{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T10:30:31Z","timestamp":1773657031457,"version":"3.50.1"},"reference-count":28,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[1997,10,1]],"date-time":"1997-10-01T00:00:00Z","timestamp":875664000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[1997,10,1]],"date-time":"1997-10-01T00:00:00Z","timestamp":875664000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["molpharm.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Pharmacology"],"published-print":{"date-parts":[[1997,10]]},"DOI":"10.1124\/mol.52.4.714","type":"journal-article","created":{"date-parts":[[2018,1,8]],"date-time":"2018-01-08T20:28:07Z","timestamp":1515443287000},"page":"714-724","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":49,"title":["The Role of \u03b11 and \u03b16 Subtype Amino-Terminal Domains in Allosteric Regulation of \u03b3-Aminobutyric Acida Receptors"],"prefix":"10.1016","volume":"52","author":[{"given":"Janet L.","family":"Fisher","sequence":"first","affiliation":[]},{"given":"Jie","family":"Zhang","sequence":"additional","affiliation":[]},{"given":"Robert L.","family":"Macdonald","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1124\/mol.52.4.714_bib1","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0031-6997(25)06840-1","article-title":"Structure and pharmacology of \u03b3-aminobutyric acidA receptor subtypes.","volume":"47","author":"Sieghart","year":"1995","journal-title":"Pharmacol. Rev."},{"key":"10.1124\/mol.52.4.714_bib2","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1038\/346648a0","article-title":"Cerebellar GABAA receptor selective for a behavioural alcohol antagonist.","volume":"346","author":"L\u00fcddens","year":"1990","journal-title":"Nature (Lond.)"},{"key":"10.1124\/mol.52.4.714_bib3","series-title":"Ligand- and Voltage-Gated Ion Channels","first-page":"265","article-title":"GABAA receptors","author":"Tyndale","year":"1995"},{"key":"10.1124\/mol.52.4.714_bib4","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S0026-895X(25)08539-6","article-title":"Selective antagonist for the cerebellar granule cell-specific \u03b3-aminobutyric acid type A receptor.","volume":"47","author":"Korpi","year":"1997","journal-title":"Mol. Pharmacol."},{"key":"10.1124\/mol.52.4.714_bib5","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/S0026-895X(25)08745-0","article-title":"Properties of putative cerebellar \u03b3-aminobutyric acidA receptor isoforms.","volume":"49","author":"Saxena","year":"1996","journal-title":"Mol. Pharmacol."},{"key":"10.1124\/mol.52.4.714_bib6","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1124\/mol.51.2.328","article-title":"Contrasting actions of lanthanum on different recombinant \u03b3-aminobutyric acid receptor isoforms expressed in L929 fibroblasts.","volume":"51","author":"Saxena","year":"1997","journal-title":"Mol. Pharmacol."},{"key":"10.1124\/mol.52.4.714_bib7","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1111\/j.1476-5381.1996.tb15221.x","article-title":"Barbiturate interactions at the human GABAA receptor: dependence on receptor subunit combination.","volume":"117","author":"Thompson","year":"1996","journal-title":"Br. J. Pharmacol."},{"key":"10.1124\/mol.52.4.714_bib8","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1016\/S0021-9258(18)45961-3","article-title":"A single histidine in GABAA receptors is essential for benzodiazepine agonist binding.","volume":"267","author":"Wieland","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1124\/mol.52.4.714_bib9","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/sj.bjp.0700931","article-title":"Alterations of the benzodiazepine site of rat \u03b16\u03b22\u03b32-GABAA receptor by replacement of several divergent amino-terminal regions with the \u03b11 counterparts.","volume":"120","author":"Im","year":"1997","journal-title":"Br. J. Pharmacol."},{"key":"10.1124\/mol.52.4.714_bib10","doi-asserted-by":"crossref","first-page":"7684","DOI":"10.1523\/JNEUROSCI.15-11-07684.1995","article-title":"A single histidine residue is essential for zinc inhibition of GABA \u03c11 receptors.","volume":"15","author":"Wang","year":"1995","journal-title":"J. Neurosci."},{"key":"10.1124\/mol.52.4.714_bib11","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/366565a0","article-title":"GABAA receptor needs two homologous domains of the \u03b2-subunit for activation by GABA but not by pentobarbital.","volume":"366","author":"Amin","year":"1993","journal-title":"Nature (Lond.)"},{"key":"10.1124\/mol.52.4.714_bib12","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1210\/mend-5-7-921","article-title":"Regulation of the human enkephalin promoter by two isoforms of the catalytic subunit of cyclic adenosine 3\u2032,5\u2032-monophosphate-dependent protein kinase.","volume":"5","author":"Huggenvik","year":"1991","journal-title":"Mol. Endocrinol."},{"key":"10.1124\/mol.52.4.714_bib13","first-page":"2745","article-title":"High-efficiency transformation of mammalian cells by plasmid DNA.","volume":"7","author":"Chen","year":"1987","journal-title":"Mol. Cell. Biol."},{"key":"10.1124\/mol.52.4.714_bib14","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1523\/JNEUROSCI.13-04-01418.1993","article-title":"Assembly of GABAA receptor subunits: analysis of transient single-cell expression utilizing a fluorescent substrate\/marker gene technique.","volume":"13","author":"Angelotti","year":"1993","journal-title":"J. Neurosci."