{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T13:00:56Z","timestamp":1774875656191,"version":"3.50.1"},"reference-count":26,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5976","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2010,4,16]]},"abstract":"<jats:title>Domain Swaps to Phenotype Shifts<\/jats:title>\n                  <jats:p>\n                    For natural selection there must be mechanisms that create phenotypic diversity, presumably from relatively simple molecular changes in an organism.\n                    <jats:bold>\n                      Peisajovich\n                      <jats:italic>et al.<\/jats:italic>\n                    <\/jats:bold>\n                    (p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" page=\"368\" related-article-type=\"in-this-issue\" vol=\"328\" xlink:href=\"10.1126\/science.1182376\">368<\/jats:related-article>\n                    ) tested the extent to which changes in phenotype can occur by systematic swapping of protein domains in the components of the biochemical signaling pathway that controls mating in yeast. Such changes decreased or increased responsiveness to yeast mating pheromone, and some translated into changes in mating efficiency. The authors propose that shuffling of modular protein domains may be an important source of phenotypic diversity in evolution and may also be a useful strategy for the engineering of biological systems.\n                  <\/jats:p>","DOI":"10.1126\/science.1182376","type":"journal-article","created":{"date-parts":[[2010,4,15]],"date-time":"2010-04-15T14:30:21Z","timestamp":1271341821000},"page":"368-372","source":"Crossref","is-referenced-by-count":130,"title":["Rapid Diversification of Cell Signaling Phenotypes by Modular Domain Recombination"],"prefix":"10.1126","volume":"328","author":[{"given":"Sergio G.","family":"Peisajovich","sequence":"first","affiliation":[{"name":"Department of Cellular and Molecular Pharmacology, University of California, San Francisco, 600 16th Street, San Francisco, CA 94158, USA."}]},{"given":"Joan E.","family":"Garbarino","sequence":"additional","affiliation":[{"name":"Department of Cellular and Molecular Pharmacology, University of California, San Francisco, 600 16th Street, San Francisco, CA 94158, USA."},{"name":"Howard Hughes Medical Institute, University of California, San Francisco, CA, USA."}]},{"given":"Ping","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Cellular and Molecular Pharmacology, University of California, San Francisco, 600 16th Street, San Francisco, CA 94158, USA."},{"name":"Center for Theoretical Biology, Peking University, Beijing 100871, China."}]},{"given":"Wendell A.","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Cellular and Molecular Pharmacology, University of California, San Francisco, 600 16th Street, San Francisco, CA 94158, USA."},{"name":"Howard Hughes Medical Institute, University of California, San Francisco, CA, USA."}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1085371"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.sbi.2004.03.011"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1083653"},{"key":"e_1_3_2_5_2","first-page":"553","article-title":"Protein building blocks preserved by recombination.","volume":"9","author":"Voigt C. 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