{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T14:23:56Z","timestamp":1779373436124,"version":"3.53.1"},"reference-count":27,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5927","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2009,5]]},"abstract":"<jats:title>Circadian Oscillations<\/jats:title>\n          <jats:p>\n            The 24-hour day-night cycle plays an important role in mammalian physiology and behavior and, as most travelers are well aware, there is an intimate link between our in-built circadian clocks and metabolic rhythms. This link is in part forged by the protein deacetylase SIRT1, which regulates the clock's molecular circuitry. SIRT1 uses as a cofactor the cellular metabolite NAD\n            <jats:sup>+<\/jats:sup>\n            , which is synthesized through a salvage pathway that includes the enzyme nicotinamide phosphoribosyltransferase (NAMPT) (see the Perspective by\n            <jats:bold>\n              <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" page=\"598\" related-article-type=\"in-this-issue\" vol=\"324\" xlink:href=\"10.1126\/science.1174132\">Wijnen<\/jats:related-article>\n            <\/jats:bold>\n            ).\n            <jats:bold>\n              Ramsey\n              <jats:italic>et al.<\/jats:italic>\n            <\/jats:bold>\n            (p.\n            <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" page=\"651\" related-article-type=\"in-this-issue\" vol=\"324\" xlink:href=\"10.1126\/science.1171641\">651<\/jats:related-article>\n            ; published online 19 March) and\n            <jats:bold>\n              Nakahata\n              <jats:italic>et al.<\/jats:italic>\n            <\/jats:bold>\n            (p.\n            <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" page=\"654\" related-article-type=\"in-this-issue\" vol=\"324\" xlink:href=\"10.1126\/science.1170803\">654<\/jats:related-article>\n            , published online 12 March) now show that NAMPT and NAD\n            <jats:sup>+<\/jats:sup>\n            levels oscillate during the daily 24-hour cycle and that this oscillation is regulated by the circadian clock. Furthermore, the oscillations in NAD\n            <jats:sup>+<\/jats:sup>\n            modulate the activity of SIRT1 feeding back into the circadian clock.\n          <\/jats:p>","DOI":"10.1126\/science.1170803","type":"journal-article","created":{"date-parts":[[2009,3,13]],"date-time":"2009-03-13T02:06:45Z","timestamp":1236910005000},"page":"654-657","source":"Crossref","is-referenced-by-count":1073,"title":["Circadian Control of the NAD\n            <sup>+<\/sup>\n            Salvage Pathway by CLOCK-SIRT1"],"prefix":"10.1126","volume":"324","author":[{"given":"Yasukazu","family":"Nakahata","sequence":"first","affiliation":[{"name":"Department of Pharmacology, School of Medicine, University of California, Irvine, Irvine, CA 92697, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saurabh","family":"Sahar","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Medicine, University of California, Irvine, Irvine, CA 92697, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Astarita","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Medicine, University of California, Irvine, Irvine, CA 92697, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milota","family":"Kaluzova","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Medicine, University of California, Irvine, Irvine, CA 92697, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Sassone-Corsi","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Medicine, University of California, Irvine, Irvine, CA 92697, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.genet.40.110405.090603"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.08.022"},{"key":"e_1_3_2_4_2","author":"Eckel-Mahan K.","unstructured":"Eckel-Mahan K., Sassone-Corsi P., Nat. 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