{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T21:14:28Z","timestamp":1779138868250,"version":"3.51.4"},"reference-count":21,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5957","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2009,11,27]]},"abstract":"<jats:title>RSV in 3D<\/jats:title>\n                  <jats:p>\n                    Respiratory syncytial virus (RSV) causes pneumonia and bronchiolitis in infants. RSV is an RNA virus in which the genomic RNA forms part of a nuclease-resistant helical ribonucleoprotein complex.\n                    <jats:bold>\n                      Tawar\n                      <jats:italic>et al.<\/jats:italic>\n                    <\/jats:bold>\n                    (p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" page=\"1279\" related-article-type=\"in-this-issue\" vol=\"326\" xlink:href=\"10.1126\/science.1177634\">1279<\/jats:related-article>\n                    ) now use x-ray and electron microscopy data to model the structure of this nucleocapsid complex and show how it can template RNA synthesis. The crystal structure shows RNA wrapped around a decameric ring of nucleocapsid protein. Combining this structure with electron microscopy data gives a model that shows how polymerase might read out the RNA bases without disassembling the nucleocapsid helix.\n                  <\/jats:p>","DOI":"10.1126\/science.1177634","type":"journal-article","created":{"date-parts":[[2009,11,27]],"date-time":"2009-11-27T18:05:58Z","timestamp":1259345158000},"page":"1279-1283","source":"Crossref","is-referenced-by-count":317,"title":["Crystal Structure of a Nucleocapsid-Like Nucleoprotein-RNA Complex of Respiratory Syncytial Virus"],"prefix":"10.1126","volume":"326","author":[{"given":"Rajiv G.","family":"Tawar","sequence":"first","affiliation":[{"name":"Institut Pasteur, Unit\u00e9 de Virologie Structurale, D\u00e9partement de Virologie and CNRS Unit\u00e9 de Recherche Associ\u00e9e (URA) 3015, 25 Rue du Dr Roux, 75724 Paris Cedex 15, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"St\u00e9phane","family":"Duquerroy","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Unit\u00e9 de Virologie Structurale, D\u00e9partement de Virologie and CNRS Unit\u00e9 de Recherche Associ\u00e9e (URA) 3015, 25 Rue du Dr Roux, 75724 Paris Cedex 15, France."},{"name":"Universit\u00e9 Paris-Sud, Facult\u00e9 d\u2019Orsay, 91405 Orsay Cedex, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clemens","family":"Vonrhein","sequence":"additional","affiliation":[{"name":"Global Phasing, Sheraton House, Castle Park, Cambridge CB3 0AX, UK."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paloma F.","family":"Varela","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Unit\u00e9 de Virologie Structurale, D\u00e9partement de Virologie and CNRS Unit\u00e9 de Recherche Associ\u00e9e (URA) 3015, 25 Rue du Dr Roux, 75724 Paris Cedex 15, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurence","family":"Damier-Piolle","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Unit\u00e9 de Virologie Structurale, D\u00e9partement de Virologie and CNRS Unit\u00e9 de Recherche Associ\u00e9e (URA) 3015, 25 Rue du Dr Roux, 75724 Paris Cedex 15, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathalie","family":"Castagn\u00e9","sequence":"additional","affiliation":[{"name":"L\u2019Institut National de la Recherche Agronomique, Unit\u00e9 de Virologie et Immunologie Mol\u00e9culaires, Domaine du Vilvert, 78350 Jouy-en-Josas, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirsty","family":"MacLellan","sequence":"additional","affiliation":[{"name":"Medical Research Council Virology Unit, University of Glasgow, Church Street, Glasgow G11 5JR, UK."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hugues","family":"Bedouelle","sequence":"additional","affiliation":[{"name":"Institut Pasteur, CNRS URA 3012, 25 Rue du Dr Roux, 75724 Paris Cedex 15, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00e9rard","family":"Bricogne","sequence":"additional","affiliation":[{"name":"Global Phasing, Sheraton House, Castle Park, Cambridge CB3 0AX, UK."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Bhella","sequence":"additional","affiliation":[{"name":"Medical Research Council Virology Unit, University of Glasgow, Church Street, Glasgow G11 5JR, UK."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Fran\u00e7ois","family":"El\u00e9ou\u00ebt","sequence":"additional","affiliation":[{"name":"L\u2019Institut National de la Recherche Agronomique, Unit\u00e9 de Virologie et Immunologie Mol\u00e9culaires, Domaine du Vilvert, 78350 Jouy-en-Josas, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F\u00e9lix A.","family":"Rey","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Unit\u00e9 de Virologie Structurale, D\u00e9partement de Virologie and CNRS Unit\u00e9 de Recherche Associ\u00e9e (URA) 3015, 25 Rue du Dr Roux, 75724 Paris Cedex 15, France."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","unstructured":"P. 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