{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T06:09:39Z","timestamp":1768457379882,"version":"3.49.0"},"reference-count":46,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6106","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2012,10,26]]},"abstract":"<jats:title>Making a Move<\/jats:title>\n          <jats:p>\n            Structural Maintenance of Chromosome (SMC) complexes act ubiquitously in chromosome processing in all domains of life, but their mode of action in living cells has remained an enigma.\n            <jats:bold>\n              Badrinarayanan\n              <jats:italic>et al.<\/jats:italic>\n            <\/jats:bold>\n            (p.\n            <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" page=\"528\" related-article-type=\"in-this-issue\" vol=\"338\" xlink:href=\"10.1126\/science.1227126\">528<\/jats:related-article>\n            ) used noninvasive millisecond single-molecule imaging to understand SMC complex molecular biochemistry in living bacterial cells with super-resolution spatial precision.\n            <jats:italic>Escherichia coli<\/jats:italic>\n            SMC complexes, which are important for chromosome segregation, formed dimers that bound to DNA in an adenosine triphosphate (ATP)\u2013dependent manner and that could be released upon ATP-hydrolysis. By functioning in pairs, the complexes are likely to be able to undergo multiple cycles of ATP-hydrolysis without being released from DNA.\n          <\/jats:p>","DOI":"10.1126\/science.1227126","type":"journal-article","created":{"date-parts":[[2012,10,25]],"date-time":"2012-10-25T19:31:32Z","timestamp":1351193492000},"page":"528-531","source":"Crossref","is-referenced-by-count":262,"title":["In Vivo Architecture and Action of Bacterial Structural Maintenance of Chromosome Proteins"],"prefix":"10.1126","volume":"338","author":[{"given":"Anjana","family":"Badrinarayanan","sequence":"first","affiliation":[{"name":"Department of Biochemistry, University of Oxford, UK."}]},{"given":"Rodrigo","family":"Reyes-Lamothe","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Oxford, UK."}]},{"given":"Stephan","family":"Uphoff","sequence":"additional","affiliation":[{"name":"Department of Physics, University of Oxford, UK."}]},{"given":"Mark C.","family":"Leake","sequence":"additional","affiliation":[{"name":"Department of Physics, University of Oxford, UK."}]},{"given":"David J.","family":"Sherratt","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Oxford, UK."}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2011.07764.x"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.74.082803.133219"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2794"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1992.tb05617.x"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02174381"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2007.05881.x"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0923-2508(91)90029-A"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.10.050"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1185757"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature05135"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.77.061906.092014"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M606723200"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7600680"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2011.08.009"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7600264"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2010.12.004"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2003.10.036"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2003.10.030"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.01863-07"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1108408"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2121-6-28"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2008.06.058"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.073866"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2005.12.040"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00412-007-0097-5"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature07098"},{"key":"e_1_3_2_28_2","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1128\/br.36.4.525-557.1972","article-title":"Pedigrees of some mutant strains of Escherichia coli K-12","volume":"36","author":"Bachmann B. 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