{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T22:56:27Z","timestamp":1767912987875,"version":"3.49.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["jpet.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"published-print":{"date-parts":[[2002,1]]},"DOI":"10.1124\/jpet.300.1.18","type":"journal-article","created":{"date-parts":[[2003,1,10]],"date-time":"2003-01-10T18:30:34Z","timestamp":1042223434000},"page":"18-25","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":41,"title":["O2-Vinyl 1-(Pyrrolidin-1-yl)diazen-1-ium-1,2-diolate Protection Againstd-Galactosamine\/Endotoxin-Induced Hepatotoxicity in Mice: Genomic Analysis Using Microarrays"],"prefix":"10.1016","volume":"300","author":[{"given":"Jie","family":"Liu","sequence":"first","affiliation":[]},{"given":"Joseph E.","family":"Saavedra","sequence":"additional","affiliation":[]},{"given":"Tong","family":"Lu","sequence":"additional","affiliation":[]},{"given":"Jian-Guo","family":"Song","sequence":"additional","affiliation":[]},{"given":"James","family":"Clark","sequence":"additional","affiliation":[]},{"given":"Michael P.","family":"Waalkes","sequence":"additional","affiliation":[]},{"given":"Larry K.","family":"Keefer","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1124\/jpet.300.1.18_bib1","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1006\/jsre.1999.5621","article-title":"Nitric oxide ameliorates actinomycin D\/endotoxin-induced apoptotic liver failure in mice.","volume":"85","author":"Akahori","year":"1999","journal-title":"J Surg Res"},{"key":"10.1124\/jpet.300.1.18_bib2","first-page":"179","article-title":"Possible roles of nitric oxide and redox cell signaling in metal-induced toxicity and carcinogenesis: a review.","volume":"19","author":"Buzard","year":"2000","journal-title":"J Environ Pathol Toxicol Oncl"},{"key":"10.1124\/jpet.300.1.18_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj3260001","article-title":"Caspases: the executioners of apoptosis.","volume":"326","author":"Cohen","year":"1997","journal-title":"Biochem J"},{"key":"10.1124\/jpet.300.1.18_bib4","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0361-9230(00)00262-8","article-title":"Nitric oxide: an inhibitor of NF-\u03baB\/Rel system in glial cells.","volume":"52","author":"Colasanti","year":"2000","journal-title":"Brain Res Bull"},{"issue":"Suppl","key":"10.1124\/jpet.300.1.18_bib5","first-page":"230","article-title":"Decrease in hepatic nitric oxide production contributes to hepatic veno-occlusive disease.","volume":"31","author":"Deleve","year":"1999","journal-title":"Hepatology"},{"key":"10.1124\/jpet.300.1.18_bib6","doi-asserted-by":"crossref","first-page":"5480","DOI":"10.1073\/pnas.070062397","article-title":"Nitric oxide inhibits tumor necrosis factor-alpha-induced apoptosis by reducing the generation of ceramide.","volume":"97","author":"De Nadai","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/jpet.300.1.18_bib7","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1084\/jem.185.4.601","article-title":"Suppression of apoptosis by nitric oxide via inhibition of interleukin-1beta-converting enzyme (ICE)-like and cysteine protease protein (CPP)-32-like proteases.","volume":"185","author":"Dimmeler","year":"1997","journal-title":"J Exp Med"},{"key":"10.1124\/jpet.300.1.18_bib8","first-page":"415","article-title":"Nitric oxide inhibits APO-1\/Fas-mediated cell death.","volume":"9","author":"Dimmeler","year":"1998","journal-title":"Cell Growth Differ"},{"key":"10.1124\/jpet.300.1.18_bib9","doi-asserted-by":"crossref","first-page":"5245","DOI":"10.4049\/jimmunol.165.9.5245","article-title":"IL-1 beta converting enzyme is a target for nitric oxide-releasing aspirin: new insights in the antiinflammatory mechanism of nitric oxide-releasing nonsteroidal antiinflammatory drugs.","volume":"165","author":"Fiorucci","year":"2000","journal-title":"J Immunol"},{"key":"10.1124\/jpet.300.1.18_bib10","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1016\/S0891-5849(00)00251-3","article-title":"Diazeniumdiolates pro- and antioxidant applications of the \u201cNONOates\u201d","volume":"28","author":"Fitzhugh","year":"2000","journal-title":"Free Radic Biol Med"},{"key":"10.1124\/jpet.300.1.18_bib11","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1002\/hep.510270316","article-title":"Role of nitric oxide in acetaminophen-induced hepatotoxicity in the