{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T03:26:59Z","timestamp":1774063619774,"version":"3.50.1"},"reference-count":31,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5947","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2009,9,18]]},"abstract":"<jats:title>Now Shown in 3D<\/jats:title>\n                  <jats:p>\n                    With the advent of systems-wide technologies and the development of analytical methods, data produced by analyzing individual or small groups of molecular components can be integrated to reassemble whole biological systems.\n                    <jats:bold>\n                      Zhang\n                      <jats:italic>et al.<\/jats:italic>\n                    <\/jats:bold>\n                    (p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" page=\"1544\" related-article-type=\"in-this-issue\" vol=\"325\" xlink:href=\"10.1126\/science.1174671\">1544<\/jats:related-article>\n                    ) have undertaken a major technological challenge: to integrate biochemical data with experimentally determined or predicted three-dimensional structures of all proteins involved in the central metabolism of a bacterial cell. This integration of large-scale data sets provides evolutionary and functional insights and furthers our understanding of the molecular assembly of complex biological networks.\n                  <\/jats:p>","DOI":"10.1126\/science.1174671","type":"journal-article","created":{"date-parts":[[2009,9,17]],"date-time":"2009-09-17T20:35:45Z","timestamp":1253219745000},"page":"1544-1549","source":"Crossref","is-referenced-by-count":166,"title":["Three-Dimensional Structural View of the Central Metabolic Network of\n                    <i>Thermotoga maritima<\/i>"],"prefix":"10.1126","volume":"325","author":[{"given":"Ying","family":"Zhang","sequence":"first","affiliation":[{"name":"Joint Center for Molecular Modeling (JCMM), Burnham Institute for Medical Research, La Jolla, CA 92037, USA."}]},{"given":"Ines","family":"Thiele","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, University of California at San Diego, La Jolla, CA 92093\u20130412, 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