299","article-title":"Contribution of STAT3 to inflammatory and fibrotic diseases and prospects for its targeting for treatment","volume":"19","author":"Kasembeli","year":"2018","journal-title":"Int J Mol Sci"},{"key":"10.1124\/pr.119.018440_bib219","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1164\/ajrccm.157.4.9707039","article-title":"Idiopathic pulmonary fibrosis: clinical relevance of pathologic classification","volume":"157","author":"Katzenstein","year":"1998","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1124\/pr.119.018440_bib220","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1182\/blood.V86.2.419.bloodjournal862419","article-title":"Thrombopoietin: the primary regulator of platelet production","volume":"86","author":"Kaushansky","year":"1995","journal-title":"Blood"},{"key":"10.1124\/pr.119.018440_bib221","doi-asserted-by":"crossref","first-page":"43361","DOI":"10.1038\/srep43361","article-title":"Low-dose radiation decreases tumor progression via the inhibition of the JAK1\/STAT3 signaling axis in breast cancer cell lines","volume":"7","author":"Kaushik","year":"2017","journal-title":"Sci Rep"},{"key":"10.1124\/pr.119.018440_bib222","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1038\/nsmb.2519","article-title":"SOCS3 binds specific receptor-JAK complexes to control cytokine signaling by direct kinase inhibition","volume":"20","author":"Kershaw","year":"2013","journal-title":"Nat Struct Mol Biol"},{"key":"10.1124\/pr.119.018440_bib223","doi-asserted-by":"crossref","first-page":"3996","DOI":"10.1158\/1078-0432.CCR-18-3274","article-title":"Combined inhibition of STAT3 and DNA repair in palbociclib-resistant ER-positive breast cancer","volume":"25","author":"Kettner","year":"2019","journal-title":"Clin Cancer Res"},{"key":"10.1124\/pr.119.018440_bib224","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s00262-017-2057-0","article-title":"The STAT3 inhibitor pyrimethamine displays anti-cancer and immune stimulatory effects in murine models of breast cancer","volume":"67","author":"Khan","year":"2018","journal-title":"Cancer Immunol Immunother"},{"key":"10.1124\/pr.119.018440_bib225","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1002\/hep.23837","article-title":"Interleukin-22 treatment ameliorates alcoholic liver injury in a murine model of chronic-binge ethanol feeding: role of signal transducer and activator of transcription 3","volume":"52","author":"Ki","year":"2010","journal-title":"Hepatology"},{"key":"10.1124\/pr.119.018440_bib226","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.ccr.2013.04.008","article-title":"Phosphorylation of EZH2 activates STAT3 signaling via STAT3 methylation and promotes tumorigenicity of glioblastoma stem-like cells","volume":"23","author":"Kim","year":"2013","journal-title":"Cancer Cell"},{"key":"10.1124\/pr.119.018440_bib227","doi-asserted-by":"crossref","first-page":"2514","DOI":"10.1089\/ars.2013.5223","article-title":"STAT3 regulation by S-nitrosylation: implication for inflammatory disease","volume":"20","author":"Kim","year":"2014","journal-title":"Antioxid Redox Signal"},{"key":"10.1124\/pr.119.018440_bib228","doi-asserted-by":"crossref","first-page":"35425","DOI":"10.1074\/jbc.M109.051516","article-title":"Signal transducer and activator of transcription 3 (STAT3) mediates amino acid inhibition of insulin signaling through serine 727 phosphorylation","volume":"284","author":"Kim","year":"2009","journal-title":"J Biol Chem"},{"key":"10.1124\/pr.119.018440_bib229","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.intimp.2017.05.005","article-title":"Therapeutic effects of zerumbone in an alkali-burned corneal wound healing model","volume":"48","author":"Kim","year":"2017","journal-title":"Int Immunopharmacol"},{"key":"10.1124\/pr.119.018440_bib230","doi-asserted-by":"crossref","first-page":"4543","DOI":"10.1091\/mbc.e07-03-0280","article-title":"Induction of cellular senescence by insulin-like growth factor binding protein-5 through a p53-dependent mechanism","volume":"18","author":"Kim","year":"2007","journal-title":"Mol Biol Cell"},{"key":"10.1124\/pr.119.018440_bib231","doi-asserted-by":"crossref","first-page":"405","DOI":"10.3389\/fphar.2017.00405","article-title":"Alantolactone improves prolonged exposure of interleukin-6-induced skeletal muscle inflammation associated glucose intolerance and insulin resistance","volume":"8","author":"Kim","year":"2017","journal-title":"Front Pharmacol"},{"key":"10.1124\/pr.119.018440_bib232","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.canlet.2013.02.010","article-title":"OPB-31121, a novel small molecular inhibitor, disrupts the JAK2\/STAT3 pathway and exhibits an antitumor activity in gastric cancer cells","volume":"335","author":"Kim","year":"2013","journal-title":"Cancer Lett"},{"key":"10.1124\/pr.119.018440_bib233","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.phymed.2018.09.172","article-title":"Orientin inhibits invasion by suppressing MMP-9 and IL-8 expression via the PKC\u03b1\/ERK\/AP-1\/STAT3-mediated signaling pathways in TPA-treated MCF-7 breast cancer cells","volume":"50","author":"Kim","year":"2018","journal-title":"Phytomedicine"},{"key":"10.1124\/pr.119.018440_bib234","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1084\/jem.20052333","article-title":"Loss of SOCS3 in T helper cells resulted in reduced immune responses and hyperproduction of interleukin 10 and transforming growth factor-\u03b2 1","volume":"203","author":"Kinjyo","year":"2006","journal-title":"J Exp Med"},{"key":"10.1124\/pr.119.018440_bib235","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.immuni.2005.09.010","article-title":"IL-6-STAT3 controls intracellular MHC class II alphabeta dimer level through cathepsin S activity in dendritic cells","volume":"23","author":"Kitamura","year":"2005","journal-title":"Immunity"},{"key":"10.1124\/pr.119.018440_bib236","doi-asserted-by":"crossref","first-page":"88","DOI":"10.3109\/08977194.2012.660936","article-title":"Biology and significance of the JAK\/STAT signalling pathways","volume":"30","author":"Kiu","year":"2012","journal-title":"Growth Factors"},{"key":"10.1124\/pr.119.018440_bib237","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0081819","article-title":"STAT3 oligonucleotide inhibits tumor angiogenesis in preclinical models of squamous cell carcinoma","volume":"9","author":"Klein","year":"2014","journal-title":"PLoS One"},{"key":"10.1124\/pr.119.018440_bib238","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.ccell.2017.11.009","article-title":"Dual targeting of oncogenic activation and inflammatory signaling increases therapeutic efficacy in myeloproliferative neoplasms","volume":"33","author":"Kleppe","year":"2018","journal-title":"Cancer Cell"},{"key":"10.1124\/pr.119.018440_bib239","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1158\/2159-8290.CD-14-0736","article-title":"JAK-STAT pathway activation in malignant and nonmalignant cells contributes to MPN pathogenesis and therapeutic response","volume":"5","author":"Kleppe","year":"2015","journal-title":"Cancer Discov"},{"key":"10.1124\/pr.119.018440_bib240","doi-asserted-by":"crossref","DOI":"10.4161\/jkst.25763","article-title":"IL-6-STAT3 signaling and premature senescence","volume":"2","author":"Kojima","year":"2013","journal-title":"JAK-STAT"},{"key":"10.1124\/pr.119.018440_bib241","doi-asserted-by":"crossref","first-page":"4524","DOI":"10.1073\/pnas.0500679102","article-title":"STAT3 regulates Nemo-like kinase by mediating its interaction with IL-6-stimulated TGFbeta-activated kinase 1 for STAT3 Ser-727 phosphorylation","volume":"102","author":"Kojima","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/pr.119.018440_bib242","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.domaniend.2017.06.001","article-title":"Adipose triglyceride lipase protein abundance and translocation to the lipid droplet increase during leptin-induced lipolysis in bovine adipocytes","volume":"61","author":"Koltes","year":"2017","journal-title":"Domest Anim Endocrinol"},{"key":"10.1124\/pr.119.018440_bib243","doi-asserted-by":"crossref","first-page":"21700","DOI":"10.1074\/jbc.C400606200","article-title":"Are STATS arginine-methylated?","volume":"280","author":"Komyod","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1124\/pr.119.018440_bib244","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1038\/leu.2017.304","article-title":"Ibrutinib modulates the immunosuppressive CLL microenvironment through STAT3-mediated suppression of regulatory B-cell function and inhibition of the PD-1\/PD-L1 pathway","volume":"32","author":"Kondo","year":"2018","journal-title":"Leukemia"},{"key":"10.1124\/pr.119.018440_bib245","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/7492904","article-title":"Are Janus kinase inhibitors superior over classic biologic agents in RA patients?","volume":"2018","author":"Kotyla","year":"2018","journal-title":"BioMed Res Int"},{"key":"10.1124\/pr.119.018440_bib246","doi-asserted-by":"crossref","first-page":"13956","DOI":"10.1073\/pnas.96.24.13956","article-title":"Stress-induced phosphorylation of STAT1 at Ser727 requires p38 mitogen-activated protein kinase whereas IFN-gamma uses a different signaling pathway","volume":"96","author":"Kovarik","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/pr.119.018440_bib247","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1002\/jcb.25076","article-title":"Dynamic mitochondrial localisation of STAT3 in the cellular adipogenesis model 3T3-L1","volume":"116","author":"Kramer","year":"2015","journal-title":"J Cell Biochem"},{"key":"10.1124\/pr.119.018440_bib248","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.molcel.2010.09.023","article-title":"Autophagy and the integrated stress response","volume":"40","author":"Kroemer","year":"2010","journal-title":"Mol Cell"},{"key":"10.1124\/pr.119.018440_bib249","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1002\/hep.23322","article-title":"Lack of interleukin-6\/glycoprotein 130\/signal transducers and activators of transcription-3 signaling in hepatocytes predisposes to liver steatosis and injury in mice","volume":"51","author":"Kroy","year":"2010","journal-title":"Hepatology"},{"key":"10.1124\/pr.119.018440_bib250","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1038\/nature22965","article-title":"PTEN counteracts FBXL2 to promote IP3R3- and Ca2+-mediated apoptosis limiting tumour growth","volume":"546","author":"Kuchay","year":"2017","journal-title":"Nature"},{"key":"10.1124\/pr.119.018440_bib251","first-page":"1257","article-title":"The roles of the myofibroblast in idiopathic pulmonary fibrosis: ultrastructural and immunohistochemical features of sites of active extracellular matrix synthesis","volume":"138","author":"Kuhn","year":"1991","journal-title":"Am J Pathol"},{"key":"10.1124\/pr.119.018440_bib252","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/0092-8674(93)80068-P","article-title":"Interleukin-10-deficient mice develop chronic enterocolitis","volume":"75","author":"K\u00fchn","year":"1993","journal-title":"Cell"},{"key":"10.1124\/pr.119.018440_bib253","doi-asserted-by":"crossref","first-page":"2463","DOI":"10.1101\/gad.1971610","article-title":"The essence of senescence","volume":"24","author":"Kuilman","year":"2010","journal-title":"Genes Dev"},{"key":"10.1124\/pr.119.018440_bib254","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/j.cell.2008.03.039","article-title":"Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network","volume":"133","author":"Kuilman","year":"2008","journal-title":"Cell"},{"key":"10.1124\/pr.119.018440_bib255","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1097\/FJC.0b013e318068dd49","article-title":"Can the protective actions of JAK-STAT in the heart be exploited therapeutically? Parsing the regulation of interleukin-6-type cytokine signaling","volume":"50","author":"Kurdi","year":"2007","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1124\/pr.119.018440_bib256","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1111\/j.1751-7133.2010.00175.x","article-title":"Deciphering STAT3 signaling in the heart: plasticity and vascular inflammation","volume":"16","author":"Kurdi","year":"2010","journal-title":"Congest Heart Fail"},{"key":"10.1124\/pr.119.018440_bib257","doi-asserted-by":"crossref","first-page":"2106","DOI":"10.1016\/j.biocel.2012.08.016","article-title":"Depletion of cellular glutathione modulates LIF-induced JAK1-STAT3 signaling in cardiac myocytes","volume":"44","author":"Kurdi","year":"2012","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1124\/pr.119.018440_bib258","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1111\/j.1365-2141.2007.06807.x","article-title":"Bone marrow fibrosis: pathophysiology and clinical significance of increased bone marrow stromal fibres","volume":"139","author":"Kuter","year":"2007","journal-title":"Br J Haematol"},{"key":"10.1124\/pr.119.018440_bib259","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s13045-018-0585-5","article-title":"Long-term effects of ruxolitinib versus best available therapy on bone marrow fibrosis in patients with myelofibrosis","volume":"11","author":"Kvasnicka","year":"2018","journal-title":"J Hematol Oncol"},{"key":"10.1124\/pr.119.018440_bib260","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/S0014-5793(98)01680-9","article-title":"Phosphoinositide 3-kinase and integrin signalling are involved in activation of Bruton tyrosine kinase in thrombin-stimulated platelets","volume":"443","author":"Laffargue","year":"1999","journal-title":"FEBS Lett"},{"key":"10.1124\/pr.119.018440_bib261","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.molimm.2015.06.015","article-title":"Cyclin-dependent kinase 5 represses Foxp3 gene expression and Treg development through specific phosphorylation of Stat3 at Serine 727","volume":"67","author":"Lam","year":"2015","journal-title":"Mol Immunol"},{"key":"10.1124\/pr.119.018440_bib262","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1038\/nrm3758","article-title":"Molecular mechanisms of epithelial-mesenchymal transition","volume":"15","author":"Lamouille","year":"2014","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1124\/pr.119.018440_bib263","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/S1074-7613(03)00332-7","article-title":"STAT3 is required for Flt3L-dependent dendritic cell differentiation","volume":"19","author":"Laouar","year":"2003","journal-title":"Immunity"},{"key":"10.1124\/pr.119.018440_bib264","doi-asserted-by":"crossref","first-page":"4302","DOI":"10.1158\/0008-5472.CAN-14-3331","article-title":"STAT3 blockade inhibits radiation-induced malignant progression in glioma","volume":"75","author":"Lau","year":"2015","journal-title":"Cancer Res"},{"key":"10.1124\/pr.119.018440_bib265","doi-asserted-by":"crossref","first-page":"3410","DOI":"10.2337\/diabetes.54.12.3410","article-title":"Inhibition of preproinsulin gene expression by leptin induction of suppressor of cytokine signaling 3 in pancreatic \u03b2-cells","volume":"54","author":"Laubner","year":"2005","journal-title":"Diabetes"},{"key":"10.1124\/pr.119.018440_bib266","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.immuni.2012.05.027","article-title":"STAT3 transcription factor promotes instability of nTreg cells and limits generation of iTreg cells during acute murine graft-versus-host disease","volume":"37","author":"Laurence","year":"2012","journal-title":"Immunity"},{"key":"10.1124\/pr.119.018440_bib267","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.immuni.2007.02.009","article-title":"Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation","volume":"26","author":"Laurence","year":"2007","journal-title":"Immunity"},{"key":"10.1124\/pr.119.018440_bib268","doi-asserted-by":"crossref","first-page":"2527","DOI":"10.1200\/jco.2014.32.15_suppl.2527","article-title":"A phase 1 dose-escalation study of BBI503, a first-in-class cancer stemness kinase inhibitor in adult patients with advanced solid tumors","volume":"32","author":"Laurie","year":"2014","journal-title":"J Clin Oncol"},{"key":"10.1124\/pr.119.018440_bib269","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S1074-7613(02)00336-9","article-title":"STAT3 is a negative regulator of granulopoiesis but is not required for G-CSF-dependent differentiation","volume":"17","author":"Lee","year":"2002","journal-title":"Immunity"},{"key":"10.1124\/pr.119.018440_bib270","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.ccr.2009.02.015","article-title":"Persistently activated Stat3 maintains constitutive NF-kappaB activity in tumors","volume":"15","author":"Lee","year":"2009","journal-title":"Cancer Cell"},{"key":"10.1124\/pr.119.018440_bib271","doi-asserted-by":"crossref","first-page":"7765","DOI":"10.1073\/pnas.1205132109","article-title":"Acetylated STAT3 is crucial for methylation of tumor-suppressor gene promoters and inhibition by resveratrol results in demethylation","volume":"109","author":"Lee","year":"2012","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/pr.119.018440_bib272","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.ccr.2014.05.019","article-title":"Drug resistance via feedback activation of Stat3 in oncogene-addicted cancer cells","volume":"26","author":"Lee","year":"2014","journal-title":"Cancer Cell"},{"key":"10.1124\/pr.119.018440_bib273","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1083\/jcb.200812060","article-title":"Acetylation and activation of STAT3 mediated by nuclear translocation of CD44","volume":"185","author":"Lee","year":"2009","journal-title":"J Cell Biol"},{"key":"10.1124\/pr.119.018440_bib274","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1136\/gut.2009.199679","article-title":"New IBD genetics: common pathways with other diseases","volume":"60","author":"Lees","year":"2011","journal-title":"Gut"},{"key":"10.1124\/pr.119.018440_bib275","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1189\/jlb.0308149","article-title":"Interleukin 21: a cytokine\/cytokine receptor system that has come of age","volume":"84","author":"Leonard","year":"2008","journal-title":"J Leukoc Biol"},{"key":"10.1124\/pr.119.018440_bib276","doi-asserted-by":"crossref","first-page":"4138","DOI":"10.1073\/pnas.0534764100","article-title":"Targeted inhibition of Stat3 with a decoy oligonucleotide abrogates head and neck cancer cell growth","volume":"100","author":"Leong","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/pr.119.018440_bib277","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.ccr.2005.03.023","article-title":"Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis","volume":"7","author":"Levine","year":"2005","journal-title":"Cancer Cell"},{"key":"10.1124\/pr.119.018440_bib278","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1158\/1535-7163.MCT-08-0154","article-title":"STAT3 inhibition in prostate and pancreatic cancer lines by STAT3 binding sequence oligonucleotides: differential activity between 5\u2032 and 3\u2032 ends","volume":"7","author":"Lewis","year":"2008","journal-title":"Mol Cancer Ther"},{"key":"10.1124\/pr.119.018440_bib279","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.lungcan.2015.09.014","article-title":"Small-molecule targeting of signal transducer and activator of transcription (STAT) 3 to treat non-small cell lung cancer","volume":"90","author":"Lewis","year":"2015","journal-title":"Lung Cancer"},{"key":"10.1124\/pr.119.018440_bib280","doi-asserted-by":"crossref","first-page":"4363","DOI":"10.1182\/blood-2012-07-441311","article-title":"The signal transducers STAT5 and STAT3 control expression of Id2 and E2-2 during dendritic cell development","volume":"120","author":"Li","year":"2012","journal-title":"Blood"},{"key":"10.1124\/pr.119.018440_bib281","doi-asserted-by":"crossref","first-page":"8222","DOI":"10.1158\/0008-5472.CAN-10-0894","article-title":"Modulation of gene expression and tumor cell growth by redox modification of STAT3","volume":"70","author":"Li","year":"2010","journal-title":"Cancer Res"},{"key":"10.1124\/pr.119.018440_bib282","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/j.bbrc.2004.08.014","article-title":"A STAT3 dimer formed by inter-chain disulphide bridging during oxidative stress","volume":"322","author":"Li","year":"2004","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1124\/pr.119.018440_bib283","doi-asserted-by":"crossref","first-page":"45395","DOI":"10.1038\/srep45395","article-title":"STAT3 and NF-\u03baB are simultaneously suppressed in dendritic cells in lung cancer","volume":"7","author":"Li","year":"2017","journal-title":"Sci Rep"},{"key":"10.1124\/pr.119.018440_bib284","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1111\/asj.13108","article-title":"\u03b2-carotene attenuates lipopolysaccharide-induced inflammation via inhibition of the NF-\u03baB, JAK2\/STAT3 and JNK\/p38 MAPK signaling pathways in macrophages","volume":"90","author":"Li","year":"2019","journal-title":"Anim Sci J"},{"key":"10.1124\/pr.119.018440_bib285","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s11010-015-2424-0","article-title":"Cryptotanshinone, a Stat3 inhibitor, suppresses colorectal cancer proliferation and growth in vitro","volume":"406","author":"Li","year":"2015","journal-title":"Mol Cell Biochem"},{"key":"10.1124\/pr.119.018440_bib286","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s11010-009-0212-4","article-title":"Regulation of ATGL expression mediated by leptin in vitro in porcine adipocyte lipolysis","volume":"333","author":"Li","year":"2010","journal-title":"Mol Cell Biochem"},{"key":"10.1124\/pr.119.018440_bib287","doi-asserted-by":"crossref","first-page":"7250","DOI":"10.4049\/jimmunol.174.11.7250","article-title":"Overexpression of Stat3C in pulmonary epithelium protects against hyperoxic lung injury","volume":"174","author":"Lian","year":"2005","journal-title":"J Immunol"},{"key":"10.1124\/pr.119.018440_bib288","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pneurobio.2015.11.001","article-title":"The emerging role of signal transducer and activator of transcription 3 in cerebral ischemic and hemorrhagic stroke","volume":"137","author":"Liang","year":"2016","journal-title":"Prog Neurobiol"},{"key":"10.1124\/pr.119.018440_bib289","doi-asserted-by":"crossref","first-page":"4556","DOI":"10.1158\/1078-0432.CCR-08-0040","article-title":"Prevention and treatment of experimental estrogen receptor-negative mammary carcinogenesis by the synthetic triterpenoid CDDO-methyl ester and the rexinoid LG100268","volume":"14","author":"Liby","year":"2008","journal-title":"Clin Cancer Res"},{"key":"10.1124\/pr.119.018440_bib290","doi-asserted-by":"crossref","first-page":"2414","DOI":"10.1158\/0008-5472.CAN-06-4534","article-title":"The synthetic triterpenoids CDDO-methyl ester and CDDO-ethyl amide prevent lung cancer induced by vinyl carbamate in A\/J mice","volume":"67","author":"Liby","year":"2007","journal-title":"Cancer Res"},{"key":"10.1124\/pr.119.018440_bib291","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1158\/1940-6207.CAPR-10-0197","article-title":"Synthetic triterpenoids prolong survival in a transgenic mouse model of pancreatic cancer","volume":"3","author":"Liby","year":"2010","journal-title":"Cancer Prev Res (Phila)"},{"key":"10.1124\/pr.119.018440_bib292","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nrc2129","article-title":"Triterpenoids and rexinoids as multifunctional agents for the prevention and treatment of cancer","volume":"7","author":"Liby","year":"2007","journal-title":"Nat Rev Cancer"},{"key":"10.1124\/pr.119.018440_bib293","doi-asserted-by":"crossref","first-page":"4531","DOI":"10.1073\/pnas.0308767101","article-title":"Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adults","volume":"101","author":"Licinio","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/pr.119.018440_bib294","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1182\/blood.V84.6.1737.1737","article-title":"Mice lacking granulocyte colony-stimulating factor have chronic neutropenia, granulocyte and macrophage progenitor cell deficiency, and impaired neutrophil mobilization","volume":"84","author":"Lieschke","year":"1994","journal-title":"Blood"},{"key":"10.1124\/pr.119.018440_bib295","doi-asserted-by":"crossref","first-page":"31055","DOI":"10.1074\/jbc.274.43.31055","article-title":"Serine phosphorylation and negative regulation of Stat3 by JNK","volume":"274","author":"Lim","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1124\/pr.119.018440_bib296","doi-asserted-by":"crossref","first-page":"5416","DOI":"10.1038\/sj.onc.1209531","article-title":"Stat3 contributes to keloid pathogenesis via promoting collagen production, cell proliferation and migration","volume":"25","author":"Lim","year":"2006","journal-title":"Oncogene"},{"key":"10.1124\/pr.119.018440_bib297","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.imlet.2009.09.003","article-title":"Dendritic cells integrate signals from the tumor microenvironment to modulate immunity and tumor growth","volume":"127","author":"Lin","year":"2010","journal-title":"Immunol Lett"},{"key":"10.1124\/pr.119.018440_bib298","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/1074-7613(95)90141-8","article-title":"The role of shared receptor motifs and common Stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13, and IL-15","volume":"2","author":"Lin","year":"1995","journal-title":"Immunity"},{"key":"10.1124\/pr.119.018440_bib299","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1097\/MCP.0b013e32835b10ec","article-title":"Asthma phenotypes and endotypes","volume":"19","author":"Lin","year":"2013","journal-title":"Curr Opin Pulm Med"},{"key":"10.1124\/pr.119.018440_bib300","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1093\/toxsci\/kfs199","article-title":"JNK-dependent Stat3 phosphorylation contributes to Akt activation in response to arsenic exposure","volume":"129","author":"Liu","year":"2012","journal-title":"Toxicol Sci"},{"key":"10.1124\/pr.119.018440_bib301","doi-asserted-by":"crossref","first-page":"2552","DOI":"10.1159\/000480216","article-title":"Role of Stat3 signaling in control of EMT of tubular epithelial cells during renal fibrosis","volume":"42","author":"Liu","year":"2017","journal-title":"Cell Physiol Biochem"},{"key":"10.1124\/pr.119.018440_bib302","doi-asserted-by":"crossref","first-page":"8150","DOI":"10.1073\/pnas.0501643102","article-title":"STAT3 nuclear import is independent of tyrosine phosphorylation and mediated by importin-alpha3","volume":"102","author":"Liu","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/pr.119.018440_bib303","doi-asserted-by":"crossref","first-page":"8","DOI":"10.3109\/07357907.2013.861471","article-title":"Blockage of STAT3 signaling pathway with a decoy oligodeoxynucleotide inhibits growth of human ovarian cancer cells","volume":"32","author":"Liu","year":"2014","journal-title":"Cancer Invest"},{"key":"10.1124\/pr.119.018440_bib304","doi-asserted-by":"crossref","first-page":"5269","DOI":"10.1172\/JCI63428","article-title":"Leukemia inhibitory factor promotes nasopharyngeal carcinoma progression and radioresistance","volume":"123","author":"Liu","year":"2013","journal-title":"J Clin Invest"},{"key":"10.1124\/pr.119.018440_bib305","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.bbrc.2006.11.147","article-title":"STAT3 activation inhibits human bronchial epithelial cell apoptosis in response to cigarette smoke exposure","volume":"353","author":"Liu","year":"2007","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1124\/pr.119.018440_bib306","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1002\/hep.28584","article-title":"Global epidemiology of nonalcoholic fatty liver disease: meta-analytic assessment of prevalence, incidence, and outcomes","volume":"64","author":"Lonardo","year":"2016","journal-title":"Hepatology"},{"key":"10.1124\/pr.119.018440_bib307","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.acuro.2018.08.003","article-title":"The role of STAT3 protein as a prognostic factor in the clear cell renal carcinoma: systematic review","volume":"43","author":"Lorente","year":"2019","journal-title":"Actas Urol Esp"},{"key":"10.1124\/pr.119.018440_bib308","doi-asserted-by":"crossref","first-page":"5292","DOI":"10.1038\/s41388-018-0340-y","article-title":"Activation of STAT3 and Bcl-2 and reduction of reactive oxygen species (ROS) promote radioresistance in breast cancer and overcome of radioresistance with niclosamide","volume":"37","author":"Lu","year":"2018","journal-title":"Oncogene"},{"key":"10.1124\/pr.119.018440_bib309","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1016\/j.thromres.2014.03.042","article-title":"Role of a Janus kinase 2-dependent signaling pathway in platelet activation","volume":"133","author":"Lu","year":"2014","journal-title":"Thromb Res"},{"key":"10.1124\/pr.119.018440_bib310","doi-asserted-by":"crossref","first-page":"7656","DOI":"10.1038\/sj.onc.1210567","article-title":"Pin1 is required for the Ser727 phosphorylation-dependent Stat3 activity","volume":"26","author":"Lufei","year":"2007","journal-title":"Oncogene"},{"key":"10.1124\/pr.119.018440_bib311","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.1002\/hep.21906","article-title":"Gut-derived commensal bacterial products inhibit liver dendritic cell maturation by stimulating hepatic interleukin-6\/signal transducer and activator of transcription 3 activity","volume":"46","author":"Lunz","year":"2007","journal-title":"Hepatology"},{"key":"10.1124\/pr.119.018440_bib312","doi-asserted-by":"crossref","first-page":"8025","DOI":"10.1073\/pnas.1401180111","article-title":"Structure of the pseudokinase-kinase domains from protein kinase TYK2 reveals a mechanism for Janus kinase (JAK) autoinhibition","volume":"111","author":"Lupardus","year":"2014","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/pr.119.018440_bib313","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1084\/jem.20080218","article-title":"Deficiency of Th17 cells in hyper IgE syndrome due to mutations in STAT3","volume":"205","author":"Ma","year":"2008","journal-title":"J Exp Med"},{"key":"10.1124\/pr.119.018440_bib314","doi-asserted-by":"crossref","first-page":"622","DOI":"10.15252\/emmm.201607052","article-title":"STAT3 