{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T07:35:58Z","timestamp":1778139358113,"version":"3.51.4"},"reference-count":27,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5910","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2009,1,2]]},"abstract":"<jats:p>\n                    Most pathogens require a relatively long period of development in their mosquito vector before they can be transmitted to a new human host; hence, only older insects are of epidemiological importance. The successful transfer of a life-shortening strain of the inherited bacterial symbiont,\n                    <jats:italic>Wolbachia<\/jats:italic>\n                    , into the major mosquito vector of dengue,\n                    <jats:italic>Aedes aegypti<\/jats:italic>\n                    , halved adult life span under laboratory conditions. The association is stable, and the\n                    <jats:italic>Wolbachia<\/jats:italic>\n                    strain is maternally inherited at high frequency. It is capable of inducing complete cytoplasmic incompatibility, which should facilitate its invasion into natural field populations and its persistence over time. Our data suggest that targeting mosquito age with inherited\n                    <jats:italic>Wolbachia<\/jats:italic>\n                    infections may be a viable strategy to reduce the transmission of pathogens such as dengue viruses.\n                  <\/jats:p>","DOI":"10.1126\/science.1165326","type":"journal-article","created":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T15:42:51Z","timestamp":1230824571000},"page":"141-144","source":"Crossref","is-referenced-by-count":804,"title":["Stable Introduction of a Life-Shortening\n                    <i>Wolbachia<\/i>\n                    Infection into the Mosquito\n                    <i>Aedes aegypti<\/i>"],"prefix":"10.1126","volume":"323","author":[{"given":"Conor J.","family":"McMeniman","sequence":"first","affiliation":[{"name":"School of Integrative Biology, The University of Queensland, Brisbane 4072, Australia."},{"name":"College of Life Sciences, Central China Normal University, Wuhan 430079, China."}]},{"given":"Roxanna V.","family":"Lane","sequence":"additional","affiliation":[{"name":"School of Integrative Biology, The University of Queensland, Brisbane 4072, Australia."},{"name":"College of Life Sciences, Central China Normal University, Wuhan 430079, China."}]},{"given":"Bodil N.","family":"Cass","sequence":"additional","affiliation":[{"name":"School of Integrative Biology, The University of Queensland, Brisbane 4072, Australia."},{"name":"College of Life Sciences, Central China Normal University, Wuhan 430079, China."}]},{"given":"Amy W.C.","family":"Fong","sequence":"additional","affiliation":[{"name":"School of Integrative Biology, The University of Queensland, Brisbane 4072, Australia."},{"name":"College of Life Sciences, Central China Normal University, Wuhan 430079, China."}]},{"given":"Manpreet","family":"Sidhu","sequence":"additional","affiliation":[{"name":"School of Integrative Biology, The University of Queensland, Brisbane 4072, Australia."},{"name":"College of Life Sciences, Central China Normal University, Wuhan 430079, China."}]},{"given":"Yu-Feng","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Integrative Biology, The University of Queensland, Brisbane 4072, Australia."},{"name":"College of Life Sciences, Central China Normal University, Wuhan 430079, China."}]},{"given":"Scott L.","family":"O'Neill","sequence":"additional","affiliation":[{"name":"School of Integrative Biology, The University of Queensland, Brisbane 4072, Australia."},{"name":"College of Life Sciences, Central China Normal University, Wuhan 430079, China."}]}],"member":"221","reference":[{"key":"e_1_3_1_2_2","first-page":"1","year":"1997","unstructured":"D. J. Gubler, in Dengue and Dengue Hemorrhagic Fever, D. J. Gubler and G. Kuno, Eds. (CAB International, New York, 1997), pp. 1\u201322.","journal-title":"Dengue and Dengue Hemorrhagic Fever"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0050068"},{"key":"e_1_3_1_4_2","first-page":"1","volume":"29","year":"1926","unstructured":"J. F. Siler, M. W. Hall, A. P. Hitchens, Philipp. J. Sci.29, 1 (1926).","journal-title":"Philipp. J. Sci."},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1987.36.143"},{"key":"e_1_3_1_6_2","unstructured":"H. M. Gilles D. A. Warrell Essential Malariology (Arnold London ed. 4 2002)."},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.en.37.010192.000245"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3156.2004.01263.x"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)04404-4"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/2041173a0"},{"key":"e_1_3_1_11_2","unstructured":"G. MacDonald The Epidemiology and Control of Malaria (Oxford Univ. Press London 1957)."},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.20.10792"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-78225-6_11"},{"key":"e_1_3_1_14_2","first-page":"271","year":"2000","unstructured":"S. P. Sinkins, S. L. O'Neill, in Insect Transgenesis: Methods and Applications, A. M. Handler and A. A. James, Eds. 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Press, Oxford, 1997), pp. 42\u201380.","journal-title":"Influential Passengers: Inherited Microorganisms and Arthropod Reproduction,"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ibmb.2004.03.025"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2011(03)00082-X"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1603\/0022-2585-40.2.125"},{"key":"e_1_3_1_19_2","unstructured":"Materials and methods are available as supporting material on Science Online."},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.01038-08"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.052466499"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/164.3.1027"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1603\/0022-2585-38.6.844"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1117607"},{"key":"e_1_3_1_25_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0016672302005827"},{"key":"e_1_3_1_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0966-842X(97)81772-6"},{"key":"e_1_3_1_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1638"},{"key":"e_1_3_1_28_2","unstructured":"We thank S. Dobson Z. Xi and Y. Fu for their advice on microinjection of mosquito eggs; C. Williams and S. Ritchie for supplying the JCU mosquito strain; and E. McGraw and members of the O'Neill laboratory for helpful comments. This research was supported by a grant from the Foundation for the NIH through the Grand Challenges in Global Health Initiative of the Bill and Melinda Gates Foundation."}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.1165326","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T03:18:42Z","timestamp":1704856722000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.1165326"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,1,2]]},"references-count":27,"journal-issue":{"issue":"5910","published-print":{"date-parts":[[2009,1,2]]}},"alternative-id":["10.1126\/science.1165326"],"URL":"https:\/\/doi.org\/10.1126\/science.1165326","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1144859.605081","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1144859.793513011","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1144859.602390","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1144859.601948","asserted-by":"object"}]},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,1,2]]}}}