{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T14:44:07Z","timestamp":1774536247776,"version":"3.50.1"},"reference-count":9,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5902","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2008,10,31]]},"abstract":"<jats:p>Wolbachia pipientis bacteria are common endosymbionts of insects that are best known for their ability to increase their prevalence in populations by manipulating host reproductive systems. However, there are examples of Wolbachia that exist in nature that seem to induce no reproductive parasitism trait and yet are able to invade populations. We demonstrate a fitness benefit for Wolbachia-infected insects that may explain this paradox. Drosophila melanogaster flies infected with Wolbachia are less susceptible to mortality induced by a range of RNA viruses. The antiviral protection associated with Wolbachia infection might be exploited in future strategies to reduce transmission of pathogens by insects.<\/jats:p>","DOI":"10.1126\/science.1162418","type":"journal-article","created":{"date-parts":[[2008,10,30]],"date-time":"2008-10-30T16:43:34Z","timestamp":1225385014000},"page":"702-702","source":"Crossref","is-referenced-by-count":1017,"title":["<i>Wolbachia<\/i>\n                    and Virus Protection in Insects"],"prefix":"10.1126","volume":"322","author":[{"given":"Lauren M.","family":"Hedges","sequence":"first","affiliation":[{"name":"School of Integrative Biology, The University of Queensland, Brisbane 4072, Australia."}]},{"given":"Jeremy C.","family":"Brownlie","sequence":"additional","affiliation":[{"name":"School of Integrative Biology, The University of Queensland, Brisbane 4072, Australia."}]},{"given":"Scott L.","family":"O'Neill","sequence":"additional","affiliation":[{"name":"School of Integrative Biology, The University of Queensland, Brisbane 4072, Australia."}]},{"given":"Karyn N.","family":"Johnson","sequence":"additional","affiliation":[{"name":"School of Integrative Biology, The University of Queensland, Brisbane 4072, Australia."}]}],"member":"221","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"crossref","unstructured":"S. L. O'Neill A. A. Hoffmann J. H. Werren Influential Passengers: Inherited Microorganisms and Arthropod Reproduction (Oxford Univ. Press Oxford 1997).","DOI":"10.1093\/oso\/9780198577867.001.0001"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1388"},{"key":"e_1_3_1_4_2","first-page":"625","volume":"2","year":"1980","unstructured":"G. Brun, N. Plus, in The Genetics and Biology of Drosophila, M. Ashburner, T. F. R. Wright, Eds. (Academic Press, New York, 1980), vol 2D, pp. 625\u2013702.","journal-title":"The Genetics and Biology of Drosophila"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-79-1-191"},{"key":"e_1_3_1_6_2","unstructured":"Materials and methods are available as supporting material on Science Online."},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2005.06.069"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1125694"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/148.1.221"},{"key":"e_1_3_1_10_2","unstructured":"We thank M. Riegler for advice and E. McGraw and F. Pringle for critical reading of the manuscript. This work was supported by funding from The University of Queensland Australian Research Council and the Foundation for the National Institutes of Health through the Grand Challenges in Global Health Initiative."}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.1162418","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T02:53:06Z","timestamp":1704855186000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.1162418"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,10,31]]},"references-count":9,"journal-issue":{"issue":"5902","published-print":{"date-parts":[[2008,10,31]]}},"alternative-id":["10.1126\/science.1162418"],"URL":"https:\/\/doi.org\/10.1126\/science.1162418","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1142035.599155","asserted-by":"object"}]},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,10,31]]}}}