promotes IFN\u03b3\/TNF\u03b1-induced muscle wasting in an NF-\u03baB-dependent and IL-6-independent manner","volume":"9","author":"Ma","year":"2017","journal-title":"EMBO Mol Med"},{"key":"10.1124\/pr.119.018440_bib315","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1016\/j.cellsig.2014.04.003","article-title":"Reduced phosphorylation of Stat3 at Ser-727 mediated by casein kinase 2 - protein phosphatase 2A enhances Stat3 Tyr-705 induced tumorigenic potential of glioma cells","volume":"26","author":"Mandal","year":"2014","journal-title":"Cell Signal"},{"key":"10.1124\/pr.119.018440_bib316","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.2337\/diacare.15.12.1892","article-title":"Current hypotheses for the biochemical basis of diabetic retinopathy","volume":"15","author":"Mandarino","year":"1992","journal-title":"Diabetes Care"},{"key":"10.1124\/pr.119.018440_bib317","doi-asserted-by":"crossref","first-page":"2589","DOI":"10.1182\/blood-2012-01-404004","article-title":"Mouse hematopoietic cell-targeted STAT3 deletion: stem\/progenitor cell defects, mitochondrial dysfunction, ROS overproduction, and a rapid aging-like phenotype","volume":"120","author":"Mantel","year":"2012","journal-title":"Blood"},{"key":"10.1124\/pr.119.018440_bib318","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1007\/s001090000137","article-title":"Serum levels of leptin and proinflammatory cytokines in patients with advanced-stage cancer at different sites","volume":"78","author":"Mantovani","year":"2000","journal-title":"J Mol Med (Berl)"},{"key":"10.1124\/pr.119.018440_bib319","first-page":"484","article-title":"STAT3\u03b2 controls inflammatory responses and early tumor onset in skin and colon experimental cancer models","volume":"4","author":"Marino","year":"2014","journal-title":"Am J Cancer Res"},{"key":"10.1124\/pr.119.018440_bib320","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1038\/ni1052","article-title":"The STAT3 isoforms alpha and beta have unique and specific functions","volume":"5","author":"Maritano","year":"2004","journal-title":"Nat Immunol"},{"key":"10.1124\/pr.119.018440_bib321","doi-asserted-by":"crossref","first-page":"20852","DOI":"10.1073\/pnas.0810958105","article-title":"Oncogenic kinase NPM\/ALK induces through STAT3 expression of immunosuppressive protein CD274 (PD-L1, B7-H1)","volume":"105","author":"Marzec","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/pr.119.018440_bib322","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1001\/jamaoncol.2017.5818","article-title":"Pacritinib vs best available therapy, including ruxolitinib, in patients with myelofibrosis: a randomized clinical trial","volume":"4","author":"Mascarenhas","year":"2018","journal-title":"JAMA Oncol"},{"key":"10.1124\/pr.119.018440_bib323","doi-asserted-by":"crossref","first-page":"457","DOI":"10.2337\/db12-0337","article-title":"Constitutive STAT3 phosphorylation contributes to skeletal muscle insulin resistance in type 2 diabetes","volume":"62","author":"Mashili","year":"2013","journal-title":"Diabetes"},{"key":"10.1124\/pr.119.018440_bib324","doi-asserted-by":"crossref","first-page":"F25","DOI":"10.1152\/ajprenal.00311.2016","article-title":"Mesenchymal stem cells protect against obstruction-induced renal fibrosis by decreasing STAT3 activation and STAT3-dependent MMP-9 production","volume":"312","author":"Matsui","year":"2017","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1124\/pr.119.018440_bib325","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1016\/S0891-5849(01)00649-9","article-title":"Activation of JAK2 by the oxidative stress generated with oxidized low-density lipoprotein","volume":"31","author":"Mazi\u00e8re","year":"2001","journal-title":"Free Radic Biol Med"},{"key":"10.1124\/pr.119.018440_bib326","doi-asserted-by":"crossref","first-page":"C1374","DOI":"10.1152\/ajpcell.00466.2002","article-title":"High glucose and endothelial cell growth: novel effects independent of autocrine TGF-beta 1 and hyperosmolarity","volume":"284","author":"McGinn","year":"2003","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1124\/pr.119.018440_bib327","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1083\/jcb.201708092","article-title":"Senescence and aging: causes, consequences, and therapeutic avenues","volume":"217","author":"McHugh","year":"2018","journal-title":"J Cell Biol"},{"key":"10.1124\/pr.119.018440_bib328","doi-asserted-by":"crossref","first-page":"3489","DOI":"10.1182\/blood.V95.11.3489","article-title":"Mice lacking flt3 ligand have deficient hematopoiesis affecting hematopoietic progenitor cells, dendritic cells, and natural killer cells","volume":"95","author":"McKenna","year":"2000","journal-title":"Blood"},{"key":"10.1124\/pr.119.018440_bib329","doi-asserted-by":"crossref","first-page":"4089","DOI":"10.4049\/jimmunol.181.6.4089","article-title":"TH17 cells mediate steroid-resistant airway inflammation and airway hyperresponsiveness in mice","volume":"181","author":"McKinley","year":"2008","journal-title":"J Immunol"},{"key":"10.1124\/pr.119.018440_bib330","doi-asserted-by":"crossref","first-page":"27539","DOI":"10.1074\/jbc.272.44.27539","article-title":"Syk and Fyn are required by mouse megakaryocytes for the rise in intracellular calcium induced by a collagen-related peptide","volume":"272","author":"Melford","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1124\/pr.119.018440_bib331","doi-asserted-by":"crossref","first-page":"2638","DOI":"10.4049\/jimmunol.0902960","article-title":"Dendritic cell (DC)-specific targeting reveals Stat3 as a negative regulator of DC function","volume":"184","author":"Melillo","year":"2010","journal-title":"J Immunol"},{"key":"10.1124\/pr.119.018440_bib332","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1097\/00024382-200014010-00008","article-title":"Distinct effects of systemic infusion of G-CSF vs. IL-6 on lung and liver inflammation and injury in hemorrhagic shock","volume":"14","author":"Meng","year":"2000","journal-title":"Shock"},{"key":"10.1124\/pr.119.018440_bib333","doi-asserted-by":"crossref","first-page":"C343","DOI":"10.1152\/ajpcell.2001.280.2.C343","article-title":"Essential role for IL-6 in postresuscitation inflammation in hemorrhagic shock","volume":"280","author":"Meng","year":"2001","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1124\/pr.119.018440_bib334","doi-asserted-by":"crossref","first-page":"3418","DOI":"10.1182\/blood-2008-12-180646","article-title":"Dendritic cell homeostasis","volume":"113","author":"Merad","year":"2009","journal-title":"Blood"},{"key":"10.1124\/pr.119.018440_bib335","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1146\/annurev-immunol-020711-074950","article-title":"The dendritic cell lineage: ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting","volume":"31","author":"Merad","year":"2013","journal-title":"Annu Rev Immunol"},{"key":"10.1124\/pr.119.018440_bib336","doi-asserted-by":"crossref","first-page":"14811","DOI":"10.1073\/pnas.1515876112","article-title":"Mutations in the linker domain affect phospho-STAT3 function and suggest targets for interrupting STAT3 activity","volume":"112","author":"Mertens","year":"2015","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/pr.119.018440_bib337","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.clml.2014.12.008","article-title":"Effects of ruxolitinib treatment on metabolic and nutritional parameters in patients with myelofibrosis from COMFORT-I","volume":"15","author":"Mesa","year":"2015","journal-title":"Clin Lymphoma Myeloma Leuk"},{"key":"10.1124\/pr.119.018440_bib338","doi-asserted-by":"crossref","first-page":"R1185","DOI":"10.1152\/ajpregu.00794.2010","article-title":"Neuronal suppressor of cytokine signaling-3 deficiency enhances hypothalamic leptin-dependent phosphatidylinositol 3-kinase signaling","volume":"300","author":"Metlakunta","year":"2011","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1124\/pr.119.018440_bib339","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1006\/excr.2001.5405","article-title":"Cell type-specific and tyrosine phosphorylation-independent nuclear presence of STAT1 and STAT3","volume":"272","author":"Meyer","year":"2002","journal-title":"Exp Cell Res"},{"key":"10.1124\/pr.119.018440_bib340","doi-asserted-by":"crossref","first-page":"7097","DOI":"10.1007\/s13277-014-1961-6","article-title":"Stat3 inhibits Beclin 1 expression through recruitment of HDAC3 in nonsmall cell lung cancer cells","volume":"35","author":"Miao","year":"2014","journal-title":"Tumour Biol"},{"key":"10.1124\/pr.119.018440_bib341","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s12931-018-0728-9","article-title":"The JAK2 pathway is activated in idiopathic pulmonary fibrosis","volume":"19","author":"Milara","year":"2018","journal-title":"Respir Res"},{"key":"10.1124\/pr.119.018440_bib342","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1111\/j.1530-0277.2010.01399.x","article-title":"Molecular mechanisms of alcoholic liver disease: innate immunity and cytokines","volume":"35","author":"Miller","year":"2011","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1124\/pr.119.018440_bib343","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/1743-7075-4-18","article-title":"The role of proopiomelanocortin (POMC) neurones in feeding behaviour","volume":"4","author":"Millington","year":"2007","journal-title":"Nutr Metab (Lond)"},{"key":"10.1124\/pr.119.018440_bib344","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1038\/nature06764","article-title":"Impaired T(H)17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome","volume":"452","author":"Milner","year":"2008","journal-title":"Nature"},{"key":"10.1124\/pr.119.018440_bib345","doi-asserted-by":"crossref","first-page":"G794","DOI":"10.1152\/ajpgi.00390.2014","article-title":"Activation of the GP130-STAT3 axis and its potential implications in nonalcoholic fatty liver disease","volume":"308","author":"Min","year":"2015","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1124\/pr.119.018440_bib346","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.imlet.2009.12.006","article-title":"Reduced expression of chemoattractant receptors by polymorphonuclear leukocytes in hyper IgE syndrome patients","volume":"130","author":"Mintz","year":"2010","journal-title":"Immunol Lett"},{"key":"10.1124\/pr.119.018440_bib347","doi-asserted-by":"crossref","first-page":"13085","DOI":"10.1002\/anie.201506889","article-title":"Rhodium(II) proximity-labeling identifies a novel target site on STAT3 for inhibitors with potent anti-leukemia activity","volume":"54","author":"Minus","year":"2015","journal-title":"Angew Chem Int Ed Engl"},{"key":"10.1124\/pr.119.018440_bib348","doi-asserted-by":"crossref","first-page":"3999","DOI":"10.1158\/1078-0432.CCR-16-0495","article-title":"Molecular pathways: cachexia signaling-A targeted approach to cancer treatment","volume":"22","author":"Miyamoto","year":"2016","journal-title":"Clin Cancer Res"},{"key":"10.1124\/pr.119.018440_bib349","article-title":"STAT3 and the hyper-IgE syndrome: clinical presentation, genetic origin, pathogenesis, novel findings and remaining uncertainties","volume":"2","author":"Mogensen","year":"2013","journal-title":"JAKSTAT"},{"key":"10.1124\/pr.119.018440_bib350","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1038\/labinvest.3700630","article-title":"Role of STAT3 in liver regeneration: survival, DNA synthesis, inflammatory reaction and liver mass recovery","volume":"87","author":"Moh","year":"2007","journal-title":"Lab Invest"},{"key":"10.1124\/pr.119.018440_bib351","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1165\/rcmb.2002-0262OC","article-title":"Inverse effects of interleukin-6 on apoptosis of fibroblasts from pulmonary fibrosis and normal lungs","volume":"29","author":"Moodley","year":"2003","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1124\/pr.119.018440_bib352","first-page":"213","article-title":"Prevention of trauma and hemorrhagic shock-mediated liver apoptosis by activation of stat3alpha","volume":"1","author":"Moran","year":"2008","journal-title":"Int J Clin Exp Med"},{"key":"10.1124\/pr.119.018440_bib353","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/j.1752-8062.2008.00076.x","article-title":"Prevention of trauma\/hemorrhagic shock-induced lung apoptosis by IL-6-mediated activation of Stat3","volume":"2","author":"Moran","year":"2009","journal-title":"Clin Transl Sci"},{"key":"10.1124\/pr.119.018440_bib354","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1038\/nm1071","article-title":"Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity","volume":"10","author":"Mori","year":"2004","journal-title":"Nat Med"},{"key":"10.1124\/pr.119.018440_bib355","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1165\/rcmb.2006-0047SF","article-title":"Oxidants and signaling by mitogen-activated protein kinases in lung epithelium","volume":"34","author":"Mossman","year":"2006","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1124\/pr.119.018440_bib356","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1111\/j.1572-0241.2005.40615.x","article-title":"Activation pattern of signal transducers and activators of transcription (STAT) factors in inflammatory bowel diseases","volume":"100","author":"Mudter","year":"2005","journal-title":"Am J Gastroenterol"},{"key":"10.1124\/pr.119.018440_bib357","doi-asserted-by":"crossref","first-page":"4980","DOI":"10.1128\/MCB.00004-10","article-title":"Doubles game: Src-Stat3 versus p53-PTEN in cellular migration and invasion","volume":"30","author":"Mukhopadhyay","year":"2010","journal-title":"Mol Cell Biol"},{"key":"10.1124\/pr.119.018440_bib358","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1097\/00054725-200502000-00001","article-title":"Signal transducers and activators of transcription 3 signaling pathway: an essential mediator of inflammatory bowel disease and other forms of intestinal inflammation","volume":"11","author":"Musso","year":"2005","journal-title":"Inflamm Bowel Dis"},{"key":"10.1124\/pr.119.018440_bib359","doi-asserted-by":"crossref","first-page":"7264","DOI":"10.1073\/pnas.0509808103","article-title":"Stat3 activation of NF-kappaB p100 processing involves CBP\/p300-mediated acetylation","volume":"103","author":"Nadiminty","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/pr.119.018440_bib360","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/ijo.2015.201","article-title":"IL-10 gene transfer upregulates arcuate POMC and ameliorates hyperphagia, obesity and diabetes by substituting for leptin","volume":"40","author":"Nakata","year":"2016","journal-title":"Int J Obes"},{"key":"10.1124\/pr.119.018440_bib361","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.jmb.2016.01.003","article-title":"Allosteric communication across STAT3 domains associated with STAT3 function and disease-causing mutation","volume":"428","author":"Namanja","year":"2016","journal-title":"J Mol Biol"},{"key":"10.1124\/pr.119.018440_bib362","doi-asserted-by":"crossref","first-page":"4338","DOI":"10.4049\/jimmunol.175.7.4338","article-title":"Activation of dendritic cells via inhibition