{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T22:25:38Z","timestamp":1775859938447,"version":"3.50.1"},"reference-count":12,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5830","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2007,6,8]]},"abstract":"<jats:p>\n                    The global endemic of cardiovascular diseases calls for improved risk assessment and treatment. Here, we describe an association between myocardial infarction (MI) and a common sequence variant on chromosome 9p21. This study included a total of 4587 cases and 12,767 controls. The identified variant, adjacent to the tumor suppressor genes\n                    <jats:italic>CDKN2A<\/jats:italic>\n                    and\n                    <jats:italic>CDKN2B<\/jats:italic>\n                    , was associated with the disease with high significance. Approximately 21% of individuals in the population are homozygous for this variant, and their estimated risk of suffering myocardial infarction is 1.64 times as great as that of noncarriers. The corresponding risk is 2.02 times as great for early-onset cases. The population attributable risk is 21% for MI in general and 31% for early-onset cases.\n                  <\/jats:p>","DOI":"10.1126\/science.1142842","type":"journal-article","created":{"date-parts":[[2007,5,3]],"date-time":"2007-05-03T21:30:48Z","timestamp":1178227848000},"page":"1491-1493","source":"Crossref","is-referenced-by-count":1348,"title":["A Common Variant on Chromosome 9p21 Affects the Risk of Myocardial Infarction"],"prefix":"10.1126","volume":"316","author":[{"given":"Anna","family":"Helgadottir","sequence":"first","affiliation":[{"name":"deCODE genetics, Sturlugata 8, IS-101 Reykjavik, Iceland."},{"name":"Landspitali University Hospital, Reykjavik, Iceland."},{"name":"Emory University School of Medicine, Atlanta, GA 30322, USA."},{"name":"University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA."},{"name":"Duke University School of Medicine, Durham, NC 27710, USA."}]},{"given":"Gudmar","family":"Thorleifsson","sequence":"additional","affiliation":[{"name":"deCODE genetics, Sturlugata 8, IS-101 Reykjavik, Iceland."},{"name":"Landspitali University Hospital, Reykjavik, Iceland."},{"name":"Emory University School of Medicine, Atlanta, GA 30322, USA."},{"name":"University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA."},{"name":"Duke University School of Medicine, Durham, NC 27710, USA."}]},{"given":"Andrei","family":"Manolescu","sequence":"additional","affiliation":[{"name":"deCODE genetics, Sturlugata 8, IS-101 Reykjavik, Iceland."},{"name":"Landspitali University Hospital, Reykjavik, Iceland."},{"name":"Emory University School of Medicine, Atlanta, GA 30322, USA."},{"name":"University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA."},{"name":"Duke University School of Medicine, Durham, NC 27710, USA."}]},{"given":"Solveig","family":"Gretarsdottir","sequence":"additional","affiliation":[{"name":"deCODE genetics, Sturlugata 8, IS-101 Reykjavik, Iceland."},{"name":"Landspitali University Hospital, Reykjavik, Iceland."},{"name":"Emory University School of Medicine, Atlanta, GA 30322, USA."},{"name":"University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA."},{"name":"Duke University School of Medicine, Durham, NC 27710, USA."}]},{"given":"Thorarinn","family":"Blondal","sequence":"additional","affiliation":[{"name":"deCODE genetics, Sturlugata 8, IS-101 Reykjavik, Iceland."},{"name":"Landspitali University Hospital, Reykjavik, Iceland."},{"name":"Emory University School of Medicine, Atlanta, GA 30322, USA."},{"name":"University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA."},{"name":"Duke University School of Medicine, Durham, NC 27710, USA."}]},{"given":"Aslaug","family":"Jonasdottir","sequence":"additional","affiliation":[{"name":"deCODE genetics, Sturlugata 8, IS-101 Reykjavik, Iceland."},{"name":"Landspitali University Hospital, Reykjavik, Iceland."},{"name":"Emory University School of Medicine, Atlanta, GA 30322, USA."},{"name":"University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA."},{"name":"Duke University School of Medicine, Durham, NC 27710, USA."}]},{"given":"Adalbjorg","family":"Jonasdottir","sequence":"additional","affiliation":[{"name":"deCODE genetics, Sturlugata 8, IS-101 Reykjavik, Iceland."},{"name":"Landspitali University Hospital, Reykjavik, Iceland."},{"name":"Emory University School of Medicine, Atlanta, GA 30322, USA."},{"name":"University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA."},{"name":"Duke University School of Medicine, Durham, NC 27710, USA."