rat.","volume":"27","author":"Gardner","year":"1998","journal-title":"Hepatology"},{"key":"10.1124\/jpet.300.1.18_bib12","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/0016-5085(95)90282-1","article-title":"Tumor necrosis factor-induced hepatic DNA fragmentation as an early marker of T cell-dependent liver injury in mice.","volume":"109","author":"Gantner","year":"1995","journal-title":"Gastroenterology"},{"key":"10.1124\/jpet.300.1.18_bib13","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0898-6568(00)00149-2","article-title":"LPS induction of gene expression in human monocytes.","volume":"13","author":"Guha","year":"2001","journal-title":"Cell Signal"},{"key":"10.1124\/jpet.300.1.18_bib14","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1002\/hep.510290222","article-title":"Glutathione peroxidase-deficient mice are more susceptible to neutrophil-mediated hepatic parenchymal cell injury during endotoxemia: importance of an intracellular oxidant stress.","volume":"29","author":"Jaeschke","year":"1999","journal-title":"Hepatology"},{"key":"10.1124\/jpet.300.1.18_bib15","first-page":"27","article-title":"Design of nitric oxide-releasing drugs.","volume":"7","author":"Keefer","year":"2000","journal-title":"Pharmaceutical News"},{"key":"10.1124\/jpet.300.1.18_bib16","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1002\/hep.510340230","article-title":"Give me iNOS or give me death.","volume":"34","author":"Kim","year":"2001","journal-title":"Hepatology"},{"key":"10.1124\/jpet.300.1.18_bib17","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1074\/jbc.272.2.1402","article-title":"Nitric oxide protects cultured rat hepatocytes from tumor necrosis factor-alpha-induced apoptosis by inducing heat shock protein 70 expression.","volume":"272","author":"Kim","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1124\/jpet.300.1.18_bib18","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1053\/jhep.2000.18291","article-title":"Nitric oxide prevents tumor necrosis factor \u03b1-induced rat hepatocyte apoptosis by the interruption of mitochondrial apoptotic signaling through S-nitrosylation of caspase-8.","volume":"32","author":"Kim","year":"2000","journal-title":"Hepatology"},{"key":"10.1124\/jpet.300.1.18_bib19","doi-asserted-by":"crossref","first-page":"31138","DOI":"10.1074\/jbc.272.49.31138","article-title":"Nitric oxide inhibits apoptosis by preventing increases in caspase-3-like activity via two distinct mechanisms.","volume":"272","author":"Kim","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1124\/jpet.300.1.18_bib20","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1006\/niox.1997.0118","article-title":"Nitric oxide: cytotoxicity versus cytoprotection\u2013how, why, when, and where?","volume":"1","author":"Kr\u00f6ncke","year":"1997","journal-title":"Nitric Oxide"},{"key":"10.1124\/jpet.300.1.18_bib21","doi-asserted-by":"crossref","first-page":"3247","DOI":"10.1038\/sj.onc.1202569","article-title":"The inhibitors of apoptosis (IAPs) and their emerging role in cancer.","volume":"17","author":"LaCasse","year":"1998","journal-title":"Oncogene"},{"key":"10.1124\/jpet.300.1.18_bib22","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1038\/sj.cdd.4400579","article-title":"The anti-apoptotic actions of nitric oxide in hepatocytes.","volume":"6","author":"Li","year":"1999","journal-title":"Cell Death Differ"},{"key":"10.1124\/jpet.300.1.18_bib23","doi-asserted-by":"crossref","first-page":"2236","DOI":"10.1093\/nar\/24.12.2236","article-title":"Inhibition of NF-kappaB DNA binding by nitric oxide.","volume":"24","author":"Matthews","year":"1996","journal-title":"Nucleic Acids Res"},{"key":"10.1124\/jpet.300.1.18_bib24","first-page":"R1202","article-title":"LPS-induced liver injury in D-galactosamine-sensitized mice requires secreted TNF-alpha and the TNF-p55 receptor.","volume":"278","author":"Nowak","year":"2000","journal-title":"Am J Physiol"},{"key":"10.1124\/jpet.300.1.18_bib25","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1006\/niox.1997.0136","article-title":"Differential effects of nonselective nitric oxide synthase (NOS) and selective inducible NOS inhibition on hepatic necrosis, apoptosis, ICAM-1 expression, and neutrophil accumulation during endotoxemia.","volume":"1","author":"Ou","year":"1997","journal-title":"Nitric Oxide"},{"key":"10.1124\/jpet.300.1.18_bib26","doi-asserted-by":"crossref","first-page":"14382","DOI":"10.1073\/pnas.97.26.14382","article-title":"Nitric oxide negatively regulates c-Jun N -terminal