of Jak2\/STAT3 signaling","volume":"175","author":"Nefedova","year":"2005","journal-title":"J Immunol"},{"key":"10.1124\/pr.119.018440_bib363","doi-asserted-by":"crossref","first-page":"464","DOI":"10.4049\/jimmunol.172.1.464","article-title":"Hyperactivation of STAT3 is involved in abnormal differentiation of dendritic cells in cancer","volume":"172","author":"Nefedova","year":"2004","journal-title":"J Immunol"},{"key":"10.1124\/pr.119.018440_bib364","doi-asserted-by":"crossref","first-page":"9525","DOI":"10.1158\/0008-5472.CAN-05-0529","article-title":"Regulation of dendritic cell differentiation and antitumor immune response in cancer by pharmacologic-selective inhibition of the janus-activated kinase 2\/signal transducers and activators of transcription 3 pathway","volume":"65","author":"Nefedova","year":"2005","journal-title":"Cancer Res"},{"key":"10.1124\/pr.119.018440_bib365","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1159\/000475890","article-title":"Targeting the KEAP1-NRF2 system to prevent kidney disease progression","volume":"45","author":"Nezu","year":"2017","journal-title":"Am J Nephrol"},{"key":"10.1124\/pr.119.018440_bib366","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s00595-005-3124-2","article-title":"Inflammatory response to pulmonary ischemia-reperfusion injury","volume":"36","author":"Ng","year":"2006","journal-title":"Surg Today"},{"key":"10.1124\/pr.119.018440_bib367","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1074\/jbc.M110.128157","article-title":"Opposing actions of extracellular signal-regulated kinase (ERK) and signal transducer and activator of transcription 3 (STAT3) in regulating microtubule stabilization during cardiac hypertrophy","volume":"286","author":"Ng","year":"2011","journal-title":"J Biol Chem"},{"key":"10.1124\/pr.119.018440_bib368","doi-asserted-by":"crossref","first-page":"3354","DOI":"10.1182\/blood-2009-08-240317","article-title":"STAT3 controls the neutrophil migratory response to CXCR2 ligands by direct activation of G-CSF-induced CXCR2 expression and via modulation of CXCR2 signal transduction","volume":"115","author":"Nguyen-Jackson","year":"2010","journal-title":"Blood"},{"key":"10.1124\/pr.119.018440_bib369","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1189\/jlb.0312126","article-title":"G-CSF-activated STAT3 enhances production of the chemokine MIP-2 in bone marrow neutrophils","volume":"92","author":"Nguyen-Jackson","year":"2012","journal-title":"J Leukoc Biol"},{"key":"10.1124\/pr.119.018440_bib370","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1038\/ncb1857","article-title":"STAT3 inhibition of gluconeogenesis is downregulated by SirT1","volume":"11","author":"Nie","year":"2009","journal-title":"Nat Cell Biol"},{"key":"10.1124\/pr.119.018440_bib371","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1093\/intimm\/dxm045","article-title":"IL-6-gp130-STAT3 in T cells directs the development of IL-17+ Th with a minimum effect on that of Treg in the steady state","volume":"19","author":"Nishihara","year":"2007","journal-title":"Int Immunol"},{"key":"10.1124\/pr.119.018440_bib372","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/35008121","article-title":"Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage","volume":"404","author":"Nishikawa","year":"2000","journal-title":"Nature"},{"key":"10.1124\/pr.119.018440_bib373","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1038\/nature05969","article-title":"Essential autocrine regulation by IL-21 in the generation of inflammatory T cells","volume":"448","author":"Nurieva","year":"2007","journal-title":"Nature"},{"key":"10.1124\/pr.119.018440_bib374","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1002\/emmm.201100604","article-title":"Genetic partitioning of interleukin-6 signalling in mice dissociates Stat3 from Smad3-mediated lung fibrosis","volume":"4","author":"O\u2019Donoghue","year":"2012","journal-title":"EMBO Mol Med"},{"key":"10.1124\/pr.119.018440_bib375","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1056\/NEJMra1202117","article-title":"JAKs and STATs in immunity, immunodeficiency, and cancer","volume":"368","author":"O\u2019Shea","year":"2013","journal-title":"N Engl J Med"},{"key":"10.1124\/pr.119.018440_bib376","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1126\/science.1108164","article-title":"Cell signaling: Stat acetylation--a key facet of cytokine signaling?","volume":"307","author":"O\u2019Shea","year":"2005","journal-title":"Science"},{"key":"10.1124\/pr.119.018440_bib377","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1146\/annurev-med-051113-024537","article-title":"The JAK-STAT pathway: impact on human disease and therapeutic intervention","volume":"66","author":"O\u2019Shea","year":"2015","journal-title":"Annu Rev Med"},{"key":"10.1124\/pr.119.018440_bib378","doi-asserted-by":"crossref","first-page":"2520","DOI":"10.1038\/sj.onc.1209281","article-title":"Loss of SOCS3 in the liver promotes fibrosis by enhancing STAT3-mediated TGF-beta1 production","volume":"25","author":"Ogata","year":"2006","journal-title":"Oncogene"},{"key":"10.1124\/pr.119.018440_bib379","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1111\/cas.12683","article-title":"Phase I study of OPB-51602, an oral inhibitor of signal transducer and activator of transcription 3, in patients with relapsed\/refractory hematological malignancies","volume":"106","author":"Ogura","year":"2015","journal-title":"Cancer Sci"},{"key":"10.1124\/pr.119.018440_bib380","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1101\/gad.1166904","article-title":"Role of the TAK1-NLK-STAT3 pathway in TGF-beta-mediated mesoderm induction","volume":"18","author":"Ohkawara","year":"2004","journal-title":"Genes Dev"},{"key":"10.1124\/pr.119.018440_bib381","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1111\/cas.12118","article-title":"Roles and mechanisms of cellular senescence in regulation of tissue homeostasis","volume":"104","author":"Ohtani","year":"2013","journal-title":"Cancer Sci"},{"key":"10.1124\/pr.119.018440_bib382","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1084\/jem.20051645","article-title":"Activation of the Flt3 signal transduction cascade rescues and enhances type I interferon-producing and dendritic cell development","volume":"203","author":"Onai","year":"2006","journal-title":"J Exp Med"},{"key":"10.1124\/pr.119.018440_bib383","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1111\/bpa.12254","article-title":"STAT3 serine 727 phosphorylation: a relevant target to radiosensitize human glioblastoma","volume":"26","author":"Ou\u00e9draogo","year":"2016","journal-title":"Brain Pathol"},{"key":"10.1124\/pr.119.018440_bib384","article-title":"Stat3 inhibitor Stattic exhibits potent antitumor activity and induces chemo- and radio-sensitivity in nasopharyngeal carcinoma","volume":"8","author":"Pan","year":"2013","journal-title":"PLoS One"},{"key":"10.1124\/pr.119.018440_bib385","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1038\/ki.2010.154","article-title":"A novel STAT3 inhibitor, S3I-201, attenuates renal interstitial fibroblast activation and interstitial fibrosis in obstructive nephropathy","volume":"78","author":"Pang","year":"2010","journal-title":"Kidney Int"},{"key":"10.1124\/pr.119.018440_bib386","doi-asserted-by":"crossref","first-page":"19001","DOI":"10.1074\/jbc.M112271200","article-title":"Control of myeloid-specific integrin alpha Mbeta 2 (CD11b\/CD18) expression by cytokines is regulated by Stat3-dependent activation of PU.1","volume":"277","author":"Panopoulos","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1124\/pr.119.018440_bib387","doi-asserted-by":"crossref","first-page":"3682","DOI":"10.1182\/blood-2006-02-003012","article-title":"STAT3 governs distinct pathways in emergency granulopoiesis and mature neutrophils","volume":"108","author":"Panopoulos","year":"2006","journal-title":"Blood"},{"key":"10.1124\/pr.119.018440_bib388","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1091\/mbc.E17-06-0342","article-title":"STAT3 controls COL1A2 enhancer activation cooperatively with JunB, regulates type I collagen synthesis posttranscriptionally, and is essential for lung myofibroblast differentiation","volume":"29","author":"Papaioannou","year":"2018","journal-title":"Mol Biol Cell"},{"key":"10.1124\/pr.119.018440_bib389","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.cell.2009.12.052","article-title":"Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression","volume":"140","author":"Park","year":"2010","journal-title":"Cell"},{"key":"10.1124\/pr.119.018440_bib390","doi-asserted-by":"crossref","first-page":"73","DOI":"10.12703\/P6-73","article-title":"Leptin signaling","volume":"6","author":"Park","year":"2014","journal-title":"F1000Prime Rep"},{"key":"10.1124\/pr.119.018440_bib391","doi-asserted-by":"crossref","first-page":"3844","DOI":"10.4049\/jimmunol.173.6.3844","article-title":"IL-6 regulates in vivo dendritic cell differentiation through STAT3 activation","volume":"173","author":"Park","year":"2004","journal-title":"J Immunol"},{"key":"10.1124\/pr.119.018440_bib392","doi-asserted-by":"crossref","first-page":"28526","DOI":"10.1074\/jbc.M001531200","article-title":"Evidence of a role for SHP-1 in platelet activation by the collagen receptor glycoprotein VI","volume":"275","author":"Pasquet","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1124\/pr.119.018440_bib393","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1096\/fj.15-273953","article-title":"STAT-3 contributes to pulmonary fibrosis through epithelial injury and fibroblast-myofibroblast differentiation","volume":"30","author":"Pedroza","year":"2016","journal-title":"FASEB J"},{"key":"10.1124\/pr.119.018440_bib394","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1093\/rheumatology\/kex347","article-title":"Role of STAT3 in skin fibrosis and transforming growth factor beta signalling","volume":"57","author":"Pedroza","year":"2017","journal-title":"Rheumatology (Oxford)"},{"key":"10.1124\/pr.119.018440_bib395","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1016\/j.ajpath.2012.12.023","article-title":"Autophagic degradation contributes to muscle wasting in cancer cachexia","volume":"182","author":"Penna","year":"2013","journal-title":"Am J Pathol"},{"key":"10.1124\/pr.119.018440_bib396","doi-asserted-by":"crossref","first-page":"4557","DOI":"10.1111\/febs.13035","article-title":"Signal transducer and activator of transcription 3 and the phosphatidylinositol 3-kinase regulatory subunits p55\u03b1 and p50\u03b1 regulate autophagy in vivo","volume":"281","author":"Pensa","year":"2014","journal-title":"FEBS J"},{"key":"10.1124\/pr.119.018440_bib397","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1084\/jem.20082683","article-title":"STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing","volume":"206","author":"Pickert","year":"2009","journal-title":"J Exp Med"},{"key":"10.1124\/pr.119.018440_bib398","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.semcancer.2013.05.008","article-title":"Regulation of autophagy by stress-responsive transcription factors","volume":"23","author":"Pietrocola","year":"2013","journal-title":"Semin Cancer Biol"},{"key":"10.1124\/pr.119.018440_bib399","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1182\/blood-2017-10-810739","article-title":"Aggressive B-cell lymphomas in patients with myelofibrosis receiving JAK1\/2 inhibitor therapy","volume":"132","author":"Porpaczy","year":"2018","journal-title":"Blood"},{"key":"10.1124\/pr.119.018440_bib400","doi-asserted-by":"crossref","first-page":"e200","DOI":"10.1038\/oncsis.2016.3","article-title":"Understanding cachexia as a cancer metabolism syndrome","volume":"5","author":"Porporato","year":"2016","journal-title":"Oncogenesis"},{"key":"10.1124\/pr.119.018440_bib401","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1001\/jama.286.3.327","article-title":"C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus","volume":"286","author":"Pradhan","year":"2001","journal-title":"JAMA"},{"key":"10.1124\/pr.119.018440_bib402","doi-asserted-by":"crossref","first-page":"13079","DOI":"10.1073\/pnas.1311557110","article-title":"Regulation of adipose tissue T cell subsets by Stat3 is crucial for diet-induced obesity and insulin resistance","volume":"110","author":"Priceman","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/pr.119.018440_bib403","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1161\/CIRCULATIONAHA.110.013847","article-title":"H11 kinase\/heat shock protein 22 deletion impairs both nuclear and mitochondrial functions of STAT3 and accelerates the transition into heart failure on cardiac overload","volume":"124","author":"Qiu","year":"2011","journal-title":"Circulation"},{"key":"10.1124\/pr.119.018440_bib404","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1210\/me.2008-0264","article-title":"STAT3 targets the regulatory regions of gluconeogenic genes in vivo","volume":"23","author":"Ramadoss","year":"2009","journal-title":"Mol Endocrinol"},{"key":"10.1124\/pr.119.018440_bib405","doi-asserted-by":"crossref","first-page":"12859","DOI":"10.1073\/pnas.192264999","article-title":"p38 MAPK enhances STAT1-dependent transcription independently of Ser-727 phosphorylation","volume":"99","author":"Ramsauer","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/pr.119.018440_bib406","doi-asserted-by":"crossref","first-page":"2316","DOI":"10.1158\/0008-5472.CAN-13-2433","article-title":"HO-3867, a safe STAT3 inhibitor, is selectively cytotoxic to ovarian cancer","volume":"74","author":"Rath","year":"2014","journal-title":"Cancer Res"},{"key":"10.1124\/pr.119.018440_bib407","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1242\/jcs.00963","article-title":"The JAK\/STAT signaling pathway","volume":"117","author":"Rawlings","year":"2004","journal-title":"J Cell Sci"},{"key":"10.1124\/pr.119.018440_bib408","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1053\/j.gastro.2005.07.055","article-title":"STAT3 NH2-terminal acetylation is activated by the hepatic acute-phase response and required for IL-6 induction of angiotensinogen","volume":"129","author":"Ray","year":"2005","journal-title":"Gastroenterology"},{"key":"10.1124\/pr.119.018440_bib409","doi-asserted-by":"crossref","first-page":"4510","DOI":"10.1093\/nar\/gkn419","article-title":"Requirement of histone deacetylase1 (HDAC1) in signal transducer and activator of transcription 3 (STAT3) nucleocytoplasmic distribution","volume":"36","author":"Ray","year":"2008","journal-title":"Nucleic Acids Res"},{"key":"10.1124\/pr.119.018440_bib410","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1210\/mend.16.4.0811","article-title":"Angiotensinogen gene expression is dependent on signal transducer and activator of transcription 3-mediated p300\/cAMP response element binding protein-binding protein coactivator recruitment and histone acetyltransferase activity","volume":"16","author":"Ray","year":"2002","journal-title":"Mol Endocrinol"},{"key":"10.1124\/pr.119.018440_bib411","doi-asserted-by":"crossref","first-page":"7611","DOI":"10.1038\/sj.onc.1206004","article-title":"Resistance