}]},{"given":"Asgeir","family":"Sigurdsson","sequence":"additional","affiliation":[{"name":"deCODE genetics, Sturlugata 8, IS-101 Reykjavik, Iceland."},{"name":"Landspitali University Hospital, Reykjavik, Iceland."},{"name":"Emory University School of Medicine, Atlanta, GA 30322, USA."},{"name":"University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA."},{"name":"Duke University School of Medicine, Durham, NC 27710, USA."}]},{"given":"Adam","family":"Baker","sequence":"additional","affiliation":[{"name":"deCODE genetics, Sturlugata 8, IS-101 Reykjavik, Iceland."},{"name":"Landspitali University Hospital, Reykjavik, Iceland."},{"name":"Emory University School of Medicine, Atlanta, GA 30322, USA."},{"name":"University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA."},{"name":"Duke University School of Medicine, Durham, NC 27710, USA."}]},{"given":"Arnar","family":"Palsson","sequence":"additional","affiliation":[{"name":"deCODE genetics, Sturlugata 8, IS-101 Reykjavik, Iceland."},{"name":"Landspitali University Hospital, Reykjavik, Iceland."},{"name":"Emory University School of Medicine, Atlanta, GA 30322, USA."},{"name":"University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA."},{"name":"Duke University School of Medicine, Durham, NC 27710, USA."}]},{"given":"Gisli","family":"Masson","sequence":"additional","affiliation":[{"name":"deCODE genetics, Sturlugata 8, IS-101 Reykjavik, Iceland."},{"name":"Landspitali University Hospital, Reykjavik, Iceland."},{"name":"Emory University School of Medicine, Atlanta, GA 30322, USA."},{"name":"University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA."},{"name":"Duke University School of Medicine, Durham, NC 27710, USA."}]},{"given":"Daniel F.","family":"Gudbjartsson","sequence":"additional","affiliation":[{"name":"deCODE genetics, Sturlugata 8, IS-101 Reykjavik, Iceland."},{"name":"Landspitali University Hospital, Reykjavik, Iceland."},{"name":"Emory University School of Medicine, Atlanta, GA 30322, USA."},{"name":"University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA."},{"name":"Duke University School of Medicine, Durham, NC 27710, USA."}]},{"given":"Kristinn P.","family":"Magnusson","sequence":"additional","affiliation":[{"name":"deCODE genetics, Sturlugata 8, IS-101 Reykjavik, Iceland."},{"name":"Landspitali University Hospital, Reykjavik, Iceland."},{"name":"Emory University School of Medicine, Atlanta, GA 30322, USA."},{"name":"University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA."},{"name":"Duke University School of Medicine, Durham, NC 27710, USA."}]},{"given":"Karl","family":"Andersen","sequence":"additional","affiliation":[{"name":"deCODE genetics, Sturlugata 8, IS-101 Reykjavik, Iceland."},{"name":"Landspitali University Hospital, Reykjavik, Iceland."},{"name":"Emory University School of Medicine, Atlanta, GA 30322, USA."},{"name":"University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA."},{"name":"Duke University School of Medicine, Durham, NC 27710, USA."}]},{"given":"Allan I.","family":"Levey","sequence":"additional","affiliation":[{"name":"deCODE genetics, Sturlugata 8, IS-101 Reykjavik, Iceland."},{"name":"Landspitali University Hospital, Reykjavik, Iceland."},{"name":"Emory University School of Medicine, Atlanta, GA 30322, USA."},{"name":"University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA."},{"name":"Duke University School of Medicine, Durham, NC 27710, USA."}]},{"given":"Valgerdur M.","family":"Backman","sequence":"additional","affiliation":[{"name":"deCODE genetics, Sturlugata 8, IS-101 Reykjavik, Iceland."},{"name":"Landspitali University Hospital, Reykjavik, Iceland."},{"name":"Emory University School of Medicine, Atlanta, GA 30322, USA."},{"name":"University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA."},{"name":"Duke University School of Medicine, Durham, NC 27710, USA."}]},{"given":"Sigurborg","family":"Matthiasdottir","sequence":"additional","affiliation":[{"name":"deCODE genetics, Sturlugata 8, IS-101 Reykjavik, Iceland."},{"name":"Landspitali University Hospital, Reykjavik, Iceland."},{"name":"Emory University School of Medicine, Atlanta, GA 30322, USA."},{"name":"University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA."},{"name":"Duke University School of Medicine, Durham, NC 27710, USA."}]},{"given":"Thorbjorg","family":"Jonsdottir","sequence":"additional","affiliation":[{"name":"deCODE genetics, Sturlugata 8, IS-101 Reykjavik, Iceland."},{"name":"Landspitali University Hospital, Reykjavik, Iceland."},{"name":"Emory University School of Medicine, Atlanta, GA 30322, USA."},{"name":"University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA."},{"name":"Duke University School of Medicine, Durham, NC 27710, USA."