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All cells show rapid translocation of proteins specific to the drug mechanism, including the drug target (topoisomerase-1), and slower, wide-ranging temporal waves of protein degradation and accumulation. However, the cells differ in the behavior of a subset of proteins. We identify proteins whose dynamics differ widely between cells, in a way that corresponds to the outcomes\u2014cell death or survival. This opens the way to understanding molecular responses to drugs in individual cells.<\/jats:p>","DOI":"10.1126\/science.1160165","type":"journal-article","created":{"date-parts":[[2008,11,20]],"date-time":"2008-11-20T21:35:38Z","timestamp":1227216938000},"page":"1511-1516","source":"Crossref","is-referenced-by-count":539,"title":["Dynamic Proteomics of Individual Cancer Cells in Response to a Drug"],"prefix":"10.1126","volume":"322","author":[{"given":"A. 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USA."},{"name":"Department of Plant Sciences, Weizmann Institute of Science, Rehovot 76100, Israel."}]},{"given":"M.","family":"Frenkel-Morgenstern","sequence":"additional","affiliation":[{"name":"Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel."},{"name":"Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA."},{"name":"Department of Plant Sciences, Weizmann Institute of Science, Rehovot 76100, Israel."}]},{"given":"I.","family":"Issaeva","sequence":"additional","affiliation":[{"name":"Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel."},{"name":"Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA."},{"name":"Department of Plant Sciences, Weizmann Institute of Science, Rehovot 76100, Israel."}]},{"given":"A.","family":"Sigal","sequence":"additional","affiliation":[{"name":"Department of Molecular Cell Biology, Weizmann Institute of Science, 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thank the Kahn Family Foundation and the Israel Science Foundation for support. We thank E. Zalckvar J. Bar I. Glinert T. Shlapok and members of the Alon laboratory for discussions. The work of M.F.-M. and E.E. is supported by the Yeshaya Horowitz Association through the Center for Complexity Science."}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.1160165","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T04:18:38Z","timestamp":1704860318000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.1160165"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,12,5]]},"references-count":38,"journal-issue":{"issue":"5907","published-print":{"date-parts":[[2008,12,5]]}},"alternative-id":["10.1126\/science.1160165"],"URL":"https:\/\/doi.org\/10.1126\/science.1160165","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1146998.605229","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1146998.604108","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1146998.617220","asserted-by":"object"}]},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,12,5]]}}}