to chemotherapy via Stat3-dependent overexpression of Bcl-2 in metastatic breast cancer cells","volume":"21","author":"Real","year":"2002","journal-title":"Oncogene"},{"key":"10.1124\/pr.119.018440_bib412","doi-asserted-by":"crossref","DOI":"10.4161\/jkst.23010","article-title":"STAT3 activation: a key factor in tumor immunoescape","volume":"2","author":"R\u00e9b\u00e9","year":"2013","journal-title":"JAK-STAT"},{"key":"10.1124\/pr.119.018440_bib413","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1186\/s40425-018-0436-5","article-title":"STAT3 antisense oligonucleotide AZD9150 in a subset of patients with heavily pretreated lymphoma: results of a phase 1b trial","volume":"6","author":"Reilley","year":"2018","journal-title":"J Immunother Cancer"},{"key":"10.1124\/pr.119.018440_bib414","doi-asserted-by":"crossref","first-page":"32538","DOI":"10.1074\/jbc.M114.595454","article-title":"Changes in signal transducer and activator of transcription 3 (STAT3) dynamics induced by complexation with pharmacological inhibitors of Src homology 2 (SH2) domain dimerization","volume":"289","author":"Resetca","year":"2014","journal-title":"J Biol Chem"},{"key":"10.1124\/pr.119.018440_bib415","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.3390\/ijms19061656","article-title":"A new perspective: mitochondrial Stat3 as a regulator for lymphocyte function","volume":"19","author":"Rincon","year":"2018","journal-title":"Int J Mol Sci"},{"key":"10.1124\/pr.119.018440_bib416","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0101182","article-title":"Identification of sites of STAT3 action in the female reproductive tract through conditional gene deletion","volume":"9","author":"Robker","year":"2014","journal-title":"PLoS One"},{"key":"10.1124\/pr.119.018440_bib417","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1083\/jcb.201009094","article-title":"Four faces of cellular senescence","volume":"192","author":"Rodier","year":"2011","journal-title":"J Cell Biol"},{"key":"10.1124\/pr.119.018440_bib418","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/0014-5793(94)00983-X","article-title":"Phosphorylation of JAK2 in thrombin-stimulated human platelets","volume":"352","author":"Rodr\u00edguez-Li\u00f1ares","year":"1994","journal-title":"FEBS Lett"},{"key":"10.1124\/pr.119.018440_bib419","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1158\/1541-7786.MCR-14-0412","article-title":"Aberrant LPL expression, driven by STAT3, mediates free fatty acid metabolism in CLL cells","volume":"13","author":"Rozovski","year":"2015","journal-title":"Mol Cancer Res"},{"key":"10.1124\/pr.119.018440_bib420","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1158\/1541-7786.MCR-16-0291","article-title":"Constitutive phosphorylation of STAT3 by the CK2-BLNK-CD5 complex","volume":"15","author":"Rozovski","year":"2017","journal-title":"Mol Cancer Res"},{"key":"10.1124\/pr.119.018440_bib421","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.1002\/ijc.30892","article-title":"Activation of the B-cell receptor successively activates NF-\u03baB and STAT3 in chronic lymphocytic leukemia cells","volume":"141","author":"Rozovski","year":"2017","journal-title":"Int J Cancer"},{"key":"10.1124\/pr.119.018440_bib422","doi-asserted-by":"crossref","first-page":"4400","DOI":"10.4049\/jimmunol.1402108","article-title":"At high levels, constitutively activated STAT3 induces apoptosis of chronic lymphocytic leukemia cells","volume":"196","author":"Rozovski","year":"2016","journal-title":"J Immunol"},{"key":"10.1124\/pr.119.018440_bib423","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1038\/onc.2015.161","article-title":"STAT3 integrates cooperative Ras and TGF-\u03b2 signals that induce Snail expression","volume":"35","author":"Saitoh","year":"2016","journal-title":"Oncogene"},{"key":"10.1124\/pr.119.018440_bib424","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1111\/cbdd.13160","article-title":"Cucurbitacin-B attenuates CCl4 -induced hepatic fibrosis in mice through inhibition of STAT-3","volume":"91","author":"Sallam","year":"2018","journal-title":"Chem Biol Drug Des"},{"key":"10.1124\/pr.119.018440_bib425","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1124\/mol.105.018051","article-title":"A novel mechanism of action of methyl-2-cyano-3,12 dioxoolean-1,9 diene-28-oate: direct permeabilization of the inner mitochondrial membrane to inhibit electron transport and induce apoptosis","volume":"69","author":"Samudio","year":"2006","journal-title":"Mol Pharmacol"},{"key":"10.1124\/pr.119.018440_bib426","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1053\/j.gastro.2008.07.014","article-title":"A randomized trial of Ustekinumab, a human interleukin-12\/23 monoclonal antibody, in patients with moderate-to-severe Crohn\u2019s disease","volume":"135","author":"Sandborn","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1124\/pr.119.018440_bib427","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1056\/NEJMoa1112168","article-title":"Tofacitinib, an oral Janus kinase inhibitor, in active ulcerative colitis","volume":"367","author":"Sandborn","year":"2012","journal-title":"N Engl J Med"},{"key":"10.1124\/pr.119.018440_bib428","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/j.cgh.2011.04.031","article-title":"Certolizumab pegol for active Crohn\u2019s disease: a placebo-controlled, randomized trial","volume":"9","author":"Sandborn","year":"2011","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1124\/pr.119.018440_bib429","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/nm1162","article-title":"Stat3 links activated keratinocytes and immunocytes required for development of psoriasis in a novel transgenic mouse model","volume":"11","author":"Sano","year":"2005","journal-title":"Nat Med"},{"key":"10.1124\/pr.119.018440_bib430","doi-asserted-by":"crossref","first-page":"4657","DOI":"10.1093\/emboj\/18.17.4657","article-title":"Keratinocyte-specific ablation of Stat3 exhibits impaired skin remodeling, but does not affect skin morphogenesis","volume":"18","author":"Sano","year":"1999","journal-title":"EMBO J"},{"key":"10.1124\/pr.119.018440_bib431","doi-asserted-by":"crossref","first-page":"e9532","DOI":"10.1371\/journal.pone.0009532","article-title":"Disruption of astrocyte STAT3 signaling decreases mitochondrial function and increases oxidative stress in vitro","volume":"5","author":"Sarafian","year":"2010","journal-title":"PLoS One"},{"key":"10.1124\/pr.119.018440_bib432","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1093\/intimm\/dxh331","article-title":"Physical and functional interactions between STAT3 and ZIP kinase","volume":"17","author":"Sato","year":"2005","journal-title":"Int Immunol"},{"key":"10.1124\/pr.119.018440_bib433","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.4049\/jimmunol.0803883","article-title":"Tristetraprolin is required for full anti-inflammatory response of murine macrophages to IL-10","volume":"183","author":"Schaljo","year":"2009","journal-title":"J Immunol"},{"key":"10.1124\/pr.119.018440_bib434","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.tcb.2007.07.009","article-title":"ROS, mitochondria and the regulation of autophagy","volume":"17","author":"Scherz-Shouval","year":"2007","journal-title":"Trends Cell Biol"},{"key":"10.1124\/pr.119.018440_bib435","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1126\/science.1496401","article-title":"Interferon-dependent tyrosine phosphorylation of a latent cytoplasmic transcription factor","volume":"257","author":"Schindler","year":"1992","journal-title":"Science"},{"key":"10.1124\/pr.119.018440_bib436","doi-asserted-by":"crossref","first-page":"848","DOI":"10.4049\/jimmunol.164.2.848","article-title":"The cytoplasmic tyrosine motifs in full-length glycoprotein 130 have different roles in IL-6 signal transduction","volume":"164","author":"Schmitz","year":"2000","journal-title":"J Immunol"},{"key":"10.1124\/pr.119.018440_bib437","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1056\/NEJMoa062897","article-title":"Maintenance therapy with certolizumab pegol for Crohn\u2019s disease [published correction appears in N Engl J Med (2007) 357:1357]","volume":"357","author":"Schreiber","year":"2007","journal-title":"N Engl J Med"},{"key":"10.1124\/pr.119.018440_bib438","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0014-5793(01)02354-7","article-title":"Ser727-dependent transcriptional activation by association of p300 with STAT3 upon IL-6 stimulation","volume":"495","author":"Schuringa","year":"2001","journal-title":"FEBS Lett"},{"key":"10.1124\/pr.119.018440_bib439","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s12964-017-0177-y","article-title":"The role of JAK-STAT signaling pathway and its regulators in the fate of T helper cells","volume":"15","author":"Seif","year":"2017","journal-title":"Cell Commun Signal"},{"key":"10.1124\/pr.119.018440_bib440","doi-asserted-by":"crossref","first-page":"46","DOI":"10.2119\/molmed.2013.00104","article-title":"Systemic administration of a cyclic signal transducer and activator of transcription 3 (STAT3) decoy oligonucleotide inhibits tumor growth without inducing toxicological effects","volume":"20","author":"Sen","year":"2014","journal-title":"Mol Med"},{"key":"10.1124\/pr.119.018440_bib441","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1158\/2159-8290.CD-12-0191","article-title":"First-in-human trial of a STAT3 decoy oligonucleotide in head and neck tumors: implications for cancer therapy","volume":"2","author":"Sen","year":"2012","journal-title":"Cancer Discov"},{"key":"10.1124\/pr.119.018440_bib442","doi-asserted-by":"crossref","first-page":"3937","DOI":"10.1074\/jbc.RA117.000528","article-title":"Stat3 and CCAAT enhancer-binding protein \u03b2 (C\/ebp\u03b2) activate Fanconi C gene transcription during emergency granulopoiesis","volume":"293","author":"Shah","year":"2018","journal-title":"J Biol Chem"},{"key":"10.1124\/pr.119.018440_bib443","doi-asserted-by":"crossref","first-page":"3853","DOI":"10.1182\/blood.V98.13.3853","article-title":"Identification and characterization of cis elements in the STAT3 gene regulating STAT3 alpha and STAT3 beta messenger RNA splicing","volume":"98","author":"Shao","year":"2001","journal-title":"Blood"},{"key":"10.1124\/pr.119.018440_bib444","doi-asserted-by":"crossref","first-page":"18967","DOI":"10.1074\/jbc.M314037200","article-title":"Structural requirements for signal transducer and activator of transcription 3 binding to phosphotyrosine ligands containing the YXXQ motif","volume":"279","author":"Shao","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1124\/pr.119.018440_bib445","first-page":"237","article-title":"Inhibitory effects of decoy-ODN targeting activated STAT3 on human glioma growth in vivo","volume":"23","author":"Shen","year":"2009","journal-title":"In Vivo"},{"key":"10.1124\/pr.119.018440_bib446","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.molcel.2012.09.013","article-title":"Cytoplasmic STAT3 represses autophagy by inhibiting PKR activity","volume":"48","author":"Shen","year":"2012","journal-title":"Mol Cell"},{"key":"10.1124\/pr.119.018440_bib447","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1073\/pnas.98.4.1543","article-title":"Constitutively activated Stat3 protects fibroblasts from serum withdrawal and UV-induced apoptosis and antagonizes the proapoptotic effects of activated Stat1","volume":"98","author":"Shen","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/pr.119.018440_bib448","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1128\/MCB.24.1.407-419.2004","article-title":"Essential role of STAT3 in postnatal survival and growth revealed by mice lacking STAT3 serine 727 phosphorylation","volume":"24","author":"Shen","year":"2004","journal-title":"Mol Cell Biol"},{"key":"10.1124\/pr.119.018440_bib449","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1002\/stem.185","article-title":"STAT3 is required for proliferation and maintenance of multipotency in glioblastoma stem cells","volume":"27","author":"Sherry","year":"2009","journal-title":"Stem Cells"},{"key":"10.1124\/pr.119.018440_bib450","doi-asserted-by":"crossref","first-page":"34733","DOI":"10.1074\/jbc.M403886200","article-title":"Suppressor of cytokine signaling 3 is a physiological regulator of adipocyte insulin signaling","volume":"279","author":"Shi","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1124\/pr.119.018440_bib451","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1038\/ncb1713","article-title":"Drosophila STAT is required for directly maintaining HP1 localization and heterochromatin stability","volume":"10","author":"Shi","year":"2008","journal-title":"Nat Cell Biol"},{"key":"10.1124\/pr.119.018440_bib452","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1007\/s00125-014-3185-0","article-title":"Adipocyte-specific deficiency of Janus kinase (JAK) 2 in mice impairs lipolysis and increases body weight, and leads to insulin resistance with ageing","volume":"57","author":"Shi","year":"2014","journal-title":"Diabetologia"},{"key":"10.1124\/pr.119.018440_bib453","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1038\/nri1226","article-title":"Regulation of JAK-STAT signalling in the immune system","volume":"3","author":"Shuai","year":"2003","journal-title":"Nat Rev Immunol"},{"key":"10.1124\/pr.119.018440_bib454","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1016\/j.jaci.2013.08.045","article-title":"Diminished allergic disease in patients with STAT3 mutations reveals a role for STAT3 signaling in mast cell degranulation [published correction appears in J Allergy Clin Immunol (2014) 133:1232]","volume":"132","author":"Siegel","year":"2013","journal-title":"J Allergy Clin Immunol"},{"key":"10.1124\/pr.119.018440_bib455","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.arr.2010.10.002","article-title":"Impact of cellular senescence signature on ageing research","volume":"10","author":"Sikora","year":"2011","journal-title":"Ageing Res Rev"},{"key":"10.1124\/pr.119.018440_bib456","doi-asserted-by":"crossref","first-page":"11177","DOI":"10.1074\/jbc.M115.641514","article-title":"Inhibition of Stat3 activation suppresses caspase-3 and the ubiquitin-proteasome system, leading to preservation of muscle mass in cancer cachexia","volume":"290","author":"Silva","year":"2015","journal-title":"J Biol Chem"},{"key":"10.1124\/pr.119.018440_bib457","article-title":"STAT3: A Novel Regulator of Airway Inflammation and Remodeling in Asthma in Sackler School of Graduate Biomedical Sciences, Tuft University (MA)","volume":"2008","author":"Simeone-Penney","year":"2008","journal-title":"ProQuest Dissertations Publishing"},{"key":"10.1124\/pr.119.018440_bib458","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0055509","article-title":"Imatinib reverses doxorubicin resistance by affecting activation of STAT3-dependent NF-\u03baB and HSP27\/p38\/AKT pathways and by inhibiting ABCB1","volume":"8","author":"Sims","year":"2013","journal-title":"PLoS One"},{"key":"10.1124\/pr.119.018440_bib459","doi-asserted-by":"crossref","first-page":"35","DOI":"10.2147\/PROM.S140011","article-title":"Impact