{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T23:04:43Z","timestamp":1773011083201,"version":"3.50.1"},"reference-count":13,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6006","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2010,11,12]]},"abstract":"<jats:p>Complex cellular machines may have evolved through a ratchet-like process called constructive neutral evolution.<\/jats:p>","DOI":"10.1126\/science.1198594","type":"journal-article","created":{"date-parts":[[2010,11,11]],"date-time":"2010-11-11T19:34:01Z","timestamp":1289504041000},"page":"920-921","source":"Crossref","is-referenced-by-count":221,"title":["Irremediable Complexity?"],"prefix":"10.1126","volume":"330","author":[{"given":"Michael W.","family":"Gray","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia B3H 1X5, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julius","family":"Luke\u0161","sequence":"additional","affiliation":[{"name":"Institute of Parasitology, Czech Academy of Sciences and Faculty of Sciences, University of South Bohemia, 37005 \u010cesk\u00e9 Bud\u0115jovice, Czech Republic."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John M.","family":"Archibald","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia B3H 1X5, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick J.","family":"Keeling","sequence":"additional","affiliation":[{"name":"Department of Botany, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. Ford","family":"Doolittle","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia B3H 1X5, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/0168-9525(93)90011-6","volume":"9","author":"Covello P. S.","year":"1993","unstructured":"Covello P. S., Gray M. W., Trends Genet. 9, 265 (1993).","journal-title":"Trends Genet."},{"key":"e_1_3_1_3_2","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/PL00006540","volume":"49","author":"Stoltzfus A.","year":"1999","unstructured":"Stoltzfus A., J. Mol. Evol. 49, 169 (1999).","journal-title":"J. Mol. Evol."},{"issue":"1","key":"e_1_3_1_4_2","doi-asserted-by":"crossref","first-page":"8597","DOI":"10.1073\/pnas.0702207104","volume":"104","author":"Lynch M.","year":"2007","unstructured":"Lynch M., Proc. Natl. Acad. Sci. U.S.A. 104 (suppl. 1), 8597 (2007).","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"e_1_3_1_5_2","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1002\/bies.10394","volume":"25","author":"Nilsen T. W.","year":"2003","unstructured":"Nilsen T. W., Bioessays 25, 1147 (2003).","journal-title":"Bioessays"},{"key":"e_1_3_1_6_2","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s00294-005-0027-0","volume":"48","author":"Luke\u0161 J.","year":"2005","unstructured":"Luke\u0161 J., Hashimi H., Z\u00edkov\u00e1 A., Curr. Genet. 48, 277 (2005).","journal-title":"Curr. Genet."},{"key":"e_1_3_1_7_2","first-page":"a003483","volume":"2","author":"Fox G. E.","year":"2010","unstructured":"Fox G. E., Cold Spring Harb. Perspect. Biol. 2, a003483 (2010).","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"e_1_3_1_8_2","volume-title":"The Origins of Genome Architecture","author":"Lynch M.","year":"2007","unstructured":"Lynch M., The Origins of Genome Architecture (Sinauer, Sunderland, MA, 2007)."},{"key":"e_1_3_1_9_2","volume-title":"The Major Transitions in Evolution","author":"Smith J. Maynard","year":"1995","unstructured":"Smith J. Maynard, Szathmary E., The Major Transitions in Evolution (Oxford Univ. Press, Oxford, 1995)."},{"key":"e_1_3_1_10_2","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/0092-8674(87)90488-0","volume":"50","author":"Akins R. A.","year":"1987","unstructured":"Akins R. A., Lambowitz A. M., Cell 50, 331 (1987).","journal-title":"Cell"},{"key":"e_1_3_1_11_2","doi-asserted-by":"crossref","first-page":"6010","DOI":"10.1073\/pnas.0801722105","volume":"105","author":"Paukstelis P. J.","year":"2008","unstructured":"Paukstelis P. J., Proc. Natl. Acad. Sci. U.S.A. 105, 6010 (2008).","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1080\/15216540600551355"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature04531"},{"key":"e_1_3_1_14_2","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/nsmb0108-23","volume":"15","author":"Sancar A.","year":"2008","unstructured":"Sancar A., Nat. Struct. Mol. Biol. 15, 23 (2008).","journal-title":"Nat. Struct. Mol. Biol."}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.1198594","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T14:08:43Z","timestamp":1704895723000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.1198594"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,11,12]]},"references-count":13,"journal-issue":{"issue":"6006","published-print":{"date-parts":[[2010,11,12]]}},"alternative-id":["10.1126\/science.1198594"],"URL":"https:\/\/doi.org\/10.1126\/science.1198594","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,11,12]]}}}