{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T21:29:34Z","timestamp":1775856574478,"version":"3.50.1"},"reference-count":52,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6114","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2012,12,21]]},"abstract":"<jats:title>Influenza Revealed<\/jats:title>\n                  <jats:p>\n                    Influenza virus, a single-stranded RNA virus, is responsible for substantial morbidity and mortality worldwide. The influenza ribonucleoprotein (RNP) complex, which carries out viral replication and transcription, is central to the virus life-cycle and to viral host adaptation (see the Perspective by\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6114\" page=\"1545\" related-article-type=\"in-this-issue\" vol=\"338\" xlink:href=\"10.1126\/science.1231588\">\n                      <jats:bold>Tao and Zheng<\/jats:bold>\n                    <\/jats:related-article>\n                    ). Structural characterization of the viral RNP has been challenging, but\n                    <jats:bold>\n                      Moeller\n                      <jats:italic>et al.<\/jats:italic>\n                    <\/jats:bold>\n                    (p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" page=\"1631\" related-article-type=\"in-this-issue\" vol=\"338\" xlink:href=\"10.1126\/science.1227270\">1631<\/jats:related-article>\n                    , published online 22 November) and\n                    <jats:bold>\n                      Arranz\n                      <jats:italic>et al.<\/jats:italic>\n                    <\/jats:bold>\n                    (p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" page=\"1634\" related-article-type=\"in-this-issue\" vol=\"338\" xlink:href=\"10.1126\/science.1228172\">1634<\/jats:related-article>\n                    , published online 22 November) now report the structure and assembly of this complex, using cryo-electron microscopy and negative-stain electron microscopy. The structures reveal how the viral polymerase, RNA genome, and nucleoprotein interact in the RNP providing insight into mechanisms for influenza genome replication and transcription.\n                  <\/jats:p>","DOI":"10.1126\/science.1227270","type":"journal-article","created":{"date-parts":[[2012,11,23]],"date-time":"2012-11-23T20:26:34Z","timestamp":1353702394000},"page":"1631-1634","source":"Crossref","is-referenced-by-count":233,"title":["Organization of the Influenza Virus Replication Machinery"],"prefix":"10.1126","volume":"338","author":[{"given":"Arne","family":"Moeller","sequence":"first","affiliation":[{"name":"National Resource for Automated Molecular Microscopy, Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA."}]},{"given":"Robert N.","family":"Kirchdoerfer","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA."}]},{"given":"Clinton S.","family":"Potter","sequence":"additional","affiliation":[{"name":"National Resource for Automated Molecular Microscopy, Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA."}]},{"given":"Bridget","family":"Carragher","sequence":"additional","affiliation":[{"name":"National Resource for Automated Molecular Microscopy, Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA."}]},{"given":"Ian A.","family":"Wilson","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA."},{"name":"The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA."}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","unstructured":"B. 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