of siltuximab on patient-related outcomes in multicentric Castleman\u2019s disease","volume":"9","author":"Sitenga","year":"2018","journal-title":"Patient Relat Outcome Meas"},{"key":"10.1124\/pr.119.018440_bib460","doi-asserted-by":"crossref","first-page":"23582","DOI":"10.1074\/jbc.M111.249235","article-title":"A distal enhancer in Il12b is the target of transcriptional repression by the STAT3 pathway and requires the basic leucine zipper (B-ZIP) protein NFIL3","volume":"286","author":"Smith","year":"2011","journal-title":"J Biol Chem"},{"key":"10.1124\/pr.119.018440_bib461","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.cardiores.2004.06.019","article-title":"Genetic depletion of cardiac myocyte STAT-3 abolishes classical preconditioning","volume":"63","author":"Smith","year":"2004","journal-title":"Cardiovasc Res"},{"key":"10.1124\/pr.119.018440_bib462","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/nchembio.1695","article-title":"Peroxiredoxin-2 and STAT3 form a redox relay for H2O2 signaling","volume":"11","author":"Sobotta","year":"2015","journal-title":"Nat Chem Biol"},{"key":"10.1124\/pr.119.018440_bib463","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.cyto.2008.08.001","article-title":"Genetic variants in STAT3 are associated with nonalcoholic fatty liver disease","volume":"44","author":"Sookoian","year":"2008","journal-title":"Cytokine"},{"key":"10.1124\/pr.119.018440_bib464","doi-asserted-by":"crossref","first-page":"116","DOI":"10.3324\/haematol.2013.088286","article-title":"STAT3-mediated activation of microRNA cluster 17\u223c92 promotes proliferation and survival of ALK-positive anaplastic large cell lymphoma","volume":"99","author":"Spaccarotella","year":"2014","journal-title":"Haematologica"},{"key":"10.1124\/pr.119.018440_bib465","first-page":"2948","article-title":"Epidermal growth factor receptor-independent constitutive activation of STAT3 in head and neck squamous cell carcinoma is mediated by the autocrine\/paracrine stimulation of the interleukin 6\/gp130 cytokine system","volume":"63","author":"Sriuranpong","year":"2003","journal-title":"Cancer Res"},{"key":"10.1124\/pr.119.018440_bib466","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/S0026-0495(97)90259-6","article-title":"Lactic acidosis and other mitochondrial disorders","volume":"46","author":"Stacpoole","year":"1997","journal-title":"Metabolism"},{"key":"10.1124\/pr.119.018440_bib467","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/cr.2010.174","article-title":"Lysine methylation of promoter-bound transcription factors and relevance to cancer","volume":"21","author":"Stark","year":"2011","journal-title":"Cell Res"},{"key":"10.1124\/pr.119.018440_bib468","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1002\/hep4.1364","article-title":"Deficient IL-6\/Stat3 signaling, high TLR7, and type I interferons in early human alcoholic liver disease: a triad for liver damage and fibrosis","volume":"3","author":"St\u00e4rkel","year":"2019","journal-title":"Hepatol Commun"},{"key":"10.1124\/pr.119.018440_bib469","doi-asserted-by":"crossref","first-page":"31408","DOI":"10.1074\/jbc.273.47.31408","article-title":"Activation of signal transducers and activators of transcription 1 and 3 by leukemia inhibitory factor, oncostatin-M, and interferon-gamma in adipocytes","volume":"273","author":"Stephens","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1124\/pr.119.018440_bib470","doi-asserted-by":"crossref","first-page":"2978","DOI":"10.1182\/blood-2013-09-523167","article-title":"A mouse model of HIES reveals pro- and anti-inflammatory functions of STAT3","volume":"123","author":"Steward-Tharp","year":"2014","journal-title":"Blood"},{"key":"10.1124\/pr.119.018440_bib471","doi-asserted-by":"crossref","first-page":"7243","DOI":"10.1073\/pnas.1507499112","article-title":"Sorafenib and its derivative SC-1 exhibit antifibrotic effects through signal transducer and activator of transcription 3 inhibition","volume":"112","author":"Su","year":"2015","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/pr.119.018440_bib472","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.canlet.2014.01.002","article-title":"Carcinogenic metalloid arsenic induces expression of mdig oncogene through JNK and STAT3 activation","volume":"346","author":"Sun","year":"2014","journal-title":"Cancer Lett"},{"key":"10.1124\/pr.119.018440_bib473","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1099\/0022-1317-83-7-1651","article-title":"PTEN is a negative regulator of STAT3 activation in human papillomavirus-infected cells","volume":"83","author":"Sun","year":"2002","journal-title":"J Gen Virol"},{"key":"10.1124\/pr.119.018440_bib474","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.canlet.2007.12.009","article-title":"Growth inhibition of human hepatocellular carcinoma cells by blocking STAT3 activation with decoy-ODN","volume":"262","author":"Sun","year":"2008","journal-title":"Cancer Lett"},{"key":"10.1124\/pr.119.018440_bib475","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1084\/jem.193.4.471","article-title":"CIS3\/SOCS3\/SSI3 plays a negative regulatory role in STAT3 activation and intestinal inflammation","volume":"193","author":"Suzuki","year":"2001","journal-title":"J Exp Med"},{"key":"10.1124\/pr.119.018440_bib476","doi-asserted-by":"crossref","first-page":"29610","DOI":"10.1074\/jbc.M111.226209","article-title":"Mitochondrial-targeted signal transducer and activator of transcription 3 (STAT3) protects against ischemia-induced changes in the electron transport chain and the generation of reactive oxygen species","volume":"286","author":"Szczepanek","year":"2011","journal-title":"J Biol Chem"},{"key":"10.1124\/pr.119.018440_bib477","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.mito.2011.08.011","article-title":"Cytoprotection by the modulation of mitochondrial electron transport chain: the emerging role of mitochondrial STAT3","volume":"12","author":"Szczepanek","year":"2012","journal-title":"Mitochondrion"},{"key":"10.1124\/pr.119.018440_bib478","doi-asserted-by":"crossref","first-page":"e485","DOI":"10.1038\/cddis.2013.18","article-title":"Mcl-1-dependent activation of Beclin 1 mediates autophagic cell death induced by sorafenib and SC-59 in hepatocellular carcinoma cells","volume":"4","author":"Tai","year":"2013","journal-title":"Cell Death Dis"},{"key":"10.1124\/pr.119.018440_bib479","doi-asserted-by":"crossref","first-page":"4143","DOI":"10.1093\/hmg\/ddr338","article-title":"Pyrimethamine inhibits adult polycystic kidney disease by modulating STAT signaling pathways","volume":"20","author":"Takakura","year":"2011","journal-title":"Hum Mol Genet"},{"key":"10.1124\/pr.119.018440_bib480","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S1074-7613(00)80005-9","article-title":"Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils","volume":"10","author":"Takeda","year":"1999","journal-title":"Immunity"},{"key":"10.1124\/pr.119.018440_bib481","doi-asserted-by":"crossref","first-page":"4652","DOI":"10.4049\/jimmunol.161.9.4652","article-title":"Stat3 activation is responsible for IL-6-dependent T cell proliferation through preventing apoptosis: generation and characterization of T cell-specific Stat3-deficient mice [published correction appears in J Immunol (2015) 194:3526]","volume":"161","author":"Takeda","year":"1998","journal-title":"J Immunol"},{"key":"10.1124\/pr.119.018440_bib482","doi-asserted-by":"crossref","first-page":"3801","DOI":"10.1073\/pnas.94.8.3801","article-title":"Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality","volume":"94","author":"Takeda","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/pr.119.018440_bib483","doi-asserted-by":"crossref","first-page":"4723","DOI":"10.1074\/jbc.M112.378984","article-title":"The import of the transcription factor STAT3 into mitochondria depends on GRIM-19, a component of the electron transport chain","volume":"288","author":"Tammineni","year":"2013","journal-title":"J Biol Chem"},{"key":"10.1124\/pr.119.018440_bib484","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.taap.2008.05.022","article-title":"Coordinated induction of Nrf2 target genes protects against iron nitrilotriacetate (FeNTA)-induced nephrotoxicity","volume":"231","author":"Tanaka","year":"2008","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1124\/pr.119.018440_bib485","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1056\/NEJM199710093371502","article-title":"A short-term study of chimeric monoclonal antibody cA2 to tumor necrosis factor alpha for Crohn\u2019s disease: Crohn\u2019s Disease cA2 Study Group","volume":"337","author":"Targan","year":"1997","journal-title":"N Engl J Med"},{"key":"10.1124\/pr.119.018440_bib486","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1200\/JCO.2010.32.9490","article-title":"Circulating interleukin (IL)-8, IL-2R, IL-12, and IL-15 levels are independently prognostic in primary myelofibrosis: a comprehensive cytokine profiling study","volume":"29","author":"Tefferi","year":"2011","journal-title":"J Clin Oncol"},{"key":"10.1124\/pr.119.018440_bib487","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.jinf.2013.11.010","article-title":"Restoration of lung surfactant protein D by IL-6 protects against secondary pneumonia following hemorrhagic shock","volume":"68","author":"Thacker","year":"2014","journal-title":"J Infect"},{"key":"10.1124\/pr.119.018440_bib488","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1038\/srep01187","article-title":"Modulation of the unfolded protein response during hepatocyte and cardiomyocyte apoptosis in trauma\/hemorrhagic shock","volume":"3","author":"Thacker","year":"2013","journal-title":"Sci Rep"},{"key":"10.1124\/pr.119.018440_bib489","doi-asserted-by":"crossref","first-page":"257","DOI":"10.4161\/jkst.22436","article-title":"The STAT3-DNMT1 connection","volume":"1","author":"Thomas","year":"2012","journal-title":"JAK-STAT"},{"key":"10.1124\/pr.119.018440_bib490","doi-asserted-by":"crossref","first-page":"17815","DOI":"10.1074\/jbc.M011405200","article-title":"Role of a JAK3-dependent biochemical signaling pathway in platelet activation and aggregation","volume":"276","author":"Tibbles","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1124\/pr.119.018440_bib491","doi-asserted-by":"crossref","first-page":"14192","DOI":"10.1074\/jbc.M111.323899","article-title":"Mechanisms of unphosphorylated STAT3 transcription factor binding to DNA","volume":"287","author":"Timofeeva","year":"2012","journal-title":"J Biol Chem"},{"key":"10.1124\/pr.119.018440_bib492","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.4049\/jimmunol.1102538","article-title":"Targeting Stat3 induces senescence in tumor cells and elicits prophylactic and therapeutic immune responses against breast cancer growth mediated by NK cells and CD4+ T cells","volume":"189","author":"Tkach","year":"2012","journal-title":"J Immunol"},{"key":"10.1124\/pr.119.018440_bib493","doi-asserted-by":"crossref","first-page":"658-e72","DOI":"10.1634\/theoncologist.2017-0325","article-title":"A first-in-human phase I study of OPB-111077, a small-molecule STAT3 and oxidative phosphorylation inhibitor, in patients with advanced cancers","volume":"23","author":"Tolcher","year":"2018","journal-title":"Oncologist"},{"key":"10.1124\/pr.119.018440_bib494","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1111\/j.1365-2443.2007.01044.x","article-title":"The dual function of hepatic SOCS3 in insulin resistance in vivo","volume":"12","author":"Torisu","year":"2007","journal-title":"Genes Cells"},{"key":"10.1124\/pr.119.018440_bib495","doi-asserted-by":"crossref","first-page":"7519","DOI":"10.1128\/MCB.19.11.7519","article-title":"Requirement for Ras\/Rac1-mediated p38 and c-Jun N-terminal kinase signaling in Stat3 transcriptional activity induced by the Src oncoprotein","volume":"19","author":"Turkson","year":"1999","journal-title":"Mol Cell Biol"},{"key":"10.1124\/pr.119.018440_bib496","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1158\/1535-7163.1533.3.12","article-title":"Inhibition of constitutive signal transducer and activator of transcription 3 activation by novel platinum complexes with potent antitumor activity","volume":"3","author":"Turkson","year":"2004","journal-title":"Mol Cancer Ther"},{"key":"10.1124\/pr.119.018440_bib497","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.ymeth.2012.02.012","article-title":"Quantitative analysis of cellular senescence phenotypes using an imaging cytometer","volume":"56","author":"Udono","year":"2012","journal-title":"Methods"},{"key":"10.1124\/pr.119.018440_bib498","doi-asserted-by":"crossref","first-page":"10422","DOI":"10.1073\/pnas.0402511101","article-title":"Central role of suppressors of cytokine signaling proteins in hepatic steatosis, insulin resistance, and the metabolic syndrome in the mouse","volume":"101","author":"Ueki","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/pr.119.018440_bib499","doi-asserted-by":"crossref","first-page":"2601","DOI":"10.1038\/onc.2012.347","article-title":"JAK\/STAT signaling in hematological malignancies","volume":"32","author":"Vainchenker","year":"2013","journal-title":"Oncogene"},{"key":"10.1124\/pr.119.018440_bib500","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.3324\/haematol.2014.119545","article-title":"A pooled analysis of overall survival in COMFORT-I and COMFORT-II, 2 randomized phase III trials of ruxolitinib for the treatment of myelofibrosis","volume":"100","author":"Vannucchi","year":"2015","journal-title":"Haematologica"},{"key":"10.1124\/pr.119.018440_bib501","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1158\/1078-0432.CCR-09-2836","article-title":"Therapeutic potential of Janus-activated kinase-2 inhibitors for the management of myelofibrosis","volume":"16","author":"Verstovsek","year":"2010","journal-title":"Clin Cancer Res"},{"key":"10.1124\/pr.119.018440_bib502","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1056\/NEJMoa1110557","article-title":"A double-blind, placebo-controlled trial of ruxolitinib for myelofibrosis","volume":"366","author":"Verstovsek","year":"2012","journal-title":"N Engl J Med"},{"key":"10.1124\/pr.119.018440_bib503","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1158\/0008-5472.CAN-07-5115","article-title":"The EGFR-STAT3 oncogenic pathway up-regulates the Eme1 endonuclease to reduce DNA damage after topoisomerase I inhibition","volume":"68","author":"Vigneron","year":"2008","journal-title":"Cancer Res"},{"key":"10.1124\/pr.119.018440_bib504","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1038\/ni.3691","article-title":"Mechanisms and consequences of Jak-STAT signaling in the immune system","volume":"18","author":"Villarino","year":"2017","journal-title":"Nat Immunol"},{"key":"10.1124\/pr.119.018440_bib505","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1242\/jcs.072520","article-title":"The role of the N-terminal domain in dimerization and nucleocytoplasmic shuttling of latent STAT3","volume":"124","author":"Vogt","year":"2011","journal-title":"J Cell