}]},{"given":"Stefan","family":"Palsson","sequence":"additional","affiliation":[{"name":"deCODE genetics, Sturlugata 8, IS-101 Reykjavik, Iceland."},{"name":"Landspitali University Hospital, Reykjavik, Iceland."},{"name":"Emory University School of Medicine, Atlanta, GA 30322, USA."},{"name":"University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA."},{"name":"Duke University School of Medicine, Durham, NC 27710, USA."}]},{"given":"Helga","family":"Einarsdottir","sequence":"additional","affiliation":[{"name":"deCODE genetics, Sturlugata 8, IS-101 Reykjavik, Iceland."},{"name":"Landspitali University Hospital, Reykjavik, Iceland."},{"name":"Emory University School of Medicine, Atlanta, GA 30322, USA."},{"name":"University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA."},{"name":"Duke University School of Medicine, Durham, NC 27710, USA."}]},{"given":"Steinunn","family":"Gunnarsdottir","sequence":"additional","affiliation":[{"name":"deCODE genetics, Sturlugata 8, IS-101 Reykjavik, Iceland."},{"name":"Landspitali University Hospital, Reykjavik, Iceland."},{"name":"Emory University School of Medicine, Atlanta, GA 30322, USA."},{"name":"University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA."},{"name":"Duke University School of Medicine, Durham, NC 27710, USA."}]},{"given":"Arnaldur","family":"Gylfason","sequence":"additional","affiliation":[{"name":"deCODE genetics, Sturlugata 8, IS-101 Reykjavik, Iceland."},{"name":"Landspitali University Hospital, Reykjavik, Iceland."},{"name":"Emory University School of Medicine, Atlanta, GA 30322, USA."},{"name":"University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA."},{"name":"Duke University School of Medicine, Durham, NC 27710, USA."}]},{"given":"Viola","family":"Vaccarino","sequence":"additional","affiliation":[{"name":"deCODE genetics, Sturlugata 8, IS-101 Reykjavik, Iceland."},{"name":"Landspitali University Hospital, Reykjavik, Iceland."},{"name":"Emory University School of Medicine, Atlanta, GA 30322, USA."},{"name":"University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA."},{"name":"Duke University School of Medicine, Durham, NC 27710, USA."}]},{"given":"W. Craig","family":"Hooper","sequence":"additional","affiliation":[{"name":"deCODE genetics, Sturlugata 8, IS-101 Reykjavik, Iceland."},{"name":"Landspitali University Hospital, Reykjavik, Iceland."},{"name":"Emory University School of Medicine, Atlanta, GA 30322, USA."},{"name":"University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA."},{"name":"Duke University School of Medicine, Durham, NC 27710, USA."}]},{"given":"Muredach P.","family":"Reilly","sequence":"additional","affiliation":[{"name":"deCODE genetics, Sturlugata 8, IS-101 Reykjavik, Iceland."},{"name":"Landspitali University Hospital, Reykjavik, Iceland."},{"name":"Emory University School of Medicine, Atlanta, GA 30322, USA."},{"name":"University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA."},{"name":"Duke University School of Medicine, Durham, NC 27710, USA."}]},{"given":"Christopher B.","family":"Granger","sequence":"additional","affiliation":[{"name":"deCODE genetics, Sturlugata 8, IS-101 Reykjavik, Iceland."},{"name":"Landspitali University Hospital, Reykjavik, Iceland."},{"name":"Emory University School of Medicine, Atlanta, GA 30322, USA."},{"name":"University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA."},{"name":"Duke University School of Medicine, Durham, NC 27710, USA."}]},{"given":"Harland","family":"Austin","sequence":"additional","affiliation":[{"name":"deCODE genetics, Sturlugata 8, IS-101 Reykjavik, Iceland."},{"name":"Landspitali University Hospital, Reykjavik, Iceland."},{"name":"Emory University School of Medicine, Atlanta, GA 30322, USA."},{"name":"University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA."},{"name":"Duke University School of Medicine, Durham, NC 27710, USA."}]},{"given":"Daniel J.","family":"Rader","sequence":"additional","affiliation":[{"name":"deCODE genetics, Sturlugata 8, IS-101 Reykjavik, Iceland."},{"name":"Landspitali University Hospital, Reykjavik, Iceland."},{"name":"Emory University School of Medicine, Atlanta, GA 30322, USA."},{"name":"University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA."},{"name":"Duke University School of Medicine, Durham, NC 27710, USA."}]},{"given":"Svati H.","family":"Shah","sequence":"additional","affiliation":[{"name":"deCODE genetics, Sturlugata 8, IS-101 Reykjavik, Iceland."},{"name":"Landspitali University Hospital, Reykjavik, Iceland."},{"name":"Emory University School of Medicine, Atlanta, GA 30322, USA."},{"name":"University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA."},{"name":"Duke University School of Medicine, Durham, NC 27710, USA."}]},{"given":"Arshed A.","family":"Quyyumi","sequence":"additional","affiliation":[{"name":"deCODE genetics, Sturlugata 8, IS-101 Reykjavik, Iceland."},{"name":"Landspitali University Hospital, Reykjavik, Iceland."},{"name":"Emory University School of Medicine, Atlanta, GA 30322, USA."},{"name":"University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA."},{"name":"Duke University School of Medicine, Durham, NC 27710, USA."}]},{"given":"Jeffrey R.","family":"Gulcher","sequence":"additional","affiliation":[{"name":"deCODE genetics, Sturlugata 8, IS-101 Reykjavik, Iceland."},{"name":"Landspitali University Hospital, Reykjavik, Iceland."},{"name":"Emory University School of Medicine, Atlanta, GA 30322, USA."},{"name":"University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA."},{"name":"Duke University School of Medicine, Durham, NC 27710, USA."}]},{"given":"Gudmundur","family":"Thorgeirsson","sequence":"additional","affiliation":[{"name":"deCODE genetics, Sturlugata 8, IS-101 Reykjavik, Iceland."},{"name":"Landspitali University Hospital, Reykjavik, Iceland."},{"name":"Emory University School of Medicine, Atlanta, GA 30322, USA."},{"name":"University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA."},{"name":"Duke University School of Medicine, Durham, NC 27710, USA."}]},{"given":"Unnur","family":"Thorsteinsdottir","sequence":"additional","affiliation":[{"name":"deCODE genetics, Sturlugata 8, IS-101 Reykjavik, Iceland."},{"name":"Landspitali University Hospital, Reykjavik, Iceland."},{"name":"Emory University School of Medicine, Atlanta, GA 30322, USA."},{"name":"University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA."},{"name":"Duke University School of Medicine, Durham, NC 27710, USA."}]},{"given":"Augustine","family":"Kong","sequence":"additional","affiliation":[{"name":"deCODE genetics, Sturlugata 8, IS-101 Reykjavik, Iceland."},{"name":"Landspitali University Hospital, Reykjavik, Iceland."},{"name":"Emory University School of Medicine, Atlanta, GA 30322, USA."},{"name":"University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA."},{"name":"Duke University School of Medicine, Durham, NC 27710, USA."}]},{"given":"Kari","family":"Stefansson","sequence":"additional","affiliation":[{"name":"deCODE genetics, Sturlugata 8, IS-101 Reykjavik, Iceland."},{"name":"Landspitali University Hospital, Reykjavik, Iceland."},{"name":"Emory University School of Medicine, Atlanta, GA 30322, USA."},{"name":"University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA."},{"name":"Duke University School of Medicine, Durham, NC 27710, USA."}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","first-page":"e85","volume":"113","year":"2006","unstructured":"T. Thom et al., Circulation113, e85 (2006).","journal-title":"Circulation"},{"key":"e_1_3_2_3_2","unstructured":"Materials and methods are available as supporting material on Science Online."},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0006-341X.1999.00997.x"},{"key":"e_1_3_2_5_2","first-page":"719","volume":"22","year":"1959","unstructured":"N. Mantel, W. Haenszel, J. Natl. Cancer Inst.22, 719 (1959).","journal-title":"J. Natl. Cancer Inst."},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2796.2002.01029.x"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.10.003"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/35025203"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000256837.40544.4a"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10038-006-0053-x"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1086\/381560"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1086\/498653"},{"key":"e_1_3_2_13_2","unstructured":"We thank the participants whose contribution made this study possible the nurses at the Icelandic Heart Association and personnel at the deCODE core facilities. The authors from deCODE genetics declare competing financial interests. deCODE genetics has applied for a patent related to this work."}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.1142842","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T03:36:45Z","timestamp":1704857805000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.1142842"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,6,8]]},"references-count":12,"journal-issue":{"issue":"5830","published-print":{"date-parts":[[2007,6,8]]}},"alternative-id":["10.1126\/science.1142842"],"URL":"https:\/\/doi.org\/10.1126\/science.1142842","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1088838.541948","asserted-by":"object"}]},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,6,8]]}}}