{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T19:51:35Z","timestamp":1776109895173,"version":"3.50.1"},"reference-count":28,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5833","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2007,6,29]]},"abstract":"<jats:p>During cytokinesis, as dividing animal cells pull apart into two daughter cells, the final stage, termed abscission, requires breakage of the midbody, a thin membranous stalk connecting the daughter cells. This membrane fission event topologically resembles the budding of viruses, such as HIV-1, from infected cells. We found that two proteins involved in HIV-1 budding\u2014tumor susceptibility gene 101 (Tsg101), a subunit of the endosomal sorting complex required for transport I (ESCRT-I), and Alix, an ESCRT-associated protein\u2014were recruited to the midbody during cytokinesis by interaction with centrosome protein 55 (Cep55), a centrosome and midbody protein essential for abscission. Tsg101, Alix, and possibly other components of ESCRT-I were required for the completion of cytokinesis. Thus, HIV-1 budding and cytokinesis use a similar subset of cellular components to carry out topologically similar membrane fission events.<\/jats:p>","DOI":"10.1126\/science.1143422","type":"journal-article","created":{"date-parts":[[2007,6,7]],"date-time":"2007-06-07T21:09:47Z","timestamp":1181250587000},"page":"1908-1912","source":"Crossref","is-referenced-by-count":672,"title":["Parallels Between Cytokinesis and Retroviral Budding: A Role for the ESCRT Machinery"],"prefix":"10.1126","volume":"316","author":[{"given":"Jez G.","family":"Carlton","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, King's College London School of Medicine, London, UK."}]},{"given":"Juan","family":"Martin-Serrano","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, King's College London School of Medicine, London, UK."}]}],"member":"221","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.74.082803.133425"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cellbio.17.1.351"},{"key":"e_1_3_1_4_2","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/S0960-9822(99)80333-9","volume":"9","year":"1999","unstructured":"V. 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Bieniasz for stimulating discussions M. Agromayor and M. Malim for critical reading of the manuscript and W. Sundquist and M. Malim for reagents. This work was supported by Career Establishment Grant G0400207 from the Medical Research Council UK. J.G.C. is a Beit Memorial Research Fellow."}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.1143422","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T03:20:56Z","timestamp":1704856856000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.1143422"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,6,29]]},"references-count":28,"journal-issue":{"issue":"5833","published-print":{"date-parts":[[2007,6,29]]}},"alternative-id":["10.1126\/science.1143422"],"URL":"https:\/\/doi.org\/10.1126\/science.1143422","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1087092.793507453","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1087092.540071","asserted-by":"object"}]},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,6,29]]}}}