Sci"},{"key":"10.1124\/pr.119.018440_bib506","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1128\/MCB.00034-14","article-title":"Signal integration and gene induction by a functionally distinct STAT3 phosphoform","volume":"34","author":"Waitkus","year":"2014","journal-title":"Mol Cell Biol"},{"key":"10.1124\/pr.119.018440_bib507","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1111\/j.1365-2443.2011.01575.x","article-title":"Phospho-Ser727 of STAT3 regulates STAT3 activity by enhancing dephosphorylation of phospho-Tyr705 largely through TC45","volume":"17","author":"Wakahara","year":"2012","journal-title":"Genes Cells"},{"key":"10.1124\/pr.119.018440_bib508","doi-asserted-by":"crossref","first-page":"3550","DOI":"10.1182\/blood-2011-12-397554","article-title":"Essential role for Stat5a\/b in myeloproliferative neoplasms induced by BCR-ABL1 and JAK2(V617F) in mice","volume":"119","author":"Walz","year":"2012","journal-title":"Blood"},{"key":"10.1124\/pr.119.018440_bib509","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/BC20090070","article-title":"Signal transducer and activator of transcription 3 (STAT3) regulates adipocyte differentiation via peroxisome-proliferator-activated receptor gamma (PPARgamma)","volume":"102","author":"Wang","year":"2009","journal-title":"Biol Cell"},{"key":"10.1124\/pr.119.018440_bib510","doi-asserted-by":"crossref","first-page":"3986","DOI":"10.4049\/jimmunol.1001101","article-title":"Histone deacetylase inhibitor LAQ824 augments inflammatory responses in macrophages through transcriptional regulation of IL-10","volume":"186","author":"Wang","year":"2011","journal-title":"J Immunol"},{"key":"10.1124\/pr.119.018440_bib511","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/2045-3701-1-14","article-title":"Tissue inhibitor of metalloproteinase 1 (TIMP-1) deficiency exacerbates carbon tetrachloride-induced liver injury and fibrosis in mice: involvement of hepatocyte STAT3 in TIMP-1 production","volume":"1","author":"Wang","year":"2011","journal-title":"Cell Biosci"},{"key":"10.1124\/pr.119.018440_bib512","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1007\/s12031-011-9702-4","article-title":"Signal transducer and activator of transcription 2 (STAT2) metabolism coupling postmitotic outgrowth to visual and sound perception network in human left cerebrum by biocomputation","volume":"47","author":"Wang","year":"2012","journal-title":"J Mol Neurosci"},{"key":"10.1124\/pr.119.018440_bib513","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S1074-7613(04)00030-5","article-title":"Transcriptional inactivation of STAT3 by PPARgamma suppresses IL-6-responsive multiple myeloma cells","volume":"20","author":"Wang","year":"2004","journal-title":"Immunity"},{"key":"10.1124\/pr.119.018440_bib514","doi-asserted-by":"crossref","first-page":"11528","DOI":"10.1074\/jbc.M413930200","article-title":"Activation of Stat3 sequence-specific DNA binding and transcription by p300\/CREB-binding protein-mediated acetylation","volume":"280","author":"Wang","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1124\/pr.119.018440_bib515","doi-asserted-by":"crossref","DOI":"10.1080\/2162402X.2018.1503913","article-title":"NEAT1 paraspeckle promotes human hepatocellular carcinoma progression by strengthening IL-6\/STAT3 signaling","volume":"7","author":"Wang","year":"2018","journal-title":"OncoImmunology"},{"key":"10.1124\/pr.119.018440_bib516","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/nm976","article-title":"Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cells","volume":"10","author":"Wang","year":"2004","journal-title":"Nat Med"},{"key":"10.1124\/pr.119.018440_bib517","first-page":"2075","article-title":"Bardoxolone methyl (CDDO-Me) as a therapeutic agent: an update on its pharmacokinetic and pharmacodynamic properties","volume":"8","author":"Wang","year":"2014","journal-title":"Drug Des Devel Ther"},{"key":"10.1124\/pr.119.018440_bib518","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/s41591-018-0221-5","article-title":"Paradoxical effects of obesity on T cell function during tumor progression and PD-1 checkpoint blockade","volume":"25","author":"Wang","year":"2019","journal-title":"Nat Med"},{"key":"10.1124\/pr.119.018440_bib519","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1038\/s41374-018-0127-3","article-title":"The STAT3 inhibitor S3I-201 suppresses fibrogenesis and angiogenesis in liver fibrosis","volume":"98","author":"Wang","year":"2018","journal-title":"Lab Invest"},{"key":"10.1124\/pr.119.018440_bib520","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1111\/j.1600-065X.2010.00949.x","article-title":"Mechanisms regulating dendritic cell specification and development","volume":"238","author":"Watowich","year":"2010","journal-title":"Immunol Rev"},{"key":"10.1124\/pr.119.018440_bib521","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1165\/rcmb.2002-0044OC","article-title":"Interleukin-11 and interleukin-6 protect cultured human endothelial cells from H2O2-induced cell death","volume":"29","author":"Waxman","year":"2003","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1124\/pr.119.018440_bib522","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1126\/science.1164551","article-title":"Function of mitochondrial Stat3 in cellular respiration","volume":"323","author":"Wegrzyn","year":"2009","journal-title":"Science"},{"key":"10.1124\/pr.119.018440_bib523","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1073\/pnas.0237137100","article-title":"STAT3 deletion during hematopoiesis causes Crohn\u2019s disease-like pathogenesis and lethality: a critical role of STAT3 in innate immunity","volume":"100","author":"Welte","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/pr.119.018440_bib524","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/0092-8674(95)90311-9","article-title":"Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation","volume":"82","author":"Wen","year":"1995","journal-title":"Cell"},{"key":"10.1124\/pr.119.018440_bib525","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/ni.3120","article-title":"NK cells link obesity-induced adipose stress to inflammation and insulin resistance","volume":"16","author":"Wensveen","year":"2015","journal-title":"Nat Immunol"},{"key":"10.1124\/pr.119.018440_bib526","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1016\/S0140-6736(06)69290-8","article-title":"Asthma: defining of the persistent adult phenotypes","volume":"368","author":"Wenzel","year":"2006","journal-title":"Lancet"},{"key":"10.1124\/pr.119.018440_bib527","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0024650","article-title":"The regulation of skeletal muscle protein turnover during the progression of cancer cachexia in the Apc(Min\/+) mouse","volume":"6","author":"White","year":"2011","journal-title":"PLoS One"},{"key":"10.1124\/pr.119.018440_bib528","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/S0301-472X(03)00045-6","article-title":"Erythropoietin-induced serine 727 phosphorylation of STAT3 in erythroid cells is mediated by a MEK-, ERK-, and MSK1-dependent pathway","volume":"31","author":"Wierenga","year":"2003","journal-title":"Exp Hematol"},{"key":"10.1124\/pr.119.018440_bib529","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1073\/pnas.86.5.1603","article-title":"Two putative protein-tyrosine kinases identified by application of the polymerase chain reaction","volume":"86","author":"Wilks","year":"1989","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/pr.119.018440_bib530","first-page":"2057","article-title":"Two novel protein-tyrosine kinases, each with a second phosphotransferase-related catalytic domain, define a new class of protein kinase","volume":"11","author":"Wilks","year":"1991","journal-title":"Mol Cell Biol"},{"key":"10.1124\/pr.119.018440_bib531","doi-asserted-by":"crossref","first-page":"289","DOI":"10.3109\/10428199909167389","article-title":"Differential substrate recognition capabilities of Janus family protein tyrosine kinases within the interleukin 2 receptor (IL2R) system: Jak3 as a potential molecular target for treatment of leukemias with a hyperactive Jak-Stat signaling machinery","volume":"32","author":"Witthuhn","year":"1999","journal-title":"Leuk Lymphoma"},{"key":"10.1124\/pr.119.018440_bib532","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1002\/eji.201040979","article-title":"PD-L1 expression on tolerogenic APCs is controlled by STAT-3","volume":"41","author":"W\u00f6lfle","year":"2011","journal-title":"Eur J Immunol"},{"key":"10.1124\/pr.119.018440_bib533","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1093\/annonc\/mdv026","article-title":"Phase I and biomarker study of OPB-51602, a novel signal transducer and activator of transcription (STAT) 3 inhibitor, in patients with refractory solid malignancies","volume":"26","author":"Wong","year":"2015","journal-title":"Ann Oncol"},{"key":"10.1124\/pr.119.018440_bib534","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1016\/j.cellsig.2012.07.001","article-title":"MiR-20a and miR-106b negatively regulate autophagy induced by leucine deprivation via suppression of ULK1 expression in C2C12 myoblasts","volume":"24","author":"Wu","year":"2012","journal-title":"Cell Signal"},{"key":"10.1124\/pr.119.018440_bib535","article-title":"Mechanisms of chronic JAK-STAT3-SOCS3 signaling in obesity","volume":"2","author":"Wunderlich","year":"2013","journal-title":"JAKSTAT"},{"key":"10.1124\/pr.119.018440_bib536","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1210\/en.2008-1241","article-title":"S-glutathionylation impairs signal transducer and activator of transcription 3 activation and signaling","volume":"150","author":"Xie","year":"2009","journal-title":"Endocrinology"},{"key":"10.1124\/pr.119.018440_bib537","doi-asserted-by":"crossref","first-page":"5819","DOI":"10.1074\/jbc.M111.295964","article-title":"Roles of STAT3 and ZEB1 proteins in E-cadherin down-regulation and human colorectal cancer epithelial-mesenchymal transition","volume":"287","author":"Xiong","year":"2012","journal-title":"J Biol Chem"},{"key":"10.1124\/pr.119.018440_bib538","article-title":"JAK-STAT in lipid metabolism of adipocytes","volume":"2","author":"Xu","year":"2013","journal-title":"JAKSTAT"},{"key":"10.1124\/pr.119.018440_bib539","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1016\/j.bbadis.2014.07.025","article-title":"Stat3 signaling activation crosslinking of TGF-\u03b21 in hepatic stellate cell exacerbates liver injury and fibrosis","volume":"1842","author":"Xu","year":"2014","journal-title":"Biochim Biophys Acta"},{"key":"10.1124\/pr.119.018440_bib540","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1756-8935-7-16","article-title":"Drosophila linker histone H1 coordinates STAT-dependent organization of heterochromatin and suppresses tumorigenesis caused by hyperactive JAK-STAT signaling","volume":"7","author":"Xu","year":"2014","journal-title":"Epigenetics Chromatin"},{"key":"10.1124\/pr.119.018440_bib541","doi-asserted-by":"crossref","first-page":"e4783","DOI":"10.1371\/journal.pone.0004783","article-title":"Chemical probes that competitively and selectively inhibit Stat3 activation","volume":"4","author":"Xu","year":"2009","journal-title":"PLoS One"},{"key":"10.1124\/pr.119.018440_bib542","article-title":"Ghrelin inhibits the differentiation of T helper 17 cells through mTOR\/STAT3 signaling pathway","volume":"10","author":"Xu","year":"2015","journal-title":"PLoS One"},{"key":"10.1124\/pr.119.018440_bib543","doi-asserted-by":"crossref","first-page":"39517","DOI":"10.1038\/srep39517","article-title":"STAT3 undergoes acetylation-dependent mitochondrial translocation to regulate pyruvate metabolism","volume":"6","author":"Xu","year":"2016","journal-title":"Sci Rep"},{"key":"10.1124\/pr.119.018440_bib544","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1038\/aps.2016.155","article-title":"A novel STAT3 inhibitor negatively modulates platelet activation and aggregation","volume":"38","author":"Xu","year":"2017","journal-title":"Acta Pharmacol Sin"},{"key":"10.1124\/pr.119.018440_bib545","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.celrep.2012.03.014","article-title":"Mouse skeletal muscle fiber-type-specific macroautophagy and muscle wasting are regulated by a Fyn\/STAT3\/Vps34 signaling pathway","volume":"1","author":"Yamada","year":"2012","journal-title":"Cell Rep"},{"key":"10.1124\/pr.119.018440_bib546","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.intimp.2013.11.029","article-title":"Remission of food allergy by the Janus kinase inhibitor ruxolitinib in mice","volume":"18","author":"Yamaki","year":"2014","journal-title":"Int Immunopharmacol"},{"key":"10.1124\/pr.119.018440_bib547","doi-asserted-by":"crossref","first-page":"4878","DOI":"10.4049\/jimmunol.164.9.4878","article-title":"IL-6 is required for the development of Th1 cell-mediated murine colitis","volume":"164","author":"Yamamoto","year":"2000","journal-title":"J Immunol"},{"key":"10.1124\/pr.119.018440_bib548","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1186\/gb-2004-5-12-253","article-title":"The Janus kinases (Jaks)","volume":"5","author":"Yamaoka","year":"2004","journal-title":"Genome Biol"},{"key":"10.1124\/pr.119.018440_bib549","doi-asserted-by":"crossref","first-page":"10967","DOI":"10.1074\/jbc.M109986200","article-title":"Transcriptional stimulation of the surfactant protein B gene by STAT3 in respiratory epithelial cells","volume":"277","author":"Yan","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1124\/pr.119.018440_bib550","doi-asserted-by":"crossref","first-page":"433","DOI":"10.18632\/oncotarget.930","article-title":"Inhibition of STAT3 with orally active JAK inhibitor, AZD1480, decreases tumor growth in neuroblastoma and pediatric sarcomas in vitro and in vivo","volume":"4","author":"Yan","year":"2013","journal-title":"Oncotarget"},{"key":"10.1124\/pr.119.018440_bib551","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1096\/fj.10-169367","article-title":"Unphosphorylated STAT and heterochromatin protect genome stability","volume":"25","author":"Yan","year":"2011","journal-title":"FASEB J"},{"key":"10.1124\/pr.119.018440_bib552","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1158\/0008-5472.939.65.3","article-title":"Novel roles of unphosphorylated STAT3 in oncogenesis and transcriptional regulation","volume":"65","author":"Yang","year":"2005","journal-title":"Cancer Res"},{"key":"10.1124\/pr.119.018440_bib553","doi-asserted-by":"crossref","first-page":"21499","DOI":"10.1073\/pnas.1016147107","article-title":"Reversible methylation of promoter-bound STAT3 by histone-modifying enzymes","volume":"107","author":"Yang","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/pr.119.018440_bib554","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1101\/gad.1553707","article-title":"Unphosphorylated STAT3 accumulates in response to IL-6 and activates transcription by binding to NFkappaB","volume":"21","author":"Yang","year":"2007","journal-title":"Genes Dev"},{"key":"10.1124\/pr.119.018440_bib555","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1210\/me.2003-0458","article-title":"Synergy