kinase\/stress-activated protein kinase by means of S-nitrosylation.","volume":"97","author":"Park","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/jpet.300.1.18_bib27","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1093\/toxsci\/50.1.98","article-title":"Enhanced transcription factor DNA binding and gene expression induced by arsenite or arsenate in renal slices.","volume":"50","author":"Parrish","year":"1999","journal-title":"Toxicol Sci"},{"key":"10.1124\/jpet.300.1.18_bib28","first-page":"1547","article-title":"Nitric oxide donor prevents hepatic and systemic perfusion decrease induced by endotoxin in anesthetized rabbits.","volume":"22","author":"Pastor","year":"1995","journal-title":"Hepatology"},{"key":"10.1124\/jpet.300.1.18_bib29","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1097\/00007890-200101270-00004","article-title":"V-PYRRO\/NO an hepato-selective nitric oxide donor improves porcine liver hemodynamics and function after ischemia reperfusion.","volume":"71","author":"Ricciardi","year":"2001","journal-title":"Transplantation"},{"key":"10.1124\/jpet.300.1.18_bib30","doi-asserted-by":"crossref","first-page":"6823","DOI":"10.1074\/jbc.274.11.6823","article-title":"Nitric oxide inhibits caspase-3 by S-nitrosation in vivo.","volume":"274","author":"Rossig","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1124\/jpet.300.1.18_bib31","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1021\/jm9701031","article-title":"Targeting nitric oxide (NO) delivery in vivo. Design of a liver-selective NO donor prodrug that blocks tumor necrosis factor-alpha-induced apoptosis and toxicity in the liver.","volume":"40","author":"Saavedra","year":"1997","journal-title":"J Med Chem"},{"key":"10.1124\/jpet.300.1.18_bib32","doi-asserted-by":"crossref","unstructured":"Stinson SF, House T, Bramhall C, Saavedra JE, Keefer LK, and Nims RW (2001) Plasma pharmacokinetics of a liver-selective nitric oxide-donating diazeniumdionate in the male C57BL\/6 mouse. Xenobiotica, in press.","DOI":"10.1080\/00498250110102665"},{"key":"10.1124\/jpet.300.1.18_bib33","first-page":"1364","article-title":"Nitric oxide synthase inhibitor increases hepatic injury with formation of oxidative DNA damage and microcirculatory disturbance in endotoxemic rats.","volume":"47","author":"Takemura","year":"2000","journal-title":"Hepatogastroenterology"},{"key":"10.1124\/jpet.300.1.18_bib34","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1097\/00024382-199510000-00009","article-title":"Inhibition of nitric oxide synthesis aggravates reperfusion injury after hepatic ischemia and endotoxemia.","volume":"4","author":"Wang","year":"1995","journal-title":"Shock"},{"key":"10.1124\/jpet.300.1.18_bib35","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1089\/152308601300185179","article-title":"Mechanisms of the antioxidant effects of nitric oxide.","volume":"3","author":"Wink","year":"2001","journal-title":"Antioxid Redox Signal"},{"key":"10.1124\/jpet.300.1.18_bib36","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1053\/gast.1997.v113.pm9322528","article-title":"Differential effects of nitric oxide synthase inhibitors on endotoxin-induced liver damage in rats.","volume":"113","author":"Vos","year":"1997","journal-title":"Gastroenterology"}],"container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524354126?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524354126?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/jpet.300.1.18","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T23:11:29Z","timestamp":1740006689000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022356524354126"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,1]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2002,1]]}},"alternative-id":["S0022356524354126"],"URL":"https:\/\/doi.org\/10.1124\/jpet.300.1.18","relation":{},"ISSN":["0022-3565"],"issn-type":[{"value":"0022-3565","type":"print"}],"subject":[],"published":{"date-parts":[[2002,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"O2-Vinyl 1-(Pyrrolidin-1-yl)diazen-1-ium-1,2-diolate Protection Againstd-Galactosamine\/Endotoxin-Induced Hepatotoxicity in Mice: Genomic Analysis Using Microarrays","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pharmacology and Experimental Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/jpet.300.1.18","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"U.S. Government","name":"copyright","label":"Copyright"}]}}