},{"key":"10.1124\/mol.52.4.714_bib15","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0028-3908(96)00150-5","article-title":"Expression of functional GABAA receptors in transfected L929 cells isolated by immunomagnetic bead separation.","volume":"36","author":"Greenfield","year":"1997","journal-title":"Neuropharmacology"},{"key":"10.1124\/mol.52.4.714_bib16","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1007\/s004240050238","article-title":"Whole cell and single channel \u03b11\u03b21\u03b32s GABAA receptor currents elicited by a \u2018multipuffer\u2019 drug application device.","volume":"432","author":"Greenfield","year":"1996","journal-title":"Pflueg. Arch. Eur. J. Physiol."},{"key":"10.1124\/mol.52.4.714_bib17","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/S0026-895X(25)09339-3","article-title":"Functional characterization of human \u03b3-aminobutyric acidA receptors containing the \u03b14 subunit.","volume":"50","author":"Wafford","year":"1996","journal-title":"Mol. Pharmacol."},{"key":"10.1124\/mol.52.4.714_bib18","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/0896-6273(90)90337-F","article-title":"Functional and molecular distinction between recombinant rat GABAA receptor subtypes by Zn2+.","volume":"5","author":"Draguhn","year":"1990","journal-title":"Neuron"},{"key":"10.1124\/mol.52.4.714_bib19","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0026-895X(25)09121-7","article-title":"Properties of recombinant \u03b3-aminobutyric acidA receptor isoforms containing the \u03b15 subunit subtype.","volume":"50","author":"Burgard","year":"1996","journal-title":"Mol. Pharmacol."},{"key":"10.1124\/mol.52.4.714_bib20","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/S0165-6147(00)89009-4","article-title":"Functional domains of GABAA receptors.","volume":"16","author":"Smith","year":"1995","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1124\/mol.52.4.714_bib21","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1126\/science.205953","article-title":"Different action of anticonvulsant and anesthetic barbiturates revealed by use of cultured mammalian neurons.","volume":"200","author":"Macdonald","year":"1978","journal-title":"Science (Washington D. C.)"},{"key":"10.1124\/mol.52.4.714_bib22","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/0006-8993(80)90325-X","article-title":"The effects of pentobarbital and related compounds on frog motoneurons.","volume":"191","author":"Nicoll","year":"1980","journal-title":"Brain Res."},{"key":"10.1124\/mol.52.4.714_bib23","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S0026-895X(25)10881-X","article-title":"Noncompetitive inhibition of \u03b3-aminobutyric acid channels by Zinc.","volume":"39","author":"Legendre","year":"1990","journal-title":"Mol. Pharmacol."},{"key":"10.1124\/mol.52.4.714_bib24","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1113\/jphysiol.1992.sp019020","article-title":"novel modulatory binding site for zinc on the GABAA receptor complex in cultured rat neurones.","volume":"447","author":"Smart","year":"1992","journal-title":"J. Physiol. (Lond.)"},{"key":"10.1124\/mol.52.4.714_bib25","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1016\/S0026-895X(25)13351-8","article-title":"Role of the \u03b2 subunit in determining the pharmacology of human \u03b3-aminobutyric acid type A receptors.","volume":"44","author":"Hadingham","year":"1993","journal-title":"Mol. Pharmacol."},{"key":"10.1124\/mol.52.4.714_bib26","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1038\/338582a0","article-title":"Importance of a novel GABAA receptor subunit for benzodiazapine pharmacology.","volume":"338","author":"Pritchett","year":"1989","journal-title":"Nature (Lond.)"},{"key":"10.1124\/mol.52.4.714_bib27","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/0304-3940(92)90741-O","article-title":"Selective potentiation of GABA-mediated Cl\u2212 current by lanthanum ion in subtypes of cloned GABAA receptors.","volume":"144","author":"Im","year":"1992","journal-title":"Neurosci. Lett."},{"key":"10.1124\/mol.52.4.714_bib28","doi-asserted-by":"crossref","first-page":"32768","DOI":"10.1016\/S0021-9258(20)30057-0","article-title":"A single amino acid of the human \u03b3-aminobutyric acid type A receptor \u03b32 subunit determines benzodiazepine efficacy.","volume":"269","author":"Mihic","year":"1994","journal-title":"J. Biol. Chem."}],"container-title":["Molecular Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026895X24133767?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026895X24133767?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/mol.52.4.714","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T10:07:06Z","timestamp":1740046026000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0026895X24133767"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,10]]},"references-count":28,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1997,10]]}},"alternative-id":["S0026895X24133767"],"URL":"https:\/\/doi.org\/10.1124\/mol.52.4.714","relation":{},"ISSN":["0026-895X"],"issn-type":[{"value":"0026-895X","type":"print"}],"subject":[],"published":{"date-parts":[[1997,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Role of \u03b11 and \u03b16 Subtype Amino-Terminal Domains in Allosteric Regulation of \u03b3-Aminobutyric Acida Receptors","name":"articletitle","label":"Article Title"},{"value":"Molecular Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/mol.52.4.714","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 1997 The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}