between signal transducer and activator of transcription 3 and retinoic acid receptor-\u03b1 in regulation of the surfactant protein B gene in the lung","volume":"18","author":"Yang","year":"2004","journal-title":"Mol Endocrinol"},{"key":"10.1124\/pr.119.018440_bib556","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.06376","article-title":"Mitochondrial Ca2+ and membrane potential, an alternative pathway for interleukin 6 to regulate CD4 cell effector function","volume":"4","author":"Yang","year":"2015","journal-title":"eLife"},{"key":"10.1124\/pr.119.018440_bib557","doi-asserted-by":"crossref","first-page":"532","DOI":"10.7150\/ijbs.15153","article-title":"Mitochondrial Stat3, the need for design thinking","volume":"12","author":"Yang","year":"2016","journal-title":"Int J Biol Sci"},{"key":"10.1124\/pr.119.018440_bib558","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.immuni.2008.05.007","article-title":"Molecular antagonism and plasticity of regulatory and inflammatory T cell programs","volume":"29","author":"Yang","year":"2008","journal-title":"Immunity"},{"key":"10.1124\/pr.119.018440_bib559","doi-asserted-by":"crossref","first-page":"9358","DOI":"10.1074\/jbc.C600321200","article-title":"STAT3 regulates cytokine-mediated generation of inflammatory helper T cells","volume":"282","author":"Yang","year":"2007","journal-title":"J Biol Chem"},{"key":"10.1124\/pr.119.018440_bib560","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.immuni.2007.11.016","article-title":"T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR \u03b1 and ROR \u03b3","volume":"28","author":"Yang","year":"2008","journal-title":"Immunity"},{"key":"10.1124\/pr.119.018440_bib561","article-title":"Regulation of insulin and leptin signaling by muscle suppressor of cytokine signaling 3 (SOCS3)","volume":"7","author":"Yang","year":"2012","journal-title":"PLoS One"},{"key":"10.1124\/pr.119.018440_bib562","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1038\/ni938","article-title":"IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages","volume":"4","author":"Yasukawa","year":"2003","journal-title":"Nat Immunol"},{"key":"10.1124\/pr.119.018440_bib563","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0960-9822(99)00268-7","article-title":"Serine phosphorylation and maximal activation of STAT3 during CNTF signaling is mediated by the rapamycin target mTOR","volume":"10","author":"Yokogami","year":"2000","journal-title":"Curr Biol"},{"key":"10.1124\/pr.119.018440_bib564","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1186\/ar4069","article-title":"An update on the hyper-IgE syndromes","volume":"14","author":"Yong","year":"2012","journal-title":"Arthritis Res Ther"},{"key":"10.1124\/pr.119.018440_bib565","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1038\/nri2093","article-title":"SOCS proteins, cytokine signalling and immune regulation","volume":"7","author":"Yoshimura","year":"2007","journal-title":"Nat Rev Immunol"},{"key":"10.1124\/pr.119.018440_bib566","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1080\/15548627.2015.1017192","article-title":"The role of STAT3 in autophagy","volume":"11","author":"You","year":"2015","journal-title":"Autophagy"},{"key":"10.1124\/pr.119.018440_bib567","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/nri1995","article-title":"Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment","volume":"7","author":"Yu","year":"2007","journal-title":"Nat Rev Immunol"},{"key":"10.1124\/pr.119.018440_bib568","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1038\/nrc3818","article-title":"Revisiting STAT3 signalling in cancer: new and unexpected biological functions","volume":"14","author":"Yu","year":"2014","journal-title":"Nat Rev Cancer"},{"key":"10.1124\/pr.119.018440_bib569","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0143964","article-title":"Piperlongumine blocks JAK2-STAT3 to inhibit collagen-induced platelet reactivity independent of reactive oxygen species [published correction appears in PLoS One (2016) 11:e0146626]","volume":"10","author":"Yuan","year":"2015","journal-title":"PLoS One"},{"key":"10.1124\/pr.119.018440_bib570","article-title":"Correction: piperlongumine blocks JAK2-STAT3 to inhibit collagen-induced platelet reactivity independent of reactive oxygen species","volume":"11","author":"Yuan","year":"2016","journal-title":"PLoS One"},{"key":"10.1124\/pr.119.018440_bib571","doi-asserted-by":"crossref","first-page":"17663","DOI":"10.1038\/srep17663","article-title":"Multiple regulation pathways and pivotal biological functions of STAT3 in cancer","volume":"5","author":"Yuan","year":"2015","journal-title":"Sci Rep"},{"key":"10.1124\/pr.119.018440_bib572","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1126\/science.1105166","article-title":"Stat3 dimerization regulated by reversible acetylation of a single lysine residue","volume":"307","author":"Yuan","year":"2005","journal-title":"Science"},{"key":"10.1124\/pr.119.018440_bib573","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1093\/cvr\/cvp285","article-title":"Role of nuclear unphosphorylated STAT3 in angiotensin II type 1 receptor-induced cardiac hypertrophy","volume":"85","author":"Yue","year":"2010","journal-title":"Cardiovasc Res"},{"key":"10.1124\/pr.119.018440_bib574","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1002\/jcp.25575","article-title":"Endothelial STAT3 activation increases vascular leakage through downregulating tight junction proteins: implications for diabetic retinopathy","volume":"232","author":"Yun","year":"2017","journal-title":"J Cell Physiol"},{"key":"10.1124\/pr.119.018440_bib575","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.canlet.2012.04.003","article-title":"DNA damage induces the IL-6\/STAT3 signaling pathway, which has anti-senescence and growth-promoting functions in human tumors","volume":"323","author":"Yun","year":"2012","journal-title":"Cancer Lett"},{"key":"10.1124\/pr.119.018440_bib576","doi-asserted-by":"crossref","first-page":"660","DOI":"10.3324\/haematol.2015.141283","article-title":"Bone marrow fibrosis in myelofibrosis: pathogenesis, prognosis and targeted strategies","volume":"101","author":"Zahr","year":"2016","journal-title":"Haematologica"},{"key":"10.1124\/pr.119.018440_bib577","doi-asserted-by":"crossref","first-page":"11228","DOI":"10.18632\/oncotarget.14495","article-title":"IL-6\/STAT3\/TWIST inhibition reverses ionizing radiation-induced EMT and radioresistance in esophageal squamous carcinoma","volume":"8","author":"Zang","year":"2017","journal-title":"Oncotarget"},{"key":"10.1124\/pr.119.018440_bib578","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0043313","article-title":"Acyloxy nitroso compounds inhibit LIF signaling in endothelial cells and cardiac myocytes: evidence that STAT3 signaling is redox-sensitive","volume":"7","author":"Zgheib","year":"2012","journal-title":"PLoS One"},{"key":"10.1124\/pr.119.018440_bib579","doi-asserted-by":"crossref","first-page":"5798","DOI":"10.1038\/ncomms6798","article-title":"STAT3 restrains RANK- and TLR4-mediated signalling by suppressing expression of the E2 ubiquitin-conjugating enzyme Ubc13","volume":"5","author":"Zhang","year":"2014","journal-title":"Nat Commun"},{"key":"10.1124\/pr.119.018440_bib580","doi-asserted-by":"crossref","first-page":"2462","DOI":"10.1182\/blood-2009-12-259630","article-title":"STAT3 controls myeloid progenitor growth during emergency granulopoiesis","volume":"116","author":"Zhang","year":"2010","journal-title":"Blood"},{"key":"10.1124\/pr.119.018440_bib581","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1002\/jcb.22936","article-title":"JAK2\/STAT3 pathway is involved in the early stage of adipogenesis through regulating C\/EBP\u03b2 transcription","volume":"112","author":"Zhang","year":"2011","journal-title":"J Cell Biochem"},{"key":"10.1124\/pr.119.018440_bib582","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.cmet.2013.07.012","article-title":"Stat3 activation links a C\/EBP\u03b4 to myostatin pathway to stimulate loss of muscle mass","volume":"18","author":"Zhang","year":"2013","journal-title":"Cell Metab"},{"key":"10.1124\/pr.119.018440_bib583","doi-asserted-by":"crossref","first-page":"eaau1167","DOI":"10.1126\/scitranslmed.aau1167","article-title":"Metabolic reprogramming toward oxidative phosphorylation identifies a therapeutic target for mantle cell lymphoma","volume":"11","author":"Zhang","year":"2019","journal-title":"Sci Transl Med"},{"key":"10.1124\/pr.119.018440_bib584","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/s00335-018-9767-2","article-title":"Human hyper-IgE syndrome: singular or plural?","volume":"29","author":"Zhang","year":"2018","journal-title":"Mamm Genome"},{"key":"10.1124\/pr.119.018440_bib585","doi-asserted-by":"crossref","first-page":"7132","DOI":"10.1128\/MCB.20.19.7132-7139.2000","article-title":"The coiled-coil domain of Stat3 is essential for its SH2 domain-mediated receptor binding and subsequent activation induced by epidermal growth factor and interleukin-6","volume":"20","author":"Zhang","year":"2000","journal-title":"Mol Cell Biol"},{"key":"10.1124\/pr.119.018440_bib586","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1161\/CIRCULATIONAHA.115.017472","article-title":"Critical roles of STAT3 in \u03b2-adrenergic functions in the heart","volume":"133","author":"Zhang","year":"2016","journal-title":"Circulation"},{"key":"10.1124\/pr.119.018440_bib587","doi-asserted-by":"crossref","first-page":"623","DOI":"10.3892\/ijmm.2013.1431","article-title":"Inhibitory effects of STAT3 decoy oligodeoxynucleotides on human epithelial ovarian cancer cell growth in vivo","volume":"32","author":"Zhang","year":"2013","journal-title":"Int J Mol Med"},{"key":"10.1124\/pr.119.018440_bib588","doi-asserted-by":"crossref","first-page":"8714","DOI":"10.1074\/jbc.M408092200","article-title":"Carbon monoxide differentially modulates STAT1 and STAT3 and inhibits apoptosis via a phosphatidylinositol 3-kinase\/Akt and p38 kinase-dependent STAT3 pathway during anoxia-reoxygenation injury","volume":"280","author":"Zhang","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1124\/pr.119.018440_bib589","doi-asserted-by":"crossref","first-page":"2156","DOI":"10.1096\/fj.06-5668fje","article-title":"Endothelial STAT3 is essential for the protective effects of HO-1 in oxidant-induced lung injury","volume":"20","author":"Zhang","year":"2006","journal-title":"FASEB J"},{"key":"10.1124\/pr.119.018440_bib590","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1074\/jbc.M208419200","article-title":"Carbon monoxide inhibition of apoptosis during ischemia-reperfusion lung injury is dependent on the p38 mitogen-activated protein kinase pathway and involves caspase 3","volume":"278","author":"Zhang","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1124\/pr.119.018440_bib591","doi-asserted-by":"crossref","first-page":"1922","DOI":"10.1158\/0008-5472.CAN-12-3175","article-title":"A novel inhibitor of STAT3 homodimerization selectively suppresses STAT3 activity and malignant transformation","volume":"73","author":"Zhang","year":"2013","journal-title":"Cancer Res"},{"key":"10.1124\/pr.119.018440_bib592","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1136\/annrheumdis-2013-204256","article-title":"Inhibition of casein kinase II reduces TGF\u03b2 induced fibroblast activation and ameliorates experimental fibrosis","volume":"74","author":"Zhang","year":"2015","journal-title":"Ann Rheum Dis"},{"key":"10.1124\/pr.119.018440_bib593","doi-asserted-by":"crossref","first-page":"42534","DOI":"10.1074\/jbc.M106044200","article-title":"MSK1 and JNKs mediate phosphorylation of STAT3 in UVA-irradiated mouse epidermal JB6 cells","volume":"276","author":"Zhang","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1124\/pr.119.018440_bib594","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.tips.2015.10.001","article-title":"Feedback activation of STAT3 as a cancer drug-resistance mechanism","volume":"37","author":"Zhao","year":"2016","journal-title":"Trends Pharmacol Sci"},{"key":"10.1124\/pr.119.018440_bib595","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0006-291X(02)02838-3","article-title":"Expression of leptin receptors and response to leptin stimulation of human natural killer cell lines","volume":"300","author":"Zhao","year":"2003","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1124\/pr.119.018440_bib596","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1038\/ni1488","article-title":"IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways","volume":"8","author":"Zhou","year":"2007","journal-title":"Nat Immunol"},{"key":"10.1124\/pr.119.018440_bib597","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1161\/CIRCULATIONAHA.112.132126","article-title":"Signal transducer and activator of transcription 3 (STAT3) regulates collagen-induced platelet aggregation independently of its transcription factor activity","volume":"127","author":"Zhou","year":"2013","journal-title":"Circulation"},{"key":"10.1124\/pr.119.018440_bib598","doi-asserted-by":"crossref","first-page":"36","DOI":"10.3389\/fcvm.2015.00036","article-title":"Pivotal importance of STAT3 in protecting the heart from acute and chronic stress: new advancement and unresolved issues","volume":"2","author":"Zouein","year":"2015","journal-title":"Front Cardiovasc Med"},{"key":"10.1124\/pr.119.018440_bib599","doi-asserted-by":"crossref","DOI":"10.4161\/jkst.24352","article-title":"Dancing rhinos in stilettos: the amazing saga of the genomic and nongenomic actions of STAT3 in the heart","volume":"2","author":"Zouein","year":"2013","journal-title":"JAK-STAT"},{"key":"10.1124\/pr.119.018440_bib600","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1684\/ecn.2013.0335","article-title":"LIF and the heart: just another brick in the wall?","volume":"24","author":"Zouein","year":"2013","journal-title":"Eur Cytokine Netw"}],"updated-by":[{"DOI":"10.1124\/pr.119.018440err","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000}}],"container-title":["Pharmacological Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031699724009608?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031699724009608?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/pr.119.018440","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T12:50:36Z","timestamp":1740747036000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0031699724009608"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":602,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["S0031699724009608"],"URL":"https:\/\/doi.org\/10.1124\/pr.119.018440","relation":{},"ISSN":["0031-6997"],"issn-type":[{"value":"0031-6997","type":"print"}],"subject":[],"published":{"date-parts":[[2020,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeting Janus Kinases and Signal Transducer and Activator of Transcription 3 To Treat Inflammation, Fibrosis, and Cancer: Rationale, Progress, and Caution","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/pr.119.018440","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 by The Author(s)","name":"copyright","label":"Copyright"}]}}