{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T16:21:33Z","timestamp":1778948493925,"version":"3.51.4"},"reference-count":35,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5778","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2006,6,2]]},"abstract":"<jats:p>\n                    The human intestinal microbiota is composed of 10\n                    <jats:sup>13<\/jats:sup>\n                    to 10\n                    <jats:sup>14<\/jats:sup>\n                    microorganisms whose collective genome (\u201cmicrobiome\u201d) contains at least 100 times as many genes as our own genome. We analyzed \u223c78 million base pairs of unique DNA sequence and 2062 polymerase chain reaction\u2013amplified 16\n                    <jats:italic>S<\/jats:italic>\n                    ribosomal DNA sequences obtained from the fecal DNAs of two healthy adults. Using metabolic function analyses of identified genes, we compared our human genome with the average content of previously sequenced microbial genomes. Our microbiome has significantly enriched metabolism of glycans, amino acids, and xenobiotics; methanogenesis; and 2-methyl-\n                    <jats:sc>d<\/jats:sc>\n                    -erythritol 4-phosphate pathway\u2013mediated biosynthesis of vitamins and isoprenoids. Thus, humans are superorganisms whose metabolism represents an amalgamation of microbial and human attributes.\n                  <\/jats:p>","DOI":"10.1126\/science.1124234","type":"journal-article","created":{"date-parts":[[2006,6,1]],"date-time":"2006-06-01T22:26:13Z","timestamp":1149200773000},"page":"1355-1359","source":"Crossref","is-referenced-by-count":3848,"title":["Metagenomic Analysis of the Human Distal Gut Microbiome"],"prefix":"10.1126","volume":"312","author":[{"given":"Steven R.","family":"Gill","sequence":"first","affiliation":[{"name":"The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA."},{"name":"Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA."},{"name":"Department of Microbiology and Immunology, 299 Campus Drive, Stanford University, Stanford, CA 94305, USA."},{"name":"Veterans Affairs Palo Alto Health Care System, Palo Alto, CA 94304, USA."},{"name":"Center for Genome Sciences, Washington University School of Medicine, St. Louis, MO 63108, USA."}]},{"given":"Mihai","family":"Pop","sequence":"additional","affiliation":[{"name":"The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA."},{"name":"Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA."},{"name":"Department of Microbiology and Immunology, 299 Campus Drive, Stanford University, Stanford, CA 94305, USA."},{"name":"Veterans Affairs Palo Alto Health Care System, Palo Alto, CA 94304, USA."},{"name":"Center for Genome Sciences, Washington University School of Medicine, St. Louis, MO 63108, USA."}]},{"given":"Robert T.","family":"DeBoy","sequence":"additional","affiliation":[{"name":"The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA."},{"name":"Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA."},{"name":"Department of Microbiology and Immunology, 299 Campus Drive, Stanford 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Hance (The Institute for Genomic Research) L. Dethlefsen and E. Bik (Stanford) and D. Leip (Washington University) for their valuable assistance. This work was supported by Defense Advanced Research Projects Agency (DARPA) and the Office of Naval Research grant no. ONR-N00014-02-1-1002 (S.R.G. K.E.N.) the W. M. Keck Foundation (J.I.G.) the Ellison Medical Foundation (D.A.R. J.I.G.) and NIH grants AI51259 (D.A.R.) and DK70977 (J.I.G.). B.S.S. is a recipient of a graduate research fellowship from the NSF (DGE-0202737). This whole-genome shotgun project has been deposited at the DNA Data Bank of Japan (DDBJ) European Molecular Biology Laboratory (EMBL) and GenBank under the project accession AAQK00000000 (subject 7) and AAQL00000000 (subject 8). The version described in this paper is the first version AAQK01000000 and AAQL01000000. All near\u2013full-length 16 S rDNA sequences were deposited at DDBJ\/EMBL\/GenBank under the accessions DQ325545 to DQ327606."}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.1124234","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T23:07:54Z","timestamp":1704841674000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.1124234"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,6,2]]},"references-count":35,"journal-issue":{"issue":"5778","published-print":{"date-parts":[[2006,6,2]]}},"alternative-id":["10.1126\/science.1124234"],"URL":"https:\/\/doi.org\/10.1126\/science.1124234","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1001228.374394","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1001228.374620","asserted-by":"object"}]},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,6,2]]}}}